Clinical trials: Radioactive Seed Implantation
High-Burden Metastatic Solid Tumors
Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease
This open-label, randomized Phase II trial evaluates whether a strategy-based, multimodal local treatment approach improves local control compared with single-modality local therapy in patients with high-burden metastatic disease…
- Trial name
- NCT07437625
- Testing
- Iodine-125 (125I) Seed Implantation (Low-Dose-Rate Brachytherapy), cryoablation, Lesion Allocation and Tumor Zoning Strategy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Li Min
Prostate Cancer, Lower Urinary Tract Symptoms
Botulinum Toxin Injection With Prostate Brachytherapy
The purpose of this study is to see if botox injection into the prostate during seed implantation (brachytherapy) for prostate cancer a) improves urinary symptoms or avoids need for urinary tract instrumentation over the 6-8…
- Conditions
- Prostate Cancer, Lower Urinary Tract Symptoms, Radioactive Seed Implantation
- Trial name
- NCT00681148
- Testing
- Botox injection, Saline injection
- Where
- United States
- Sponsor
- Emory University
Brachytherapy, Non-small Cell Lung Cancer
I-125 Seeds Implantation in the Treatment of Recurrent Lung Cancer After Radiotherapy
Patients with recurrence after radiotherapy are often encountered in clinical practice.Patients with recurrence after radiotherapy are less likely to undergo surgery or secondary radiotherapy, and the guidelines recommend only…
- Trial name
- RISIRLC (NCT04071418)
- Testing
- 3D-printing Template-assisted CT-guided I-125 Seeds Implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Thyroid Neoplasms
Clinical Efficacy of 125I Seed Implantation in the Treatment of Refractory Differentiated Thyroid Cancer
A retrospective analysis was conducted on RAIR-DTC patients who underwent radioactive 125I seed implantation from January 2015 to February 2022 at Jiangxi Cancer Hospital. Prescription dose: 80~120 Gy.
- Trial name
- NCT06362772
- Testing
- Iodine-125 brachytherapy
- Volunteers
- 36 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Recurrent Rectal Cancer, 125I Seeds Implantation
CTV Exploration of 3D-PT Assisted CT-guided I-125 Seeds Implantation for Recurrent Rectal Cancer
This study is to explore the progression-free survival time (PFS) , overall survival time (OS), quality of life and side effects between two different clinical target volumes in the treatment of 3D printing template-assisted…
- Conditions
- Recurrent Rectal Cancer, 125I Seeds Implantation, Clinical Target Volume
- Trial name
- NCT04710589
- Testing
- CTV
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Prostate Cancer
Robotic Seed Implantation for Prostate Cancer Brachytherapy
A robotic brachytherapy device will be used to assist physicians in performing seed implantation to the prostate. EUCLIDIAN is the first robotic system designed to allow automatic placement of radioactive seeds by robot and thus…
- Trial name
- EUCLIDIAN (NCT01341288)
- Testing
- EUCLIDIAN Robot
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
HCC - Hepatocellular Carcinoma, 125I Seeds Implantation
PD-1 Inhibitor Combined With 125I Seed Implantation for Hepatocellular Carcinoma's Extrahepatic Metastasis: Efficacy and Safety
This study aims to explore the effectiveness and safety of 125I seed implantation in the treatment of hepatocellular carcinoma (HCC) with extrahepatic metastases, and to compare the efficacy differences between PD-1 inhibitor…
- Trial name
- NCT06991907
- Testing
- 125I seed implantation, PD-1 Inhibitors
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Malignant Tumor of Head and/or Neck
3D-PCT Combined With CT-guided Radioactive I-125 Seed Implantation in the Treatment of Head and Neck Tumors
The purpose of this study is to verify the accuracy, short-term efficacy and side effects of 3D printing coplanar template combined with CT-guided I-125 seeds implantation in the treatment of malignant tumors of the head and neck.
- Trial name
- NCT05421507
- Testing
- Radioactive Iodine-125 Seeds Implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Brachytherapy, Desmoid Tumor
CT-guided Radioactive Iodine-125 Seed Implantation for Recurrent Desmoid Tumors
This study aimed to explore the long-term outcomes of CT-guided radioactive iodine-125 (I-125) seed implantation (RISI) for recurrent desmoid tumor.
- Conditions
- Brachytherapy, Desmoid Tumor, Radioactive Iodine-125 Seed Implantation
- Trial name
- NCT06195085
- Testing
- CT-guided radioactive iodine-125 seed implantation
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Peking University Third Hospital
Malignant Obstructive Jaundice
Comparison of Two Seed Strand Implantation Techniques for Biliary Cancer
This study aimed to compare the safety and effectiveness of two different methods for fabricating and implanting Iodine-125 (^125^I) radioactive seed strands combined with a metal stent for treating malignant obstructive…
- Trial name
- NCT07381439
- Testing
- Percutaneous transhepatic biliary stenting with conventional linear ^125^I seeds strand, Percutaneous transhepatic biliary stenting with novel spiral ^125^I seeds strand
- Where
- China
- Volunteers
- 105 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Oligometastatic Disease
125I Seed Implantation Plus Systemic Therapy for Oligoprogressive NSCLC or Colorectal Cancer
Most patients with metastatic cancer eventually develop resistance to systemic therapy. A subset of patients experience oligoprogression, characterized by progression at a limited number of lesions while other disease sites…
- Trial name
- NCT07333651
- Testing
- Standard-of-Care Systemic Therapy, 125I Seed Implantation
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Li Min
Early Stage Breast Cancer
Partial Breast Irradiation Using Interstitial Permanent Palladium-103 Seed Implant
Permanent Breast Seed Implant (PBSI) has been demonstrated to be a well accepted and well tolerated form of partial breast radiotherapy.
- Trial name
- PBSI (NCT02297672)
- Testing
- Stranded palladium seed interstitial implant, 3 dimensional breast ultrasound, Computerized tomography (CT)
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- British Columbia Cancer Agency
Unresectable Solid Tumors
SEED-CRYO: Sequential 125I Seed Implantation Followed by Cryoablation vs Single-Modality Local Therapy in Unresectable Solid Tumors
This open-label, randomized Phase II trial evaluates whether sequential iodine-125 seed implantation followed by cryoablation improves local tumor control versus single-modality local therapy (125I seeds alone or cryoablation…
- Trial name
- NCT07450352
- Testing
- Iodine-125 (125I) Seed Implantation, cryoablation, Sequential 125I Seed Implantation Followed by Cryoablation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Li Min
Prostatic Neoplasms, Cancer of the Prostate
Hemi-Ablative Prostate Brachytherapy
This clinical study will evaluate side effects, quality of life and cancer control in patients with prostate cancer diagnosed on only one side of the prostate gland.
- Trial name
- HAPpy (NCT02632669)
- Testing
- Hemigland focal LDR brachytherapy
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Prostate Cancer
Efficacy of Prostate Seed Implantation for Local Control of Early Stage Prostate Cancer
The primary goal of this project is to evaluate the efficacy of prostate seed implantation for the treatment of early stage prostate cancer for patients treated at Summa Health System/Akron City Hospital and Salem Community…
- Trial name
- NCT00773305
- Volunteers
- 200 people
- Sponsor
- Summa Health System
Prostate Cancer Patients Undergoing External Radiation and Seed Implantation
Palladium-103 Seed Implant and Single Daily Dosing of Uroxatral Vs. Twice Daily Dosing of Flomax- A 3 Month Retrospective Efficacy Analysis
In the past ten years, newer drugs with more selective affinity for the alpha-receptor have been introduced. Alfuzosin (Uroxatral) and Tamulosin(Flomax are two second generation alpha-blockers.
- Trial name
- NCT00264017
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Dattoli Cancer Center and Brachytherapy Research Institute
Rectum Cancer, Recurrent, Brachytherapy, Radioisotope
The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy
This study observes the efficacy and side effects of 3D-printing non co-planar template(3D-PNCT) assisted with CT-guidance for radioactive Iodine-125 seed(RIS) brachytherapy in pelvic recurrent rectum carcinoma retrospectively…
- Trial name
- NCT03890926
- Testing
- radioactive Iodine-125 seed implantation under the guidance of 3D template
- Volunteers
- 66 people
- Sponsor
- Peking University Third Hospital
Metastatic Solid Tumors
Image-Guided 125I Seed Implantation Plus Standard Systemic Therapy for Patients With Multiple Metastatic Lesions
Patients with more than five and up to ten metastatic lesions often have limited tolerance for surgery, radiotherapy, or thermal ablation because of cumulative treatment burden or expected toxicity.
- Trial name
- NCT07333664
- Testing
- Standard-of-Care Systemic Therapy, Iodine-125 (125I) Seed Implantation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Li Min
Pancreatic Cancer
Iodine-125 Seed Implantation Therapy for Locally Advanced Pancreatic Cancer
This study evaluates the application of 3D-printed template for iodine-125 seed implantation therapy in patients with locally advanced pancreatic cancer.
- Trial name
- NCT03882866
- Testing
- 3D-printed non-coplanar template, 3D-printed coplanar template
- Where
- 8 sites in China
- Volunteers
- 220 people
- Sponsor
- Ruijin Hospital
Prostate Cancer (Diagnosis), Prostate Cancer Patients Who Have Brachytherapy Seed Implant
Immune Biomarkers in Prostate Cancer Patients Treated With Brachytherapy
Analysis of peripheral immune cells before, during, and after brachytherapy treatment. Corresponding analysis of tissue samples collected during brachytherapy treatment.
- Conditions
- Prostate Cancer (Diagnosis), Prostate Cancer Patients Who Have Brachytherapy Seed Implant, Prostate Cancer Patients Treated by Radiotherapy, Prostate Cancer Recurrent
- Trial name
- NCT07131956
- Where
- 3 sites in Germany
- Volunteers
- 200 people
- Sponsor
- University of Erlangen-Nürnberg Medical School