Clinical trials: SARCOIDOSIS
Idiopathic Pulmonary Fibrosis (IPF), Sarcoidosis
Expand Pulmonary Rehabilitation to Other Chronic Respiratory Diseases Than COPD
The purpose of this pilot randomized clinical trial is to evaluate the willingness, acceptance, adherence and signs of benefits of structured home-based pulmonary rehabilitation (HPR) and supervised pulmonary tele-rehabilitation…
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Sarcoidosis, Bronchiectasis, Asthma Bronchiale
- Trial name
- ExPuRe (NCT06636487)
- Testing
- pulmonary tele-rehabilitation (PTR), Home-based pulmonary rehabilitation (HPR), Control
- Where
- 5 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Sarcoidosis, Pulmonary Hypertension
Registry of Sarcoidosis Associated Pulmonary Hypertension (RESAPH)
Registry to follow patients with sarcoidosis associated pulmonary hypertension
- Trial name
- RESAPH (NCT01467791)
- Testing
- Observation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Cincinnati
Lymphadenitis
Linear Endosonography for the Assessment of Sarcoidosis Stage O
Patients are often referred for E(B)US examination and sampling of enlarged mediastinal and/or hilar lymph nodes that are not visible on a standard chest X-ray but are discovered by accident on CT scan performed outside the…
- Trial name
- LASSO (NCT01383226)
- Testing
- Thoracic endosonography
- Where
- 9 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sarcoidosis
Impact of Chemokine Receptor 5 (CCR5) Inhibition on Sarcoidosis Immunophenotypes
The study hypothesizes that inhibition of the receptor CCR5 by maraviroc will diminish inflammation in patients with sarcoidosis.
- Trial name
- GRADS (NCT02134717)
- Testing
- all subjects will receive maraviroc 300mg orally twice a day for 6 weeks, Bronchoscopy with bronchoalveolar lavage, venipunctures
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Kevin F. Gibson
Tuberculosis, Sarcoidosis
TB and Sarcoidosis Granuloma
Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here we compared the immunological micro-environments of granulomas from TB and sarcoidosis patients using in situ sequencing (ISS) transcriptomic analysis and…
- Trial name
- NCT06396910
- Testing
- Spatial transcriptomics
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Sarcoidosis of the Heart, Cardiomyopathy
Implantable Cardiac Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis
The purpose of this study is to identify patients with cardiac sarcoidosis who may be at risk for sudden death.
- Trial name
- NCT01013311
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Sarcoidosis, Granuloma Annulare
Tyrosine Kinase 2 (TYK2) for GA and CS
To investigate the role of an oral TYK2 inhibitor for the treatment of patients with moderate to severe sarcoidosis with cutaneous involvement (CSAMI score of 10 or greater) and GA (defined as a BSA involvement of at least 5%)…
- Trial name
- NCT06725264
- Testing
- Deucravacitinib
- Where
- United States
- Sponsor
- Yale University
Endobronchial Mucosal Pathology in Pulmonary Sarcoidosis
Endobronchial Mucosal Biopsy in Patients With Suspected Pulmonary Sarcoidosis
This prospective interventional study was done between May and September 2020. We included 20 patients from the chest department, Alexandria Main University Hospital (AMUH) with the inclusion criteria of having suspected…
- Trial name
- NCT04904939
- Testing
- Bronchoscopic mucosal biopsy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Pulmonary Sarcoidosis
Treatment of Pulmonary Sarcoidosis With Pentoxifylline
Sarcoidosis is a disease most commonly affecting the lungs, but it can also involve lymph nodes, skin, liver, spleen, eyes, bones, and glands. The cause of the disease is unknown.
- Trial name
- NCT00001877
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sarcoidosis
Genomic Research in Sarcoidosis
This project is designed to address the following hypothesis: Distinct patterns in lung microbiome are characteristic of sarcoidosis phenotypes and reflected in changes in systemic inflammatory responses as measured by peripheral…
- Trial name
- GRADS Sarc (NCT01831739)
- Where
- 9 sites in United States
- Volunteers
- 368 people
- Sponsor
- University of Pittsburgh
Sarcoidosis, COVID-19
Number of Participants Diagnosed With Sarcoidosis by Bronchoscopic Transbronchial Needle Aspiration After COVID- 2019 .
The goal of this observational study is to learn about sarcoidosis development after COVID-19 infection. The main question it aims to answer is: prevalence of Sarcoidosis among patients previously infected with COVID-19.
- Trial name
- NCT06043882
- Testing
- flexible bronchoscopy
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Ain Shams University
Lymphadenopathy, Lung Cancer
EBUS-TBNA vs Flex 19G EBUS-TBNA
This is a prospective randomised diagnostic clinical study to determine whether the use of a new flexible sampling needle can improve the yield of endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA).
- Conditions
- Lymphadenopathy, Lung Cancer, Sarcoidosis, Lymphoma
- Trial name
- NCT02916459
- Testing
- 21G EBUS-TBNA needle, Flexible 19G EBUS-TBNA needle
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Heidelberg University
Lung Cancer (Diagnosis), Sarcoidosis
Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease
This study aims to better understand the role of immune system cells in lung diseases such as lung cancer, sarcoidosis, and chronic obstructive pulmonary disease (COPD).
- Conditions
- Lung Cancer (Diagnosis), Sarcoidosis, Chronic Obstructive Pulmonary Disease, Immunotherapy Resistance
- Trial name
- IMMUNOPUMON2 (NCT07384897)
- Testing
- Peripheral Blood Collection for Immune Profiling
- Where
- Belgium
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Sarcoidosis
The Effect of Quercetin in Sarcoidosis
The exact cause of the chronic lung disease sarcoidosis is still unknown. Consequently, a complete efficacious treatment is still not available. Earlier studies indicate an important key role for oxidative stress, i.e.
- Trial name
- NCT00402623
- Testing
- quercetin
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Maastricht University Medical Center
Sarcoidosis, Cutaneous Sarcoidosis
ACTHAR Gel for Cutaneous Sarcoidosis: An Open Label Trial
ACTHAR gel has efficacy in the treatment of cutaneous sarcoidosis
- Trial name
- NCT02348905
- Testing
- ACTHAR Gel 40 units twice weekly, ACTHAR Gel 80 units twice weekly.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albany Medical College
Lung Cancer, Sarcoidosis
Fractionated Versus Target-controlled Propofol Administration in Bronchoscopy
After randomization, the subjects undergo flexible bronchoscopy either with fractionated propofol administration or with propofol-TCI.
- Conditions
- Lung Cancer, Sarcoidosis, Interstitial Pneumonia
- Trial name
- NCT02246023
- Testing
- Flexible bronchoscopy in moderate sedation, Oxygen saturation, Blood pressure
- Where
- Switzerland
- Volunteers
- 78 people
- Sponsor
- Daniel Franzen
Sarcoidosis
High-definition Videobronchoscopy in Sarcoidosis
In the last few years, high-definition (HD) videobronchoscopy has become widely available in the market and will progressively become the standard of care for airway inspection and sampling, as it provides substantially higher…
- Trial name
- NCT04743596
- Testing
- High-Definition Videobronchoscopy
- Where
- 5 sites in Italy, Netherlands and 1 more
- Volunteers
- 152 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sarcoidosis, Sleep Apnea, Obstructive
Prevalence of Obstructive Sleep Apnea Syndrome in Sarcoidosis and Impact of CPAP Treatment on Associated Fatigue Status
Sarcoidosis is a multisystemic granulomatous disease that affects individuals worldwide without known pathogenesis, and the role of comorbidities has not been fully assessed in the scientific literature.
- Conditions
- Sarcoidosis, Sleep Apnea, Obstructive, Fatigue
- Trial name
- SARCOIDOSAS (NCT03926832)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Diseases, Pulmonary Fibrosis
Diffuse Fibrotic Lung Disease
To determine the effects of cyclophosphamide compared with prednisone, dapsone, or high-dose intermittent 'pulse' therapy with methylprednisolone in patients with idiopathic pulmonary fibrosis.
- Conditions
- Lung Diseases, Pulmonary Fibrosis, Sarcoidosis
- Trial name
- NCT00000596
- Testing
- prednisone, cyclophosphamide, dapsone
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sarcoidosis, Cardiomyopathies
Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis
The aim of the study is to find better and more specific non-invasive methods to diagnose and stage cardiac sarcoidosis with the use of advanced imaging modalities, simultaneous 3T MRI and PET.
- Trial name
- NCT03561025
- Testing
- 18F-FDG-PET/MRI, 18F-GE180-PET/MRI
- Where
- Norway
- Volunteers
- 33 people
- Sponsor
- St. Olavs Hospital