Clinical trials: Respiratory Distress Syndrome of Newborn
Acute Respiratory Distress Syndrome
Validation of a Simple Approach to Estimate Alveolar Recruitability in ARDS Patients
This study will test the validity of a new approach to assess alveolar recruitability at the bedside in comparison to direct measurements of lung volume and derecruitment.
- Trial name
- NCT02457741
- Where
- 3 sites in Canada, China and 1 more
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants
Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Oral feeding of neonates while on nasal continuous positive airway pressure (NCPAP) is a common practice in many neonatal intensive care units (NICU) all over the country.
- Conditions
- Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants, Respiratory Aspiration, Newborn, Premature
- Trial name
- NCT02661256
- Testing
- NCPAP, Varibar® Thin Liquid Barium Sulfate for Suspension
- Volunteers
- 7 people
- Sponsor
- NYU Langone Health
Respiratory Distress Syndrome, Newborn, Premature Birth
Prophylactic Minimally Invasive Surfactant Evaluation
The purpose of this study is to explore the question: Does prophylactic administration of exogenous surfactant in the delivery room, using a minimally-invasive technique, improve outcome in preterm infants 22-29 weeks' gestation…
- Trial name
- PreProMISe (NCT06007547)
- Testing
- Poractant Alfa
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Acute Respiratory Distress Syndrome
Quantitative Computed Tomography for Mortality Risk Stratification in ARDS
Acute respiratory distress syndrome remains a deadly disease with hospital mortality remaining between 40 to 50%. ARDS mortality risk factors have been identified from patient history, common clinical and biological variables in…
- Trial name
- CT4ARDS-2 (NCT06113276)
- Testing
- Low dose computed tomography to evaluate biomechanical parameters in the lung
- Where
- 4 sites in France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon
Respiratory Distress Syndrome
Non-Invasive High-Frequency Oscillatory Ventilation vs Conventional Ventilation for Preterm Neonates.
Given the high burden of respiratory distress syndrome (RDS) and its complications in resource-constrained settings, identifying effective, low-risk interventions is imperative.
- Trial name
- NCT07307079
- Testing
- Non-Invasive High-Frequency Oscillatory Ventilation, Conventional Mechanical Ventilation
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Muhammad Aamir Latif
Acute Respiratory Distress Syndrome, COVID-19 Respiratory Infection
Evaluation of the Efficiency and Complications of the Consequtive Proning in Covid -19 ICU
Thirty -one confirmed Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2 ) infected patients with Acute Respiratory Distress Syndrome (ARDS) and placed in prone position(PP) for 3 times (PP1, PP2, PP3)consecutively will…
- Trial name
- NCT05387356
- Testing
- prone position
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Kecioren Education and Training Hospital
Acute Respiratory Distress Syndrome (ARDS)
The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol
The objective of this study is to evaluate the association between positive end-expiratory pressure (PEEP) setting and cardiac function, as measured by cardiac index, in patients with acute respiratory distress syndrome (ARDS)…
- Trial name
- NCT01714583
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Yale University
Extremely Low Birth Weight Infants, Respiratory Distress Syndrome, Newborn
LUS AT BIRTH IN INFANTS BORN BEFORE 26 WEEKS
All infants born before 26 weeks born in a hospital included in the registry will receive a LU at birth, before the first dose of surfactant. We will register as well the length of IMV, NIV or the need of IMV in the whole sample.
- Trial name
- MINI-LUS (NCT06394583)
- Testing
- Lung ultrasound
- Volunteers
- 150 people
- Sponsor
- Andaluz Health Service
Hypoxemic Respiratory Failure, Oxygen Toxicity
Handling Oxygenation Targets in the Intensive Care Unit
Handling oxygenation targets (HOT) is standard of care in the intensive care unit (ICU), however the quality and quantity of evidence is low and potential harm has been reported.
- Trial name
- HOT-ICU (NCT03174002)
- Testing
- Oxygen
- Where
- 37 sites in Denmark, Finland and 5 more
- Volunteers
- 2,928 people
- Sponsor
- Aalborg University Hospital
Respiratory Distress Syndrome, Surfactant Administration by Aerosolization
Does The Surfactant Administration by Aerosolization Effective?
The present study was designed to evaluate, in premature babies with RDS breathing spontaneously, the efficacy of combined treatment with nasal continuous positive airway pressure (CPAP) and aerosolized surfactant.
- Trial name
- NCT02825953
- Testing
- surfactant, nasal continuous positive airway pressure, non-invasive intermittent positive-pressure ventilation
- Volunteers
- 75 people
- Sponsor
- nihat demir
Acute Respiratory Distress Syndrome, COVID-19
Predictors of Severe COVID-19 Outcomes
This is a longitudinal, multi-center, observational study collecting diverse biological measurements and clinical and epidemiological data for the purpose of enabling a greater understanding of the onset of severe outcomes…
- Trial name
- PRESCO (NCT04388813)
- Where
- 8 sites in United States
- Volunteers
- 494 people
- Sponsor
- Verily Life Sciences LLC
ARDS, Human
PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial
This study is a multicentric randomized controlled study.The objective of this study is to compare the prognosis of patients with ARDS between EIT-oriented individualized PEEP and traditional lower PEEP/FiO2 table-oriented PEEP…
- Trial name
- NCT05307913
- Testing
- EIT-guided PEEP, Table-guided PEEP
- Where
- China
- Volunteers
- 676 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome (ARDS), Post Intensive Care Syndrome (PICS)
An Observational Study to Identify New Health Problems Arising After an Intensive Care Unit Admission in People With Acute Respiratory Distress Syndrome in the United States
This is an observational study in which data already collected from people with acute respiratory distress syndrome (ARDS) admitted to an intensive care unit (ICU) are studied.
- Trial name
- SeeMe Tool (NCT06272942)
- Testing
- An ICU admission and a temporally related ARDS diagnosis
- Where
- United States
- Volunteers
- 640,058 people
- Sponsor
- Bayer
Acute Respiratory Distress Syndrome, Delirium
Cognitive Dysfunctions Associated With Delirium in Critically-ill ARDS Patients
Early cognitive assessment of critically-ill acute respiratory distress syndrome (ARDS) patients with delirium using a multidimensional electrophysiological evaluation battery (mEEG) to identify and characterize the neural…
- Trial name
- DeSign (NCT06206473)
- Testing
- mEEG assessment
- Sponsor
- University Hospital, Toulouse
nCPAP, BiPAP
Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins Infants
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -bi-level positive airway pressure(BiPAP) or nasal continuous positive airway pressure (nCPAP) -as a primary mode of…
- Conditions
- nCPAP, BiPAP, Respiratory Distress Syndrome
- Trial name
- NCT03235661
- Testing
- BiPAP, nCPAP
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
COVID-19 Severe Pneumonia, Acute Lung Injury
Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia
This study evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of ravulizumab administered in adult participants with coronavirus disease 2019 (COVID-19) severe pneumonia, acute lung injury, or acute…
- Conditions
- COVID-19 Severe Pneumonia, Acute Lung Injury, Acute Respiratory Distress Syndrome, Pneumonia, Viral
- Trial name
- NCT04369469
- Testing
- Ravulizumab, BSC
- Where
- 39 sites in United States, France and 3 more
- Volunteers
- 202 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Respiratory Distress Syndrome
Early PP Monitored by EIT in Patients With ARDS
Acute Respiratory Distress Syndrome (ARDS) is a syndrome characterized by respiratory distress and refractory hypoxemia caused by pulmonary and extra-pulmonary factors.
- Trial name
- NCT05822869
- Testing
- EIT-guided mechanical ventilation strategy, Lung protective ventilation group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Chao Yang Hospital
Cardiac Arrest, Respiratory Distress Syndrome
Pre Hospital Evaluation of Video Laryngoscopy
The objective of this work is to compare standard intubation with video laryngoscope (Glide scope Ranger ) in French pre hospital multicentric study.
- Conditions
- Cardiac Arrest, Respiratory Distress Syndrome, Shock, Acute Post-trauma Stress State
- Trial name
- EVE (NCT01374061)
- Testing
- Classical intubation, GLIDESCOPE
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Pilot Trial of Surfactant Booster Prophylaxis For Ventilated Preterm Neonates
A research study that will evaluate if giving surfactant medication to premature babies weighing < 1250 gm at birth during the second and third weeks of life will help their lungs.
- Trial name
- NCT00208039
- Testing
- Infasurf
- Volunteers
- 89 people
- Sponsor
- Children's Hospital of Philadelphia
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
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