Clinical trials: Red Blood Cells
Malaria, Plasmodium Falciparum
A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21
This is a Phase Ib multi-stage Plasmodium falciparum malaria vaccine study to assess the safety and immunogenicity of the blood-stage vaccine candidate RH5.2 virus-like particle (VLP) in Matrix-MTM and the pre-erythrocytic stage…
- Trial name
- NCT05357560
- Testing
- Matrix-M with RH5.2 VLP and/or R21
- Where
- The Gambia
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Infant Development
Effect of a Mix of Dairy Lipids and Plant Oils in Infant Formula on Omega-3 Fatty Acid in Red Blood Cells
The objective of this study is to determine whether the use of a mix of dairy lipids and plant oils in infant formula can increase the sum of omega-3 fatty acids levels in membrane phospholipids of red blood cells (RBC) in 4…
- Trial name
- REBECA (NCT01611649)
- Testing
- Formula containing dairy lipids and plant oils, Formula containing plant oils, Formula containing dairy lipids and plant oils, DHA+ARA
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Lactalis
Alzheimer Disease
Erythrocyte Complement Receptor 1 and Alzheimer Disease
Main objective: investigate whether a functional polymorphism of CR1 (length, number of binding sites in C4b C3b, erythrocyte density, rate of soluble CR1 ...) so determined genetic or acquired, is a susceptibility factor for the…
- Trial name
- NCT01565434
- Testing
- CR1 impact
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Healthy Diet
Nutritional Study on the Beneficial Effects of Canned Fish Consumption on Healthy Adult Population
There is sufficient evidence on the beneficial effects of fish consumption on health, mainly associated with the content of omega-3 polyunsaturated fatty acids (EPA and DHA) present mainly in blue fish.
- Trial name
- TUNACAN (NCT05213273)
- Testing
- nutritional guidelines to promote healthy diet and increase fish intake
- Where
- Spain
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Sara Arranz Martinez
Aging, Erythrocyte Glutathione Deficiency
Energetics and Function in Older Humans
The investigators have previously reported that older patients with HIV are deficient in glutathione (GSH) due to decreased availability of cysteine and glycine, and that oral supplementation with cysteine (as n-acetylcysteine)…
- Conditions
- Aging, Erythrocyte Glutathione Deficiency, Muscle Weakness
- Trial name
- NCT02348762
- Testing
- Cysteine (as n-acetylcysteine) and Glycine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Metabolic Adaptation to High-Intensity Interval Training
Carbonic Anhydrase II Responses to Basketball-Specific High-Intensity Interval Training
This study aims to examine whether erythrocyte carbonic anhydrase II can be used as a biological marker of metabolic adaptation to basketball-specific high-intensity interval training.
- Trial name
- CAII-BASKET (NCT07377851)
- Testing
- Basketball-Specific High-Intensity Interval Training
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Iron Deficiency Anemia
Measuring Erythrocyte Iron Incorporation From Different Dosing Regimens in Anemic Women
Iron-deficient anaemic subjects are likely to benefit most from oral iron supplements, but supplementation schedules vary widely in clinical practice, absorption is low and compliance is poor due to mild gastrointestinal side…
- Trial name
- NCT03623997
- Testing
- Iron stable isotope labeled iron(II) sulfate
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Whole Blood Donation and Leukoreduction
Clinical Investigation to Evaluate the Hemanext® Oxygen Reduction System - Pivotal Trial
The primary goal of Hemanext. is to improve red cell storage through novel storage methods. Based on our review of the pertinent literature, there is substantial evidence suggesting that prolonged exposure to oxygen during…
- Trial name
- NCT03301779
- Testing
- Hemanext Red Blood Cell Processing System
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hemanext
Red Blood Cell Folate
Bioavailability of Folic Acid Fortified Bread
Folic acid is the synthetic form of vitamin folate. Because of its high stability and bioavailability, it is the form of folate added to bread in Canada to reduce birth defects.
- Trial name
- NCT01570088
- Testing
- Folic acid, L-5-MTHF
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hypoxia, Erythropoiesis
Effects of Intermittent Hypoxia Training With Iron Supplementation on Red Blood Cells and Iron Levels in Trained Athletes
This study investigates how training under conditions of reduced oxygen (intermittent hypoxia) affects the body's ability to produce red blood cells and manage iron levels, compared to training under normal oxygen conditions.
