Clinical trials: Risk of Fracture
Osteoporosis and Fracture Risk in Pregnant Women
Pregnancy and Lactation- Associated Osteoporosis
Pregnancy-Associated Osteoporosis is a condition characterized by loss of bone mass and fragility fractures during pregnancy or breastfeeding, often due to the increased calcium request from fetus.
- Trial name
- POI (NCT07031557)
- Testing
- EchoStation Implementing REMS Technology, Nutritional and Fracture Risk Assessment Questionnaires
- Where
- Italy
- Volunteers
- 1,230 people, healthy volunteers welcome
- Sponsor
- Parma University Hospital
Compression Fracture
QOCA®-Image Medical Platform - Smart VCF Risk Management System
This project aims to develop and validate an automatic detection and classification system for vertebral compression fractures on computer tomography (CT) images using an artificial intelligence (AI) system (named Smart Bone) by…
- Trial name
- NCT04384211
- Testing
- Computer Assisted Detection Software For Vertebral Fractures
- Where
- Taiwan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Weight Loss, Bone Density
The Effect of Weight Loss and Dietary Protein Intake on Bone
The purpose of this study is to learn how the amount of protein during moderate weight loss influences bone health. We will also examine how two levels of protein intake affects diet quality.
- Trial name
- NCT00473031
- Testing
- Caloric restriction, high protein, Caloric restriction; normal protein, Counseling
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Radius Fractures
Young Goalkeeper's Fracture: Radiographic Findings
The aim of this project is to evaluate retrospectively goalkeeper's fractures in children using the children fracture classification and to evaluate the distal radius tilt angle of the growth plate on plain radiographs of the…
- Trial name
- Goalkeeper (NCT02840188)
- Testing
- Radius tilt angle
- Where
- Switzerland
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Osteoporosis, With or Without Treatment, Bisphosphonate Treatment
Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use
Bisphosphonates are drugs that prevent bone loss by blocking the activity of cells that normally resorb bone. The most common examples of these drugs are Boniva and Fosamax.
- Conditions
- Osteoporosis, With or Without Treatment, Bisphosphonate Treatment, Atypical Femur Fracture, Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ)
- Trial name
- NCT01875458
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pulmonary Disease, Chronic Obstructive, Osteoporosis
CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD
The goal of this translational study is to establish a newly emerging CT-based tool for the characterization of changes in bone micro-architecture and assessment of their implications for fracture-risk in a population of COPD…
- Trial name
- NCT03534934
- Testing
- Vital signs, Urine Pregnancy Test, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Punam K Saha
Fracture, Fractures, Hip
The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
Hip fractures occur nearly twice as often for older adults residing in long-term care as they do in older adults of a similar age still living in other settings.
- Conditions
- Fracture, Fractures, Hip, Osteoporosis
- Trial name
- PREVENT (NCT04947722)
- Testing
- PREVENT Program
- Where
- Canada
- Volunteers
- 3,060 people, healthy volunteers welcome
- Sponsor
- McMaster University
Osteoporosis, Bone Loss, Age Related
Osteoporosis Choice Decision Aid for Use of Bisphosphonates in Postmenopausal Women
To develop a decision aid to support the decision to use (or not use) bisphosphonates in postmenopausal women at risk for osteoporotic fractures, and to assess the impact of the decision aid on start and six month adherence to…
- Conditions
- Osteoporosis, Bone Loss, Age Related, Postmenopausal Bone Loss, Postmenopausal Osteoporosis
- Trial name
- NCT00578981
- Testing
- Osteoporosis Choice Decision Aid
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Delirium
With the Development of Research, New Algorithms and Technologies Have Emerged, One of Which is Machine Learning. Machine Learning Can Extract Key Factors From Vast Amounts of Data, Identify Underlying Patterns, and Predict Future Trends. In Recent Years, Machine Learning Has Been Widely Used in
The aim of this study is to construct a predictive model for postoperative delirium in elderly patients with hip fractures. The main question it answers is to construct a risk prediction model for hip fractures in the elderly…
- Trial name
- POD (NCT07121309)
- Where
- China
- Volunteers
- 901 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Osteoporosis Risk, Fracture of Femur
Prediction Model of Hip Fragility Fracture Realistic Data From a Traumatology Department and Orthogeriatric Ward.
