Clinical trials: Randomized Clinical Trial
Pharmacokinetics, Pharmacodynamics
Study to Evaluate Pharmacokinetic and Pharmacodynamic Drug Interactions and Safety of IY-NS250 and IY-NT-SR
This study comparative evaluation of safety and pharmacokinetic and pharmacodynamic properties in oral repeat administration of IY-NS250 and IY-NT-SR in healthy adult
- Trial name
- NCT06725992
- Testing
- IY-NS250, IY-NT-SR
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Zika Virus Infection
Safety and Immunogenicity of BBV121
To evaluate the safety, tolerability, and immunogenicity of two-doses of three-sequentially escalating cohort (2.5 µg, 5 µg and 10 µg) of BBV121 (purified inactivated adsorbed Zika virus vaccine) compared with Placebo (Alum).
- Trial name
- Zika (NCT04478656)
- Testing
- BBV121
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
Pain
A Randomized Trial Comparing "Push" Versus "Pull" Technology for Mobilizing Pain Evidence Into Practice Across Different Health Professions
Pain is a problem for many Canadians. Unfortunately, many doctors, nurses, therapists, and psychologists have trouble keeping up to date and applying the latest research that might help patients suffering with pain.
- Trial name
- NCT01348802
- Testing
- Push + Pull, Pull
- Where
- Canada
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- McMaster University
Periodontitis, Adult
Early Versus Delayed Orthodontic Treatment After Periodontal Surgery on Periodontal Health in Periodontally Compromised Patients
RESEARCH QUESTION: Will there be a difference in periodontal health of two groups of periodontally compromised orthodontic patients with early and delayed start of orthodontic treatment after periodontal surgery? Population…
- Trial name
- NCT05466253
- Testing
- Fixed Orthodontic treatment
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Landing Biomechanics, Jumping Performance
Effectiveness of Core Training on the Biomechanics of Jump Landing in Amateur Female Basketball Players
The goal of this clinical trial is to evaluate the effectiveness of a core training intervention on jump-landing biomechanics in female amateur basketball players.
- Conditions
- Landing Biomechanics, Jumping Performance, Trunk Stability
- Trial name
- NCT06633237
- Testing
- Core training program in female amateur basketball players
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Aneurysmal Subarachnoid Hemorrhage
Human Albumin for Clinical Outcome in Aneurysmal Subarachnoid Hemorrhages
Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful acute neurological condition with overwhelmingly high rate of associated morbidities and mortality.
- Trial name
- HASH (NCT06548477)
- Testing
- Human albumin
- Where
- Qatar
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Human Immunodeficiency Virus (HIV)
ComBaCaL HIV Prevention TwiCs
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- CoPrev (NCT07581600)
- Testing
- CoPrev model, Referral to the nearest responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Clinical High Risk for Psychosis
Randomized Controlled Trial of Aspirin vs Placebo in the Treatment of Pre-psychosis
The primary objective of this study is to determine whether aspirin is effective in alleviating symptoms of the clinical high risk (CHR) syndrome for psychosis.
- Trial name
- NCT02047539
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy Adult Participants
Effects of an Arabinoxylan-enriched Rusk on Postprandial Glucose, Insulin, Glucagon-like Peptide-1 and Appetite Responses
The aim of the present pilot randomized controlled trial is to compare the effects of the following: 1)-rusk enriched with arabinoxylans (r-rich), 2)-rusk not enriched (r-standard) on blood glucose, insulin values, glucagon like…
- Trial name
- NCT07682857
- Testing
- Enriched rusk, Standard rusk
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Cesarean Delivery
A RCT of Labor Induction at 39 Weeks in Low - Risk Women in China
The investigators are committed to identifying the optimal timing of delivery for low-risk pregnancies. While current guidelines typically recommend induction at 41 weeks, emerging evidence suggests that elective induction at 39…
- Trial name
- LIRIC (NCT07082530)
- Testing
- Labor Induction at 39 Weeks, Expectant management
- Where
- China
- Volunteers
- 1,074 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Oxidative Stress
Inspired Oxygen on Oxidative Stress and Breath Volatile Organic Compound Composition in Healthy Volunteers
High inspiratory oxygen fractions are known to induce oxidative stress and lipid peroxidation. The degrading products of oxidative stress induced lipid peroxidation are in part volatile and appear in breath where they can be…
- Trial name
- NCT02577692
- Testing
- Oxygen, Ambient
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Klinikum der Universitaet Muenchen, Grosshadern
Scar, Skin Scarring
Scar Appearance After Postoperative Hydrocolloid Dressing Versus Standard Petrolatum Ointment
Patients will be randomized either to receive standard daily dressing or hydrocolloid dressing using a randomization generator. After closing the wound with the sutures,the scar will be covered by a hydrocolloid dressing, which…
- Conditions
- Scar, Skin Scarring, Skin Cancer, Wound Heal
- Trial name
- NCT05618912
- Testing
- Hydrocolloid dressing, Petrolatum jelly dressing
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pain
Effect of Standardized Patient-Based Pain Management Program
When the studies were examined, no educational study was found to examine the effect of the standardized patient-based pain management program on the pain attitudes, self-efficacy and beliefs of nursing students.
- Trial name
- NCT06709430
- Testing
- Classical education group, Standardized Patient Group
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Granulocyte Colony-Stimulating Factor (G-CSF) Mobilization
CHRONO-MOBILIZE: Chronotherapy of G-CSF for CD34+ Mobilization in Healthy Donors
Healthy donors are commonly mobilized with granulocyte colony-stimulating factor (G-CSF) to collect peripheral blood stem cells for allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- CHRONO-MOBILIZ (NCT07423728)
- Testing
- G-CSF (Granulocyte colony-stimulating factor)
- Where
- 3 sites in China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Airway Obstruction
Maxillary Expansion Effects in Children With Upper Airway Obstruction
The most frequent causes of mouth breathers are the adenotonsillar hypertrophy. Adenotonsillectomy is the main choice for the elimination of the obstruction.
- Trial name
- NCT03004300
- Testing
- Rapid maxillary expansion, Adenotonsillectomy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Tourniquets
Ischemic Preconditioning and Thiol-disulfide Balance
Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases.
- Trial name
- NCT05082207
- Testing
- Remote Ischemic Preconditioning
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Flexible Fiberoptic Bronchoscopy Versus Flexible Intubation Video Endoscope FIVE in Obese Patients
Comparison of Endotracheal Intubation Using Flexible Fiberoptic Bronchoscopy Versus Flexible Intubation Video Endoscope (FIVE) in Obese Patients Undergoing Elective Surgeries Under General Anesthesia: A Randomized Controlled Trial
Tracheal intubation is one of the most common medical procedures performed in hospitals. On one hand, it is highly successful and easy to perform using a rigid laryngoscope.
- Trial name
- NCT03423563
- Testing
- Flexible fiberoptic bronchoscopy, Fexible intubation video endoscopy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Death, Nosocomial Infection
Prophylactic Probiotics in Premature Infants
This study tries to determine whether the oral administration of a specific probiotic (good bacteria) in premature infants hospitalized in a neonatal intensive care unit may prevent infections and the development of a severe…
- Trial name
- C3P (NCT00727363)
- Testing
- Lactobacillus reuteri
- Where
- 8 sites in Colombia
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- Colombian Neonatal Research Network
Endodontic Inflammation
Comparison Between the Vibringe and the Conventional Needle
The Vibringe is the first endodontic sonic irrigation system that enables delivery and activation of the irrigation solution in the root canal, in only one step.
- Trial name
- NCT03551587
- Testing
- Vibringe
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dietary Modification, Bread
Testing the Effect of Whole-wheat Sourdough Bread Compared to White Bread on Healthy Individuals
Bread is the most common grain product in the world, with consumption surpassing 3 billion individuals per year. Sourdough whole-grain bread is considered a healthy alternative to white, refined-wheat bread.
- Conditions
- Dietary Modification, Bread, Gastrointestinal Microbiome, Hematologic Tests
- Trial name
- NCT02936362
- Testing
- Consumption of sourdough bread, Consumption of white bread
- Where
- 2 sites in Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
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