Clinical trials: Rapid Diagnosis
Atrial Fibrillation
Low Versus High Dose Magnesium Sulfate in the Early Management of Rapid Atrial Fibrillation
Objective: To assess the efficacy and the safety of high (9g) and low dose (4.5g) of MgS in the immediate treatment of rapid AF.
- Trial name
- NCT00965874
- Testing
- Magnesium Sulfate high dose, Magnesium Sulfate low dose
- Where
- Tunisia
- Volunteers
- 450 people
- Sponsor
- University of Monastir
Hyperkalemia
A Study to Detect Hyperkalemia Using Smartphone-enabled Electrocardiogram (EKG)
The purpose of this study is to validate the real-world performance of a previously developed Artificial Intelligence - Electrocardiogram (AI-ECG) algorithm for identification of hyperkalemia with a six-lead mobile-enhanced…
- Trial name
- REACT (NCT05441852)
- Where
- United States
- Volunteers
- 1,151 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee, Bone Diseases
mFFE MRI Versus CT for Cortical Bone Evaluation in Knee Osteoarthritis
This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT.
- Trial name
- NCT07827443
- Volunteers
- 80 people
- Sponsor
- Assiut University
Interstitial Lung Diseases
Efficacy and Safety of Golidocitinib for Rapidly Progressive Interstitial Lung Disease
The goal of this clinical trial is to learn whether adding the JAK inhibitor golidocitinib to standard corticosteroid therapy works to treat rapidly progressive interstitial lung disease (RP-ILD) in patients with acute worsening.
- Trial name
- NCT07737249
- Testing
- golidocitinib plus corticosteroid, non-JAK inhibitor immunosuppressant plus corticosteroid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Mild Cognitive Impairment, Lewy Body Dementia, Parkinson's Disease Rapid Eye Movement Sleep Behavior Disorder, Parkinson's Disease Dementia
A Study of Clenbuterol (CST-103) Co-administered With Nadolol (CST-107) in Subjects With Neurodegenerative Disorders
This is a Phase II, randomized, placebo-controlled, double-blind, crossover study on the CNS and pharmacodynamic effects of clenbuterol (CST-103) co-administered with nadolol (CST-107) in 4 subject populations with…
- Trial name
- CLIN-011 (NCT04739423)
- Where
- 7 sites in Australia, New Zealand and 1 more
- Volunteers
- 41 people
- Sponsor
- CuraSen Therapeutics, Inc.
Influenza
Rapid Vaccination of Hard-To-Reach Populations
The purpose of this study is to develop and determine the effectiveness of a multi-level community participatory intervention designed to rapidly immunize hard-to-reach populations, including substance users, within disadvantaged…
- Trial name
- NCT00155974
- Testing
- Community-based vaccine outreach intervention
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- The New York Academy of Medicine
Maxillary Anomaly, Asymmetric Maxillary Arch (Disorder)
Effects of Asymmetric Rapid Maxillary Expansion on Dentoskeletal Structures in Mixed Dentition
The aim of this clinical trial was to determine the efficacy of a locked modified bonded acrylic rapid maxillary expansion appliance, also known as an asymmetric rapid maxillary expansion appliance (ARME), in patients with a true…
- Conditions
- Maxillary Anomaly, Asymmetric Maxillary Arch (Disorder), Cross Bite
- Trial name
- ARME (NCT06486324)
- Testing
- A locked modified acrylic bonded rapid maxillary expansion appliance (ARME)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Celal Irgin
Renal Cell Carcinoma
Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal Cell Carcinoma
This is a pilot, single-center, single-arm study where 20 patients with metastatic or unresectable clear cell renal cell carcinoma will receive same sequential treatment strategy (Cabozantinib for 12 weeks, then proceed with…
- Trial name
- NCT05188118
- Testing
- Cabozantinib, Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obsessive-Compulsive Disorder
Understanding How Ketamine Brings About Rapid Improvement in OCD
The purpose of this study is to understand how ketamine brings about rapid improvement in Obsessive-Compulsive Disorder (OCD) symptoms.
- Trial name
- MKET (NCT02624596)
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus
Switch From U-100 Insulin Analog to U-500 Regular Insulin in Pumps for Type 2 Diabetes
The aim of the study was to perform a 3-year retrospective analysis from a cohort of patients with type 2 diabetes that were treated by a pump device and were uncontrolled despite high U-100 insulin requirements.
