Clinical trials: Rectosigmoid Cancer
Solid Tumor, Colorectal Cancer
Live Biotherapeutic Product GB104 Phase 1 Study in Colorectal Cancer
Prospective, open label, multi-dose, sequential dose escalation, single-center, Phase 1 trial
- Conditions
- Solid Tumor, Colorectal Cancer, Sigmoid Colon Cancer, Rectosigmoid Junction Cancer
- Trial name
- NCT05943041
- Testing
- GB104(Level 1), GB104(Level 2), GB104(Level 3)
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- GILongevity
Non-resectable Metastatic Cancer of the Lung, Non-resectable Metastatic Cancer of the Colon
Viewpoints on the Social Representations and Rationale Concerning the Choices of Patients, Doctors and Caregivers With Regard to the Management of Patients With Non-resectable Metastatic Cancer of the Colon, Stomach, Bile Ducts, Rectum, Pancreas or Lung, or Gastrointestinal Neuroendocrine Tumours
Reflexion on the therapeutic strategies to implement in patients at the end of life is advancing rapidly in France. However, beyond the choices presented to patients, sometimes even the decision to carry on, to limit or to stop…
- Conditions
- Non-resectable Metastatic Cancer of the Lung, Non-resectable Metastatic Cancer of the Colon, Non-resectable Metastatic Cancer of the Rectosigmoid Junction, Non-resectable Metastatic Cancer of the Stomach
- Trial name
- EOLE (NCT03328065)
- Testing
- Interviews, Questionnaires
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Rectal Cancer, Rectosigmoid Cancer
A Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in Low Anterior Resection
This is a randomized, controlled, parallel, multicenter study to determine the difference in post-operative anastomotic leak rate in low anterior resection procedures where colon and rectal tissue perfusion is evaluated using…
- Trial name
- PILLAR III (NCT02205307)
- Testing
- PINPOINT, SPY Elite
- Where
- 24 sites in United States
- Volunteers
- 347 people
- Sponsor
- Novadaq Technologies ULC, now a part of Stryker
Rectal Carcinoma, Rectosigmoid Carcinoma
Testing Diet Intervention Versus Non-Diet Intervention for Management of Bowel Symptoms in Rectal Cancer Survivors
This phase II trial studies how a diet intervention works in improving bowel dysfunction symptoms related in colon or rectal cancer survivors.
- Trial name
- NCT04205955
- Testing
- Best Practice, Dietary Intervention, Message
- Where
- 226 sites in United States, Guam
- Volunteers
- 95 people
- Sponsor
- SWOG Cancer Research Network
Colorectal Cancer Genetics, Young Adult
Role of CD133 & Microsatellite Status in Evaluation of Rectosigmoid Cancer Young Adults Received Neoadjuvant Treatment
Microsatellite instability is more common in colorectal cancer ( CRC) young patient which is associated with good prognosis and is considered as a predictor for good response to preoperative chemoradiotherapy.
- Trial name
- NCT03002727
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Colorectal Cancer
ColoSeal™ ICD System Safety and Feasibility Studies
The studies aim to evaluate the safety and feasibility of the ColoSeal Intraluminal Colonic Diversion (ICD) System in two prospective, multicenter, single-arm studies.
- Trial name
- PROTECT I (NCT06402188)
- Testing
- ColoSeal ICD Device
- Where
- 3 sites in Armenia, Georgia and 1 more
- Volunteers
- 90 people
- Sponsor
- Averto Medical, Inc.
Tubeless NOSES, Traditional Laparoscopic Radical Resection
Tubeless NOSES Versus Laparoscopic Radical Resection for Rectosigmoid Cancers
This study is designed to evaluate the short-term and long-term results after Tubeless NOSES for the resection of Rectosigmoid Cancers compared with traditional laparoscopic radical resection.
- Conditions
- Tubeless NOSES, Traditional Laparoscopic Radical Resection, Rectosigmoid Cancers
- Trial name
- CORNER (NCT04037956)
- Testing
- Tubeless NOSES, traditional laparoscopic radical resection
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Machine Learning, Surgery
Establishment of a Feasibility Model for NOSE Surgery Based on Machine Learning
The goal of this observational study is to test in patients with resectable rectosigmoid cancers. The main question it aims to answer is establishment of a feasibility model for predicting natural orifice specimen extraction…
- Conditions
- Machine Learning, Surgery, Rectosigmoid Cancer, Natural Orifice Specimen Extraction Surgery
- Trial name
- NCT05797064
- Testing
- Natural Orifice Specimen Extraction Surgery
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Rectal Cancer, Rectosigmoid Cancer
mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer
Patients with locally advanced rectal or rectosigmoid cancer staged cT3 CRM-negative with MRI will receive 6 cycles of neoadjuvant treatment with mFOLFOX6 (Arm A) vs. mFOLFOX6 + aflibercept (Arm B) followed by surgery.
- Trial name
- NCT03043729
- Testing
- Oxaliplatin, 5-FU, Leucovorin
- Where
- Germany
- Volunteers
- 119 people
- Sponsor
- AIO-Studien-gGmbH
Colonic Neoplasms
Artificial Intelligence for Leaving in Situ Colorectal Polyps.
