Clinical trials: Randomized Clinical Trial
Rheumatoid Arthritis
A Single Ascending Dose Clinical Trial to Find the Maximum Tolerable Dose of HL237 in Healthy Male Subject
HL237 is a new autoimmune therapeutic agent for rheumatoid arthritis, including the basic structure of biguanide in metformin, an existing diabetes drug. The immune modulating activity of HL237 was demonstrated in animal model.
- Trial name
- NCT03278470
- Testing
- HL237
- Where
- South Korea
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.
Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety, Pre-operative Anxiety
Effects of Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety for Patients Undergoing Elective Surgery
This study is a pilot randomized controlled trial (RCT) conducted at Tin Shui Wai Hospital to evaluate the effectiveness of a mobile-based mindfulness intervention in reducing preoperative anxiety among patients scheduled for…
- Conditions
- Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety, Pre-operative Anxiety, Postoperative Pain, Postoperative Use of Analgesics
- Trial name
- NCT07005973
- Testing
- mobile-based mindfulness intervention
- Where
- Hong Kong
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
Post Traumatic Stress Disorder (PTSD), Addiction
Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
This is a randomized controlled Phase II clinical trial designed to evaluate the effects of N-acetylcysteine (NAC) in reducing Alcohol Use Disorder (AUD) severity and Post Traumatic Stress Disorder (PTSD) symptomatology among…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
- Trial name
- NCT02966873
- Testing
- N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Tooth Extraction Status Nos
The Effect of Chamomile on Healing After Tooth Extraction
After impacted wisdom tooth extraction, patients frequently complain of pain, edema, and limited mouth opening. After the procedure, patients are routinely recommended to use chlorhexidine and physiological serum-based…
- Trial name
- NCT06770166
- Testing
- Physiological serum mouthwash, Chlorhexidine mouthwash, Chamomile mouthwash
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- reyhan saglam-dogu
Mindfulness, Occupational Stress
Are Mindfulness Programs in the Workplace Effective at Reducing Stress
The objective of this study is to determine whether a mindfulness coaching program was efficacious at reducing work stress, improving psychological and physical health outcomes, and improving work outcomes.
- Trial name
- NCT04425356
- Testing
- LifeXT Program
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Hyperglycemia, Postprandial
Effect of Baobab Fruit on Postprandial Glycaemia in Healthy Adults
Baobab fruits have been traditionally used in Africa due to its therapeutic proprieties attributed to it high polyphenol content.
- Trial name
- NCT05140629
- Testing
- Baobab fruit aqueous extract
- Where
- Portugal
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Nodular Basal Cell Carcinoma
Surgery Versus Combined Treatment With Curettage and Imiquimod for Nodular Basal Cell Carcinoma
Basal cell carcinoma (BCC) is a slow-growing, locally invasive malignant epidermal skin tumour. It is the most common malignant disease in Caucasians, representing approximately 80% of all cases of skin cancer and is therefore an…
- Trial name
- SCIN (NCT02242929)
- Testing
- Imiquimod 5% cream with prior curettage, Standard surgical excision
- Where
- Netherlands
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Patellar Tendinopathy
Transcranial Direct Current Stimulation on Functionality and Pain in Individuals With Patellar Tendinopathy
The aim of the present study is to investigate the effectiveness of transcranial direct current stimulation (tDCS) prior to a therapeutic eccentric exercise program on parameters related to pain and functionality in individuals…
- Trial name
- NCT06729437
- Testing
- tDCS + Therapeutic eccentric exercise
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Malaria
Trial to Evaluate the Safety and Immunogenicity of a Placental Malaria Vaccine Candidate (PRIMVAC ) in Healthy Adults
The primary objective of the study is to evaluate the safety of 3 different dosages (20µg - 50µg and 100µg) of a placental malaria vaccine candidate (PRIMVAC vaccine) adjuvanted either with Alhydrogel® or GLA-SE, and administered…
- Trial name
- PRIMALVAC (NCT02658253)
- Testing
- PRIMVAC, GLA-SE, Alhydrogel
- Where
- 2 sites in Burkina Faso, France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Acute Pain
Effects Of Intravenous Oxytocin On Peripheral Sensory Afferents Using Microneurography
The goal of this clinical trial is to learn if oxytocin reduces pain in a small area of skin after pulses of non-burning heat by changing how nerves in the heated area react to pressing a thin, bendable plastic bristle and a…
- Trial name
- PAINOXY (NCT07409753)
- Testing
- Intravenous Oxytocin
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Randomized Controlled Trial
Effectiveness of a Peer-led Pain Management Program
Objective: To evaluate the efficacy of a peer-led pain management program (PAP) in improving pain self-efficacy, reduce pain, enhancing use of drugs and non-drug methods and quality of life among nursing home residents…
- Trial name
- NCT03823495
- Testing
- 12-week PAP
- Where
- Hong Kong
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Pneumococcal Diseases
A Study to Evaluate 20vPnC in Healthy Chinese Infants
The purpose of this study is to evaluate a study vaccine called 20-valent pneumococcal conjugate vaccine (20vPnC). The study will assess whether the study vaccine is safe to use in healthy infants.
- Trial name
- NCT07754539
- Testing
- 20vPnC, 13vPnC
- Where
- 4 sites in China
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Pfizer
Enterovirus Infections, Influenza
Evaluation of the Safety and Immunogenicity of Simultaneously Administration of EV71 Vaccine and Influenza Vaccine
Subjects will be recruited and divided into 3 groups: 1. Experimental Group (378 subjects): combined immunization of EV71 vaccine and influenza vaccine; 2. Control Group A (378 subjects): EV71 vaccine only; 3.
- Trial name
- NCT04091880
- Testing
- EV71 vaccine and influenza vaccine, EV71 vaccine, influenza vaccine
- Where
- China
- Volunteers
- 1,134 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
Influenza, Tetanus
Increasing Vaccine Uptake Among Veterans at the Atlanta VA Health Care System
The Office of Evaluation Sciences is collaborating with Emory University and the Atlanta VA Health Care System to increase adult immunizations uptake among veterans.
- Conditions
- Influenza, Tetanus, Diphtheria, Pertussis
- Trial name
- NCT03950986
- Testing
- Modified clinical reminders
- Where
- United States
- Volunteers
- 67,000 people, healthy volunteers welcome
- Sponsor
- Atlanta VA Medical Center
Satisfaction, Personal
Participant Satisfaction With the BUILD Mobile Application
This study explores user satisfaction with the BUILD mobile application.
- Trial name
- NCT05948670
- Testing
- DISC-MVP, DISC-CON
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Woebot Health
Lifestyle-related Condition, Overweight and Obesity
Study of Omega-3 Fatty Acids Regarding Ergogenic, Anti-inflammatory and Obesity Inhibitory Effects in 8 Year Old Children
This study hypothesizes that supplementation of omega-3 fatty acids (OM3) can increase physical activity, inhibit rapid gain in body weight and BMI in both sedentary and normally active 8 year old children.
- Conditions
- Lifestyle-related Condition, Overweight and Obesity, Essential Fatty Acid Deficiency
- Trial name
- STOPP-8 OM3 (NCT01323283)
- Testing
- Omega-3
- Where
- Sweden
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Breast Cancer, Prostate Cancer
Redes III Patient Navigator Qol Study
This proposed 5-year Redes En Acción research study involves a mixed-methods approach that occurs in two phases across two distinct and diverse HL communities.
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT02275754
- Testing
- PN+LCNC, PN Only
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Depression
Digitally Enhanced Stepped-Care for Depression in Primary Care
This pilot, three-arm randomized clinical trial (N=40; 2:1:1) will evaluate the feasibility and preliminary efficacy of a digitally enhanced stepped-care approach for depression treatment in primary care.
- Trial name
- NCT07634705
- Testing
- Behavioral Activation Therapy App, Telehealth Delivered Behavioral Activation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Mother-Infant Bonding
Mandala Intervention on Mother-Infant Bonding and Parenting Self-Efficacy After Negative Birth Experiences
The purpose of this randomized controlled trial is to evaluate the impact of a mandala-based art intervention on mother-infant bonding and parenting self-efficacy among primiparous women (first-time mothers) who have had a…
- Trial name
- NCT07461922
- Testing
- Mandala Coloring, Free Coloring
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Stress, Stress (Psychology)
Effect of Magnesium-, Vitamin C- and Grape Seed Extract-Enriched Date Bars on Perceived Stress and Salivary Cortisol Levels in Young Women
This randomized controlled trial aims to evaluate the effect of a 4-week daily consumption of a functional date bar enriched with magnesium, vitamin C, and grape seed extract on perceived stress and salivary cortisol levels in…
- Trial name
- NCT07585422
- Testing
- Functional Bar
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- K.G. Razumovsky Moscow State University of Technologies and Management
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