Clinical trials: Relationship Conflict
Bacterial Infections, Pneumonia, Pneumocystis Carinii
A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children
This study compares 2 different treatments administered to try to prevent serious bacterial infections (such as pneumonia) in HIV-positive children.
- Conditions
- Bacterial Infections, Pneumonia, Pneumocystis Carinii, HIV Infections
- Trial name
- NCT00000811
- Testing
- Azithromycin, Atovaquone, Sulfamethoxazole-Trimethoprim
- Where
- 75 sites in United States, Puerto Rico
- Volunteers
- 690 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis, Sepsis Associated DIC
A Study to Learn About the Occurrence of Disseminated Intravascular Coagulation in People With Sepsis and Further Worsening of Sepsis
This is an exploratory study in which data from people with sepsis (a serious condition in which the body responds to an infection that damages vital organs) admitted to an Intensive care unit (ICU) who will receive treatment are…
- Trial name
- NCT06986798
- Testing
- Local standard medical care
- Where
- 31 sites in Austria, Belgium and 5 more
- Volunteers
- 150 people
- Sponsor
- Bayer
Postoperative Pain, Postoperative Nausea and Vomiting
The Effects of Preoperative Physical Activities on Surgeries
Recommendation is strong on physical activity (PA) in the prehabilitation of Enhanced Recovery After Surgery (ERAS) for various types of surgeries. The evidence is however weak regarding ERAS protocols.
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting, Prehabilitation, Physical Activities
- Trial name
- NCT04739787
- Volunteers
- 5,500 people
- Sponsor
- Chiayi Christian Hospital
Parent-Child Relations, Dental Fear
Parental Presence and Preschoolers' Behavior
Purpose: This study aimed to assess the effect of parental active/passive presence technique (PAP/PPP) on the overall behavior of preschool children with different intelligence and fear levels.
- Trial name
- NCT04580316
- Testing
- Parental active presence, Parent passive presence
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Opioid Sensitivity, Individual Difference
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans
Within-subject, double-blind, placebo-controlled examination of opioid abuse potential in healthy individuals as a function of A118G SNP on the OPRM1 gene.
- Conditions
- Opioid Sensitivity, Individual Difference, Abuse Opioids
- Trial name
- NCT02360371
- Testing
- Within-subject test of blinded study medication
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Depression - Major Depressive Disorder, Anxiety
Comparative Effects of Acceptance and Commitment Therapy, Cognitive Behavioral Therapy, and Treatment-as-Usual on Depression Among People With Marital Crisis
This parallel three-arm, single-blind (assessor-blinded), randomized controlled trial (RCT) aims to compare the effects of ACT, CBT, and treatment-as-usual (TAU) on the severity of depressive symptoms (primary outcome), the…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Marital Conflict
- Trial name
- NCT07808021
- Testing
- Acceptance and Commitment Therapy, Cognitive Behavioral Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Universiti Sains Malaysia
Prostate Cancer
A Prospective Longitudinal Study of Health-Related Quality of Life in Men With Clinically Localized Prostate Cancer
to prospectively assess the health-related quality of life (HRQOL) changes during the first year after different treatment modalities for localized prostate cancer.
- Trial name
- NCT00777452
- Where
- South Korea
- Volunteers
- 93 people
- Sponsor
- Samsung Medical Center
The Primary Study Objective is to Assess the Efficacy and, Safety of Extended 4-week Heparin Prophylaxis Compared to
ONE WEEK VERSUS FOUR WEEK HEPARIN PROPHYLAXIS AFTER LAPAROSCOPIC SURGERY FOR COLORECTAL CANCER.
Overall, only limited evidence exists regarding the clinical benefit of antithrombotic prophylaxis after laparoscopic surgery for cancer.
- Conditions
- The Primary Study Objective is to Assess the Efficacy and, Safety of Extended 4-week Heparin Prophylaxis Compared to, Prophylaxis Given for 8±2 Days After Planned Laparoscopic, Surgery for Colorectal Cancer.
- Trial name
- PRO-LAPS I (NCT01589146)
- Testing
- Heparin, Low-Molecular-Weight
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Of Perugia
Age Related Cataracts
Posterior Capsule Opafication of Different Hydrophobic Acrylic Intraocular Lenses: Vivinex iSert P261 vs.Clareon IOL
On the day of surgery, the first eye to be operated is randomised to receive a Vivinex , HOYA Surgical Optics GmbH or an Clareon, Alcon, Fort Worth, Texas. The second eye to be operated receives the other IOL type.