This two parallel-arms, randomized, multicenter trial is aimed at investigating safety and effectiveness of a Computer-Aided-Diagnosis (CADx)-assisted leave-in-situ strategy (Leave-In-Situ Arm) as opposed to a resect-all strategy…
- Trial name
- NCT05500248
- Testing
- Leave In Situ, Standard
- Where
- Italy
- Volunteers
- 919 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Rectal Cancer
Sigmoid Take-off, New Rectum Definition
The diversity of definitions for the rectosigmoid junction is becoming a major obstacle to the standardization of optimal treatment of rectal cancers.
- Trial name
- NCT04293835
- Testing
- Whether to have intestinal-related disease
- Where
- China
- Volunteers
- 835 people
- Sponsor
- Peking University Third Hospital
Locally Advanced Rectal Adenocarcinoma, Metastatic Rectal Adenocarcinoma
Circulating Tumor Cells in Patients With Locally Advanced Rectal Cancer
This study looks at the level of circulating tumor elements (cancer cells or DNA pieces floating in the blood) and how it may be related to how the tumor responds to standard treatment in patients with rectal cancer that has…
- Conditions
- Locally Advanced Rectal Adenocarcinoma, Metastatic Rectal Adenocarcinoma, Rectosigmoid Adenocarcinoma, Recurrent Rectal Adenocarcinoma
- Trial name
- NCT02874885
- Testing
- Biospecimen Collection
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma
This study is designed primarily to establish efficacy and estimate resource utilization. The short-term hypothesis is that the dose of capecitabine (825 mg/m2 twice/day 5 days per week) during the course of radiation therapy is…
- Trial name
- NCT00216424
- Testing
- Capecitabine (Xeloda)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- James A. Haley Veterans Administration Hospital
Colorectal Cancer
Safety Study of Totally Laparoscopic Resection With Natural Orifice Specimen Extraction (NOSE) for Rectosigmoid Cancer
The purpose of this study is to compare the safety and efficacy of laparoscopic resection with natural orifice specimen extraction versus conventional laparoscopic surgery for sigmoid colon or rectal cancer.
- Trial name
- NCT02635503
- Testing
- transrectal specimen extraction, Conventional laparoscopic surgery
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Epithelial Ovarian Cancer, Rectosigmoid Cancer Metastatic
Rectosigmoid Resection vs Seromuscular Tumor Shaving in Ovarian Cancer Surgery
Ovarian cancer is the most common cause of death in gynecological cancer. Approximately 75% of epithelial ovarian cancers are detected at an advanced stage.
- Trial name
- NCT04665635
- Testing
- Rectosigmoid resection
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Cukurova University
Ovarian Cancer (OvCa)
Rectosigmoid Lesion Excision vs. Resection: A Non-Inferiority Randomized Comparison in Advanced Ovarian Cancer
Colorectum is the most common site of metastasis in ovarian cancer. Regarding intestinal surgery, there is controversy over whether to choose bowel resection or tumor removal, and currently, there are no prospective randomized…
- Trial name
- RSEnTrail (NCT07616310)
- Testing
- Rectosigmoid Lesion Excision +tumor cell debulking surgery, Rectosigmoid Resection +tumor cell debulking surgery
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rectal Cancer, Rectosigmoid Cancer
Physical Activity in Rectal Cancer Survivors
The goal of this clinical trial is to test a telehealth-based personalized physical activity intervention in adult patients diagnosed with Stage I-III rectal cancer.
- Trial name
- NCT06435975
- Testing
- Physical Activity, Survey, Telehealth Lifestyle Coaching
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Colorectal Cancer
ColoCare Study - Colorectal Cancer Cohort
ColoCare is an international prospective cohort study of stage I-IV colorectal cancer patients (ICD-10 C18-C20).
- Trial name
- NCT02328677
- Where
- 7 sites in United States, Germany
- Volunteers
- 5,000 people
- Sponsor
- University of Utah
Cancer Survivor, Stage I Rectosigmoid Cancer
Personalized Dietary Intervention in Managing Bowel Dysfunction and Improving Quality of Life in Stage I-III Rectosigmoid Cancer Survivors
This pilot clinical trial studies how well personalized dietary intervention works in managing bowel dysfunction and improving quality of life in stage I-III rectosigmoid cancer survivors.
- Conditions
- Cancer Survivor, Stage I Rectosigmoid Cancer, Stage II Rectosigmoid Cancer, Stage III Rectosigmoid Cancer
- Trial name
- NCT03063918
- Testing
- Informational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
Rectosigmoid Adenocarcinoma
Role of Low Inferior Mesenteric Artery Ligation During Laparoscopic Surgery for Rectosigmoid Cancer
During sigmoid or rectal cancer surgery, dissection of lymphnodes at the origin of inferior mesenteric artery is mandatory. Nevertheless, ligation of the origin of IMA should compromise blood supply to left colon and affect…
- Trial name
- NCT03557528
- Testing
- Laparoscopic colorectal resection
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Roma La Sapienza