Clinical trials: Refractory Angina Pectoris
Coronary Artery Disease, Angina Pectoris
Radiosurgery of Ganglion StELlatum In Patients With REFractory Angina Pectoris
The core hypothesis to be tested is that the radiosurgery of stellate ganglion (left one or both if left-sided without full relief of symptoms) is an effective therapy of refractory angina pectoris in patients with no other…
- Conditions
- Coronary Artery Disease, Angina Pectoris, Myocardial Ischemia
- Trial name
- RELIEF-AP (NCT05600751)
- Testing
- Radiosurgery of ganglion stellatum
- Where
- 2 sites in Czechia
- Volunteers
- 10 people
- Sponsor
- University Hospital Ostrava
Safety Issues, Efficacy, Self
Lower Silesia Sinus Reducer Registry
Lower Silesia Sinus Reducer Registry is a , single-center, single-arm registry including patients with chronic disabling refractory angina pectoris (Canadian Cardiovascular Society [CCS] classes 2-4) despite maximally tolerated…
- Trial name
- LSSRR (NCT06288165)
- Testing
- Coronary Sinus Reducer Implantation
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Refractory Angina, Microvascular Angina
Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries and Coronary Microvascular Dysfunction.
To demonstrate the feasibility and efficacy of the CS Reducer for the treatment of patients with ischaemia and non-obstructed coronary arteries (INOCA) and coronary microvascular dysfunction (CMD) and through a nested mechanistic…
- Conditions
- Refractory Angina, Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Disease
- Trial name
- REMEDY-PILOT (NCT05492110)
- Testing
- Coronary sinus reducer, Invasive coronary physiology
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Imperial College London
Refractory Angina, Chronic Stable Angina
Coronary Arteriogenetic Heparinized Exercise
This study evaluates the addition of heparin to a 2-week cycle of physical rehabilitation in the treatment of refractory angina.
- Trial name
- CARHEXA (NCT03350737)
- Testing
- Physical rehabilitation, Heparin
- Where
- Serbia
- Volunteers
- 32 people
- Sponsor
- Clinical Centre of Serbia
Refractory Angina
Use of the Neovasc Coronary Sinus Reducer System for the Treatment of Refractory Angina Pectoris in Patients With Ngina Class 3-4 Who Are Not Candidates for Revascularization
The purpose of this study is to implant the Reducer in patients with the symptoms of refractory angina, that suffer from refractory angina who demonstrate reversible ischemia.
- Trial name
- Reducer (NCT01566175)
- Testing
- Neovac coronary sinus reducer
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Stable Angina, Refractory Angina
Wave Crossover ECP Study for Simplified Therapy
The purpose of this study is to demonstrate substantial equivalence between Pression's Wave PRO System and a commercially available predicate ECP device to support a U.S. 510(k) submission for the Wave PRO System.
- Trial name
- WaveCRESST (NCT06571370)
- Testing
- External Counterpulsation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Pression
Refractory Angina Pectoris
Extracorporeal Shockwave Therapy for the Treatment of Advanced Angina Pectoris
Low intensity shockwaves have been proven in animal studies to induce local growth of new blood vessels from existing ones. The hypothesis of this study is that shockwave therapy could improve the symptoms of patients with…
- Trial name
- NCT01219218
- Testing
- Cardiac Extracorporeal Shockwave Therapy generator (Cardiospec)
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- Medispec
Refractory Angina Pectoris
Effect of Daily Remote Ischemic Conditioning on the Life Quality of Refractory Angina Pectoris Patients
The purpose is to test whether daily ischemic conditioning of the arms over 30 days could reduce the frequency and severity of angina pectoris and improve the life quality of refractory angina pectoris patients.
- Trial name
- D-RIC-RAP (NCT02499250)
- Testing
- remote ischemic conditioning (TDFT-12-A2), Optimal medical treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Navy General Hospital, Beijing
Coronary Artery Disease, Angina Pectoris
Impact of Coronary Sinus Flow Reducer on Coronary Microcirculation and Myocardial Ischemia
The increasing number of coronary revascularization procedures, coupled with improvements in drug therapy, has significantly extended the lifespan of patients with coronary artery disease (CAD).
- Trial name
- NCT06266065
- Testing
- Coronary Sinus Reducer
- Where
- Croatia
- Volunteers
- 25 people
- Sponsor
- Clinical Hospital Centre Zagreb
Coronary Artery Disease, Refractory Angina
Safety and Efficacy of Autologous Endothelial Progenitor Cell CD 133 for Therapeutic Angiogenesis
The purpose of this study is to determine whether transendocardial injections of autologous endothelial progenitor cells CD 133 is safe and feasible in patients with refractory angina.
- Trial name
- PROGENITOR (NCT00694642)
- Testing
- Selected CD 133+ cells
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Pilar Jimenez Quevedo
Refractory Angina, Coronary Artery Disease
Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.
This is a two-part study, comprised of an initial open-label run-in phase (Part 1) in a subset of 3 subjects to provide first data regarding safety, and feasibility of the percutaneous endovascular catheter-facilitated…
- Trial name
- EXACT2 (NCT07048808)
- Testing
- XC001
- Where
- 14 sites in United States
- Volunteers
- 106 people
- Sponsor
- XyloCor Therapeutics, Inc.
Coronary Artery Disease, Ischemia
Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial)
The primary purpose of this trial is to determine the safety of XC001 (AdVEGFXC1) in patients who suffer from angina caused by coronary artery disease and have no other treatment options.
- Conditions
- Coronary Artery Disease, Ischemia, Angina Refractory, Cardiovascular Diseases
- Trial name
- EXACT (NCT04125732)
- Testing
- AdVEGFXC1
- Where
- 16 sites in United States
- Volunteers
- 41 people
- Sponsor
- XyloCor Therapeutics, Inc.
Chronic Total Occlusion of Coronary Artery, Chronic Angina
VasoStar Vibrational Guidewire System to Facilitate Crossing Coronary Artery Chronic Total Occlusions
The goal of this project is to provide an improvement in wire performance to expedite crossing difficult lesions in the coronary vasculature.
- Trial name
- VST100 (NCT06193954)
- Testing
- VasoStar guidewire system
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- VasoStar, LLC
Coronary Artery Disease, Angina (Stable)
Coronary Sinus Reducer Therapy for Persisting Angina
Refractory angina due to advanced obstructive coronary artery disease (CAD) remains a major clinical problem with limited evidence-based treatment options.
- Trial name
- REDUCE ANGINA (NCT07485985)
- Testing
- Coronary sinus reducer
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Angina, Coronary Disease
Prospective, Controlled and Randomized Clinical Trial on Cardiac Cell Regeneration With Laser and Autologous Bone Marrow Stem Cells, in Patients With Coronary Disease and Refractory Angina
Coronary disease is one of the most frequent pathology of the modern world and the leading cause of death in the investigators country.
- Trial name
- NCT01214499
- Testing
- Transmyocardial revascularization (TMR) with Holmium YAG laser, Transmyocardial revascularization (TMR) with Holmium YAG laser plus the patient's own stem cells extracted from bone marrow.
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Coronary Microvascular Disease, Refractory Angina
COSIMA: COronary SInus Reducer for the Treatment of Refractory Microvascular Angina
Patients with refractory microvascular angina fulfilling the predefined inclusion and exclusion criteria will be enrolled in this randomized trial.
- Trial name
- COSIMA (NCT04606459)
- Testing
- Coronary sinus reducer, Optimal medical therapy
- Where
- Germany
- Volunteers
- 144 people
- Sponsor
- Johannes Gutenberg University Mainz
Refractory Angina Pectoris
IMR Evaluation in Patients with Coronary Sinus Reducer Implantation (INROAD Study)
The INROAD is an investigator-driven, prospective, study in which patients undergoing coronary sinus reducer implantation (Reducer) for chronic refractory angina undergo evaluation of the index of microcirculatory resistance…
- Trial name
- INROAD (NCT05174572)
- Testing
- IMR
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Consorzio Futuro in Ricerca
Refractory Angina Pectoris
CoROnary SinuS Reducer implantatiOn for ischemiA reDuction
Patients with refractory angina pectoris have low quality of life and reduced exertional capacity. Studies have shown that the coronary sinus reducer (CSR) implantation improves the quality of life.
- Trial name
- CrossRoad (NCT04121845)
- Testing
- Coronary Sinus Reducer device
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Angina Pectoris, Coronary Disease
Cardiac Rehabilitation for the Treatment of Refractory Angina
The purpose of this study is to determine whether cardiac rehabilitation is a successful treatment for refractory angina, in relation to improvements in cardiovascular risk factors, physical ability, symptomology, quality of life…
- Trial name
- NCT00411359
- Testing
- Cardiac rehabilitation
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- National Heart and Lung Institute
Refractory Angina Pectoris
Extracorporeal Shockwave Therapy for the Treatment of Refractory Chronic Angina Pectoris
Low intensity shockwaves have been proven in animal studies to induce local growth of new blood vessels from existing ones. The hypothesis of this study is that shockwave therapy could improve the symptoms of patients with…
- Trial name
- NCT01567644
- Testing
- Cardiac Extracorporeal Shockwave Therapy generator (Cardiospec)
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Medispec