- Trial name
- NCT04371497
- Volunteers
- 65 people
- Sponsor
- University Hospital, Caen
Snakebite, Envenoming, Snake
Broad-spectrum Rapid Antidote: Varespladib IV to Oral Trial for Snakebite (BRAVIO)
This is a multicenter,randomized,double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability and efficacy of a continuous rate infusion (CRI) of IV varespladib followed by transition to the oral…
- Trial name
- BRAVIO (NCT05717062)
- Testing
- Varespladib intravenous form, varespladib-methyl- oral form
- Where
- 10 sites in United States
- Volunteers
- 140 people
- Sponsor
- Ophirex, Inc.
Overactive Bladder
Sham Controlled Trial of Rapid Induction Percutaneous Tibial Nerve Stimulation
The aim of this study is to determine the efficacy of an accelerated course for percutaneous tibial nerve stimulation (PTNS) induction to treat overactive bladder symptoms.
- Trial name
- NCT03547518
- Testing
- PTNS treatment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Corewell Health East
Traumatic Brain Injury (TBI) Patients
Correlation and Rapid Analysis of Neurological Injury Using Markers
Each year, approximately 69 million people worldwide suffer from traumatic brain injuries (TBI), representing a significant burden on public health, society, and the economy.
- Trial name
- NCT06834659
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università Vita-Salute San Raffaele
Sepsis, Systemic Inflammatory Response Syndrome
Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?
The aim of this project is to test the utility of The Gene Z device (as of 2018 Gene Z no longer being used), now using In-Dx and other rapid identification techniques that the investigators have developed in the lab on…
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome, Infection Mixed, Infection, Bacterial
- Trial name
- NCT01904188
- Testing
- Gene Z or other rapid diagnostic techniques developed in our lab (as of 2018 not using Gene Z - now using In-Dx along with other developed techniquesregularly)
- Where
- 2 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Michigan State University
COVID-19
Evaluation of the Integration of Ag-RDTs for COVID-19 in MNCH, HIV and TB Services in Cameroon and Kenya
In many national Coronavirus Disease 2019 (COVID-19) response plans, including in Kenya and Cameroon, antigen detection tests are being used to improve access for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)…
- Trial name
- NCT05498727
- Testing
- Integration of SARS-CoV 2 Testing in HIV, MNCH and TB Clinics
- Where
- 2 sites in Cameroon, Kenya
- Volunteers
- 527,184 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Infertility
Fast Track to Fertility
The Fast Track to Fertility (FTF) program is an algorithmic text messaging communication and patient education platform designed to improve the efficiency the fertility workup.
- Trial name
- FTFRCT (NCT07154888)
- Testing
- Fast Track to Fertility Algorithmic Text Messaging Platform
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Pennsylvania
Renal Failure
Desflurane vs. Sevoflurane in Endovascular Aortic Repair
Randomized Clinical Trial following the evaluation of the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours…
- Trial name
- NCT03917186
- Testing
- Sevoflurane, Desflurane
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Begoña Quintana Villamandos
Major Depressive Disorder
Rapid Antidepressant Effects of Leucine
This randomized double-blind placebo-controlled crossover study seeks to evaluate the antidepressant effect of L-leucine, an essential amino acid, in patients with Major Depressive Disorder (MDD).
- Trial name
- NCT03079297
- Testing
- L-Leucine, Maltodextrin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Texas Southwestern Medical Center
Schizophrenia
Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome
Background: The present study aims to identify the mechanisms underlying the deficit in facial emotion recognition reported both in schizophrenia and the 22q11.2 deletion syndrome, and thus, reveal a distinction between the two…
- Trial name
- FaSchi22 (NCT02634671)
- Testing
- schizophrenia, the 22q11 deletion syndrome, control group
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Schizophrenia, Schizoaffective Disorders
Rapid Versus Conventional Titration of Quetiapine in Schizophrenia/Schizoaffective Disorder
The purpose of this study is to determine whether increasing the amount (dose) of quetiapine IR (immediate release formulation) more rapidly than conventional dose increases, improves the control of symptoms as measured by the…
- Conditions
- Schizophrenia, Schizoaffective Disorders, Psychotic Disorders
- Trial name
- RAPID (NCT00457899)
- Testing
- Quetiapine IR (Immediate Release)
- Where
- 12 sites in United Kingdom
- Volunteers
- 234 people
- Sponsor
- AstraZeneca
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