Clinical trials: Reward
Binge-Eating Disorder
Decision Making, Daily Experiences, and Brain Activity in Young Adult Women
The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities.
- Trial name
- NCT04125589
- Testing
- Speaking Activity, Talking Activity
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Healthy Volunteers
Effect of Intragastric Administration of Fatty Acids on Generalized Reward Sensitivity
This study aim to investigate the influence of intragastrically infused fatty acid on the generalization of responses to reward within the food domain and between financial and sexual domains.
- Trial name
- NCT02984150
- Testing
- dodecanoic acid, saline
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Schizophrenia
Pan European Collaboration on Antipsychotic Naive Schizophrenia (PECANS)
The investigators want to relate disturbances in first-episode schizophrenic patients in (dopaminergic) D2 receptors, brain structure, brain function, and information processing to each other and to psychopathology.
- Trial name
- PECANS (NCT01154829)
- Testing
- amisulpride, aripiprazole
- Where
- Denmark
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
The Effects of Losartan on Social Reward
The aim of the study is to investigate the effect of losartan (50mg, single dose) on social reward
- Trial name
- NCT04604756
- Testing
- Losartan
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy
The Effects of Losartan on Reward Reinforcement Learning
This study aims to investigate whether a single dose of losartan (50 mg) can affect learning from positive and negative outcomes and its related neural mechanisms.
- Trial name
- NCT04604938
- Testing
- Losartan
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Eating Disorders, Anxiety
Excessive Avoidance Behaviors in Anorexia Nervosa: the Role of Reward
This study investigates excessive avoidance behaviors in patients with a diagnosis of Anorexia Nervosa (AN) compared to a healthy control group.
- Conditions
- Eating Disorders, Anxiety, Anorexia Nervosa
- Trial name
- NCT04405440
- Testing
- Behavioral avoidance task
- Where
- 2 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bram Vervliet
Stress Eating, Reward-based Eating
Bringing Awareness Into Eating
The purpose of this study is to test an app-based mindful eating intervention to decrease the reward value of unhealthy food.
- Conditions
- Stress Eating, Reward-based Eating, Craving-related Eating
- Trial name
- NCT04021745
- Testing
- App-based mindful eating
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Brown University
Addiction Nicotine
Self-activation in Individuals With and Without Nicotine Dependence
The purpose of this study is to see if a non-medication intervention can increase motivation and reward processing to non-drug reward cues (for example, a picture of one's favorite food) in individuals with and without nicotine…
- Trial name
- NCT03170258
- Testing
- Neurofeedback (from fMRI and/or EEG)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy
A Study To Examine Safety, Pharmacokinetics, And Pharmacodynamic Of Pf 06412562 In Healthy Males
This study is designed to investigate the safety, tolerability pharmacokinetics and pharmacodynamic effects of PF-06412562 following multiple dose administration as MR tablets in healthy adult males.
- Trial name
- NCT02306876
- Testing
- PF-06412562 3mg BID, PF-06412562 15mg BID
- Where
- 3 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Pfizer
Overweight, Obesity
Cue-Reward Learning and Weight Gain in Youth
The objective of the study is to compare children at low risk for obesity (two healthy weight parents) to children at high risk for obesity (two overweight parents) in their response rate to food taste and in their rate of…
- Trial name
- ChildLearn (NCT03254576)
- Testing
- Functional MRI
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity
Reward Mechanisms in Obesity
The study aims to investigate the effects of 3.0 mg of liraglutide on reward brain circuits in human obesity and to better understand its effects on weight loss (in patients without diabetes).
- Trial name
- LIRAOB (NCT03347890)
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zoltan Pataky
Major Depressive Disorder, Substance Use Disorder
Defining Neurobiological Links Between Substance Use and Mental Illness
Background: Nicotine dependence leads to about 480,000 deaths every year in the United States. People with major depressive disorder (MDD) are twice as likely to use nicotine compared to the general population.
- Conditions
- Major Depressive Disorder, Substance Use Disorder, Normal Physiology
- Trial name
- NCT05538910
- Testing
- Nicotine Patch
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Stress, Psychological
Stress-Induced Inflammation and Reward Processing
Anhedonia, or loss of interest or pleasure, is a key feature of depression and transdiagnostic construct in psychopathology. Both theory and compelling evidence from preclinical models implicates stress-induced inflammation as a…
- Trial name
- NCT03828604
- Testing
- Stress; Trier Social Stress Task
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy Normal Weight
Meal Texture and Satiety
The aim of the present study is to compare the nutritional compensation between iso-caloric meals of various textures (liquid vs solid) in health young adults.
- Trial name
- FEED (NCT04041752)
- Testing
- SOLID, LIQUID_P, LIQUID_L
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
Transcranial Focused Ultrasound (tFUS) Modulation of Reward Network
Aim: Evaluate whether sonicating the Nucleus Accumbens (NAc) with transcranial focused ultrasound modifies functional connectivity between the NAc and the prefrontal cortex (PFC).
- Trial name
- NCT05986019
- Testing
- transcranial focused ultrasound (tFUS)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Diagnosis and Treatment of Depression
A Study of Diagnosis and Treatment of Depression Based on Biological Evidence of Dopamine Reward Pathway
This study will recruit depressed patients unresponsive to selective serotonin reuptake inhibitor antidepressant treatment, first-degree relatives (parents or siblings) of depressed patients, schizophrenia, Parkinson's disease…
- Trial name
- NCT03148509
- Testing
- risperidone, aripiprazole, bupropion
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University
Major Depressive Disorder
Neuroimaging Studies of Reward Processing in Depression
This study investigates stress-related signaling of glutamate and dopamine within the reward-processing circuit in Major Depressive Disorder (MDD), and whether they can be used to predict depressive symptoms in the future.
- Trial name
- NCT03026036
- Testing
- PET Scan with Raclopride
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Nutrition Intervention
Rewarding Healthy Food Choices: a Mobile Serious Game Intervention in Adolescents
The aim of this study is to conduct an outcome and process evaluation of the REWARD intervention, a serious game intervention using reward-based strategies as a main method to trigger healthy snacking in Flemish adolescents.
- Trial name
- REWARD (NCT02622165)
- Testing
- The REWARD serious game intervention
- Where
- Belgium
- Volunteers
- 1,463 people, healthy volunteers welcome
- Sponsor
- University Ghent
Depression, Major Depressive Disorder
Reward Emotion Learning and Ketamine Study
Ketamine's efficacy as an antidepressant is now well established yet the mechanisms underlying its antidepressant effect are yet to be fully described.
- Conditions
- Depression, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- RELAKS (NCT04850911)
- Testing
- Ketamine Hydrochloride
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Opioid Use Disorder, Substance Use Disorders
SMART Brain Health in African-Americans
The investigators hypothesize that opioid use in African-Americans will be associated with hypodopaminergic alleles that alter the threshold for activating feelings of reward and pleasure within the dopaminergic system, and that…
- Conditions
- Opioid Use Disorder, Substance Use Disorders, Dopamine Dysregulation Syndrome, African Americans
- Trial name
- SMART (NCT03861832)
- Testing
- KB220Z
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Howard University