Clinical trials: Randomized Clinical Trial
Rabies
A Phase 3 Clinical Trial for a Rabies Vaccine (Vero Cell) for Human Use in Healthy Chinese Subjects
The purpose of this single-centre, randomized, double-blind, parallel control, phase 3 study is to evaluate the safety and immunogenicity of a rabies vaccine (Vero Cell) for human use in healthy Chinese subjects aged 10-60 years…
- Trial name
- NCT02491541
- Testing
- Changchun Werersai, Jilin Maifeng
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Malaria, Mosquito-Borne Disease
Evaluation of the Protective Efficacy of a Spatial Repellent to Reduce Malaria Prevalence in Uganda
A cluster-randomized double-blinded control trial will be conducted in Uganda to demonstrate and quantify the protective efficacy (PE) of Mossie-GO, an active spatial repellent system disseminating transfluthrin, in reducing the…
- Trial name
- Mossie-GO (NCT06232954)
- Testing
- Mossie-Go containing treated transfluthrin disc, Mossie-Go containing untreated blank disc
- Where
- Uganda
- Volunteers
- 5,600 people, healthy volunteers welcome
- Sponsor
- Africa Power Limited
Hemiplegia, Cerebral Palsy
Bimanual Training in Children With Hemiplegia
A randomized control trial of bimanual training in children with hemiplegia. The protocols have been developed at Columbia University to be child friendly and draws upon our experience since 1997 with constraint-induced movement…
- Conditions
- Hemiplegia, Cerebral Palsy, Children
- Trial name
- HABIT (NCT01413594)
- Testing
- HABIT
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Teachers College, Columbia University
Female Athletes, Neuromuscular Training
Proprioception, Motor Control and Injury Risk on Female Wrestlers
This study aimed to examine the effect of a 4-week neuromuscular balance-based training program on landing mechanics as reflected by the Landing Error Scoring System-Real Time (LESS-RT), together with associated changes in knee…
- Conditions
- Female Athletes, Neuromuscular Training, Proprioception, Postural Balance
- Trial name
- NCT07504666
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Arsenic Poisoning, Environmental Exposure
Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire
The goals of this clinical trial are to: 1. gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (>5 μg/L)…
- Conditions
- Arsenic Poisoning, Environmental Exposure, Water-Related Diseases
- Trial name
- NCT07103356
- Testing
- Water Pitcher Filtration System
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Anxiety
The Effectiveness of Virtual Reality on Anxiety Reduction in Women Undergoing Elective Egg Cryopreservation.
A randomized trial assessing the effectiveness of virtual reality exposure prior to an oocyte retrieval procedure in terms of anxiety level .
- Trial name
- VRFORANXIETY (NCT06280222)
- Testing
- The VR instrument - Oculus Quest 2
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Preeclampsia
ToRsemide for pOstpartum HYpertension
Currently there is no intervention to prevent persistent postpartum hypertension in preeclamptic women. Physiologically, the use of a pharmacokinetically predictable loop-diuretic is a reasonable intervention to increase…
- Trial name
- TROPHY (NCT02813551)
- Testing
- Torsemide
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Mortality Through Six Months of Age, Vitamin A Deficiency
Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh
The purpose of this trial is determine whether a 50,000 IU oral dose of vitamin A delivered to newborn infants within the first days of life, reduces six-month infant mortality by at least 15%.
- Trial name
- NCT00128557
- Testing
- vitamin A supplementation (15,000 ug retinol equivalents or 50,000 IU)
- Where
- Bangladesh
- Volunteers
- 15,937 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Relapse
"Comparative Evaluation of 3 Dimensional Changes of Dentition in Post Orthodontic Patients With Immediate vs Delayed (Post 24 Hours) Retainer Delivery
Orthodontic treatment goals can be expressed as achieving ideal tooth alignment, esthetic, functional occlusion and stability. Various occlusal changes occur after active phase of orthodontic treatment, these unwanted changes are…
- Trial name
- NCT05879601
- Testing
- immediate orthodontic retainer delivery, delayed orthodontic retainer delivery.
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
HIV Infection
Immunogenicity and Safety of 4 Prime-boost Combinations of HIV Vaccine Candidates in Healthy Volunteers
The development of a safe and effective HIV-1 vaccine strategy would probably be the best solution for the ultimate control of the worldwide AIDS pandemic.
- Trial name
- VRI01 (NCT02038842)
- Testing
- LIPO-5, MVA HIV-B (MVATG17401), GTU®-MultiHIV B: 0.5 mL IM via Biojector® 2000 and 0.5mL IntraDermic, 3 shots
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Prolonged Grief Symptoms
Ericksonian Hypnosis Versus CBT for Prolonged Grief
Effects of Ericksonian Hypnotherapy Versus Cognitive Behavioral Therapy on Prolonged Grief Among University Students in Istanbul: A Randomized None-clinical Controlled Trial This randomized controlled trial explores the efficacy…
- Trial name
- NCT06398886
- Testing
- Ericksonian Hypnosis, Cognitive Behavioral Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Dental Caries
Selective Caries Removal (SCR) Versus Pulpotomy in Preventing Pulp Necrosis and Apical Periodontitis
The study design is a randomized controlled trial and up to 120 teeth, 50 in each of the 2 groups, will be enrolled from the patients at the National University Centre for Oral Health Singapore (NUCOHS) Endodontic unit.
- Trial name
- NCT04672070
- Testing
- Selective Caries Removal, Pulpotomy
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Postoperative Retention of Urine
Effect of Preoperative Tamsulosin on Postoperative Urinary Retention
Approximately 25-30% of patients experience postoperative urinary retention after female pelvic surgery with mid-urethral sling placement. These patients are discharged home with a foley catheter for a few days.
- Trial name
- NCT05753670
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Diabete Type 2, Cardio Respiratory Fitness
Evaluate the Effect of Remote Exercise Intervention on Blood Glucose Control and Physical Fitness in T2DM Patients
The intervention group received 12 weeks of continuous remote intervention combined with health education. The control group only received 12 weeks of continuous health education, and the content and frequency were the same as…
- Trial name
- NCT07676773
- Testing
- Remote Exercise + Health Education, Health Education
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences
Total Knee Arthroplasty, Pain Management
Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel
A prospective, randomized control study will be conducted to compare postoperative pain control in a series of patients treated with either: 1. a local cocktail. 2. a local cocktail plus Exparel. 3.
- Trial name
- NCT02571283
- Testing
- Cocktail, Exparel, Marcaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Safety, Adverse Event Following Immunisation
Safety of RIV4 Versus IIV4 in Pregnant Women
This is a prospective, randomized clinical trial. During the study, pregnant women will be randomized (1:1) to receive RIV4 or IIV4. Vaccines will be administered by licensed providers.
- Conditions
- Safety, Adverse Event Following Immunisation, Birth Outcomes
- Trial name
- NCT03969641
- Testing
- Quadrivalent Recombinant Influenza Vaccine, Quadrivalent Inactivated Influenza Vaccine
- Where
- 3 sites in United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Duke University
Altitude Hypoxia
Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on postural control in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536429
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Immediate Implant
Buccal Plate Augmentation Using Sticky Bone With Simultaneous Immediate Implant Placement
the aim of this study is to clinically assess pink esthetic score following Buccal Plate Augmentation using Sticky Bone versus usage of Sticky Bone as a jumping gap filling material with simultaneous immediate implant placement…
- Trial name
- NCT06642753
- Testing
- immediate implant with buccal plate augmentation using sticky bone, immediate implant with sticky bone as a filling material in the jumping gap
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Oral Health
Effect of Probiotics Containing Yogurts on the Composition of Biofilms in Patients Under Orthodontic Treatment
Aim: To assess in vivo if the intake of yogurt containing Bifidobacterium animalis ssp. lactis DN- 1173010 probiotic for a period of 2 weeks affects the salivary levels or biofilms of mutans streptococci and the lactobacilli of…
- Trial name
- NCT01657539
- Testing
- Yogurt containing probiotics
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Respiratory Tract Infections
Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infections
The investigators earlier clinical study in 754 young Finnish men demonstrated a significant negative association of serum 25-OHD concentration with acute respiratory tract infections.
- Trial name
- NCT00973583
- Testing
- vitamin D
- Where
- Finland
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Tampere University
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