- Trial name
- Clarinex (NCT04369482)
- Testing
- Alcon Clareon, Hoya Vivinex
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Pregnancy Related, Thyroid Stimulating; Hormone, C
Correlation Between Levothyroxine and Blood Th17/Treg in Pregnant Women With Normal-high TSH and Positive TPOAb
The purpose of this clinical trial is to understand the impact of different doses of levothyroxine on the immune inflammatory response in pregnant women with normal-high TSH and positive TPOAb in the first half of pregnancy.
- Trial name
- NCT06527859
- Testing
- Levothyroxin
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital of Zhengzhou University
Sepsis
Differential Clinical Phenotypes Of Early CD4+ And CD8+ T-Cell Recovery And Association With 28-Day Mortality In Sepsis Patients
This is a retrospective non-interventional cohort study. Medical records of adult patients with sepsis admitted to the intensive care unit will be retrospectively reviewed.
- Trial name
- NCT07787780
- Testing
- CD4+/CD8+ T-cell dynamic recovery status
- Where
- China
- Volunteers
- 303 people
- Sponsor
- Sichuan Provincial People's Hospital
Agitated; State, Acute Reaction to Stress
Dexmedetomidine Combined With Hydromorphone in Tonsillectomy and Adenoidectomy
Tonsillectomy and adenoidectomy is one of the most common pediatric surgeries, and agitation and severe postoperative pain have been considered a very common complications.
- Trial name
- NCT03760809
- Testing
- Dexmedetomidine 0.5μg／kg, Dexmedetomidine 1μg／kg
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Critical Illness
Association Between Resuscitation Orders and Mortality in ICU Patients
The hypothesis of the study is that a resuscitation order other than full code is associated with increased mortality among critically ill patients.
- Trial name
- NCT06373068
- Testing
- Resuscitation orders
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Karolinska Institutet
Catheter Related Complication
Comparison of Tramadol and Dexmedetomidine in the Prevention of Urinary Catheter Discomfort in Urinary Surgery
The investigators aimed to compare the effects of tramadol and dexmedetomidine, which are commonly used in anesthesia, on preventing catheter-related bladder discomfort.
- Trial name
- NCT04314050
- Testing
- Tramadol, Dexmedetomidine, control
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Ankara Diskapi Training and Research Hospital
Simulation Training
Different Reality Simulation Education Methods on Nursing Students
To compare the impact of simulation practices using a high-reality simulator, hybrid simulator and task-trainers on tracheal aspiration levels of nursing students' knowledge, skills, satisfaction, and self-confidence.
- Trial name
- Experimental (NCT07435233)
- Testing
- High-Fidelity Simulation, Hybrid Simulation, Training mannequin
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Karadeniz Technical University
Cystic Fibrosis
Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF
In the literature, there is no study that evaluates the endothelial function and arterial stiffness together and investigates its relationship with exercise capacity and respiratory functions in children with CF of different…
- Trial name
- NCT04259983
- Testing
- Maximal exercise test, Endothelial dysfunction assessment, Arterial stiffness assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Polycystic Ovary Syndrome, Estro-progestin Drugs
Effect of Two Different Dosages of Ethinyl-estradiol in Association With Drospirenone in Women With Polycystic Ovary Syndrome.
The estrogenic component of estro-progestin (EP) is responsible for a negative impact on the metabolic and lipid assessment in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT01519401
- Testing
- 3 mg drospirenone and 20 µg ethinyl-estradiol, 3 mg drospirenone and 30 µg ethinyl-estradiol
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Postmenopause
Pharmacogenetic Study of Different Hormone Therapies in Recent Menopause Women
This is cross-over, randomized clinical trial, with objective to evaluate the effects of low-dose oral hormone therapy and non-oral hormone therapy on endothelial function markers (fibrinogen, von Willebrand factor, c-reactive…
- Trial name
- NCT01432028
- Testing
- Estradiol and Progesterone, Estradiol and Drospirenone
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Denusa Wiltgen
Nicotine Dependence
Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine
Comparison of the pharmacokinetics and pharmacodynamics of two different nicotine salt concentrations and free-base nicotine using an open vape pod system
- Trial name
- NCT04170907
- Testing
- standardized vaping protocol
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Drug Abuse/Dependence
Understanding Drug Abuse Treatment Outcomes
Background: Although some treatments for substance abuse are considered effective for some people who are drug dependent, many others do not benefit as much over time.
- Trial name
- NCT01678833
- Where
- 2 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)