Clinical trials: Renal Stones
Kidney Calculi, Ureter Calculi
Comparing Treatment of Urolithiasis Between Disposable and Reusable Ureteroscope
Reusable flexible ureteroscopes are widely used to treat various upper urinary tract diseases including urinary stones. However, they require a long turnover time between procedures because of the sterilization process.
- Trial name
- NCT03040466
- Testing
- reusable fiberoptic ureteroscope, disposable digital ureteroscope
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of California, San Francisco
Nephrolithiasis, Uric Acid
Pathogenesis of Uric Acid Nephrolithiasis: Role of Pioglitazone/Weight Loss
The investigators will randomize overweight and obese iuan patients to Pio (45 mg/day, highest approved dose or placebo), WL (10% of body weight, following the established program used in the Diabetes Prevention Program), or…
- Trial name
- NCT04370093
- Testing
- Pioglitazone 45 mg, Weight Loss, Pioglitazone + Weight Loss
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Texas Southwestern Medical Center
Kidney Stone
Effect of Tamsulosin on Stone Expulsion and Pain Resolution in ED Patients With Ureterolithiasis
Tamsulosin (Flowmax)is approved by the FDA for the treatment for enlarged prostate. Several studies regarding the use of Tamsulosin for the treatment of lower kidney stones have been carried out in the non-Emergency Department…
- Trial name
- Flowmax (NCT00762424)
- Testing
- Flowmax
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- WellSpan Health
Kidney Stone, Pain, Postoperative
Perioperative Pregabalin in Ureteroscopy
This is a randomized, placebo-controlled, double-blinded study examining the use of perioperative pregabalin in ureteroscopy with stent placement.
- Conditions
- Kidney Stone, Pain, Postoperative, Addiction, Opioid Use
- Trial name
- NCT04122196
- Testing
- Pregabalin 300mg
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Missouri-Columbia
Pain, Urinary Stone
Prospective Randomized Controlled Trial for Pain Relief After Office Ureteral Stent Removal
This is a prospective randomized double-blind controlled trial assessing the benefits of intramuscular ketorolac before or immediately after office ureteral stent removal.
- Conditions
- Pain, Urinary Stone, Urinary Calculi
- Trial name
- NCT04112160
- Testing
- Ketorolac, normal saline
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Texas Southwestern Medical Center
Kidney Stones
Feasibility and Impact of a Decision Rule for Imaging of Emergency Department Patients With Suspected Kidney Stone
This is the third phase (feasibility and impact) of a three-phase project designed to derive, validate and test the feasibility and impact of implementing clinical decision support to safely limit the use of Computerized…
- Trial name
- NCT01869647
- Testing
- Ultra low dose CT scan, Regular CT or Low Dose CT scan, No imaging
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- Yale University
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Cystinuria
TCUPS- Tolvaptan Use in Cystinuria and Urolithiasis: A Pilot Study
The goal of this research project is to establish that in short-term use, tolvaptan is a safe and potentially effective new therapy for cystinuria, by conducting a short-term pilot study of the safety and tolerability of this…
- Trial name
- TCUPS (NCT02538016)
- Testing
- Tolvaptan
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Caleb Nelson
Nephrolithiasis
Evaluation of a Nonopioid Recovery Pathway Following Surgery for Kidney Stones
Evaluation of a nonopioid recovery pathway after percutaneous nephrolithotomy is a pragmatic pilot study that will apply the knowledge and experience gained with development of an outpatient opioid reduction protocol to…
- Trial name
- NCT04597619
- Testing
- Novel Nonopioid Pathway
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Miriam Hospital
Kidney Stones, Nephrolithiasis
Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and…
- Trial name
- NCT05365477
- Testing
- Empiric Therapy: Diet, Empiric Therapy: Drug, Selective Therapy: Diet
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Vanderbilt University Medical Center
Renal Colic, Kidney Stone
Erector Spinae Plane Block for Uncomplicated Renal Colic
This research study is to determine how well the Erector Spinae Plane Block (ESPB) works for kidney stone pain and any possible side effects.