- Conditions
- Hypoxia, Erythropoiesis, Iron Metabolism Disorders
- Trial name
- IHIT-IRON (NCT07720960)
- Testing
- Control group (CG), Hypoxia group (HG): trained at simulated altitudes between 4,450 and 5,850 m
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Néstor Vicente-Salar
Cardiac Surgery, Erythrocyte Transfusion
Mechanism and Repository Study for the Red Cell Storage Duration Study
A large multicenter randomized controlled trial of approximately 1700 critically ill patients' status post complex cardiac surgery with sternotomy, called the Red Cell Storage Duration Study (RECESS), is currently ongoing.
- Trial name
- MARS (NCT01541319)
- Where
- 13 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Sudden Cardiac Death, Sudden Cardiac Arrest
Effects of Stearidonic Acid-Containing Foods on Eicosapentaenoic Acid Levels in Red Blood Cells and Omega-3 Index
The purpose of this study is to assess the effect of stearidonic acid when used as a food ingredient on eicosapentaenoic enrichment of red blood cell membranes and Omega-3 Index in men and women.
- Conditions
- Sudden Cardiac Death, Sudden Cardiac Arrest, Cardiovascular Disease
- Trial name
- NCT01749202
- Testing
- Sunflower Oil Softgels, EPA softgels, Sunflower Oil Food
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Solae, LLC
Red Cell Survival in Healthy Volunteers
Recovery and Lifespan of Red Blood Cells From Pathogen-reduced, Stored Blood Units
The pilot study has two objectives: 1) to assess the post-infusion viability of INTERCEPT RBC by measuring the 24 hour post-infusion recovery ("PTR24") and lifespan of autologous RBCs prepared with the INTERCEPT System for RBC…
- Trial name
- BIO-CR-RBC (NCT03384407)
- Testing
- Red cell survival in INTERCEPT treated red cells
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Cardiovascular Diseases
Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
The risk of cardiovascular disease is determined by the complex interplay between an individual's genetic make-up, lifestyle, and the environment.
- Trial name
- GENBIO (NCT04931498)
- Testing
- Questionnaire, Anthropometric measurements: height, weight, and body fat, Blood pressure and heart rate
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Blood Donors
Evaluation of Whole Blood With CPD Anticoagulant and AS-7/SOLX Additive Solution
This study will evaluate a new blood collection and filtration system that is intended to be used to collect, filter, separate and store red blood cells and, separately, plasma.
- Trial name
- NCT02145507
- Testing
- SOLX (Investigational), AS-3 (Control)
- Where
- 2 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Haemonetics Corporation
Sickle Cell Disease, Sickle Cell Anemia
Carbon Monoxide Levels and Sickle Cell Disease Severity
Background: Some people with sickle cell disease have different health problems than others. This may be related to how easily and frequently the red blood cells break apart in the blood.
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Anemia, Sickle Cell
- Trial name
- NCT01547793
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
The Focus is on the Detection of the Consequences of Autologous Blood Transfusion in Healthy Volunteers
Biological Parameters Changes After Autologous Blood Transfusion of Red Blood Cells (200 ml) in Healthy Volunteers.
The purpose of this study is to evaluate if differences between samples of subjects obtained before autologous blood transfusion or samples of non-transfused subjects and samples of subjects after autologous blood transfusion can…
- Trial name
- AUTOT-SPORT (NCT03889834)
- Testing
- Autologous Blood Transfusion, No transfusion
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Transfusion, Autologous, Blood Doping
Detecting Autologous Transfusion by Measuring Alterations in the Dynamics of Red Blood Cell Maturation and Recycling
A total of 40 subjects will be recruited for participation in this study. 20 subjects (10 males and 10 females) will be randomized to the active group (those receiving re-infusion of autologous blood) and 20 subjects (10 males…
- Trial name
- NCT02684747
- Testing
- Autologous Transfusion
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Utah
Healthy
Differential Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Platelet, Endothelial and Vascular Function
The purpose of this study was to determine whether supplementation with oils enriched with long chain n-3 PUFA, either EPA or DHA, had a differential effect on platelet, endothelial and vascular function.
- Trial name
- NCT01735357
- Testing
- EPA-rich triacylglycerol oil, DHA-rich triacylglycerol oil
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- King's College London
Hemodialysis Complication
Exercise Therapy on Rheological Functions of Erythrocyte in Hemodialysis
To improve aerobic capacity, muscular function, and health-related quality of life in patients with end-stage renal disease (ESRD), regular exercise is recommended.
- Trial name
- NCT06575634
- Testing
- Supervised exercise training
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital