Clinical trials: Rheumatic Disorder
Healthy Volunteers, Rheumatoid Arthritis
A Study to Evaluate Safety and Pharmacokinetics of ZB002 in Healthy Participants and Participants With Rheumatoid Arthritis
This double-blind, randomized, placebo-controlled study will assess the safety and pharmacokinetics of ZB002 in healthy participants and in participants with rheumatoid arthritis (RA). The study consists of 2 parts.
- Trial name
- NCT05638854
- Testing
- ZB002
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Zenas BioPharma (USA), LLC
Osteoarthritis
Blood Loss Reduction After Total Knee Arthroplasty. Comparison Topical Tranexamic Acid vs Platelet Rich Plasma
The investigators will include patients who will be schedule for total knee arthroplasty with a diagnosis of osteoarthritis. The patients will be divided in two groups.
- Trial name
- NCT02650856
- Testing
- Group 1 Tranexamic Acid, Group 2 Platelet rich plasma
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Fetal Distress
Evaluation of Fetal Cardiac Function in Rheumatic Heart Disease (RHD) Patients
The goal of this study is to evaluate fetal myocardial performance in patients with heart diseases in comparison to normal pregnant patients.
- Trial name
- RHD (NCT03095937)
- Where
- Egypt
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gout
A Study to Determine the Safety, Tolerability, PK and Preliminary PD of SSS11 in Chinese Healthy Adult Volunteers
To evaluate the safety, tolerability, PK and preliminary PD of SSS11 for injection in chinese healthy adult volunteers.
- Trial name
- NCT04047394
- Testing
- PEGylated recombinant candida urate oxidase
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Crohn's Disease, Rheumatoid Arthritis
OTIS Cimzia Pregnancy Registry
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Crohn's Disease, Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01797224
- Where
- United States
- Volunteers
- 925 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Knee Osteoarthritis
Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis
As an activator of inhibiting nuclear factor kB receptor, denosumab affects osteoclast differentiation and development by inhibiting OPG/RANKL-RANK bone regulatory axis pathway.
- Trial name
- CSODITTOKO (NCT06357741)
- Testing
- Denosumab
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Fibromyalgia, Postural Lordosis
Trunk Position Sense, Postural Stability and Spinal Posture in Fibromyalgia
This study aims to investigate trunk position sense, postural stability and spine posture in fibromyalgia patients and healthy women.
- Conditions
- Fibromyalgia, Postural Lordosis, Postural Kyphosis, Proprioception
- Trial name
- NCT03757702
- Testing
- Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Arthritis, Knee Osteoarthritis
Immediate Effects Of Alliance Therapy In Modulation Of Pain And Disability In Subjects With Knee Osteoarthritis
INTRODUCTION: The Osteoarthritis (OA) is the most common type of joint disease, its features include joint space narrowing, osteophytes formation of the joint margins, motor deficit, reduced strength, and persistent pain.
- Trial name
- NCT03928054
- Testing
- Kinesio Taping and therapeutic alliance
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Fibromyalgia, Chronic Low Back Pain
Mapping Stress and Pain Interactions (G072323N)
The over-arching goal of this observational (case-control, with a cross-sectional and longitudinal arm) study is to comprehensively map stress system (dys)function (including reactivity and recovery) in people with primary…
- Conditions
- Fibromyalgia, Chronic Low Back Pain, Subacute Low Back Pain
- Trial name
- STRAIN (NCT06892977)
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Ghent
Osteoarthritis
Joint Self-Assessment Forms for Knee, Ankle and Shoulder
The present study represents the pilot phase of the project aimed at developing anatomical site-specific self-assessment questionnaires (shoulder, knee and ankle) that can advise the subject of the need for an orthopaedic…
- Trial name
- NCT06343857
- Testing
- self-assessment questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Rheumatoid Arthritis
Addition of H.P. Acthar Gel to Treatment Regimen of Patients With Rheumatoid Arthritis
This small study is to investigate the efficacy and safety of Acthar as an adjunct therapy in patients with active rheumatoid arthritis (RA) who have had an inadequate response to disease modifying antirheumatic drugs (DMARDs)…
- Trial name
- NCT02434757
- Testing
- H.P. Acthar Gel
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ronald J. Rapoport, MD
Fibromyalgia
Aquatic Physical Therapy in Fibromyalgia
Objective: To investigate whether patients undergoing aquatic physiotherapy in groups improve their functional capacity, by means of the distance covered in the six-minute walk test (6WT), and to compare this with a control…
- Trial name
- NCT00615654
- Testing
- aquatic physical therapy
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sao Camilo University Center
Arthritis, Juvenile Idiopathic, Enthesitis-Related Arthritis, Juvenile
Juvenile Arthritis Quantitative Imaging
This observational study aims to develop and validate quantitative magnetic resonance imaging biomarkers as measures of disease activity in juvenile idiopathic arthritis (JIA).
- Trial name
- JAQI (NCT02684695)
- Testing
- MRI scan (adolescent spine protocol), MRI scan (whole body protocol)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Osteoarthritis
Group Physical Therapy for Knee Osteoarthritis
Osteoarthritis (OA) is a common cause of pain and disability. Physical therapy is a key part of treatment for OA, but VA Medical Centers are often limited in their capacity to provide physical therapy services for veterans with…
- Trial name
- NCT00642772
- Testing
- Group Physical Therapy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Hypertriglyceridemia, Gout
Apolipoprotein CIII Reduction Via Colchicine
The aim of this trial will be to determine an effect-size for the administration of chronic low-dose colchicine in the reduction of serum levels of triglycerides (TG), very-low density lipoproteins (VLDL), and apolipoprotein CIII…
- Conditions
- Hypertriglyceridemia, Gout, Pericarditis
- Trial name
- NCT02083510
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Healthy Volunteers, Sjögren's Syndrome
A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a condition when the body's immune system attacks glands that produce fluids, such as the tear and saliva glands. This leads to dry eyes and a dry mouth.
- Trial name
- NCT06544642
- Testing
- ASP5502
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Rheumatoid Arthritis
Effects of Tofacitinib on Body Composition, Bone Mineral Density and Bone Marrow Adiposity in Patients With Rheumatoid Arthritis: the TOFAT Project
Inflammatory rheumatic diseases (IRD), such as rheumatoid arthritis, are characterized by adverse changes in body composition. Lean mass and bone mineral density are usually reduced while adiposity (total fat mass, visceral…
- Trial name
- TOFAT (NCT04175886)
- Testing
- Tofacitinib
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Pre - Delivery Pregnant Women, Chronic Pain
Assessment of Central Pain in the Peripartum Period
Chronic pain is common. Up to 10% of the Population has been estimated to suffer from chronic pain and up to 5% of the female population has been estimated to suffer from widespread, chronic pain and tenderness, thus fulfilling…
- Conditions
- Pre - Delivery Pregnant Women, Chronic Pain, Pain During Delivery
- Trial name
- NCT01291680
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Osteoarthritis, Knee, Inflammation Knees
How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response
This study compares two total knee replacement implants to asses muscle function and quality, and the immune response to the implants.
- Trial name
- NCT04105179
- Testing
- Zimmer NexGen LPS-Flex, Smith & Nephew Journey II
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Fibromyalgia
Developing Biomarkers for Fibromyalgia
The hypothesis of this study is that biological markers are present in the body that are good indicators of chronic pain. Eligible participants will be assessed at baseline and after receiving a series of acupuncture or "sham"…
- Trial name
- Biomarkers (NCT00932061)
- Testing
- Traditional Acupuncture
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Michigan
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