Clinical trials: Respiratory Inflammation
Allergic Rhinitis, Asthma
Leukotriene D4 Nasal Provocation Test in Allergic Rhinitis
Leukotrienes play critical roles in the inflammatory process in allergic rhinitis and bronchial asthma, therefore, anti-leukotriene therapy is part of treatment for asthma.
- Trial name
- NCT01963741
- Testing
- leukotriene D4, histamine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Mild Chronic Obstructive Pulmonary Disease, Respiratory Symptoms
GOLD Stage I Chronic Obstructive Pulmonary Disease (COPD)
Recently integrated in clinical practice, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification states that a mild (stage I) chronic obstructive pulmonary disease (COPD) is present, in a smoker, when…
- Conditions
- Mild Chronic Obstructive Pulmonary Disease, Respiratory Symptoms, Physical Activity
- Trial name
- GOLD (NCT01360788)
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Laval University
COPD, Chronic Obstructive Pulmonary Disease
Effectiveness and Safety of BIO-11006 Inhalation Solution to Treat the Overproduction of Mucus and Inflammation in COPD
The symptoms associated with COPD include overproduction of mucus and inflammation in the lungs. Overproduction of mucus results in impaired lung function and it encourages bacterial growth and associated COPD exacerbations.
- Trial name
- BREATH-1 (NCT00648245)
- Testing
- BIO-11006 Inhalation Solution, BIO-11006
- Where
- 14 sites in United States
- Volunteers
- 172 people
- Sponsor
- BioMarck Pharmaceuticals, Ltd.
Nosocomial Infection, Pneumonia
Pilot Study of the Utility of Empiric Antibiotic Therapy for Suspected ICU-Acquired Infection
Infection developing in the intensive care unit is a common complication of critical illness, but notoriously difficult to diagnose.
- Conditions
- Nosocomial Infection, Pneumonia, Systemic Inflammatory Response Syndrome, Critical Illness
- Trial name
- NCT00438269
- Testing
- Site-specific empiric regimens included: Meropenem, Piperacillin/tazobactam, Ciprofloxacin and cefazolin +/- metronidazole
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Canadian Critical Care Trials Group
Allergic Inflammation, Asthma
The COX-2 Gene and the Immune System
Background: The immune system contains several different types of cells in the blood and other parts of the body. The body can fight infections well with the right balance of these cell types.
- Trial name
- NCT01678222
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Covid19
COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation
The purpose of this study is to test whether Fisetin, a senolytic drug, can assist in preventing an increase in the disease's progression and alleviate complications of coronavirus due to an excessive inflammatory reaction.
- Trial name
- NCT04476953
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Asthma, Inflammation
Mucins and Toll-like Receptors in Asthma
This study raises two main hypotheses: 1) Asthmatics patients who present with bronchial hypersecretion differ phenotypically from asthmatic patients without hypersecretion and 2) mucins in asthmatic patients with hypersecretion…
- Trial name
- MUCITOLL (NCT02948153)
- Testing
- clinical study
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Lung Diseases, Lung Inflammation
Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery
The purpose of this study is to analyze the impact of the intravenous (IV) or paravertebral (PV) lidocaine administration during the intraoperative period of lung resection surgery on the appearance of postoperative…
- Conditions
- Lung Diseases, Lung Inflammation, Lung Injury, Acute, Postoperative Complications
- Trial name
- NCT03905837
- Testing
- Lidocaine, Remifentanil
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Francisco Andres de la Gala
Gastroesophageal Reflux, Asthma
Elucidation of Acid-Induced Pulmonary Inflammation
This study will evaluate how heartburn may lead to different types of inflammation in one's airways. Additionally, the study will determine whether aggressive treatment of heartburn results in improvement in both symptoms of…
- Trial name
- NCT00361972
- Testing
- lansoprazole
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Utah
Post-Acute Sequelae of SARS-CoV-2 Infection, Long COVID
Observational Study of Intranasal IVIG in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients Undergoing Medical Tourism
This observational study is being conducted by Healing Hope International to collect real-world data on an emerging treatment approach for Long COVID in patients with immunodeficiency.
- Conditions
- Post-Acute Sequelae of SARS-CoV-2 Infection, Long COVID, Long COVID Fatigue, Long COVID Syndrome
- Trial name
- IVIG-LC (NCT06992401)
- Volunteers
- 50 people
- Sponsor
- Tamara C Tamas
Acute Respiratory Distress Syndrome
The Effects of Different Ventilator Strategies on Inflammation and Injury in Normal Lungs
This research is being done to determine if there is a way the investigators can improve the techniques that they use to assist patients with their breathing during surgery.