The aim of the project is to build a prediction model of hip fragility fracture using hospital data routinely collected in the traumatology department from the last 12 years and up to date Explainable Artificial Intelligence…
- Conditions
- Osteoporosis Risk, Fracture of Femur, Fragility
- Trial name
- NCT06545487
- Testing
- BLOOD SAMPLE
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Osteoporosis, Osteoporotic Fracture of Vertebra
Development and Evaluation of an Exercise Intervention for Prevention of Vertebral Osteoporosis and Deformity in Postmenopausal Women
Osteoporotic fractures of the vertebrae (bones in the back) cause substantial pain and disability. Exercise could help to prevent these fractures by increasing bone strength and improving posture.
- Conditions
- Osteoporosis, Osteoporotic Fracture of Vertebra, Postural, Thoracic Kyphosis
- Trial name
- NCT04660825
- Testing
- A resistance band exercise programme, Control
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Tibial Stress Fracture
Effects of Footstrike Transition on Tibial Stress Fracture Risk
Biomechanical literature suggests that runners who utilize a mid or forefoot strike pattern may suffer from a reduced incidence of chronic injuries compared to a rearfoot strike.
- Trial name
- NCT05786079
- Testing
- Footstrike modification, Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Central Lancashire
Type 2 Diabetes Mellitus, Bone Fractures
Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes
This multicenter, prospective, observational cohort study will assess bone differences in women and men with type 2 diabetes mellitus (T2DM) with and without fragility fractures.
- Trial name
- DiabOS (NCT02551315)
- Where
- 5 sites in Switzerland
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy, Osteopenia
Clinical Study to Predict the Risk of Bone Fractures With the POROUS Ultrasound Device
Osteoporosis is a widespread medical condition among older people. It causes the bones to weaken and become more likely to break.
- Conditions
- Healthy, Osteopenia, Osteoporosis
- Trial name
- POROUS-preFX (NCT06567054)
- Testing
- Measurements with the POROUS R3C ultrasound device at the midshaft tibia, DXA measurement of the hip and lumbar spine, DXA-based Vertebral Fracture Assessment (VFA)
- Where
- 6 sites in Austria, Germany and 1 more
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- POROUS GmbH
Osteoporosis, Fracture Risk Assessment
New Tools for Assessing Fracture Risk
The goal of this study is to determine whether two new, non-X-ray techniques can discriminate between high-energy fractures of normal bone (trauma) and low-energy fractures (fragility) of osteoporotic bone.
- Trial name
- NCT02436356
- Testing
- Osteoprobe-Reference Point Indentation (RPI), Dual-energy X-ray absorptiometry (DXA) Scans, MRI
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hip Fracture
Nutritional Risk Factors for Hip Fracture: a Case Control Study
Low Body Mass Index (BMI) is a risk factor for hip fracture, but it is unknown if it is the low BMI per se that increases risk of hip fracture or if specific micro-nutrients contribute.
- Trial name
- NCT01738776
- Where
- Norway
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Osteoporosis, Osteopenia
The Impact of Hormonal Contraceptive Use and Lifestyle Factors on Fracture Risk and Bone Quality in Young Female Adults
The study on hand is based on a cross-sectional design and aims to acquire 1) descriptive data on the physical state and health condition of female soldiers in the German armed forces.
- Conditions
- Osteoporosis, Osteopenia, Fracture Reduction, Body Composition
- Trial name
- FH (NCT06608862)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bundeswehr University Munich
Osteoporosis, Osteopenia
Effects of OsteoStrong vs. Individually Adapted and Combined Training on Bone Health
The aim of this clinical trial is to investigate the effect of the OsteoStrong training method and the Individually Adapted and Combined Training on the bone health of older women with high fracture risk.
- Conditions
- Osteoporosis, Osteopenia, Bone Density, Low, Bone Loss
- Trial name
- NCT05721014
- Testing
- OsteoStrong, Individually Adapted and Combined Physical Training
- Where
- Sweden
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Osteoporosis, Accidental Falls
Geriatric Health Exam Osteoporosis Screening
BACKGROUND: The World Health Organization Fracture Risk Assessment Tool (WHO FRAX®) Taiwanese calculator is freely available on line to help osteoporosis management.
- Conditions
- Osteoporosis, Accidental Falls, Fracture
- Trial name
- NCT01934387
- Where
- Taiwan
- Volunteers
- 1,319 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Osteoporosis
Clinical Validation of BBCT-hip
The clinical study is aimed at assessing the accuracy of the in silico methodology BBCT-hip. BBCT-hip takes as inputs the subject-specific height and weight, and the CT scan of his femur to predict the risk of fracture for the…
- Trial name
- ValidaBBCT-hip (NCT06270758)
- Testing
- CT scan at the femur
- Where
- 2 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli