Clinical trials: Refractory Ventricular Tachycardia
Tachycardia, Ventricular
Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)
RADIATE-VT is a pivotal, multicenter, randomized trial comparing safety and efficacy between cardiac radioablation (CRA) using the Varian CRA System and repeat catheter ablation (CA), for patients with high-risk refractory…
- Trial name
- RADIATE-VT (NCT05765175)
- Testing
- Varian Cardiac Radioablation (CRA), Catheter Ablation (CA)
- Where
- 11 sites in United States
- Volunteers
- 380 people
- Sponsor
- Varian, a Siemens Healthineers Company
Cardiac Arrest, Ventricular Fibrillation
VectOr ChAnge defibriLlatIon in Refractory Shockable rhyThms
Management of cardiac arrest according to published guidelines has remained largely unchanged for a decade. Thames Valley Air Ambulance provide Critical Care Paramedic and Physician teams who respond to cardiac arrests and offer…
- Conditions
- Cardiac Arrest, Ventricular Fibrillation, Ventricular Tachycardia
- Trial name
- VOCALIST (NCT05926973)
- Testing
- Enhanced cardiac arrest bundle
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Thames Valley Air Ambulance
Tachycardia, Ventricular
Stereotactic Ablative Radiotherapy (SAbR) for Treatment of Ventricular Tachycardia (VT) Refractory Standard Invasive Ablation Techniques
The purpose of this study is to evaluate the clinical efficacy and safety of stereotactic ablative radiotherapy (SAbR), also known as stereotactic body radiation therapy (SBRT), for treatment of ventricular tachycardia (VT)…
- Trial name
- NCT04334811
- Testing
- Stereotactic ablative radiotherapy
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Ventricular Tachycardia, Myocardial Infarction
Cardiac Radioablation for VT
The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed…
- Trial name
- NCT06593418
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Corewell Health East
Refractory Ventricular Tachycardia
PrOsPective Cohort Study for STereotactic Arhythmia Radioablation (STAR) of Refractory Ventricular Tachycardia
This is a multicenter, interventional study. The study will enroll patients that fulfill the inclusion criteria over a 33-month period.
- Trial name
- POPSTAR (NCT06294782)
- Testing
- STereotactic Arhythmia Radioablation (STAR)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
Advanced Reperfusion Strategies for Refractory Cardiac Arrest
This is a Phase II, single center (Under the Center for Resuscitation Medicine at the University of Minnesota Medical School), partially blinded, prospective, intention to treat, safety and efficacy clinical trial, randomizing…
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia
- Trial name
- ARREST (NCT03880565)
- Testing
- Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Refractory Ventricular Tachycardia
STereotactic RadioAblation by Multimodal Imaging for VT (STRA-MI-VT)
Study of multimodal-imaging guided stereotactic body radiotherapy (SBRT) for ventricular tachycardia (VT) ablation.
- Trial name
- STRA-MI-VT (NCT04066517)
- Testing
- SBRT
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Centro Cardiologico Monzino
Ventricular Tachycardia
Radiosurgery for the Treatment of Refractory Ventricular Extrasystoles and Tachycardias
Patients with refractory ventricular extrasystoles or tachycardia not eligible for catheter ablation will receive single fraction stereotactic body radiation therapy (cardiac radiosurgery) with 25 Gy.
- Trial name
- RAVENTA (NCT03867747)
- Testing
- Cardiac Radiosurgery
- Where
- 6 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Schleswig-Holstein
Refractory Ventricular Tachycardia
Stereotactic Ablative Radiotherapy for Refractory Ventricular Tachycardia
Single arm, phase Ib/2a dose escalation study with an expansion cohort to determine the maximal tolerated dose (MTD) for stereotactic ablative radiotherapy of targets in the cardiac myocardium and to make a preliminary assessment…
- Trial name
- NCT03349892
- Testing
- Stereotactic Ablative Radiotherapy (SABR)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Los Angeles
Tachycardia, Ventricular
CyberHeart's Cardiac Arrhythmia Ablation Treatment: Patients With Refractory Ventricular Tachycardia/Fibrillation
The objective of this clinical investigation is to evaluate: 1. the safety and efficacy of the CyberHeart System, CardioPlan™ Software and Laptop, in treating patients with refractory ventricular tachycardia (VT) using the…
- Trial name
- NCT02661048
- Testing
- CyberHeart System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Varian, a Siemens Healthineers Company
Cardiac Arrhythmia, Cardiac
Phase I/II Randomized Study of Stereotactic Ablative Radiotherapy (SABR) Versus Standard of Care for Refractory Structural Cardiac Arrhythmias (SABR-HEART)
Phase I: For the Phase I portion, there will be up to 15 patients treated with SABR and followed for 6 months post-treatment to ensure no significant acute grade 3 or 4 toxicity from SABR treatment.
- Conditions
- Cardiac Arrhythmia, Cardiac, Ventricular Tachyarrhythmias
- Trial name
- NCT05084391
- Testing
- stereotactic ablative radiotherapy (SABR), Standard of Treatment
- Sponsor
- M.D. Anderson Cancer Center
Ventricular Tachycardia
Noninvasive Cardiac Radioablation for Ventricular Tachycardia Refractory to Medication and Catheter Ablation
The purpose of this study is to evaluate the safety and efficacy of cardiac radioablation (CRA) as a means of noninvasive treatment of ventricular tachycardia (VT) refractory to both medication and catheter ablation.
- Trial name
- RAD 1901 (NCT04757688)
- Testing
- Cardiac radioablation (CRA)
- Where
- United States
- Sponsor
- John Stahl
Refractory Ventricular Tachycardia
Saline Enhanced Radiofrequency (SERF) Needle Ablation for Refractory VT
The Thermedical Ablation System and Durablate catheter is indicated for use in patients with recurrent, sustained, monomorphic ventricular tachycardia (SMVT) refractory to drug therapy and conventional (approved) catheter…
- Trial name
- NCT05337241
- Testing
- Saline Enhanced Radiofrequency (SERF) Ablation
- Where
- 7 sites in United States, Canada
- Volunteers
- 130 people
- Sponsor
- Thermedical, Inc.
Ventricular Tachycardia
Percutaneous Inferior Cervical Sympathetic Block for Treatment of Refractory Ventricular Tachycardia
The purpose of this research study is to examine the effect of percutaneous inferior cervical sympathetic block on life threatening abnormal heart rhythms called ventricular tachycardia or ventricular fibrillation that can lead…
- Trial name
- NCT04770051
- Testing
- Percutaneous inferior cervical sympathetic block
- Sponsor
- University of Missouri-Columbia
Radiotherapy; Complications, Ventricular Tachycardia
Stereotactic Ablative Radiotherapy for the Treatment of Refractory Ventricular Tachycardia
Ventricular tachycardia (VT) is an abnormal rhythm arising from the bottom chambers (ventricles) of the heart. The hearts of most patients who develop VT have been previously damaged by a myocardial infarction (heart attack) or…
- Conditions
- Radiotherapy; Complications, Ventricular Tachycardia, Structural Heart Abnormality, Heart Failure
- Trial name
- SABRE-VT (NCT05696522)
- Testing
- Stereotactic ablative radiotherapy
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Barts & The London NHS Trust
Refractory Ventricular Tachycardia
Prospective Randomized Clinical Trial for Effect of Stellate Ganglion Block in Medically Refractory Ventricular Tachycardia
The investigators will compare the effects of PSGB(percutaneous stellate ganglion block) in patients with recurrent sustained VT/VF in spite of appropriate medical therapy and cardio-version/ defibrillation after correction of…
- Trial name
- NCT02646501
- Testing
- Antiarrhythmic drug, percutaneous stellate ganglion block (PSGB)
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Ventricular Tachycardia, Chagas Disease
SBRT in Chagas Disease Ventricular Tachycardia
This is an observational study of 10 Chagas Disease patients with Ventricular Tachycardia that have failed prior catheter ablation or have this procedure contraindicated due to clinical status.
- Conditions
- Ventricular Tachycardia, Chagas Disease, Cardiac Arrhythmia
- Trial name
- NCT04984265
- Testing
- Stereotactic Body Radiation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Ventricular Tachycardia
Bipolar Ventricular Tachycardia (VT) Study
This non-randomized study will examine the safety and efficacy of irrigated bipolar radiofrequency (RF) ablation in the treatment of ventricular tachycardia (VT) in patients for whom standard VT unipolar RF ablation has been…
- Trial name
- NCT02374476
- Testing
- Bipolar Ablation
- Where
- 6 sites in United States
- Volunteers
- 145 people
- Sponsor
- Srinivas Dukkipati
Cardiac Arrest, Sudden Cardiac Death
Treatment of Ventricular Tachyarrhythmias Refractory To Shock With Beta Blockers: The SHOCK and BLOCK Trial
The purpose of this research study is to evaluate the effectiveness of metoprolol, a "beta blocker," in treating patients in the hospital with a cardiac arrest. It will be given intravenously (given into a vein).
- Conditions
- Cardiac Arrest, Sudden Cardiac Death, Ventricular Fibrillation, Tachycardia, Ventricular
- Trial name
- Shock n Block (NCT00401882)
- Testing
- Epinephrine, Metoprolol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- David Haines, MD