Clinical trials: SCI - Spinal Cord Injury
Spinal Cord Injury
Aquatic vs. Land Locomotor Training Overground Locomotor Training in Improving Ambulatory Function and Health-Related Quality of Life
The aim of this study is to define and evaluate the efficacy of Aquatic Locomotor Training (ALT) compared to overground Locomotor Training in improving ambulatory function and health-related quality of life.
- Trial name
- ALT (NCT02774603)
- Testing
- Aquatic Locomotor Training, Land Locomotor Training
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Spinal Cord Injuries, Rehabilitation
Feasibility of Home-Based Rehabilitation on Body Composition, Some Anthropometric Measures and Muscular Strength After Interruption 4-5 Years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq
Feasibility of Home-Based Rehabilitation on Body Composition, some Anthropometric Measures and Muscular Strength after interruption 4-5 years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq Summary…
- Conditions
- Spinal Cord Injuries, Rehabilitation, Exercises
- Trial name
- HBRP-SCI (NCT06230627)
- Testing
- Home-Based Rehabilitation rogram
- Where
- Tunisia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Mosul
Spinal Cord Injury, Autonomic Dysreflexia
The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Dysregulation of blood pressure (BP), secondary to decentralized autonomic nervous system (ANS) control of the cardiovascular system, often results in chronic hypotension and orthostatic hypotension (OH) in persons with spinal…
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Baroreceptor Integrity, Sympathetic Integrity
- Trial name
- NCT02893553
- Testing
- Midodrine Hydrochloride, Pyridostigmine Bromide, Mirabegron
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury at T7-T10 Level, War Injuries Due to Bullets and Fragments
Effects of a Home-Based Rehabilitation on Anthropometric Measures, Sensory-Motor Functions and Independence After Spinal Cord Injury
Background: The scarcity of resources for spinal cord injury (SCI) rehabilitation constitutes a significant obstacle, particularly in war-torn regions experiencing a rise in such injuries.
- Conditions
- Spinal Cord Injury at T7-T10 Level, War Injuries Due to Bullets and Fragments, Spinal Cord Injury L1- L5, Spinal Cord Injury No Sensory/Motor in S4-S5
- Trial name
- HBRSCI (NCT06444672)
- Testing
- Home-based Rehabilitation program, Knee-Ankle-Foot-Orthosis
- Where
- Iraq
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Mosul
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS)
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility…
- Conditions
- Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke
- Trial name
- INTENT (NCT07521930)
- Testing
- INTENT Neural Interface System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Paraplegia, Tetraplegia
Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI
A study comparing short-term delivery of epidural spinal stimulation versus transcutaneous spinal stimulation.
- Conditions
- Paraplegia, Tetraplegia, Paralysis, Quadraplegia
- Trial name
- NCT05095454
- Testing
- Percutaneous epidural electrical spinal stimulation, Transcutaneous electrical spinal stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kristin Zhao, PhD
Spinal Cord Injuries
Task-oriented Arm/Hand Skill Rehabilitation and Therapy Dose Dimensions in Subacute Spinal Cord Injury Rehabilitation
The study is a multicenter longitudinal observational study. The therapy content and the therapy dosage of arm/skill training for patients with cervical spinal cord injury (SCI) will be observed for the primary objective.
- Trial name
- NCT05452707
- Testing
- Observation and questionnaire of active therapy
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 47 people
- Sponsor
- Hasselt University
Spinal Cord Injuries (SCI), Spinal Cord Injury
Study on Preliminary Safety and Efficacy of Epidural Electrical Stimulation to Manage Lower Urinary Tract Dysfunction After Spinal Cord Injury
This clinical trial aims to assess the preliminary safety and efficacy of Epidural Electrical Stimulation (EES) therapy in managing lower urinary tract dysfunction in individuals with sub-acute or chronic spinal cord injury…
- Trial name
- ReeVoid (NCT06845904)
- Testing
- WaveWriter Alpha™ neurostimulation system
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spinal Cord Injuries
Cognitive Behavioural Therapy (CBT) For Improving Emotional Well Being in Spinal Cord Injuries (SCI)
The purpose of the study is to determine whether or not a brief psychological treatment called cognitive behaviour therapy will help people who have suffered a spinal cord injury to cope better with their current circumstances.
