Clinical trials: Rhinitis
Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis
Bioequivalence Study of Azelastine Hydrochloride/ Fluticasone Propionate 137 Microgram/50 Microgram Nasal Spray and Dymista Nasal Spray
Single dose (four sprays) bioequivalence study of Azelastine Hydrochloride/ Fluticasone Propionate 137 microgram/50 microgram Nasal Spray and 'DYMISTA' (Azelastine Hydrochloride/Fluticasone Propionate) Nasal Spray 137…
- Trial name
- NCT06180083
- Testing
- Azelastine Hydrochloride/ Fluticasone propionate nasal spray, 'DYMISTA' NASAL SPRAY
- Where
- India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Seasonal Allergic Rhinitis
To Investigate Drug-drug Interaction and Relative Bioavailability Between the FDC AzelastineHCL/Beclomethasone Dipropionate Nasal Spray, & Beclomethasone Dipropionate Nasal Spray in the Test Vehicle, and RinoClenil® Nasal Spray
An open label, randomized, three-treatment, three-period, crossover, single dose study, to investigate drug-drug interaction and relative bioavailability between the fixed dose combination Azelastine hydrochloride /…
- Trial name
- NCT04817800
- Testing
- 140/100 μg Azelastine hydrochloride/Beclomethasone Dipropionate)
- Where
- Jordan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Asthma, Allergic Rhinitis
Genetics of the Early and Late Response to Allergen Challenge
The investigators are investigating the early and late responses to allergen challenge. The research participants who the investigators will study (from three cohorts) will be part of independently-approved studies involving…
- Trial name
- NCT01113697
- Where
- 5 sites in Canada
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Nasal Polyps, Asthma
Assessment of Oral and Nasal Breathing With Sensors Analyzing Algorithm
The goal of this observational study is to learn about the agreement between sensors analyzing algorithm and body plethysmography in measuring oral and nasal breathing in healthy adults, and in patients with chronic…
- Conditions
- Nasal Polyps, Asthma, COPD, Allergic Rhinitis
- Trial name
- NCT05869071
- Testing
- Sensor analyzing software (own development), Body plethysmograph
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Allergic Rhinitis
Allergic Rhinitis Combination Pharmacotherapy Efficacy Study
Combination pharmacotherapy is often used in people who have failed mono-therapies in managing their bothersome allergic rhinitis symptoms .
- Trial name
- NCT04601324
- Testing
- Fluticasone Propionate, Azelastine hydrochloride and fluticasone propionate, Rupatadine
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Paul's Sinus Centre
Allergic Rhinitis
The Effects of OC000459 on Nasal Mediators
This is the first proof of concept study for OC000459 and is undertaken to assess the effects of the compound on the development of inflammatory cytokines in a model (nasal allergen challenge model) that is validated and…
- Trial name
- NCT00290381
- Testing
- Oxagen OC000459
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Trevor Hansel
Hayfever
Repeat Nasal Allergen Challenge
This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more…
- Trial name
- NCT00290368
- Testing
- Skin Prick Test, Nasal allergen challenge, Nasal filter paper placement
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diphenhydramine Causing Adverse Effects in Therapeutic Use, Hyperthermia
Diphenhydramine and Sweating
In 2012, it was estimated that nearly 1 in 4 Canadians suffer from allergic rhinitis. To add, 78% of individuals working in predisposing environments are predicted to develop occupational rhinitis.
- Conditions
- Diphenhydramine Causing Adverse Effects in Therapeutic Use, Hyperthermia, Allergic Rhinitis, Sweating
- Trial name
- BENEXE2022 (NCT05586477)
- Testing
- Diphenhydramine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Asthma, Allergic Rhinitis
Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.
To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.
- Conditions
- Asthma, Allergic Rhinitis, Chronic Obstructive Pulmonary Disease(COPD), Atopic Dermatitis
- Trial name
- NCT05330637
- Testing
- Climate and environment in Sanya
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Chronic Rhinitis
Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis
The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients.
- Trial name
- NCT05626621
- Testing
- Azelastine (137 mcg/spray) Nasal Spray and Mometasone (50 mcg/spray) Nasal Spray, Mometasone Nasal Irrigation (1 mg capsule), Mometasone (1 mg) and Azelastine (1 mg) Nasal Irrigation
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Allergic Rhinitis
The Efficacy Of Elonide Nasal Corticosteroids In Managing Allergic Rhinitis
The aim of this clinical study is to compare the efficacy of Elonide Nasal Spray to Nasonex Nasal Spray and Placebo (non-active ingredient) in the management of allergic rhinitis. There are two hypotheses of this study: 1.
- Trial name
- NCT05912192
- Testing
- Elonide Nasal Spray, Nasonex Nasal Spray, Normal saline
- Where
- Malaysia
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Seasonal Allergic Rhinitis, Rhinovirus
Biomarkers in Nasal Samples of Seasonal Allergic Rhinitics
The purpose of this study is to analyze nasal samples for the presence of biomarkers of allergic inflammation as well as cold and flu infections, and compare these samples both in and out of an individual's active allergy season.
- Trial name
- GSK AR ELF (NCT04670627)
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Asthma, Dermatitis, Atopic
A Long-Term Examination of Asthma From Childhood Through Adolescence
Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma symptoms disappear and treatment can be stopped; however, for some of these people, asthma symptoms return in adulthood.
- Conditions
- Asthma, Dermatitis, Atopic, Rhinitis, Urticaria
- Trial name
- NCT00541255
- Where
- United Kingdom
- Volunteers
- 1,313 people, healthy volunteers welcome
- Sponsor
- Isle of Wight NHS Trust
Allergic Rhinitis, Allergic Rhinitis Due to Grass Pollen
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of B244 in Healthy Volunteers and Subjects With Seasonal Allergic Rhinitis
This is a Prospective, Controlled, Double Blinded, Single Center, Randomized, 3 Arm, Parallel Assignment, Phase 1b/2a Study to assess the safety, tolerability, and preliminary efficacy of B244 delivered as an intranasal spray in…
- Conditions
- Allergic Rhinitis, Allergic Rhinitis Due to Grass Pollen, Healthy Volunteers
- Trial name
- NCT03290248
- Testing
- B244 suspension, Vehicle
- Where
- 2 sites in United States, Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- AOBiome LLC
Allergic Rhinitis
HDM and Silver Birch NAC Standardisation
This study aims to establish dose-responses to nasal allergen challenge using silver birch pollen and house dust mite allergen extracts in participants with allergic rhinitis, sensitised to either or both of these allergens.
- Trial name
- NCT05378594
- Testing
- Nasal allergen challenge
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Allergic Rhinitis, Asthma in Children
Oral Findings in Pediatric Patients With Allergic Rhinitis and/or Asthma
The aim of the study was to evaluate if there were differences in oral findings between patients diagnosed with allergic rhinitis and/or asthma and a control group of health people.
- Conditions
- Allergic Rhinitis, Asthma in Children, Dental Caries, Periodontal Diseases
- Trial name
- NCT05576142
- Testing
- Oral examination
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Asthma, Allergic Rhinitis
Association of Transcutaneous Pulse CO-oximetry With Inflammatory Lung Diseases
This is a pilot cross-sectional study of measured transcutaneous CO-oximetry in children with inflammatory and non-inflammatory conditions.
- Conditions
- Asthma, Allergic Rhinitis, Cystic Fibrosis, Pneumonia
- Trial name
- COOX (NCT02831348)
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Hyperactivity, Allergic Rhinitis Due to House Dust Mite
Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial pain or loss of smell is…
- Conditions
- Hyperactivity, Allergic Rhinitis Due to House Dust Mite, Chronic Rhinosinusitis With Nasal Polyps
- Trial name
- NCT04286542
- Testing
- Cold, dry air
- Where
- Belgium
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allergic Rhinitis
Impact Of Montelukast On Allergic Rhinitis And Its Inflammatory Makers
To examine the efficacy of Montelukast as an adjunct to INCS in patients with allergic rhinitis.
- Trial name
- NCT05381207
- Testing
- Montelukast Oral Tablet
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Influenza Infection
Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine in Healthy Adults
Background: The flu is a common viral infection that can be deadly for certain people. Vaccines against flu have been developed to teach the body to prevent or fight the infection.
- Trial name
- NCT03814720
- Testing
- VRC-FLUNPF099-00-VP (H1ssF_3928)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)