Clinical trials: Sadness
Cystic Fibrosis
SAD and MAD of Inhaled AR-501 in Health Adults and P. Aeruginosa Infected Cystic Fibrosis Subjects
This is a Phase 1/2a randomized, double-blind, two-part, dose-ascending, multicenter study of AR-501 (gallium citrate) solution, administered via inhalation, in healthy adult and P.
- Trial name
- NCT03669614
- Testing
- Inhaled AR-501
- Where
- 25 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Aridis Pharmaceuticals, Inc.
Bacterial Infections
SAD/MAD Safety and PK Study of QPX9003 (Novel Polymyxin) in Normal Healthy Volunteers
The worldwide spread of resistance to antibiotics among gram-negative bacteria, particularly members of the ESKAPE group of pathogens, has resulted in a crisis in the treatment of hospital acquired infections.
- Trial name
- QPX9003 (NCT04808414)
- