Clinical trials: Randomized Clinical Trial
Edentulous Alveolar Ridge
Two-piece Zirconia Implants With Two Various Platforms
24 patients with missing premolar teeth and healed sockets will be recruited. They will be randomized into two groups to supplied with tissue-level (n=12) or bone-level (n=12) 10-mm long 4-mm wide zirconia implants.
- Trial name
- ZircImpl (NCT06012071)
- Testing
- Zirconia dental implants
- Where
- Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Type II Diabetes Mellitus, Gestational Diabetes Mellitus
Intrapartum Glycemic Control With Insulin Infusion Versus Rotating Fluids
This study will determine whether rotating intravenous (IV) fluid is better than receiving insulin to control a baby's blood sugar after delivery in laboring women with diabetes.
- Trial name
- NCT03912363
- Testing
- Rotating fluids protocol, Insulin infusion protocol
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
COVID 19
Post Exposure Prophylaxis in Healthcare Workers Exposed to COVID-19 Patients
More cases of COVID-19 pandemic are being reported daily around the world. It is highly infectious and, over 7 million people have been infected and more than 400,000 people have died globally till this date.
- Trial name
- HCQ-COVID19 (NCT04437693)
- Testing
- Hydroxychloroquine
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Contraception
Randomized Controlled Trial of Structured Contraceptive Counseling in Adult Women
In the United States, highly effective methods of birth control are often not used. Healthcare providers use birth control counseling and patient education as ways to increase the usage of birth control.
- Trial name
- NCT00746993
- Testing
- Structured contraceptive counseling
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Columbia University
Oral Health
Effect of Aloe Vera Mouthwashes on the Oral Health of Children
Prevention of dental problems by controlling plaque is the best solution to maintain oral health and prevent high cost of dental treatments.
- Trial name
- NCT04009616
- Testing
- Aloe Vera mouthwash, Chlorhexidine mouthwash
- Where
- Syria
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Damascus University
Healthy
Oral Bioavailability,and Food Effect Study and Single Ascending Dose PK Study in Healthy Male Volunteers
This 2-part study will assess the effect of formulation and food on the pharmacokinetics of Indoximod in healthy volunteers. Part 1 is an open-label, 3-period, 6-sequence study.
- Trial name
- NCT03372239
- Testing
- Indoximod base formulation, Indoximod HCL (salt) formulation
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NewLink Genetics Corporation
Total Knee Arthroplasty
Efficacy of Single Injection Femoral Nerve Block With Liposomal Bupivacaine for Total Knee Arthroplasty
The purpose of this study is to compare the quality and duration of pain relief after a total knee replacement provided by a single shot of standard bupivacaine versus a single shot of liposomal bupivacaine, at the site of the…
- Trial name
- NCT01977339
- Testing
- Liposome Bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Metabolic Syndrome X
Effect of Food Consumption on microRNA Related to Metabolic Syndrome
The objective of the Project is to assess the effect of traditional food on the expression of micro-ribonucleic acid (miRNA), which regulate genes related to glucose metabolism. It will be a randomized experimental research.
- Trial name
- EFCMRNAMS (NCT02606812)
- Testing
- Traditional-food
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Juárez Autónoma de Tabasco
HIV
HIV Vaccine in HIV-uninfected Adults
The purpose of this study is to test whether delayed boosting (an extra administration of a vaccine) with the IHV01 (FLSC) protein and A244/AHFG with or without ALFQ will cause the body to make higher amounts of antibodies or…
- Trial name
- RV546 (NCT04658667)
- Testing
- IHV01, A244, ALFQ
- Where
- 2 sites in Thailand
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Molar Incisor Hypomineralization
Minimally Invasive Treatment for Permanent Molars Affected With Molar-incisor Hypomineralization Defects
In this prospective randomized clinical trial, the is aim to compare the clinical and radiographic success of 3 minimally invasive treatment protocols on permanent first molars affected with MIH over 24 months.
- Trial name
- NCT05748067
- Testing
- SDF, HVGIC restoration, SSC
- Where
- Jordan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Quality of Life, Health Promotion
A Randomized Control Trial of Conversations Advancing Resilience and Empowerment (CARE) Intervention
The investigators propose to implement and evaluate the effectiveness of the peer-led CARE Intervention designed to mitigate health differences among rural and low-income communities in Texas.
- Conditions
- Quality of Life, Health Promotion, Blood Pressure Monitoring, Self
- Trial name
- CARE (NCT07698964)
- Testing
- Conversations Advancing Resilience and Empowerment (CARE)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas Rio Grande Valley
Posterior Single Edentulous Sites
Monolithic Zirconia Posterior Single Crowns: a Randomized Clinical Trial.
Monolithic Zirconia Posterior Single Crown cost-efficiency study. Objective and subjective analysis will be performed through FIPS and PROMs scales to evaluate treatment quality outcomes.
- Trial name
- NCT06865209
- Testing
- Monolithic Zirconia Posterior Single Screw Retained Implant Crowns
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Bone Resorption
Vertical Augmentation Using Onlay Versus Inlay Autogenous Graft With Simultaneous Implant Placement.
Using autogenous Chin block for vertical augmentation with simultaneous implant placement at anterior maxilla region comparing between the Onlay and Inlay grafting techniques.
- Trial name
- NCT03052387
- Testing
- assigned intervention
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Regeneration
Regenerative Ability of Immature Necrotic Permanent Teeth Using Different Scaffolds
The goal of this clinical trial is to compare effect of different scaffolds on the regenerative potential of young permanent immature teeth with necrotic pulp.
- Trial name
- regeneration (NCT06693739)
- Testing
- Platelet rich fibrin, hyaluronic acid, no scaffold
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pregnancy Complications
Oral Prophylactic Measures on the Occurrence of Pre-eclampsia (OP-PE)
Pre-eclampsia (PE) remains a major source of maternal and perinatal morbidity and mortality especially in low- and middle-income settings.
- Trial name
- OP-PE (NCT04989075)
- Testing
- Oral prophylactic intervention
- Where
- Senegal
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
Diabetes, Senile Dementia, Alzheimer Type
A Study of Mobile Medical Supportive Care Program for Family Caregivers With Dementia Combined With Diabetes
The purpose of this project is to evaluate the effectiveness of the clinical application of a mHealth supportive care program for family caregivers with dementia combined with diabetes based on the supportive care framework.
- Trial name
- NCT06785857
- Testing
- mHealth Supportive Care Program, Offline supportive care
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuanjiao Yan
Aggressive Periodontitis
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
The aim of this study is to assess the clinical outcomes of full-mouth ultrasonic debridement combined with clarithromycin or amoxicillin + metronidazole association for the treatment of generalized aggressive periodontitis…
- Trial name
- NCT02969928
- Testing
- Full-mouth ultrasonic debridement, Clarithromycin, Amoxicillin
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Foot Surgery, Ankle Surgery
Liposomal Bupivacaine With Dexamethasone for Foot Surgery
This study aims to understand the ideal formulation to utilize in saphenous nerve and popliteal nerve blocks for foot and ankle procedures.
- Conditions
- Foot Surgery, Ankle Surgery, Post Operative Pain, Popliteal Nerve Block
- Trial name
- NCT06465992
- Testing
- Exparel 266 MG Per 20 ML Injection, Bupivacaine Hcl 0.75% Inj, Dexamethasone
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Intrauterine Growth Restriction Asymmetrical
L-arginine in Treatment of Intrauterine Growth Restriction
Intrauterine growth restriction is an important problem in neonatal care. Intrauterine growth restriction (IUGR) is defined as a fetal weight below the 10th percentile for gestational age.
- Trial name
- NCT03321292
- Testing
- L-arginine 1000 mg and Acetylesalicylic acid75mg, acetylsalicylic acid 75 mg
- Where
- Egypt
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Episiotomy Wound, Wound Healing
Episiotomy Wound Care, Episiotomy Wound Healing and Pain Perception
The World Health Organization (WHO) and professional societies recommend restricted episiotomy instead of routine episiotomy. However, since the 1990s, there has been evidence of the risks of the procedure, and although routine…
- Conditions
- Episiotomy Wound, Wound Healing, Pain, Training, Toilet
- Trial name
- NCT05358236
- Testing
- Episiotomy Wound Care and Genital Hygiene Training
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
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