Clinical trials: Respiratory Insufficiency Requiring Mechanical Ventilation
Respiratory Insufficiency Requiring Mechanical Ventilation
Effects of Neuromuscular Electrical Stimulation on Critically Ill Patients With Mechanical Ventilation
Up to 25% of patients who require mechanical ventilation (MV) more than seven days in the intensive care unit (ICU) develop muscle weakness, which comprises deep muscle weakness , including the respiratory muscles.Early active…
- Trial name
- NCT05217511
- Testing
- Neuromuscular Electrical Stimulation
- Where
- China
- Volunteers
- 47 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload
The Efficient PICU Fluid Care Evaluation
The goal of this clinical trial is to evaluate and prevent fluid overload in critically ill, mechanically ventilated children. The main questions it aims to answer are: 1.
- Conditions
- Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload, Fluid Balance
- Trial name
- LESSER-2 (NCT06644508)
- Testing
- Strict adherence to European guidelines
- Where
- 3 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Respiratory Insufficiency Requiring Mechanical Ventilation
Registry for Automated Mechanical VEntilation in Adults
The aim of the here proposed study is to assess safety, performance and provide real world evidence (RWE) of the Hamilton Medical AG automated mechanical ventilation software packages in consecutive critically ill patients…
- Trial name
- RAVE (NCT06655805)
- Testing
- Non-invasive ventilation, Invasive mechanical ventilation, high-flow nasal oxygen
- Where
- 4 sites in Switzerland
- Volunteers
- 1,000 people
- Sponsor
- Hamilton Medical AG
Covid19, Respiratory Failure
Nebulised Heparin in Patients With Severe COVID-19
The Can nebulised HepArin Reduce morTality and time to Extubation in Patients with COVID-19 Requiring mechanical ventilation Meta-Trial (CHARTER-MT) is a prospective collaborative individual patient data analysis of randomised…
- Trial name
- CHARTER-MT (NCT04545541)
- Testing
- Nebulised unfractionated heparin (UFH)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Australian National University
Respiratory Failure, Acute Respiratory Distress Syndrome
Observational Cohort Study of Distribution of Ventilation in Pediatrics Requiring Mechanical Ventilation by Electrical Impedance Tomography
Respiratory disorders are the leading cause of respiratory failure in children. Thousands of children are admitted to a pediatric intensive care unit each year and placed on mechanical ventilators.
- Conditions
- Respiratory Failure, Acute Respiratory Distress Syndrome, Acute Lung Injury
- Trial name
- EIT (NCT02247700)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston Children's Hospital
Respiratory Failure, Respiratory Insufficiency
Evaluating Safety and Efficacy of Umbulizer in Patients Requiring Intermittent Positive Pressure Ventilation
Randomized, control crossover study comparing Umbulizer's efficacy to traditional mechanical ventilators
- Conditions
- Respiratory Failure, Respiratory Insufficiency, Respiratory Arrest
- Trial name
- NCT04030208
- Testing
- Umbulizer, Traditional Mechanical Ventilator
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Umbulizer LLC
Lung Disease, Hypoxemia
Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation
The purpose of this pilot study is to evaluate whether administration of nitric oxide (NO)gas by oxygen hood at 20 ppm significantly increases PaO2, as compared to placebo gas (oxygen), within one hour of initiation and with no…
- Conditions
- Lung Disease, Hypoxemia, Respiratory Acidosis
- Trial name
- NCT00041548
- Testing
- nitric oxide for inhalation, Oxygen
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mallinckrodt
Acute Respiratory Failure Requiring Mechanical Ventilation
Eye-Control Trial: Wearable Eye-Tracking Device as Means of Communication
The purpose of this study is to evaluate the feasibility of use of a wearable communication device for critically ill patients who are admitted to the intensive care unit (ICU) and mechanically ventilated.
- Trial name
- NCT04582149
- Testing
- EyeControl Eye-tracking Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Acute Respiratory Failure Requiring Intubation
A Study on the Assessment of Difficult Weaning in Patients With Acute Respiratory Failure Undergoing Mechanical Ventilation Based on Machine Learning EIT-pendelluft: A Multicenter Retrospective Study.
Invasive mechanical ventilation (IMV) is a common method used in the ICU to assist breathing and promote gas exchange. When a patient's condition improves, the weaning process (WP) should be initiated.
- Trial name
- NCT06756204
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Ruijin Hospital
Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure
A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)
Amyotrophic lateral sclerosis (ALS) is a disease that causes weakness of the muscles of the body. The disease can eventually lead to severe breathing problems, which is the most common cause of death from ALS.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure, Neuromuscular Disease Patients, Neuromuscular Disease
- Trial name
- EVENT ALS (NCT07071935)
- Testing
- Non-invasive ventilation
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Pennsylvania
Patients With Moderate to Severe Pain Requiring Analgesic Medications
Observation and Study on the Application of Different Analgesic Regimens in Critically Ill Patients Without Mechanical Ventilation
Pain management is a common treatment measure in the Intensive Care Unit (ICU). Due to their underlying diseases and invasive treatments, patients often experience discomfort and pain, leading to agitation, unplanned extubation…
- Trial name
- NCT07031453
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Early Mobility, Critically Ill
Early Mobilization in Ventilated SEpsis & Acute Respiratory Failure Study
Early mobilization in Ventilated sEpsis \& acute Respiratory failure Study: EVER Study
- Trial name
- EVER (NCT04582760)
- Testing
- early mobilization
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Respiratory Failure
Effects of PBMT-sMF in Mechanically Ventilated Patients
The goal of this clinical trial is to evaluate the effectiveness of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) in adult patients who require mechanical ventilation.
- Trial name
- NCT06454006
- Testing
- Active PBMT-sMF
- Where
- Brazil
- Volunteers
- 112 people
- Sponsor
- University of Nove de Julho
Respiratory Insufficiency
Clinical Trial of a Computer-driven Weaning System for Patients Requiring Mechanical Ventilation
The purpose of this study is to compare the efficacy of a computer-assisted ventilator weaning system (Drager Smartcare) to our current standard of care in the medical intensive care unit.
- Trial name
- NCT00606554
- Testing
- Computer-assisted weaning program, Standard of Care weaning
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Boston Medical Center
Ventilator Weaning, Mechanical Ventilation
Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients
The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in…
- Conditions
- Ventilator Weaning, Mechanical Ventilation, Respiratory Insufficiency Requiring Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07120438
- Volunteers
- 55 people
- Sponsor
- Gadjah Mada University
Acute Respiratory Failure
Study Comparing Two Ventilation Modes NAVA (Neurally Adjusted Ventilatory Assist) Mode and Spontaneous Breathing With Inspiratory Pressure Support (IPS) Mode in Consecutive Patients Hospitalized for Acute Respiratory Failure Requiring Mechanical Ventilation With Endotracheal Tube.
This is a multicenter, prospective, randomized, open-label study which compared two ventilation modes: spontaneous NAVA mode and spontaneous breathing with IPS mode (the latter is considered as the reference ventilatory mode) in…
- Trial name
- NCT02018666
- Testing
- NAVA endotracheal tube
- Where
- 11 sites in France
- Volunteers
- 129 people
- Sponsor
- Clinact
Hematological Malignancy, Acute Respiratory Failure
Prognosis of Hematological Cancer Patient Underwent Mechanical Ventillation
This observational cohort aimed to re-evaluate the outcome of hematologic cancer patients admitted to the intensive care unit of Mansoura oncology center through a cohort study as regards their need for mechanical ventilation…
- Conditions
- Hematological Malignancy, Acute Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT02562105
- Testing
- Mechanical ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Respiratory Failure, Infant
Inhaled Nitric Oxide by Oxygen Hood in Neonates
Inhaled nitric oxide (iNO) improves oxygenation in term infants with respiratory failure. However, iNO has been primarily used in infants receiving mechanical ventilation.
- Conditions
- Respiratory Failure, Infant, Persistent Fetal Circulation
- Trial name
- NCT00732537
- Testing
- inhaled Nitric Oxide, Oxygen (>90% by hood) - standard therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Acute Respiratory Failure, Shock
Impact of Early Enteral vs. Parenteral Nutrition on Risk of Gastric-Content Aspiration in Patients Requiring Mechanical Ventilation and Catecholamines
To evaluate the impact of enteral nutrition on microaspiration of gastric content and pharyngeal secretions
- Trial name
- NCT03411447
- Testing
- Parenteral nutrition, Enteral nutrition
- Where
- 6 sites in France
- Volunteers
- 139 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Respiratory Insufficiency Requiring Mechanical Ventilation
Evaluation on the Effect of Acupuncture and Neuromuscular Electrical Stimulation on Mechanical Ventilation Patients
Acupuncture is a treatment intervention used globally for a wide variety of disorders. Its efficacy has been established over the course of 3000 years, originating in Asia and diversifying worldwide.The scientific basis for…
- Trial name
- NCT05221710
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Affiliated Hospital of Qingdao University