Clinical trials: Resolution of Pathologic Process
Covid19
Analysis of the Pathophysiology and Pathology of Coronavirus Disease 2019 (COVID-19), Including Chronic Morbidity
NAPKON-HAP is the deep phenotyping platform of the National Pandemic Cohort Network (NAPKON) in Germany. NAPKON is a data and biospecimen collection of patients with COVID-19 and is part of the University Medicine Network (NUM)…
- Trial name
- NCT04747366
- Where
- 11 sites in Germany
- Volunteers
- 750 people
- Sponsor
- Charite University, Berlin, Germany
Atherosclerosis
Atherosclerotic Plaque Characterization
The purpose of this study is to utilize high-resolution CMR carotid imaging for the characterization of carotid wall volumes and plaque content in patients with clinical significant carotid atherosclerosis.
- Trial name
- APC (NCT00861653)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Piedmont Healthcare
Metastatic Cancer, Prostate Cancer
Calcium-41 (41Ca) Chloride Aqueous Solution in Diagnosing Patients With Prostate Cancer and Bone Metastasis
RATIONALE: Diagnostic procedures, such as radionuclide imaging using calcium-41 (41Ca) chloride aqueous solution, may help predict progressive disease in patients with prostate cancer and bone metastasis.
- Trial name
- UCDCC#217 (NCT00918645)
- Testing
- 41 Ca
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, Davis
Otitis Media With Effusion
Osteopathic Otitis Media Research Study
The purpose of this study is to determine if the application of osteopathic manipulative medicine speeds the rate of resolution of middle ear effusion (fluid) in children following an episode of acute otitis media.
- Trial name
- OOMRS (NCT00520039)
- Testing
- osteopathic manipulative medicine (OMM)
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Chronic Obstructive Pulmonary Disease
Efficacy Safety Study of Arformoterol QD Dosing Versus BID Dosing in COPD
To evaluate the efficacy and safety of arformoterol tartrate inhalation solution 30μg/4mL QD (two 15μg/2mL dosed in combination) over a 24-hour period compared to arformoterol tartrate inhalation solution 15μg/2 mL BID in…
- Trial name
- NCT00571428
- Testing
- Arformoterol Tartrate Inhalation Solution
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Sumitomo Pharma America, Inc.
End Stage Renal Disease
The Impact of Delflex on Mesothelial Cell Viability and Peritoneal Transport
The purpose of this study is to evaluate the impact of Delflex neutral pH (a biocompatible peritoneal dialysis solution) on mesothelial cell viability and peritoneal transport.
- Trial name
- Delflex (NCT01292863)
- Testing
- Active Comparator: Conventional peritoneal dialysis solution, Experimental: Novel biocompatible dialysis solution
- Sponsor
- University of North Carolina, Chapel Hill
Osteoporosis in Post-menopausal Women
Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMD
Osteoporosis is associated with a high risk of fractures, disability, loss of independence, and excess mortality. Zoledronic acid is an established first-line treatment in Sweden, but many patients at high fracture risk remain at…
- Trial name
- STRONG-HIP (NCT07772609)
- Testing
- Romosozumab, Zoledronic Acid 5 MG in 5 ML Injection, Calcium 500 mg and Vitamin D3 800 IU
- Where
- 9 sites in Sweden
- Volunteers
- 216 people
- Sponsor
- Sahlgrenska University Hospital
Gambling
Biomarkers of Online Gambling Addiction
The purpose of this study is to identify alterations of motivational processes related to decision making in uncertainty condition associated with gambling addiction: by studying the dynamics between brain systems involved in…
- Trial name
- BLUNDER (NCT02862821)
- Testing
- HR-EEG
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Kidney Injury, Renal Insufficiency, Chronic
Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury (BASIC Trial)
As iodinate contrast media (CM) has been widely used in current medical practice, contrast induced acute kidney injury (CI-AKI) has been an important issue.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast Media Reaction
- Trial name
- NCT02799368
- Testing
- CJ Plasma Solution A Injection, CJ 0.9% Normal Saline Injection
- Where
- South Korea
- Volunteers
- 493 people
- Sponsor
- Seoul National University Hospital
Age Related Macular Degeneration
A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)
This study proposes to use a new instrument (AO-OCT/AF: adaptive optics - optical coherence tomography/autofluorescence) combined with a data processing method to image the retinal pigment epithelium (RPE) of the eye in normal…
- Trial name
- NCT03963817
- Testing
- adaptive optics AO-OCT/AF instrument
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gastroesophageal Reflux Disease
Structure and Function of the Gastro-esophageal Junction
Aims of research project: To identify key features of the gastro-esophageal junction (structure and function) that protects the esophagus from gastro-esophageal reflux investigated by combined high resolution manometry and…
- Trial name
- NCT01053585
- Testing
- Baclofen
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Esophageal Motility Disorders
Establishing a Correlation Between HRM and UGI MM Studies
A retrospective and prospective cohort, quantitative data collection with the goal of comparing preoperative High Resolution Manometry HRM results to Upper Gastrointestinal Marshmallow ,UGI MM results, in patients undergoing…
- Trial name
- MMvsMANO (NCT06314893)
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Lexington Health Incorporated
HIV, Anal Dysplasia
Application of Oral Bacteriotherapy to Promote Anal HPV Clearance in HIV Positive Individuals
Published studies suggest that oral probiotic intake can promote the clearance of HPV genital infection and HPV related genital dysplasia in HIV negative women.
- Trial name
- HPVinHIV (NCT04099433)
- Testing
- Vivomixx
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Cardiac Disease
Accelerated Contrast-Enhanced High Resolution Whole Heart Cardiac MRI
Coronary artery disease (CAD) is the leading cause of death in the United States. Cardiac MRI is a non-invasive non-ionizing technique for a comprehensive cardiac exam, which can be used in the diagnosis of CAD.
- Trial name
- NCT02550366
- Testing
- MRI Contrast
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Dry Socket
Efficacy of Pure Honey Dressing in Contrast to Alvogyl in the Resolution of Dry Socket
Dry socket, or Alveolar Osteitis, is the most common complication that can follow a tooth extraction. Over the years, various approaches have been employed to expedite the healing process and alleviate the associated symptoms.
- Trial name
- NCT06456060
- Testing
- Alvogyl, Honey
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Watim Medical & Dental College
Asthma, Pulmonary Function
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring.
- Conditions
- Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
- Trial name
- VCSIP (NCT06106646)
- Testing
- No active intervention in this protocol (previously randomized to Vitamin C)
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- Oregon Health and Science University
Surgical Wound Infection
Clinical Assessment of Next Science Solution on Gustilo and Anderson Type II and IIIA or IIIB Tibial Fractures
This is a prospective, randomized, controlled, double-blinded clinical feasibility study of subjects that are being treated for Gustilo and Anderson Type II or IIIA or IIIB Tibial Fractures
- Trial name
- NCT04906642
- Testing
- Next Science, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Next Science TM
Giant Cell Arteritis, Visual Impairment
Visual Involvement in Giant Cell Arteritis
This observational study aims to enhance the description of the different ways Giant Cell Arteritis (GCA) affects vision. The latest technology and knowledge are used to improve how we diagnose and predict patient outcomes.
- Conditions
- Giant Cell Arteritis, Visual Impairment, Central Retinal Artery Occlusion, Anterior Ischemic Optic Neuropathy
- Trial name
- Visu-GCA (NCT06500728)
- Testing
- Fluorescein and Indocyanine green Angiography, High-resolution Optical Coherence Tomography, Angio-Optical Coherence Tomography
- Where
- Italy
- Volunteers
- 762 people
- Sponsor
- ASST Fatebenefratelli Sacco
Surgical Site Infection (SSI), Spine Surgery
Investigation of the PREVENTIA® Irrigation Solution for Reducing Bacteria in Spinal Surgery With Implants - A Comparative Study
Spinal surgery carries a risk of surgical wound infections (i.e., the entry of bacteria). Despite various preventive measures, such infections continue to occur, particularly in operations involving implants.
- Conditions
- Surgical Site Infection (SSI), Spine Surgery, Surgical Site Infection Prevention
- Trial name
- PROTECT-SPINE (NCT07667036)
- Testing
- Preventia Surgical Solution, 0.9 % NaCl
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Universität Luzern
Functional Disorder of Stomach, Healthy
Elucidating Mechanisms That Underlie the Symptomatology of Functional Dyspepsia Using Novel Techniques and Its Therapeutic Validation Using Neuromodulators
The goal of this study is to investigate the mechanisms of impaired gastric accommodation and emptying, dysfunctional duodenum, and micro-inflammation using novel imaging techniques of SPECT/CT, gastric emptying scintigraphy…
- Trial name
- NCT06213948
- Testing
- Mirtazapine 15 MG
- Where
- Malaysia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
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