Clinical trials: Reversal of Neuromuscular Blockade
Neuromuscular Blockade, Renal Impairment
Neuromuscular Blockade in Patients With Severe Renal Impairment
This study is intended to be a single-site, prospective, randomized, double-blinded study that intends to enroll a total of 60 patients with severe renal impairment undergoing surgery with general endotracheal anesthesia at…
- Trial name
- NCT03904550
- Testing
- Cisatracurium + Neostigmine, Rocuronium + Sugammadex
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Urinary Retention Postoperative, Laparoscopic Cholecystectomy
Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine Versus Sugammadex
This study is intended to be a single-site, prospective, randomized, controlled study that intends to enroll a total of 230 patients undergoing laparoscopic cholecystectomy at Parkland Hospital.
- Conditions
- Urinary Retention Postoperative, Laparoscopic Cholecystectomy, Neuromuscular Blockade, Sugammadex
- Trial name
- NCT05794503
- Testing
- Neostigmine, Sugammadex
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Neuromuscular Blockade Reversal Agent, Perioperative Complications
Sugammadex-Induced Clenching During Neuromuscular Blockade Reversal
Study Objective: This study aims to evaluate the incidence, severity, and risk factors of sugammadex-induced mouth clenching during neuromuscular blockade (NMB) reversal in adult surgical patients.
- Conditions
- Neuromuscular Blockade Reversal Agent, Perioperative Complications, Anesthesia, General, Sugammadex
- Trial name
- NCT06962007
- Testing
- Sugammadex 1 mg/kg Group, Sugammadex 2 mg/kg Group, Sugammadex 4 mg/kg Group
- Where
- South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Neuromuscular Blockade, Neuromuscular Blockade, Residual
Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade
The aim of the present study will be to evaluate by means of a prospective randomized clinical trial, the time required for the reversal of moderate neuromuscular blockade (NMB) (Train-of-four count = 3; TOFc 3) to Train-of-four…
- Trial name
- NCT05037006
- Testing
- Sevoflurane - Neostigmine 30, Sevoflurane - Neostigmine 50, Sevoflurane - Neostigmine 70
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Hypersensitivity, Anaphylaxis
A Study to Evaluate the Incidence of Hypersensitivity After Administration of Sugammadex in Healthy Participants (MK-8616-101)
The purpose of this study is to assess the potential for hypersensitivity symptoms upon repeat exposure to sugammadex. Healthy participants will be randomized to one of three treatment arms: sugammadex 4 mg/kg, sugammadex 16…
- Trial name
- NCT02028065
- Testing
- Sugammadex
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Block, Residual, Pain
Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults
This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty.
- Conditions
- Neuromuscular Block, Residual, Pain, Postoperative Nausea
- Trial name
- NCT07187037
- Testing
- Methylprednisolone (MP), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Neuromuscular Blockade
Effect of Magnesium Sulphate on Neostigmine
The purpose of this study is to evaluate the effect of magnesium sulphate on neostigmine-induced reversal of neuromuscular block by rocuronium
- Trial name
- NCT03020706
- Testing
- Magnesium Sulfate, Injectable
- Where
- South Korea
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Residual Neuromuscular Blockade, Curarization, Postoperative Residual
Validation of the REPS Prediction Tool
Neuromuscular blocking agents' (NMBA) use during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Residual Neuromuscular Blockade, Curarization, Postoperative Residual, Postoperative Respiratory Complication
- Trial name
- NCT03585400
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 101,510 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Microlaryngoscopy, Rigid Bronchoscopy
Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy
Use of Muscle relaxant and reversal with Sugammadex at end of airway procedures will reduce the time to extubation after end of procedure
- Trial name
- NCT03111121
- Testing
- Sugammadex, neostigmine, glycopyrrolate
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Brain Tumors
Effect of Sugammadex for Reversal of Rocuronium-induced Neuromuscular Block on Perioperative Management of Awake Craniotomy
Effect of sugammadex for reversal of rocuronium-induced neuromuscular block on Perioperative Management of awake Craniotomy
- Trial name
- NCT05202899
- Testing
- sugammadex
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Neuromuscular Blockade
The Effect of Sugammadex Versus Neostigmine During Neuromuscular Blockade Reversal
Patients who undergo surgery receive drugs called neuromuscular blocking agents (NMBA) that to block the activity of muscles. When the surgery is over, the block needs to be reversed.
- Trial name
- NCT03579589
- Testing
- Sugammadex vs Neostigmine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Respiratory Insufficiency
Effect of Neuromuscular Blockade and Reversal on Breathing
In this study the investigators will assess (i) the effect of partial neuromuscular blockade (NMB; TOF ratio 0.8 and 0.6) induced by low-dose rocuronium on the ventilatory response to isocapnic hypoxia and (ii) the effect over…
- Trial name
- BREATH (NCT02845375)
- Testing
- Sugammadex, Neostigmine
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Anesthesia Recovery
"Low Dose Sugammadex Combined With Neostigmine and Glycopyrrolate Versus Full Dose Sugammadex for Reversal of Rocuronium-induced Neuromuscular Blockade: a Cost Saving Strategy"
Prospective Randomized non inferiority Trial involving adult patients undergoing elective surgery under general anesthesia.56 Patients will be enrolled in 2 groups : full dose sugammadex vs half dose sugammadex for reversal of…
- Trial name
- NCT02375217
- Testing
- Sugammadex, Neostigmine, glycopyrrolate
- Where
- Lebanon
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Neuromuscular Block, Residual
Diaphragm Function After Reversal of Rocuronium-induced Neuromuscular Blockade With Sugammadex or Neostigmine in Children
This study is to evaluate the recovery of diaphragm function and atelectasis after reversal of neuromuscular blockade with Neostigmine and Sugammadex using lung ultrasound and diaphragm ultrasound for children aged 2 to 7 who are…
- Trial name
- NCT05724550
- Testing
- Sugammadex, Neostigmine
- Where
- South Korea
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Neuromuscular Blockade
Pilot Study on the Pharmacodynamics of Sugammadex in Morbidly Obese Patients: Reversal of Deep Neuromuscular Blockade
Should the dose of sugammadex in morbid obese patients be calculated on the real body weight or the ideal body weight? To study the pharmacodynamics of sugammadex in morbidly obese patients by comparing 1 mg/kg IBW versus 1 mg/kg…
- Trial name
- MOS (NCT01855217)
- Testing
- Sugammadex
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Neuromuscular Blocking Agents, Urinary Retention After Procedure
NMBA Reversal and Postoperative Urinary Retention
In this single-center retrospective cohort study of adult patients who underwent surgery under general anesthesia at Beth Israel Deaconess Medical Center between September 2016 and January 2024, the association between the choice…
- Conditions
- Neuromuscular Blocking Agents, Urinary Retention After Procedure, Urinary Retention Postoperative, Neuromuscular Blockade Reversal Agent
- Trial name
- NCT06948409
- Testing
- Choice of reversal agent (sugammadex or neostigmine [with muscaranic antagonist])
- Where
- United States
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Reversal of Neuromuscular Blockade
A Single Ascending Dose of HRS-2162 in Healthy Subjects
The study is being conducted to evaluate the safety and tolerability of HRS-2162 injection in a single dose in healthy subjects, as well as the characteristics of PK/PD
- Trial name
- NCT07195604
- Testing
- HRS-2162
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Neuromuscular Blockade
Comparison of Sugammadex and Neostigmine During PACU Stay
Sugammadex was approved for post-operative use in the operating room (OR) and post-anesthesia recovery unit (PACU) of our quaternary facility, Tampa General Hospital.
- Trial name
- NCT04096144
- Testing
- Neuromuscular Blocking Agents
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Shoulder Pain, Anesthesia
The Effect of Deep Neuromuscular Block and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity in Shoulder Surgery Using a Deltopectoral Approach
The study evaluates wether deep neuromuscular block during entire surgical procedure to the gleno-humeral joint or the proximal humerus using a deltoideo-pectoral approach results in less muscular damage to the deltoid muscle and…
- Trial name
- NCT03643913
- Testing
- Deep neuromuscular block, Moderate neuromuscular block, Neuromuscular Blocking Agents and reversing agents
- Where
- Belgium
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neuromuscular Blockade, Neuromuscular Block, Residual
Different Doses of Neostigmine for Reversal of Moderate Neuromuscular Blockade in Children
There is no recent information on the required dose of neostigmine for the reversal of cisatracurium-induced moderate neuromuscular blockade (NMB) [Train-of-four (TOF) count = 1-3)] in children.
- Conditions
- Neuromuscular Blockade, Neuromuscular Block, Residual, Neuromuscular Block Prolonged
- Trial name
- NCT05053594
- Testing
- Neostigmine 10 mcg/kg, Neostigmine 20 mcg/kg, Neostigmine 30 mcg/kg
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo