Clinical trials: Randomized Clinical Trial
Low Back Pain
The Efficacy of A Smartphone Application in Treating Non-Specific Low Back Pain
Evaluating the efficacy of a newly developed self-monitored mobile application in reducing office workers low back pain.
- Trial name
- NCT03994458
- Testing
- Smartphone Full version application, Samartphone limited version application
- Where
- Jordan
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Gynecologic Surgical Procedures, Hysterectomy
Testing of the Drug Tranexamic Acids as Prophylaxis of Bleeding in Benign Surgical Removal of the Uterus
In Denmark, 4400 women annually undergo hysterectomy on benign background (surgical removal of the uterus). 10% of these women experience bleeding complications.
- Conditions
- Gynecologic Surgical Procedures, Hysterectomy, Tranexamic Acid
- Trial name
- PeTraH (NCT01940419)
- Testing
- Tranexamic Acid
- Where
- Denmark
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Hillerod Hospital, Denmark
Anesthesia; Functional, Anesthesia
The Efficacy of 20 mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery
This clinical trial aims to investigate the efficacy of 20 mg Parecoxib when it is given as an addition to 20 ml 0.75% ropivacaine in patients receiving ultrasound-guided supraclavicular brachial plexus block prior to the upper…
- Trial name
- RCT (NCT03480165)
- Testing
- Parecoxib 20 MG/ML, Ropivacaine
- Where
- Malaysia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Anal Dysplasia, Human Papillomavirus
The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Infection by certain high-risk oncogenic types of HPV (HR-HPV) is the major cause of several cancers in men, notably squamous cell carcinoma…
- Conditions
- Anal Dysplasia, Human Papillomavirus, Anal Cancer
- Trial name
- HPV-SAVE (NCT02503111)
- Testing
- The Hyfrecator ® 2000 Electrosurgical System, Observation Alone
- Where
- 4 sites in Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Adolescent - Emotional Problem, Parent Child Relationship
Randomized Controlled Trial of a Family-focused Intervention for Caregivers and Young Adolescents (Phase 3 of FLOURISH)
The aim of this study is to conduct a multi-country randomized waitlist controlled trial to evaluate the effectiveness, cost-effectiveness, and scalability of the optimized Parenting for Lifelong Health (PLH) for Parents and…
- Conditions
- Adolescent - Emotional Problem, Parent Child Relationship, Family Functioning, Well-Being, Psychological
- Trial name
- FLOURISH (NCT07240571)
- Testing
- Optimized Parenting for Lifelong Health (PLH) for Parents and Teens
- Where
- 2 sites in Moldova, North Macedonia
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- University of Klagenfurt
HCV
TMC435350-TiDP16-C109: A Safety Study for TMC435350 in an Oral Solution Containing Either 100, 200 or 400 mg Equivalent of TMC435350 or Placebo in Healthy Japanese Male Volunteers
The purpose of this study is to evaluate the safety and tolerability of three different doses of TMC435350 compared to placebo in healthy Japanese males.
- Trial name
- NCT00752544
- Testing
- TMC435350
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Dysuria
Pain Outcomes During Rigid Cystoscopy in Females With and Without Cystoscopic Sheath Obturator
Rigid cystoscopy is a common procedure to evaluate lower urinary tract symptoms in females. This procedure can be done with or without an instrument called a sheath obturator.
- Trial name
- NCT05152199
- Testing
- Cystoscopy - with use of obturator sheath, Cystoscopy - without use of obturator sheath
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Todd Moyerbrailean DO FACOG
Blood Loss, Surgical
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS.
- Trial name
- NCT06725732
- Testing
- Tranexamic Acid (TXA), Tranexamic Acid
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Aggressive Periodontitis, Generalized
Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis
The aim of this project is to compare the efficacy and the local effect of the association of single or repeated application of photodynamic therapy (PDT) with antibiotic agents using Amoxicillin + Metronidazole or Clarithromycin…
- Trial name
- NCT03132714
- Testing
- Full-mouth ultrasonic debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
COVID-19, Respiratory Tract Infections
The Protective Effect of Mask Wearing Against Respiratory Tract Infections
In this trial the researchers plan to recruit 4,000 volunteers to be randomly allocated either wearing face masks in public spaces where they are close to other people, or not wear face masks in such circumstances.
- Trial name
- NCT05690516
- Testing
- Wearing face masks
- Where
- Norway
- Volunteers
- 4,575 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Headache, Intranasal Ketamine
"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
This is a randomized, single-blind, placebo controlled trial to evaluate the efficacy of sub-dissociative dose ketamine versus standard care therapy for acute headache management of in patients presenting to the emergency…
- Trial name
- THINK (NCT03081416)
- Testing
- Ketamine, Normal saline, Metoclopramide
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Infertility
Long Protocol and Growth Hormone in Poor Responders
The long down regulation protocol is widely used in the in vitro fertilization cycles, now it will be assessed regarding its efficacy, in poor responder females undergoing in vitro fertilization cycles, alone and after the…
- Trial name
- NCT02338206
- Testing
- Growth hormone
- Where
- Egypt
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
HIV, HIV Testing
Home-based Intervention to Test and Start
This study aims to establish the causal impact of two interventions - micro-incentives and a male-sensitive HIV- specific decision support app - on population-level HIV viral load and HIV-related mortality in men, as well as on…
- Conditions
- HIV, HIV Testing, Linkage to Care
- Trial name
- HITS (NCT03757104)
- Testing
- micro-incentive, EPIC-HIV, micro-incentive and EPIC-HIV
- Where
- South Africa
- Volunteers
- 4,667 people, healthy volunteers welcome
- Sponsor
- Africa Health Research Institute
Acupuncture Therapy
Using Omics Technology to Explore the Mechanism of Acupuncture Treatment of Different Acupoints of Knee Osteoarthritis
In recent years, commonly used Omics techniques, including genomics, proteomics, metabolomics, have been applied in the studies on the mechanism of acupuncture effect.
- Trial name
- NCT04733352
- Testing
- acupuncture
- Where
- 2 sites in Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Ankle Injuries
Percussive Therapy Reduced EMG Activity During Calf Raise in Limbs With and Without Chronic Ankle Instability
To examine the acute effect of percussive therapy on peak calf muscle activation during standing heel raise in subjects with and without chronic ankle instability (CAI).
- Trial name
- NCT06343207
- Testing
- Percussive massage gun therapy
- Where
- Czechia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Distal Radius Fractures, Wrist Fracture
Unstable Distal Radius Fractures With Dorsal Dislocation in Patients Aged 18-64 Years. Volar Locking Plate (VLP) vs Closed Reduction and Percutaenous Pinning (CRPP).
120 patients age 18-64 years with dorsally displaced distal radius fractures AO-type A2, A3 and C1 are recruited from Oslo Casualty Medical Centre (Oslo Skadelegevakt).
- Conditions
- Distal Radius Fractures, Wrist Fracture, Colles' Fracture
- Trial name
- NCT04716309
- Testing
- Open reduction and volar locking plate and closed reduction and K-wires.
- Where
- Norway
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Infant Pain Management
White Noise and Buzzy for Reducing Pain During Infant Vaccination
This randomized controlled trial aims to evaluate the effectiveness of two non-pharmacological methods-white noise and the Buzzy device-in reducing pain experienced by infants during routine vaccination.
- Trial name
- NCT07286721
- Testing
- Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Paralytic Ileus
The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section
Following all abdominal surgery, paralytic ileus commonly develops. Surgeons have traditionally withheld postoperative oral intake until the return of bowel function to prevent related complications.
- Trial name
- GUM01 (NCT01131416)
- Testing
- Gum chewing
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Flumazenil Adverse Reaction, Ambulatory Surgery
Reversal of Remimazolam by a Single Dose of Flumazenil
Remimazolam, a brand-new sedative which has benzodiazepine property. It is an ultra-short acting sedative and regarded as a proper drug for procedural sedation.
- Conditions
- Flumazenil Adverse Reaction, Ambulatory Surgery, Postoperative Nausea, Remimazolam
- Trial name
- NCT05382806
- Testing
- Flumazenil
- Where
- South Korea
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center