Clinical trials: Recurrent Pterygium
Pterygium of Right Eye, Pterygium of Left Eye
Comparison of Recurrence Between Mini-SLET and Limbal-Conjunctival Autograft Techniques in Primary Pterygium
The surgical treatment options for pterygium, an abnormal growth on the eye's frontal surface can be treated with several surgical techniques.
- Conditions
- Pterygium of Right Eye, Pterygium of Left Eye, Pterygium of Both Eyes, Pterygium
- Trial name
- NCT06402643
- Testing
- Pterygium Excision
- Where
- Mexico
- Volunteers
- 68 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Recurrent Pterygium, Conjunctival Scarring
Digital Colorimetric Scale for Recurrent Pterygium Scar Assessment
This observational study aims to evaluate and validate a digital colorimetric scale for the objective assessment of conjunctival scarring in patients with recurrent pterygium.
- Trial name
- DCS-PTER (NCT07458126)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Pterygium
Safety and Efficacy of CBT-001 Ophthalmic Solution in Patients With Pterygium
Stage 1: Single Ascending Dose, Safety, Tolerability and Pharmacokinetics (n=24) Stage 2: Multiple Dose, Safety and Efficacy Study with 28-day Dosing and 5 months Followup (n=51)
- Trial name
- Pterygium (NCT03049852)
- Testing
- CBT-001 single dose, Vehicle, CBT-001 Multi-dose
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cloudbreak Therapeutics, LLC
Pterygium
Comparing Two Surgical Methods to Prevent Pterygium Regrowth
This study compares two surgical techniques for preventing the regrowth of a pterygium, a non-cancerous growth on the eye. After surgically removing the pterygium, surgeons will cover the area with either a flap of nearby tissue…
- Trial name
- NCT07277426
- Testing
- Conjunctival Rotational Flap, Conjunctival Autograft
- Volunteers
- 342 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Recurrent Pterygium of Eye
Evaluation of Conjunctival Autografting With MMC Application Versus Ologen Implantation of Recurrent Pterygium
Ologen implantation with conjunctival autografting shows promising results in surgical management of recurrent pterygium comparable to MMC application with conjunctival autografting with mild non vision threatening postoperative…
- Trial name
- NCT04419038
- Testing
- conjunctival autografting augmented with topical application of Mitomycin C, conjunctival autografting augmented with Ologen implantation
- Volunteers
- 63 people
- Sponsor
- Menoufia University
Recurrent Pterygium
Bevacizumab Injection for Recurrent Pterygium
Blockade of vascular endothelial growth factor (VEGF) with bevacizumab has been used to treat abnormal vascular conditions of the anterior segment of the eye.
- Trial name
- NCT02007174
- Testing
- Bevacizumab, Medical Treatment, Argon laser treatment
- Where
- Mexico
- Volunteers
- 38 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Pterygium, Primary
Conjunctival Autologous Transplantation Using Fibrin Glue in Primary Pterygia
To evaluate the recurrence and postoperative complications rates after conjunctival autograft surgery using fibrin adhesive for primary pterygium
- Trial name
- NCT00949728
- Testing
- Conjunctival autograft using fibrin glue
- Where
- Brazil
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Hospital de Olhos Sadalla Amin Ghanem
Glaucoma, Pterygium
Ologen (OculusGen)-Glaucoma and Pterygium Historical Control Study in China Beijing Hospital
The purpose of this study is to determine whether the OculusGen Collagen Matrix is effective and safe to implant as an aid of glaucoma and pterygium surgeries.
- Trial name
- NCT00320762
- Testing
- OculusGen Biodegradable Collagen Matrix Implant
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Pro Top & Mediking Company Limited
Recurrent Pterygium, Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation
Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation Treating Recurrent Pterygium Trial
To observe the effect of micro-conjunctival autografting combined with amniotic membrane transplantation on the postoperative recurrence, complications and ocular surface symptoms among patients with recurrent pterygium.
- Trial name
- NCT05362253
- Testing
- Micro-Conjunctival Autograft Combined with Amniotic Membrane Transplantation, Conventional Autologous Conjunctival Transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yifeng Yu
Pterygium, Bevacizumab
Topical Bevacizumab for Preventing Recurrent Pterygium
The purpose of this study is to determine whether bevacizumab eye drop is effective in the treatment of recurrent pterygium.
- Conditions
- Pterygium, Bevacizumab, VEGF, Anti-VEGF
- Trial name
- NCT01311960
- Testing
- bevacizumab eye drop 0.05%, normal saline 0.9%
- Where
- Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Pterygium
Efficacy and Safety of Sub-tenon Ranibizumab for Recurrent Pterygia
Ranibizumab, an effective antineovascular drug, will be studied for safety and efficacy in pterygium, a neovascular disorder of the ocular surface.
- Trial name
- NCT01169909
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Recurrent Pterygium
Strategies for Management of Recurrent Pterygium
Pterygium is a common eye disease. Its mechanism remains unknown but studies suggest that it is related to exposure to ultraviolet rays and ocular dryness.
- Trial name
- REPEAT (NCT02530801)
- Testing
- Bevacizumab, 5 fluorouracil
- Volunteers
- 25 people
- Sponsor
- University of Nottingham
Glaucoma, Pterygium
Ologen (OculusGen)-Glaucoma and Pterygium Historical Control Study in Beijing Remin Hospital
The purpose of this study is to determine whether the ologen (OculusGen) Collagen Matrix is effective and safe to implant as an aid of glaucoma and pterygium surgeries.
- Trial name
- NCT00321035
- Testing
- OculusGen Biodegradable Collagen Matrix Implant
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Pro Top & Mediking Company Limited
Pterygium
Intralesional Ranibizumab on Pterygium Vascularity, Size and Recurrence Rate: a Pilot Study
The purpose of this study is to evaluate the pterygium vascularity and size before and after intralesional ranibizumab injection and to evaluate its recurrence rate following pterygium excision surgery.
- Trial name
- NCT02342392
- Testing
- ranibizumab
- Volunteers
- 36 people
- Sponsor
- Universiti Sains Malaysia
Pterygium, Pterygium of the Conjunctiva and Cornea
CsA vs MMC for Preventing Pterygium Recurrence
aimed to compare the efficacy and safety of topical cyclosporin A (CsA) versus mitomycin C (MMC) as adjunctive therapies in preventing pterygium recurrence after surgical excision.
- Trial name
- MMC (NCT06944132)
- Testing
- Excision of the pterygium, Post-operative application of CsA, Intra-operative application of MMC
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Pterygium of the Conjunctiva and Cornea
Randomized Controlled Trial of Subconjunctival Bevacizumab Injection in Impending Recurrent Pterygium
Hypothesis: Subconjunctival bevacizumab injection may potentially suppress neovascularization in pterygium, preventing or retarding the progression of recurrence.
- Trial name
- NCT01288404
- Testing
- Fluorometholone, Bevacizumab
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Pterygium
Pterygium Treatment Using Single Beta-therapy as Adjuvant Treatment Compared to Conjunctival Autograft
PURPOSE: To affirm the effectiveness and complication rate of postoperative single-dose beta-irradiation (RT) with (90) Sr in the case of primary pterygium in a clinical trial.
- Trial name
- NCT01024257
- Testing
- beta-irradiation, conjunctival autograft
- Where
- Brazil
- Sponsor
- Marilia Medicine School
Conjunctival Autograft
Fibrin Glue vs. Suture in Pterygium Surgery
The use of Fibrin glue to place conjunctival graft will be as effective as suturing the graft, but will require much less operative time and will be better tolerated by the patients.
- Trial name
- NCT01158014
- Testing
- Fibrin Glue, Quixil, Suture
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Dr. Guy Ben-Simon, MD
Pterygium
Determinants of Pterygium Occurrence and Recurrence in a Rural African Population
The aim of the study is to find out why pterygium occurs and recurs in a rural African population. Participants will be interviewed on personal and lifestyle information, family history of pterygium, environmental exposure and…
- Trial name
- NCT00713180
- Testing
- Pterygium excision followed by grafting
- Where
- South Africa
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Anguria, Peter, M.D.
Recurrent Pterygium of Eye, Steroid-Induced Glaucoma
Topical 0.2% Loteprednol Etabonate vs. Topical 0.1% Dexamethasone in Impending Recurrent Pterygium
The objective of this study was to evaluate the efficacy of topical 0.2% loteprednol etabonate, a 'soft steroid', compared with topical 0.1% dexamethasone, which is widely used in postoperative pterygium excision to prevent the…
- Trial name
- NCT04075227
- Testing
- 0.2% loteprednol etabonate, 0.1% dexamethasone
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Wannisa Suphachearabhan