Clinical trials: Rectal Cancer, completed
Rectal Cancer
Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer
Total mesorectal excision (TME) is a rather new operation technique in the treatment of rectal cancer. It is known to reduce the rate of local recurrences. However, the influence on long-term survival is unclear.
- Trial name
- NCT00910143
- Testing
- conventional rectal surgery, total mesorectal excision
- Where
- Switzerland
- Volunteers
- 194 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Neoadjuvant Chemoradiotherapy, Rectal Tumor
Outcomes of Resection at Different Times Between the End of Neoadjuvant Treatment and Surgery
Neoadjuvant radio-chemotherapy (NRCT) represents a milestone in the treatment of selected rectal tumours. Ideal time interval between the end of NRCT and surgery is still debated; a 6-8 weeks time interval is considered optimal…
- Conditions
- Neoadjuvant Chemoradiotherapy, Rectal Tumor, Surgery, Surgery--Complications
- Trial name
- NCT04013347
- Testing
- Rectal Resection
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Campus Bio-Medico University
Anal Cancer
ART: Anal Squamous Cell Carcinoma: Investigation of Functional Imaging During chemoRadioTherapy
This is a single arm, single centre imaging study which will be offered to all consecutive, eligible patients receiving radical chemoradiation therapy (CRT) for anal cancer within Oxford University Hospitals.
- Trial name
- ART (NCT02145416)
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Oxford
Microsatellite Stable, Mismatch Repair Protein Proficient
Pembrolizumab, Capecitabine, and Bevacizumab for Treating Colorectal Cancer
This phase II trial studies the side effects and best dose of capecitabine when given together with pembrolizumab and bevacizumab, and investigates how well they work in treating patients with microsatellite stable colorectal…
- Conditions
- Microsatellite Stable, Mismatch Repair Protein Proficient, Stage III Colorectal Cancer AJCC v7, Stage IIIB Colorectal Cancer AJCC v7
- Trial name
- NCT03396926
- Testing
- Bevacizumab, Capecitabine, Specimen collection
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Colorectal Cancer, Colorectal Disorders
Reducing Colonoscopies in Patients Without Significant Bowel Disease
Investigating people with bowel symptoms uses a test that detects traces of blood in the stools, the FIT test. There are many possible reasons for positive tests. A few people have cancer.
- Conditions
- Colorectal Cancer, Colorectal Disorders, Colorectal Adenoma, Colorectal Polyp
- Trial name
- RECEDE (NCT04516785)
- Testing
- FIT and VOC
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,181 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Colorectal Neoplasm, Colonic Polyps
Clinical Study of Real Time Colorectal Polyp Diagnosis During Colonoscopy - the VALID Colonoscopy Study
The investigators hypothesize that high definition colonoscopy with close focus narrow band imaging features has a high diagnostic accuracy for colorectal polyp histology, and can replace formal pathologic assessment in cases of…
- Trial name
- VALID (NCT01288833)
- Testing
- Close focus HD NBI Colonoscopy System
- Where
- 2 sites in United States
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Rectal Cancer
Pilot Trial of KD018 With Neo-Adjuvant Concurrent Chemo-Radiation Therapy in Patients With Locally Advanced Rectal Cancer
This pilot study focuses on KD018 and will investigate the effect of this agent on reducing the Gastrointestinal (GI) toxicity associated with combined modality therapy of locally-advanced rectal cancer.
- Trial name
- NCT02178644
- Testing
- Chemo with concomitant Capecitabine and KD018
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Yale University
Colonoscopy, Colorectal Neoplasms
Interest of Artificial Intelligence in Cancer Screening Colonoscopy
Artificial Intelligence (AI) to predict the histology of polyps per colonoscopy, offers a promising solution to reduce variation in colonoscopy performance.
- Conditions
- Colonoscopy, Colorectal Neoplasms, Intestinal Polyps, Deep Learning
- Trial name
- IA COLO (NCT04921488)
- Testing
- screening colonoscopy
- Where
- 5 sites in France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Bordeaux
Colorectal Cancer
Vorinostat and IV Fluorouracil/Leucovorin (5FU/LV) in Patients With Metastatic Colorectal Cancer
This protocol will investigate the use of vorinostat (suberoylanilide hydroxamic acid - SAHA) in combination with infusional 5-FU and leucovorin for the treatment of metastatic colorectal cancer patients who have failed standard…
- Trial name
- NCT00336141
- Testing
- Suberoylanilide hydroxamic acid
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Colorectal Cancer
Study of Enzastaurin With 5-Fluorouracil/Leucovorin (5-FU/LV) Plus Bevacizumab as Maintenance Regimen Following First Line Therapy for Metastatic Colon Cancer
This study will evaluate the addition of enzastaurin to 5-FU (5-fluorouracil)/LV (leucovorin) plus bevacizumab in the maintenance of best response obtained with 6 cycles of first-line therapy consisting of 5-FU/LV + oxaliplatin…
- Trial name
- NCT00612586
- Testing
- Enzastaurin, Leucovorin (LV), 5-fluorouracil (5-FU)
- Where
- 26 sites in United States, Austria and 4 more
- Volunteers
- 117 people
- Sponsor
- Eli Lilly and Company
Liver Metastases
CAR-T Hepatic Artery Infusions and Sir-Spheres for Liver Metastases
This is an open label fixed dose phase Ib of anti-CEA CAR-T cells hepatic artery infusions and yttrium-90 SIR-Spheres in patients with CEA-expressing liver metastases.
- Trial name
- HITM-SIR (NCT02416466)
- Testing
- anti-CEA CAR-T cells, Sir-Spheres
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Roger Williams Medical Center
Colorectal Cancer, Metastatic Cancer
Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Cryosurgery kills cancer cells by freezing them.
- Trial name
- NCT00008294
- Testing
- FOLFOX regimen, dexamethasone, floxuridine
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hepatitis C, Renal Cell Carcinoma
Association Between Hepatitis C Infection and Renal Cell Carcinoma
The purpose of this study is to determine if there is an association between hepatitis C infection and kidney cancer. All patients who are diagnosed with kidney cancer and who will either have a biopsy or surgery will be offered…
- Conditions
- Hepatitis C, Renal Cell Carcinoma, Colorectal Cancer
- Trial name
- NCT01405183
- Testing
- Hepatitis C testing
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Henry Ford Health System
Colorectal Neoplasms
Immunological and Oxidative Stress Response in Relation to Abdominal Cancer Surgery
The aim of this study is to characterize the systemic stress response (SSR) induced in patients undergoing colorectal cancer (CRC) surgery. The project is a clinical prospective study.
- Trial name
- IMOX (NCT03473327)
- Volunteers
- 37 people
- Sponsor
- Zealand University Hospital
Colorectal Cancer, Islet Cell Tumor
Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastases
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.
- Conditions
- Colorectal Cancer, Islet Cell Tumor, Liver Cancer, Metastatic Cancer
- Trial name
- NCT00019786
- Testing
- isolated perfusion, melphalan, conventional surgery
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Colorectal Cancer
Molecular Stool Testing for Colorectal Cancer Surveillance
Rationale: Since January 2014 the Dutch screening programme for bowel cancer has been implemented. Screening will increase the demand for surveillance.
- Trial name
- MOCCAS (NCT02715141)
- Testing
- Collection of stool sample
- Where
- Netherlands
- Volunteers
- 3,966 people
- Sponsor
- The Netherlands Cancer Institute
Laparoscopic Colorectal Surgery
HEAT HumiGard Evaluation Study
During long surgical procedures under general anaesthetic, patients' body temperatures sometimes drop below 36°C. This is classified as hypothermia.
- Trial name
- HEAT (NCT04164706)
- Testing
- HumiGard device
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cardiff and Vale University Health Board
Rectal Adenocarcinoma, Colon Adenocarcinoma
Audit of Surgery for Colorectal Cancer
The aim of this project is to audit the surgical care in patients treated for colorectal adenocarcinoma. This study focused on collecting data from all consecutive cases of colon and rectal adenocarcinoma operated at the National…
- Trial name
- AuditCR (NCT04349384)
- Testing
- Colorectal resection
- Where
- Morocco
- Volunteers
- 136 people
- Sponsor
- Institut National d'Oncologie, Morocco
Metastatic Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8
Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
This phase I trial is to find out the best dose, possible benefits, and/or side effects of riluzole and how well it works in combination with standard of care mFOLFOX6 and bevacizumab in treating patients with colorectal cancer…
- Conditions
- Metastatic Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8, Stage IVB Colorectal Cancer AJCC v8
- Trial name
- NCT04761614
- Testing
- Bevacizumab, Fluorouracil, Leucovorin Calcium
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ning Jin
Metastatic Colorectal Cancer
ImmunoTEP With 68-Ga in Metastatic Colo Rectal Cancer
Evaluation of the sensitivity of the immuno-PET PET / CT pretargeted with the bispecific anti-CEA x anti-HSG TF2 antibody and IMP-288 peptide labeled with Gallium-68 for imaging potential candidate patients for surgery of local…
- Trial name
- iTEP Colon (NCT02587247)
- Testing
- TF2 antibody/68Ga-IMP-288
- Where
- 2 sites in France
- Volunteers
- 11 people
- Sponsor
- Nantes University Hospital
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