Clinical trials: Resuscitation, Burn
Burns
Fluid Resuscitation in Patients Suffering From Burns Injury
This clinical study compares two fluid resuscitation treatments in patients suffering from burns injury. The treatments are Volulyte® and Human Serum Albumin (HSA) which will be administered as infusion solutions.
- Trial name
- NCT01689506
- Testing
- Volulyte, Human Serum Albumin
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Fresenius Kabi
Severe Thermal Injury, Greater Than 20% TBSA
Vitamin C for Severe Thermal Injuries
Animal and human data have supported the notion that administration of large doses of Vitamin C has beneficial effects on those subjects suffering from large burns.
- Trial name
- NCT01587261
- Testing
- Vitamin C
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Burns
Pre-hospital Care in Burn Patients Presenting to Tertiary Care Centers of Nepal
This cross-sectional study investigates pre-hospital practices among burn patients presenting to a tertiary care center in Nepal.
- Trial name
- NCT06779500
- Where
- Nepal
- Volunteers
- 196 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Burns
Comparison of Fluid Resuscitation in Pediatric Burn Patients Using Crystalloids and With Albumin on Day Two.
The goal of this comparative, interventional randomized controlled trial is to use albumin during resuscitation in pediatric burn patients on day 2, as it can reduce extravasation of fluids and decrease the overall fluid…
- Trial name
- NCT06224777
- Testing
- 5% Albumin (human) Solution, Paeds solution
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- King Edward Medical University
Burn Shock
Evaluation of Sublingual Microcirculation in Burn During Resuscitation
The adequacy of fluid resuscitation will be monitored in burn patients using microcirculation. Microcirculation camera will be placed on the base of the tongue and at different four quadrants.
- Trial name
- NCT05096559
- Testing
- Microcirculation cytocam
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Jugular Veins, Radial Artery
The Value of Central Venous-arterial Carbon Dioxide Difference
By observing the changes of Central venous-arterial partial pressure difference of carbon dioxide [P (v-a) CO2] in liquid resuscitation during early escharectomy in patients with large-scale burns, We investigate the effect of P…
- Conditions
- Jugular Veins, Radial Artery, Carbon Dioxide
- Trial name
- NCT04761237
- Testing
- Goal-directed fluid therapy (GDET)
- Volunteers
- 118 people
- Sponsor
- Liang Bing
Burn, War-Related Injuries
ASV and Targeted Fluid Resuscitation in Severe Burns
This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive…
- Conditions
- Burn, War-Related Injuries, Mechanical Ventilation, Infusion Fluid
- Trial name
- BURN-ASV/TFR (NCT07689097)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Burn Injury
The Acute Burn ResUscitation Multicenter Prospective Trial
This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25%…
- Trial name
- ABRUPT2 (NCT04356859)
- Testing
- Albumin Human
- Where
- 26 sites in United States, Canada
- Volunteers
- 101 people
- Sponsor
- American Burn Association
Burns
The Effects of Viscoelastometry Guided Resuscitation During Burn Excision on Post Resuscitation Infections
This is a randomized controlled trial to compare viscoelastometric (VE) guided transfusion to standard practice transfusion in severe thermal injury burn excision on the utilization of blood products, effects on coagulation and…
- Trial name
- NCT03730415
- Testing
- Viscoelastic (VE) Guided Transfusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Syndecan 1, Severe Burn
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients
The purpose of this observational study is to examine whether Endotheliopathy of Trauma (EoT) is present in severely burned patients and how it is affected by burn debridement surgery.
- Conditions
- Syndecan 1, Severe Burn, Endotheliopathy of Trauma, Endothelial Glycocalyx
- Trial name
- GlycoBURN (NCT06670248)
- Testing
- Debridement Surgery, Sdc-1 Level Measurement
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Burns
Fluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation
Fluid resuscitation in burn patients is associated with major macrocirculatory and microcirculatory disturbances that have been poorly described.
- Trial name
- NCT00326729
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Burn Centre
Burn Any Degree Involving 20-29 Percent of Body Surface, Burn Any Degree Involving 30-39 Percent of Body Surface
Oral Rehydration Therapy in Burn Patients
In patients with moderate to severe thermal injuries (> 20% TBSA) adequate fluid resuscitation is the main priority to achieve successful outcomes.
- Conditions
- Burn Any Degree Involving 20-29 Percent of Body Surface, Burn Any Degree Involving 30-39 Percent of Body Surface, Burn Any Degree Involving 40-49 Percent of Body Surface, Burn Any Degree Involving 50-59 Percent of Body Surface
- Trial name
- ORT (NCT02124265)
- Testing
- CeraLyte 90
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Burns
Inflammatory Consequences of Crystalloids in Severely Burned Patients
This is a pilot study, but the investigators will also observe key immunological events with potential significance. The global objective is to study the inflammatory profiles of PlasmaLyte and Ringer's Lactate used in the…
- Trial name
- NCT04893382
- Testing
- PlasmaLyte for fluid resuscitation, Ringer's Lactate for fluid resuscitation
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burn
Colloid Improves Organs Function in Resuscitation of Extensive Burn Patients
The present study was to evaluate the effectiveness of colloid compared with crystalloids for fluid resuscitation in critical burn patients with total burn surface area ≥50%.
- Trial name
- NCT01939613
- Testing
- colloids
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Tang-Du Hospital
Burns
Early Fluid Resuscitation With Balanced HES 130/0.4 [6%] in Severe Burn Injury
RCT colloids versus cristalloids only in severe burn victims. Trial with medicinal product
- Trial name
- NCT01012648
- Testing
- Fluid resuscitation, HES 130/0.4 (6%), Voluven balanced vs. Lactated Ringer's solution
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Burns
The Effect of High Dose Vitamin C in Burn Patients
The purpose of this study is to see if intravenous Vitamin C will decrease the amount of IV fluids needed following burn injury in the first 48 hours.
- Trial name
- Vitamin C (NCT00350077)
- Testing
- Intravenous Vitamin C, Vitamin C
- Where
- United States
- Sponsor
- United States Army Institute of Surgical Research
Burns
Albumin Use in Burn Patients
This is a study of why and how physicians use albumin during the first 72 hours after a burn injury.
- Trial name
- NCT00609414
- Where
- 12 sites in United States, Canada
- Volunteers
- 460 people
- Sponsor
- University of North Carolina, Chapel Hill
Septic Shock, Severe Trauma
REAnimation Low Immune Status Markers
The fact that sepsis disrupts immune system homeostasis by inducing an initial cytokine storm, that participates to occurrence of organ failures and early death, followed by a compensatory anti-inflammatory response leading to…
- Conditions
- Septic Shock, Severe Trauma, Severe Burn, Major Surgery
- Trial name
- REALISM (NCT02638779)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Microcirculation, Burns
A Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury
The main objective of our study is to focus on the efficiency of standard fluid resuscitation in promoting tissue perfusion in severe burns patients (>15% TBSA).
- Conditions
- Microcirculation, Burns, Resuscitation
- Trial name
- MIPA (NCT04500197)
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Maasstad Hospital
Severe Burns, Fluid Resuscitation
Fluid Resuscitation in Burn Patients
Balanced solutions with low chloride concentration could represent an alternative to high chloride concentration solutions. Such balanced solutions contain other acid as buffers (i.e. acetate and/or gluconate).
- Trial name
- CARE (NCT03118362)
- Testing
- Plasmalyte, Ringer lactate
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris