Clinical trials: Respiratory Inflammation
Premature Birth, Neonatal Hypoglycemia
Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm Babies
The goal of this observational study was to compare two doses of dexamethasone given to pregnant women at risk of preterm birth. Dexamethasone is a medicine used before birth to help a baby's lungs mature.
- Conditions
- Premature Birth, Neonatal Hypoglycemia, Maternal Infection During Pregnancy, Neurodevelopmental Disorder of Foetus
- Trial name
- NCT07765329
- Testing
- Dexamethasone 12 mg Every 12 Hours, Dexamethasone 6 mg Every 12 Hours
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Stella Maris Women and Children Hospital
Common Cold, Pharyngitis
Alleviation of Common Cold Symptoms
Upper respiratory infections (URIs) have long posed a significant burden to the US healthcare system. Well before the coronavirus disease of 2019 (COVID-19) pandemic they have been among the most common acute outpatient…
- Conditions
- Common Cold, Pharyngitis, Fever, Congestion
- Trial name
- NCT06106880
- Testing
- Wintergreen Throat Spray and Aspirin Tablet
- Where
- 6 sites in United States
- Volunteers
- 157 people
- Sponsor
- Applied Biological Laboratories Inc
Pneumonia, Ventilator-Associated
Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients
Clinical presentation of patients after severe injury such as a severe infection, trauma or extensive burns is characterized by the simultaneous occurrence of dysregulation of the initial inflammatory response and…
- Trial name
- IGNORANT (NCT05843786)
- Testing
- Interferon gamma
- Where
- 9 sites in France
- Volunteers
- 132 people
- Sponsor
- Hospices Civils de Lyon
Cystic Fibrosis
IL-17 Neutrophils in CF Lung Inflammation
The purpose of this study is to determine whether IL-17 polymorphonuclear leukocytes (PMNs) are central to the disease pathology in CF.
- Trial name
- NCT02025829
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University Hospitals Cleveland Medical Center
Acute Respiratory Failure, Encephalopathy
Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment
This study evaluates a novel arm restraint compared with traditional soft wrist restraints in older critically ill patients. The primary outcome is upper extremity mobility measured by actigraphy, and secondary outcomes include…
- Conditions
- Acute Respiratory Failure, Encephalopathy, ARDS, Sepsis
- Trial name
- NCT04067622
- Testing
- Exersides
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Vermont
Pulmonary Disease, Chronic Obstructive
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation
Depemokimab is being developed as a treatment for individuals with moderate to severe COPD. The aim of this study is to assess the efficacy and safety of depemokimab as an add-on medicine in participants with uncontrolled…
- Trial name
- ENDURA-1 (NCT06959095)
- Testing
- Depemokimab
- Where
- 281 sites in United States, Argentina and 21 more
- Volunteers
- 981 people
- Sponsor
- GlaxoSmithKline
Severe Acute Respiratory Failure
Intensive Care - GLObal Study on Severe Acute Respiratory Infection
IC-GLOSSARI (The Intensive Care GLObal Study on Severe Acute Respiratory Infection) is a multicentre, prospective, observational,14-day inception cohort study designed and conducted by the ESICM Trials Group to investigate the…
- Trial name
- NCT01936207
- Where
- Belgium
- Volunteers
- 800 people
- Sponsor
- European Society of Intensive Care Medicine
Critical Illness, Heart Failure
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress
Serious acute heart and lung illnesses like heart failure, severe COVID, and sepsis often leave survivors struggling not only physically, but also with lasting depression, anxiety, and stress.
- Conditions
- Critical Illness, Heart Failure, Sepsis, Ards
- Trial name
- Lift 3 (NCT07634419)
- Testing
- Lift mobile mindfulness, Enlighten Recovery education program
- Where
- 3 sites in United States
- Volunteers
- 450 people
- Sponsor
- Duke University
Pleural Empyema
Evaluating Antibiotic Course Upon Adequate Treatment of Empyema
The study compares treatment strategies for treatment of pleural empyema (infected fluid in the chest). It will compare standard of care antibiotic course, 2-6 weeks, to a shorter course of antibiotics, 7 days.
- Trial name
- EvACUATE (NCT07862361)
- Testing
- shortened antibiotic course, Standard medical treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Cystic Fibrosis
Probiotics on Intestinal Inflammation in Cystic Fibrosis
Cystic fibrosis (CF) is a complex systemic disease that mainly involves the respiratory and gastrointestinal (GI) tracts. The polymicrobial community composition of respiratory and GI tracts is influenced by both genetic and…
- Trial name
- NCT01961661
- Testing
- Lactobacillus rhamnosus GG
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Federico II University
Sepsis, Ventilator Associated Pneumonia
Intravenous Clarithromycin in Septic Syndrome
The aim of this clinical trial is to clarify the clinical efficacy of clarithromycin as immunotherapy for the management of septic syndrome by ventilator-associated pneumonia.
- Trial name
- NCT00297674
- Testing
- Intravenous Clarithromycin
- Where
- 3 sites in Greece
- Volunteers
- 200 people
- Sponsor
- University of Athens
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sepsis, Influenza
Platelet Immune Responses in Aging and Influenza and Sepsis (INVACS)
Aging is associated with immunosenescence and impaired host defense mechanisms, contributing to influenza-related morbidity and mortality.
- Trial name
- NCT03010410
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Intermountain Health Care, Inc.
Empyema, Pleural
VATS Decortication Versus IR Guided Chest Tube Insertion With Fibrinolytics for the Management of Empyema
The American Association of Thoracic Surgery defines empyema as pus in the pleural space. It is a common thoracic surgery presentation with an estimated 65,000 cases occurring annually in the United States.
- Trial name
- DICE (NCT03584113)
- Testing
- Video assisted thorascopic decortication, Interventional radiology guided chest tube insertion with MIST2 trial fibrinolytics
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Dr. Wiley Chung
Nasal Polyps, Chronic Rhinosinusitis With Nasal Polyps
Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps
Impaired olfaction is one of the major complaints of patients with nasosinus polyposis, with nasal obstruction. In case of failure of medical treatment for patients with polyposis nasosinusal, they may use endoscopic surgery…
- Conditions
- Nasal Polyps, Chronic Rhinosinusitis With Nasal Polyps, Olfaction Disorders
- Trial name
- OIPN (NCT04104594)
- Testing
- Sniffin Stick Test, numerical evaluation scale for olfaction, numerical evaluation scale for nasal obstruction
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sinusitis, Maxillary Sinusitis
A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with amoxicillin/clavulanate potassium in the treatment of adults with rapid onset of severe inflammation/infection of…
- Trial name
- NCT00249210
- Testing
- levofloxacin
- Volunteers
- 614 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Severe COVID-19
Impact of Post-ARDS Covid-19 Sedation on Persistent Neuroinflammation
ICU Patients admitted after ARDS due to COVID infection should be weaned from invasive mechanical ventilation as quickly as possible.
- Trial name
- PET-DEXDOCOVID (NCT05233605)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Allergic Rhinitis, Allergic Rhinitis (AR)
Effect of Combined Probiotics and Vitamin D on Symptoms of Allergic Rhinitis
The goal of this clinical trial is to learn if taking probiotics, vitamin D, or both together can help lower symptoms of allergic rhinitis (AR) and improve quality of life in adults.
- Trial name
- NCT07115342
- Testing
- Standard Allergic Rhinitis Treatment, Combined Vitamin D and Probiotics Supplementation
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Immunotherapy, Seasonal Allergic Rhinitis
Regulatory Lymphocytes in Patients Treated With Specific Immunotherapy
The purpose of this study is to determine whether specific subcutaneous immunotherapy affects fractions of regulatory T lymphocytes and histamine H2 receptor expression and ZAP70 in regulatory T lymphocytes.
- Trial name
- NCT01475188
- Testing
- Allergovit
- Where
- Poland
- Volunteers
- 41 people
- Sponsor
- Ministry of Science and Higher Education, Poland
Cystic Fibrosis
Bronchial Inflammation of Small Airways in Patients With Cystic Fibrosis
In the planned study, 60 patients with mild cystic fibrosis (CF) with and without the involvement of small airways (small airway disease - SAD) are to be compared with a historical control group matched in age and gender.
- Trial name
- FRA-MUKO (NCT01479166)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
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