- Trial name
- CBT (NCT00861393)
- Testing
- CBT, Waitlist CBT
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Toronto Rehabilitation Institute
Spinal Cord Injury, Tetraplegia
Effects of Exercise in People With Tetraplegia
This study is designed to assess the impact of exercise and supplementation on measures of fitness, function, and cardiovascular disease risk factors/modifiers in individuals with spinal cord injury (SCI).
- Trial name
- NCT01202019
- Testing
- Circuit Resistance Training (CRT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Spinal Cord Injuries, Paralysis
Adipose Stem Cells for Traumatic Spinal Cord Injury
The purpose of this study is to determine if mesenchymal stem cells (MSC) derived from the fat tissue can be safely administered into the cerebrospinal fluid (CSF) of patients with spinal cord injury.
- Trial name
- CELLTOP (NCT03308565)
- Testing
- Autologous, Adipose derived Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mohamad Bydon
Spinal Cord Injury, Acquired Brain Injury
Quality of Life in Adult Neurological Patients
The purposes of this study were to evaluate the influence of an interdisciplinary rehabilitation program in the improvement of the health-related quality of life among adult neurological patients and to identify the…
- Conditions
- Spinal Cord Injury, Acquired Brain Injury, Poliomyelitis
- Trial name
- NCT01573936
- Testing
- Physical therapy, occupational therapy, psycotherapy, medical consultations
- Volunteers
- 70 people
- Sponsor
- Associação de Assistência a Criança Deficiente
Spinal Cord Injury
Pilot Study: The Role of Macrophage Migration Inhibitory Factor (MIF) in Spinal Cord Injury
The purpose of the study is to investigate inflammatory and other substances that may be elevated in the blood and blood cells following spinal cord injury (SCI).
- Trial name
- NCT00919581
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Injuries, Spinal Cord
Diaphragm Pacing After Spinal Cord Injury
Respiratory dysfunction is the leading cause of death in individuals with spinal cord injuries (SCIs). Nearly one quarter of all SCI cases involve injury to the upper spinal cord segments which impairs neural activation of the…
- Trial name
- NCT02556125
- Testing
- Diaphragm pacing
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Florida
Spinal Cord Injury, Chronic Pressure Ulcers
Subcutaneous Injection and Ultrasonic Dispersion of Cefazolin Into Chronic Pelvic-Region Pressure Ulcers in Persons With Spinal Cord Injury
Pressure ulcers (PU) are skin breakdowns that often form after blood flow in the skin is reduced from prolonged and repeated exposure to externally applied forces.
- Trial name
- NCT02584426
- Testing
- Ultrasonic Distribution of Cefazolin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries, Neuropathic Pain
Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury
The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with chronic spinal cord injury.
- Trial name
- VRWalk (NCT05005026)
- Testing
- VR Game 1, VR Game 2
- Where
- 3 sites in United States, Australia
- Volunteers
- 250 people
- Sponsor
- Texas A&M University
Spinal Cord Injuries and Disorders (SCI/D)
Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury
This study will use a randomized controlled design with an active attention control group to evaluate an intervention intended to reduce social isolation and loneliness in persons with SCI/D.
- Trial name
- NCT05295108
- Testing
- Caring Connections, Attention control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Chicago Association for Research and Education in Science
Acute Spinal Cord Injury, Acute Spinal Paralysis
"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation
Prospective, single center study designed to assess blood biomarkers for classifying injury severity and predict neurologic recovery in traumatic spinal cord injured (SCI) patients.
- Conditions
- Acute Spinal Cord Injury, Acute Spinal Paralysis, Spinal Cord Injuries, Trauma, Spinal Cord
- Trial name
- SCRIBBLE (NCT05244408)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Injury, Spinal Cord
The Crosstalk Between the Epigenome and Mitochondria in SCI
SCI is a devastating neurological disorder for which there are not yet restorative therapies. Thus, there is a need to explore new therapeutic strategies to treat SCI patients.
- Trial name
- CEM-SCI (NCT06537427)
- Testing
- Data collection
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Spinal Cord Injuries, Fatigue; Muscle, Heart
Fatigue Induced by Overground Wheelchair Propulsion in Persons With a Spinal Cord Injury: Upper Limb Saving or Straining?
What are the implications of wheelchair propulsion-induced fatigue for the development of shoulder pain and how can this knowledge improve prevention programs? With this project, the "Shoulder Health and Mobility group" of the…
- Trial name
- NCT03153033
- Testing
- Fatigue protocol
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Swiss Paraplegic Research, Nottwil