- Trial name
- NCT01003730
- Testing
- Ventilator settings
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Sepsis, Acute Respiratory Distress Syndrome
A Validation Study on a Prognostic Prediction Model for Respiratory Tract Infections
This study adopted a prospective, single-center, open-label design, aiming to evaluate the efficacy of the RTI clinical outcome prediction model in predicting clinical outcomes in subjects with acute respiratory tract infections.
- Conditions
- Sepsis, Acute Respiratory Distress Syndrome, Community Acquired Pneumonia, Transcriptome
- Trial name
- NCT07109310
- Testing
- RTImodel001
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis, Septicemia
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
In this study, the investigators will deploy a software-based clinical decision support tool (eCARTv5) into the electronic health record (EHR) workflow of multiple hospital wards.
- Conditions
- Sepsis, Septicemia, Respiratory Failure, Hemodynamic Instability
- Trial name
- NCT05893420
- Testing
- eCARTv5 clinical deterioration monitoring, Standard of care control
- Where
- 3 sites in United States
- Volunteers
- 30,000 people
- Sponsor
- AgileMD, Inc.
Covid19
LLLT Treatment of Lung Inflammation in COVID-19
To determine if a reduction of pneumonic inflammation occurs after treatment with Low-Level Laser Therapy (LLLT) applying red-light technology in the respiratory system of COVID-19 patients suffering from acute viral pneumonia.
- Trial name
- NCT04524715
- Testing
- Non-invasive red LLLT treatment to chest of patient.
- Where
- United States
- Sponsor
- Ward Photonics LLC
Covid-19
Hydrogen Therapy in Patients With Moderate Covid-19
SARS-CoV-2 is the agent responsible for a new infectious respiratory disease called Covid-19 (for CoronaVirus Disease 2019) which is mainly characterized by potentially severe and fatal lung damage.
- Trial name
- H2Covid (NCT04633980)
- Testing
- Mixture 3,6% H2 in N2 (96.4%)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Evaluation of Sleep Apnea Related Inflammation With CRP, ESR and Neutrophil toLymphocyte Ratio
There is some evidence suggesting that OSA is associated with low level of systemic inflammation and oxidative stress. Low level systemic inflammation and subsequent vascular damage has been implicated as the underlying mechanism…
- Trial name
- NCT02272608
- Testing
- Evaluation of Sleep Apnea Related Inflammation with CRP, ESR and Neutrophil toLymphocyte Ratio
- Volunteers
- 279 people
- Sponsor
- Ordu University
COVID-19, Cytokine Storm
Fluoxetine to Reduce Intubation and Death After COVID19 Infection
This project will test the efficacy of fluoxetine to prevent serious consequences of COVID-19 infection, especially death. Becoming sick with COVID-19 virus or any other serious respiratory condition is not fun.
- Trial name
- NCT04377308
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Pneumonia, Ventilator-Associated, Pneumonia
Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria
Secondary infections remain a major cause of mortality in critically ill patients, mainly because of high prevalence of multidrug-resistant microorganisms.
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Bloodstream Infection, Sepsis
- Trial name
- NCT04839653
- Testing
- Oral Paste(0,5 g) containing 10 mg of polymyxin B, 10 mg of gentamycin and 150 mg of amphotericine B or 500 000 U of nistatin q6h, Suspension (10 ml) containing 100 mg of polymyxin B, 80 mg of gentamycin, 350 mg of amphotericine B or 8000000 U of nistation and 500 mg of vancomycin q6h, Intravenous Antibacterial Agent - a 3-day course of systemic cefotaxime 1 g q6h or ceftriaxone 1 g qd
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- MEDSI Clinical Hospital 1, ICU
Covid19
Ketogenic Diet as Protective Factor During COVID-19
The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives.
- Trial name
- NCT04615975
- Testing
- Ketogenic diet with phytoextracts
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- University of Padova
Lung Injury, Lung Inflammation
The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe Resection
The objective of this study was to discuss the effects of different ventilation modes on patients with plasma inflammatory factor and respiratory function in patients with pulmonary removal.
- Trial name
- NCT06514729
- Testing
- Adopting different ventilation modes during the operation
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Mao Enting
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