Clinical trials: Randomized Clinical Trial
Pharyngitis, Dysphonia
The Use of Osteopathic Medical Manipulation to Decrease the Incidence and Severity of Post-Operative Sore Throat
Post-operative sore throat (POST) ranks as the 8th most undesirable effect in the post-operative period and is noted by up to 90% of patients receiving an endotracheal tube.
- Trial name
- NCT03720301
- Testing
- Osteopathic Manipulation Treatment
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Bioavailability and Pharmacokinetics
Silymarin Bioavailability Study
This study seeks to evaluate and compare the pharmacokinetics of a novel micellar silymarin formulation with that of a standard silymarin formulation.
- Trial name
- NCT06882681
- Testing
- LipoMicel Milk Thistle, Unformulated Milk Thistle Extract
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Isura
Gummy Smile, Altered Passive Eruption of Teeth
Clinical Evaluation of Gingivalstat Approach Compared to Conventional Esthetic Crown Lengthening on the Stability of The Gingival Margin in Patients With Altered Passive Eruption.
When performing crown lengthening surgery, especially in the esthetic zone, the positional stability of gingival tissues is considered a prime important goal.
- Conditions
- Gummy Smile, Altered Passive Eruption of Teeth, Healthy Participants
- Trial name
- NCT07041541
- Testing
- Esthetic Crown Lengthening, Esthetic Crown Lengthening using GingivalStat approach
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Prescribing, Off-Label
CMO Letter to Reduce Unnecessary Antibiotic Prescribing and Broad Spectrum Prescribing Winter 2018-9
This trial aims to reduce unnecessary prescription of antibiotics and broad spectrum antibiotics by general practitioners (GPs) in England.
- Trial name
- CMO2018-9 (NCT03862794)
- Testing
- new social norm feedback letter with bar chart, standard social norm feedback letter
- Where
- United Kingdom
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Public Health England
Hiv
Pharmacy-based PrEP Delivery in Kenya
A cluster-randomized control trial (cRCT) testing different cost-sharing models for the delivery of HIV pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) services at private pharmacies in Kenya.
- Trial name
- NCT05842122
- Testing
- Client-sustained delivery of pharmacy PrEP/PEP, Implementor-sustained delivery of pharmacy PrEP/PEP, Counselor-supported delivery of pharmacy PrEP/PEP
- Where
- 2 sites in Kenya
- Volunteers
- 5,808 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Computer, Screening
Computer-assisted Psychosocial Risk Assessment (CaPRA) for Refugee Health and Settlement
The purpose of this study was to examine preliminary effect of Computer-assisted Psychosocial Risk Assessment tool (CaPRA) among Afghan refugees visiting medical professionals (family physicians or nurse practitioners) at a…
- Conditions
- Computer, Screening, Decision Support System, Primary Care
- Trial name
- CaPRA (NCT01427829)
- Testing
- Computer-assisted Psychosocial Risk Assessment (CaPRA)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Volunteer
A Trial to Learn if Single Ascending Intravenous (IV) Doses of REGN7508 Are Safe and Well Tolerated, and How it Works in the Body of Healthy Adult Participants
This study is researching an experimental drug called REGN7508 (called "study drug"). The aim of this study is to see how safe and tolerable the study drug is in healthy participants.
- Trial name
- NCT05603195
- Testing
- REGN7508 (IV), REGN7508 (SC)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Pelvic Floor Disorders, Stress Urinary Incontinence
Educating Women About Pelvic Floor Disorders During Pregnancy
The purpose of this study is to assess the increase in knowledge of pregnant patients regarding pelvic floor disorders when comparing two educational interventions: written handouts vs interactive workshops.
- Conditions
- Pelvic Floor Disorders, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT05440539
- Testing
- Written Handouts, Interactive Workshop
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
HPV, HPV Vaccine
Digital Interventions to Increase HPV Vaccination Intentions Among Nigerian Caregivers
This study evaluates whether different types of digital health communication can increase parents' intention to vaccinate their daughters against human papillomavirus (HPV) in Nigeria.
- Trial name
- NCT07498075
- Testing
- Chatbot counseling, Misinformation-resistance pre-bunking inoculation, Short edutainment
- Where
- Nigeria
- Volunteers
- 3,340 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dental Caries
Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid
This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.
- Trial name
- NCT03143023
- Testing
- arginine toothpaste, fluoride toothpaste
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Proximal Contacts, Zirconia Crowns
Proximal Contact Tightness of Zirconia Crowns: Digital Intraoral Scanning vs Conventional Impressions
We will be comparing the proximal contacts of zirconia crowns and adjacent natural teeth in two groups. One receiving crowns fabricated via digital intra oral scanning means.
- Trial name
- PCT (NCT07142746)
- Testing
- Digital intra oral scanning, Conventional impression
- Where
- Pakistan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
IUD Insertion
Self-Administered Lidocaine Gel for Pain Management With IUD Insertion
For intrauterine device (IUD) insertion, currently there are no standardized clinical guidelines for pain management. The investigators aim to explore whether adequate pain relief is possible through self-administered…
- Trial name
- SALUD (NCT02738203)
- Testing
- Vaginal 2% Lidocaine, Surgical Lubricant Jelly
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Stanford University
Polycystic Ovary Syndrome, Insulin Resistance
Acupuncture or Metformin for Insulin Resistance in Women With PCOS
The hypothesis is that acupuncture is equally effective as metformin (both treatments combined with lifestyle management) in improving whole body glucose homeostasis in insulin resistant women with polycystic ovary syndrome…
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Hyperandrogenism
- Trial name
- PIAII (NCT02647827)
- Testing
- Lifestyle management, Acupuncture, Metformin
- Where
- 2 sites in China, Sweden
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Resistance Training
Training-induced Muscle Strength and Its Role in Interface Pressure in Inelastic Compression
The present study will answer the following question: what are the effects of strength gain and muscle hypertrophy on interface pressure, static stiffness index, and working pressure amplitude in the elderly using inelastic…
- Trial name
- NCT05023642
- Testing
- resistance training
- Where
- 2 sites in Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pró Circulação®
Executive Function, School Readiness
Playful Physical Activity Program and Executive Function in Preschool Children
This randomized controlled trial evaluates the effects of an 8-week cognitively enriched playful physical activity program on executive functions and school readiness in preschool children.
- Trial name
- NCT07488286
- Testing
- Playful Physical Activities, Standard Physical Education Group
- Where
- Tunisia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Monira Aldhahi
Gingival Health, Crowding of Anterior Mandibular Teeth
To Compare the Effects of Lip Bumper Appliance in Rate of Lower Incisor Alignment After First Premolar Extractions
The goal of this clinical trial is to check the effects of lip bumper appliance contribution to driftodontics after designated tooth extractions that are already part of orthodontic treatment plan.
- Trial name
- NCT06929754
- Testing
- Lip bumper
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bahria University
Streptococcus Pneumoniae Pneumonia
Phase Ⅱ Clinical Trial of 24-valent Pneumococcal Polysaccharide Conjugate Vaccine
In the treatment of pneumococcal diseases, the common use of penicillin-based antimicrobial agents has led to drug resistance, which has become a global challenge. Therefore, disease prevention through vaccination is essential.
- Trial name
- NCT07035054
- Testing
- low dose-1, low dose-2, high dose
- Where
- China
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Employee Well-being, Work-related Outcomes
Effectiveness of a Multi-Modal Workplace Rest Cabin on Worker Well-Being
This study examines whether access to a rest cabin in the workplace supports employee well-being. Employees of a Canadian insurance company are randomly assigned to one of two groups: immediate access to the rest cabin or a…
- Trial name
- RECHARJME-RCT (NCT07322354)
- Testing
- Recharjme Multi-Modal Rest Cabin
- Where
- 4 sites in Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Laval University
Skin Laxity
Injectable Poly-L-Lactic Acid for Volumization and Adipogenesis of the Hip Dell
To assess the safety, efficacy and subject satisfaction associated with volumization of the hip dell with injectable poly-L-lactic acid (PLLA), or Sculptra® Aesthetic (Galderma Laboratories, Fort Worth, TX).
- Trial name
- NCT05269654
- Testing
- injectable poly-L-lactic acid, Normal Saline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Pain, Acute, Head and Neck Cancer
Topical Anaesthesia in Cutaneous Head and Neck Surgery
This study aims to assess if EMLA or ethyl chloride spray are effective in reducing the pain associated with local anaesthetic administration in cutaneous surgery of the head and neck compared to a placebo and control group…
- Conditions
- Pain, Acute, Head and Neck Cancer, Cutaneous Tumor
- Trial name
- NCT06274905
- Testing
- EMLA, Ethyl chloride, Aqueous cream BP
- Where
- Ireland
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital Waterford
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