- Trial name
- NCT05625802
- Testing
- Erector Spinae Plane Block (ESPB), Ropivacaine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Kidney Calculi, Ureteral Calculi
Study of Ketorolac Versus Opioid for Pain After Endoscopy
A double blind randomized controlled trial designed to compare pain control and safety with ketorolac and oxycodone in the post-operative setting for patients undergoing ureteroscopy for treatment of urinary stones.
- Trial name
- SKOPE (NCT03888144)
- Testing
- Oxycodone, Ketorolac
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Kidney Stones
Occlusion Balloon vs. 5FR Ureteral Catheter
Occlusion Balloon catheter provides the ability to occlude the exit of the kidney pelvis during percutaneous nephrolithotomy (PCNL) and potentially prevents the migration of stone fragments into the ureter.
- Trial name
- NCT06798753
- Testing
- Occlusion Balloon Catheter, 5FR Ureteral Catheter
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Urinary Lithiasis, Kidney Diseases
Toradol to Reduce Ureteroscopic Symptoms Trial
Double blinded randomized controlled clinical trial to assess the impact of intraoperative Toradol on post-operative pain scores for patients undergoing ureteroscopy for urinary stone management.
- Conditions
- Urinary Lithiasis, Kidney Diseases, Kidney Stone, Pain, Postoperative
- Trial name
- TRUST (NCT03111381)
- Testing
- Toradol
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Yale University
Kidney Stone, Renal Stone
Antibiotic Selection Using Next Generation Sequencing vs Urine Culture
This is a randomized controlled clinical study evaluating the use of next-generation sequencing (NGS) to improve antibiotic prescribing before ureteroscopy or percutaneous nephrolithotomy.
- Conditions
- Kidney Stone, Renal Stone, Infection, Bacterial
- Trial name
- ACCESS (NCT04404855)
- Testing
- NGS + Antibiotic Recommendation, Standard of Care treatment
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Nephrolithiasis
Thulium vs. Hol:YAG Laser
This is a randomized prospective study to compare stone free rates and operative efficiency of two laser systems used during retrograde intrarenal surgery for kidney stone disease: 1.
- Trial name
- NCT05808257
- Testing
- Thulium Fibre Laser, Holmium:Yttrium-Aluminum-Garnet
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Nephrolithiasis, Urinary Tract Infections
A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])
When patients are going to have surgery to remove large kidney stones (percutaneous nephrolithotomy [PCNL]), it is not clear whether the patients benefit from a course of prophylactic preoperative oral antibiotics; currently both…
- Trial name
- NCT02384200
- Testing
- nitrofurantoin monohydrate/macrocrystalline capsules, ampicillin, gentamicin
- Where
- 8 sites in United States, Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Ureteral Calculus, Ureterolithiasis
Silodosin Versus Tamsulosin for Treatment of Ureteral Stones
Ureteral calculi, commonly known as kidney stones, are a frequent cause of Emergency Department (ED) visits. These stones can get caught in the ureter (the tube connecting the kidney to the bladder) and cause symptoms including…
- Conditions
- Ureteral Calculus, Ureterolithiasis, Ureteral Stone
- Trial name
- NCT02369744
- Testing
- Silodosin, Tamsulosin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Albert Einstein Healthcare Network
Renal Stone, Nephrolithiasis
Impact Ureteral Sheath Design During Ureteroscopy
The purpose of this study is to assess whether one of two ureteral access sheaths is safer for patients undergoing ureteroscopy. Both sheaths are FDA approved devices and commercially available.
- Conditions
- Renal Stone, Nephrolithiasis, Urolithiasis
- Trial name
- NCT03349099
- Testing
- Cook Flexor, Boston Scientific Navigator
- Volunteers
- 95 people
- Sponsor
- The Cleveland Clinic
Nephrolithiasis, Hyperoxaluria
Use of Oral Probiotics to Reduce Urinary Oxalate Excretion
The purpose of this study was to determine the effect of two probiotic preparations (Agri-King Synbiotic and Oxadrop) on urinary oxalate excretion in patients with mild hyperoxaluria.
- Conditions
- Nephrolithiasis, Hyperoxaluria, Crohn's Disease
- Trial name
- NCT00587041
- Testing
- Oxadrop, Agri-King Synbiotic (AKSB)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic