Clinical trials: Replacement
Osteoarthritis
Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study
The purpose of this study is to determine if there is a patient satisfaction preference of Fixed Bearing versus Mobile Bearing Unicompartmental Knee Arthroplasty (UKA) in patients who are at a minimum two years post operative.
- Trial name
- NCT02633085
- Testing
- Fixed Bearing or Mobile Bearing UKA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Knee Replacement, Total Knee Arthroplasty
Trial of Liposomal Bupivacaine for TKA
Total knee arthroplasty (TKA), also known as a knee replacement, is a procedure performed to reduce severe pain and improve function of the joint.
- Conditions
- Knee Replacement, Total Knee Arthroplasty, Post-Operative Pain
- Trial name
- NCT05635916
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northern Light Mercy Hospital
Arteriosclerosis, Acute Myocardial Infarction
Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity
Women and men show marked differences in cardiovascular risk profile and outcome. Women experience fewer cardiovascular events than men before menopause, but this relationship seems to reverse at menopause.
- Conditions
- Arteriosclerosis, Acute Myocardial Infarction, Cardiovascular Events, Menopause
- Trial name
- NCT05985447
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Hyperglycemia, Obesity Prevention
The Impact of Low Glycemic Index Nutritional Shake on Glucose Regulation in Overweight and Obese Adults
Low glycemic index nutritional shakes have clinically shown to improve post-prandial glycemic responses in acute laboratory control studies.
- Trial name
- SHAKE (NCT06856460)
- Testing
- powder shake with very low glycemic index, Ceral Breakfast
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Ankle Arthritis
Total Ankle Replacement: Clinical and Radiological Outcomes
This retrospective and prospective study intends to evaluate the epidemiology and effectiveness of ankle joint surgery in patients operated from January 2011 to March 2026, evaluating the results both clinically and…
- Trial name
- NCT03650010
- Testing
- Total ankle replacement
- Where
- Italy
- Volunteers
- 1,066 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Tricuspid Valve Disease
CorMatrix Cor TRICUSPID ECM Valve Replacement Study
The Pivotal Study of the Cor TRICUSPID ECM Valve (or Cor PEDIATRIC Tricuspid ECM Valve). This study follows the EFS and is now to determine the safety and efficacy of the Cormatrix Cor TRICUSPID Valve for any patients requiring…
- Trial name
- NCT02397668
- Testing
- CorMatrix Cor TRICUSPID ECM Valve
- Where
- 4 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Corvivo Cardiovascular, Inc.
Recession
Aesthetic Evaluation of Two Piece 3mm Implants for Single Tooth Replacement of Maxillary Laterals and Mandibular Incisors
Aesthetic evaluation of two piece 3mm implants for single tooth replacement of maxillary laterals and mandibular incisors
- Trial name
- NCT01346345
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr.Suzanne Caudry Implant Dentistry and Periodontics
Fertility, Implantation, Embryo
Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)
This study looks at progesterone, a hormone that prepares the womb lining (endometrium) for pregnancy, in women having a frozen embryo transfer after IVF.
- Trial name
- PROMICOFET (NCT07818278)
- Testing
- Oestrogel® 0.75 mg (estradiol transdermal gel), Progesterone 200 mg vaginal capsules, Endometrial biopsy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Total Knee Arthroplasty, Knee Replacement
Investigating Patient Satisfaction With Smart Knee Implants
The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee…
- Conditions
- Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT06968143
- Testing
- Smart Knee Implant
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Tobacco Use Cessation
Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
The goal of this research study is to learn about 2 different interactive methods that are designed to help people with HIV/AIDS stop smoking.
- Trial name
- NCT02302859
- Testing
- Nicotine Patch, Questionnaires, Pamphlet
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hormone Replacement Therapy
Effects of Estradiol on Menopausal Breast
The purpose of this study is to evaluate the effects on breast in postmenopausal women randomized to either oestradiol in combination with DRSP or E2 in combination with NETA during six months.
- Trial name
- BrAVA (NCT00785317)
- Testing
- Angemin vs Activelle
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Total Knee Replacement
Knee4Life Project: Empowering Knee Recovery After Total Knee Replacement Through Digital Health
The research project will investigate the extent to which a smartphone camera sensor tool can help predict and measure knee stiffness and pain after Total Knee Replacement Surgery (TKR) and how a tool such as this could be…
- Trial name
- K4L (NCT06429462)
- Testing
- smartphone camera sensor tool
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Knee Osteoarthritis
Gait Analysis of a Lateral-Pivot Design Total Knee Replacement
Previous motion analysis studies have demonstrated excellent ability to distinguish subtle differences in gait between normal subjects and those suffering from arthritis.
- Trial name
- NCT04275362
- Testing
- DJO Empowr PS Knee System, Stryker Triathlon Total Knee System, Biomet Vanguard Complete Knee System
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- More Foundation
Arthroplasty, Overweight and Obesity
Healthy Living After Knee Replacement
The purpose of this study is to examine if a weight loss program designed for adults after knee replacement improves weight loss, physical activity, pain, and function, as well as if the program is cost effective, as compared to…
- Trial name
- NCT05190666
- Testing
- PACE Weight Loss program, Chronic Disease Self-Management
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Smoking
Naltrexone and Patch for Smokers
The aim of this study is to investigate the effects of naltrexone, alone and combined with nicotine patch, on responses of smokers to smoking cues after 10 hours of tobacco deprivation.
- Trial name
- NCT00018213
- Testing
- Naltrexone Hydrochloride, Transdermal Nicotine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Astigmatism Bilateral
Evaluation of Wear Experience With a Weekly Replacement Soft Contact Lens in Neophyte Lens Wearers With Astigmatism
This open-label study is of adults with astigmatism who have never worn contact lenses. Subjects will be fit into a one week planned-replacement contact lenses and will wear lenses for approximately 3 weeks.
- Trial name
- NCT06751225
- Testing
- One week replacement soft contact lenses
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University