Clinical trials: Respiratory Distress Syndrome, Newborn
Acute Respiratory Distress Syndrome, ARDS
Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Adults
This study is designed to evaluate the safety and efficacy of fostamatinib in hospitalized adult participants with acute respiratory distress syndrome (ARDS).
- Trial name
- FOSTA-ARDS (NCT06564207)
- Testing
- Fostamatinib
- Volunteers
- 40 people
- Sponsor
- Inova Health Care Services
Neonatal, Premature Birth
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function
This is a study to see if an extra 2 weeks of continuous positive airway pressure (CPAP) in stable preterm infants in the neonatal intensive care unit (NICU) can cause increased lung growth and lung function in the infants as…
- Conditions
- Neonatal, Premature Birth, Respiratory Distress Syndrome
- Trial name
- NCT04295564
- Testing
- Additional 2 weeks of CPAP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cynthia McEvoy
Critical Illness, ARDS
Assessment of Lung Recruitablity of Acute Respiratory Distress Syndrome With SARS-CoV-2 Pneumonia by Electrical Impedance Tomography
Novel coronavirus (SARS-CoV-2: severe acute respiratory coronavirus 2) pneumonia often develop the acute respiratory distress syndrome (ARDS).
- Trial name
- NCT04473300
- Where
- Japan
- Volunteers
- 43 people
- Sponsor
- Osaka University
ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT)
Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS
The aim of the this study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT), Positive End Expiratory Pressure (PEEP), Acute Lung Injury
- Trial name
- DELTA (NCT04247477)
- Testing
- Ventilation strategy
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Angers
Premature Birth
Effects of L-Carnitine Supplementation on Respiratory Distress Syndrome
The aim of the present study was to investigate the efficacy of L-carnitine therapy on the occurrence and prognosis of respiratory distress syndrome
- Trial name
- NCT03630367
- Testing
- Dexamethasone, L-Carnitine 1G/5mL Injection
- Where
- Egypt
- Sponsor
- Assiut University
Very Low Birth Weight Infant, Respiratory Distress Syndrome in Premature Infant
Enteral Nutrition Tolerance And REspiratory Support (ENTARES)
This research study aims to evaluate the relation between non-invasive ventilation and feeding tolerance in preterms with respiratory distress syndrome (RDS).
- Conditions
- Very Low Birth Weight Infant, Respiratory Distress Syndrome in Premature Infant, Enteral Feeding Intolerance
- Trial name
- ENTARES (NCT03548324)
- Testing
- HHHFNC, NCPAP
- Where
- 13 sites in Italy
- Volunteers
- 280 people
- Sponsor
- University of Turin, Italy
COVID-19 Acute Respiratory Distress Syndrome
Rehabilitation of Critically Ill Patients With SARS-CoV-2 Variants in ICU With Limited Resources
Acute rehabilitation in critically ill patients can improve post-intensive care unit (post-ICU) physical function. Scientific evidence has considered neuromuscular electrical stimulation (NMES) as a promising approach for the…
- Trial name
- NCT05450120
- Testing
- Functional Rehabilitation, Neuromuscular Electrical Stimulation
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Universidade Federal de Sao Carlos
ARDS, RDS
Surfactant for Neonate With Acute Respiratory Distress Syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) in neonates has been defined, the role of surfactant is not clear. This study aimed to determine whether ARDS neonate would benefit from surfactant when oxygenation deteriorated on…
- Conditions
- ARDS, RDS, Surfactant
- Trial name
- NCT03217162
- Testing
- surfactant combined with mechanical ventilation (MV), mechanical ventilation (MV)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Respiratory Distress Syndrome, Cronic Lung Disease
Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure
The specific aims of this study are to evaluate the amount of high flow nasal cannula (HFNC) gas flow required to generate an equivalent positive distending pressure as that provided by nasal continuous positive airway pressure…
- Trial name
- NCT00356668
- Testing
- High Flow Nasal Cannula
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
ARDS, Acute Respiratory Distress Syndrome
Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome.
Acute respiratory distress syndrome (ARDS) accounts for almost 10% of intensive care units (ICU) admissions. Three ARDS stages have been defined, based on the PaO2/FIO2 ratio measured with positive end-expiratory pressure (PEEP)…
- Conditions
- ARDS, Acute Respiratory Distress Syndrome, Intensive Care Unit, Mechanical Ventilation
- Trial name
- PROMILD (NCT05056090)
- Testing
- Patients will receive MV in PP
- Where
- France
- Volunteers
- 656 people
- Sponsor
- University Hospital, Grenoble
COVID-19, Mechanical Ventilation Pressure High
Different PEEP Settings of COVID-19 Induced ARDS
This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March…
- Conditions
- COVID-19, Mechanical Ventilation Pressure High, Acute Respiratory Distress Syndrome
- Trial name
- NCT04359251
- Testing
- Gas exchanges at different PEEP, lung mechanics at different PEEP, Hemodynamics changes at different PEEP
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome
Prediction of Outcomes With a Miniaturized Transesophageal Echocardiography Probe in Patients With Acute Respiratory Distress Syndrome
The Superior Vena cava Respiratory Collapse Index (cVCS) is a haemodynamic parameter measured exclusively by transoesophageal ultrasound (TEE), which is used to assess cardiac precharge-dependence status.
- Trial name
- PreMiTE-ARDS (NCT03763773)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Respiratory Distress Syndrome, Adult
Effects of Positive End-expiratory Pressure and Tidal Volume on Fluid Responsiveness of Acute Respiratory Distress Syndrome
Fluid responsiveness (FR)refers to the ability of heart to increase its stroke volume in response to volume load.Low tidal volume and high PEEP exerts contrast effect on the prediction of fluid responsiveness, the aim of this…
- Trial name
- NCT01716962
- Testing
- Infusion of 6% tetrastarch for a total of 500 ml
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Respiratory Distress Syndrome
Etiology and Outcomes of Tropical Acute Respiratory Distress Syndrome
This is a prospective observational study done to know the etiology and outcomes of Acute Respiratory Distress Syndrome.
- Trial name
- NCT01450527
- Where
- India
- Volunteers
- 64 people
- Sponsor
- All India Institute of Medical Sciences
Acute Respiratory Distress Syndrome, Lung Diseases
SILtuximab in Viral ARds (SILVAR) Study
This study will evaluate the efficacy and safety of siltuximab compared with normal saline in combination with standard of care (SOC) in selected hospitalized patients with COVID-19 previously treated with corticosteroids or…
- Conditions
- Acute Respiratory Distress Syndrome, Lung Diseases, Pneumonia, Respiratory Tract Infections
- Trial name
- SILVAR (NCT04616586)
- Testing
- Siltuximab, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 555 people
- Sponsor
- RECORDATI GROUP
Respiratory Distress Syndrome, Surfactant Administration by Aerosolization
Does The Surfactant Administration by Aerosolization Effective?
The present study was designed to evaluate, in premature babies with RDS breathing spontaneously, the efficacy of combined treatment with nasal continuous positive airway pressure (CPAP) and aerosolized surfactant.
- Trial name
- NCT02825953
- Testing
- surfactant, nasal continuous positive airway pressure, non-invasive intermittent positive-pressure ventilation
- Volunteers
- 75 people
- Sponsor
- nihat demir
Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction
Ventilator-induced Right Ventricular Injury During EIT-based PEEP Titration in Patients With ARDS
Right ventricular failure may be associated with mortality in patients with acute respiratory distress syndrome (ARDS). Mechanical ventilation may promote right ventricular failure by inducing alveolar overdistention and…
- Trial name
- RIGHTENARDS (NCT05583461)
- Testing
- Positive end-expiratory pressure titration
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Padova
Respiratory Distress Syndrome, Neonatal Death
Implementing LISA Surfactant in Nigeria
Implement surfactant (BLES®) replacement therapy using the Less Invasive Surfactant Administration technique in six tertiary institutions in Nigeria and evaluate its impact on 72-hour neonatal mortality in premature infants born…
- Trial name
- NCT05714865
- Testing
- Surfactant
- Where
- 6 sites in Nigeria
- Volunteers
- 349 people
- Sponsor
- Indiana University
Fibrosis, Lung Disease
Safety and Efficacy Study of Depelestat in Acute Respiratory Distress Syndrome (ARDS) Patients
The study is aimed to assess safety of Depelestat treatment, as well as efficacy on prevention and treatment of alveolar inflammation in early pulmonary fibrosis in patients suffering from persistent Acute Respiratory Distress…
- Conditions
- Fibrosis, Lung Disease, Respiratory Disorders, Respiratory Distress Syndrome, Adult
- Trial name
- NCT00455767
- Testing
- EPI-hNE4
- Where
- 14 sites in France, Italy and 2 more
- Volunteers
- 84 people
- Sponsor
- Debiopharm International SA
ARDS, Human, Burns
Predictive Factors, Demographics and Mortality for ARDS in Burn Patients
This retrospective study characterizes the clinical course and identifies four independent predictors of Acute Respiratory Distress Syndrome (ARDS) after burn injury (post-burn ARDS; pbARDS).
- Conditions
- ARDS, Human, Burns, Lung Diseases
- Trial name
- NCT03807232
- Volunteers
- 400 people
- Sponsor
- University of Zurich
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