Clinical trials: RhA - Rheumatoid Arthritis
Rheumatic Disease, Rheumatic Disorder
Survey About Diet in Chronic Inflammatory Rheumatic Diseases
A French Survey on patients' practices, knowledge and beliefs about diet in chronic inflammatory rheumatic diseases (rheumatoid arthritis, psoriatic arthritis, spondylarthritis) Use of a questionnaire about what patients have…
- Conditions
- Rheumatic Disease, Rheumatic Disorder, Inflammatory Rheumatism, Rheumatoid Arthritis
- Trial name
- NCT05283096
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 203 people
- Sponsor
- Poitiers University Hospital
Rheumatoid Arthritis
Assess Structural Damage in Rheumatoid Arthritis Using Biomarkers and Radiography
Recruited patients will include those about to begin Disease-Modifying Antirheumatic Drug) DMARD therapy or about to change DMARD therapy.
- Trial name
- NCT01476956
- Testing
- Observational study
- Where
- 36 sites in United States, Canada and 8 more
- Volunteers
- 571 people
- Sponsor
- CARE ARTHRITIS LTD.
Osteoarthritis, Hip, Rheumatoid Arthritis
Exception Cementless Hip Stem
This study is a multicenter, retrospective and prospective, non-controlled, non-randomized post market clinical follow-up study.
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Inflammatory Arthritis, Congenital Hip Dysplasia
- Trial name
- Exception (NCT04349046)
- Testing
- Total hip arthoplasty (THA)
- Where
- 6 sites in Belgium, France
- Volunteers
- 332 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis
Investigation of Immunological and Pharmacological Factors for Response to Adalimumab in Rheumatoid Arthritis
Interventional study with minimal risks and constraints, prospective, mono-centric.
- Trial name
- PROMETHEE (NCT03110094)
- Testing
- Adalimumab, Healthy volunteers
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Rheumatoid Arthritis, Psoriatic Arthritis
Therapeutic Strategy Associated With bDMARDs or tsDMARDs in Rheumatoid Arthritis and Psoriatic Arthritis
This is a longitudinal, observational, prospective, multicentre study conducted in France, among a representative sample of rheumatology doctors.
- Trial name
- STRATEGE2 (NCT05082805)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nordic Pharma SAS
Rheumatoid Arthritis
Switching Anti-TNF-Alpha Agents in Rheumatoid Arthritis (RA)
Rheumatoid Arthritis (RA) is a systemic inflammatory autoimmune disorder that leads to inflammation and progressive joint damage affecting 2.5 million people in the United States.
- Trial name
- NCT00796705
- Testing
- Adalimumab, Etanercept
- Where
- 16 sites in United States
- Volunteers
- 13 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis
Effects of a Rehabilitation Program on Physical Performance and Disease Self-management in Rheumatoid Arthritis.
The purpose of this study is to evaluate the effects of a group-based exercise and educational program for people with Rheumatoid Arthritis (RA) on physical performance and disease-self-management.
- Trial name
- NCT01307787
- Testing
- experimental Fit-program, no intervention
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- University Medical Center Groningen
Rheumatoid Arthritis
A Safety and Efficacy Study of Golimumab (CNTO 148) in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy
The purpose of this study is to evaluate the safety and effectiveness of golimumab in patients with active rheumatoid arthritis despite Methotrexate therapy. Another objective is to evaluate the pharmacokinetics of golimumab.
- Trial name
- NCT00727987
- Testing
- CNTO 148, Methotrexate (MTX)
- Where
- 65 sites in Japan
- Volunteers
- 269 people
- Sponsor
- Janssen Pharmaceutical K.K.
Rheumatoid Arthritis
Study to Assess the Efficacy and Safety of Rituximab in Patients With Rheumatoid Arthritis
This study will assess the efficacy and safety of different treatment regimens of rituximab (MabThera®/Rituxan®), corticosteroids, and placebo, combined with methotrexate (MTX), in patients with active rheumatoid arthritis (RA).
- Trial name
- NCT00074438
- Testing
- methotrexate, rituximab, corticosteroids
- Volunteers
- 465 people
- Sponsor
- Genentech, Inc.
Rheumatoid Arthritis
Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Anti-Tumor Necrosis Factor α (Anti-TNFα) Agents (CAIN457F2309 and CAIN457F2309E1)
The core and extension studies assessed the safety and efficacy of secukinumab when added to a background therapy in patients with active rheumatoid arthritis who are intolerant to or have had an inadequate response to anti-TNF-α…
- Trial name
- NURTURE 1 (NCT01350804)
- Testing
- AIN457, Abatacept
- Where
- 117 sites in United States, Brazil and 13 more
- Volunteers
- 551 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose CFZ533 in Rheumatoid Arthritis Patients
This is a first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single intravenous and subcutaneous doses of CFZ533 in healthy subjects and intravenous doses in rheumatoid…
- Trial name
- NCT02089087
- Testing
- CFZ533
- Where
- 6 sites in United States, Taiwan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis, Arthritis
A Study of Peresolimab (LY3462817) in Participants With Moderately-to-Severely Active Rheumatoid Arthritis
The main purpose of this study is to assess the safety and efficacy of peresolimab in adult participants with moderately-to-severely active rheumatoid arthritis.
- Conditions
- Rheumatoid Arthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
- Trial name
- RESOLUTION-1 (NCT05516758)
- Testing
- Peresolimab
- Where
- 131 sites in United States, Argentina and 9 more
- Volunteers
- 491 people
- Sponsor
- Eli Lilly and Company
Degenerative Arthritis, Osteoarthritis
Total Knee Replacement With Duracon® and Vanguard™ Prostheses
The purpose of this study is to compare range of motion, Knee Society Scores, and duration of surgery for different total knee prostheses.
- Conditions
- Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
- Trial name
- NCT00588887
- Testing
- Duracon®, Vanguard™
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Biomet Orthopedics, LLC
Rheumatoid Arthritis
Real Life Dosing of Remicade for Rheumatoid Arthritis in Austria Monitored Over 9 Infusions (Study P03756)(COMPLETED)
This is a prospective, open-label, 1-arm, multicenter observational study to determine the average Remicade dosage and time span between 9 infusions in subjects with rheumatoid arthritis (RA)
- Trial name
- NCT00725621
- Testing
- Infliximab
- Volunteers
- 516 people
- Sponsor
- Merck Sharp & Dohme LLC
Arthritis, Rheumatoid
Study to Evaluate the Efficacy and Safety of GSK3196165 Plus Methotrexate in Subjects With Active Moderate-Severe Rheumatoid Arthritis
This is a randomised, Phase IIb, dose-adaptive, multicentre, double-blind, parallel group, placebo-controlled study with the primary objective to assess the efficacy of GSK3196165, in combination with methotrexate (MTX), in…
- Trial name
- NCT02504671
- Testing
- GSK3196165, MTX, Folic acid
- Where
- 64 sites in Bulgaria, Canada and 12 more
- Volunteers
- 222 people
- Sponsor
- GlaxoSmithKline
Arthritis, Rheumatoid
A Safety and Pharmacokinetics Study in Participants With Rheumatoid Arthritis
The purpose of this study is to examine the safety and efficacy of this antibody in participants with rheumatoid arthritis. Part A of the study is an initial dose escalation phase Part B of the study is a randomized allocation of…
- Trial name
- NCT00380744
- Testing
- LY2189102
- Where
- 14 sites in United States, Poland
- Volunteers
- 121 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
Effect of Proactive Therapeutic Drug Monitoring on Maintenance of Sustained Disease Control in Adults With Rheumatoid Arthritis on a Subcutaneous TNF Inhibitor: The Rheumatoid Arthritis Therapeutic DRUg Monitoring Trial (RA-DRUM)
The goal of this clinical trial is to compare therapeutic drug monitoring (TDM) versus Standard of care in patients with rheumatoid arthritis treated with a subcutaneous tumor necrosis factor inhibitor (adalimumab).
- Trial name
- RA-DRUM (NCT06440629)
- Testing
- Therapeutic drug monitoring (TDM) of adalimumab
- Where
- 22 sites in Austria, Italy and 4 more
- Volunteers
- 387 people
- Sponsor
- Diakonhjemmet Hospital
Rheumatoid Arthritis
A Study of the Effects of Oral Prednisone in Patients With Rheumatoid Arthritis (MK0000-088)
The study will compare the effects of prednisone vs placebo on synovial blood flow and overall DAS (disease activity score) in patients with rheumatoid arthritis.
- Trial name
- NCT00746512
- Testing
- Prednisone 15 mg, Prednisone 7.5 mg
- Volunteers
- 45 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis, Swelling Joint
Characterization of Regulatory T Lymphocytes in the Synovial Fluid of Patients Affected by Rheumatoid Arthritis.
In rheumatoid arthritis (RA) the clinical response to anti-TNFα is related to an increase in the number or in the function of Treg lymphocytes in the peripheral blood of patients.
- Conditions
- Rheumatoid Arthritis, Swelling Joint, Joint Fluid, Characterization of Regulatory T Lymphocytes
- Trial name
- CATERLIS (NCT03293667)
- Testing
- Exploratory synovial fluid analysis
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
Effects of Achieving SDAI Remission on Joint Space Outcomes Progression in Early Rheumatoid Arthritis: an HR-pQCT Study
Objectives: To elucidate the effects of achieving sustained simple disease activity index (SDAI) remission in the progression of joint space outcomes using high-resolution peripheral quantitative CT (HR-pQCT) in patients with…
- Trial name
- NCT04324892
- Testing
- Treat to target
- Where
- Hong Kong
- Volunteers
- 110 people
- Sponsor
- Chinese University of Hong Kong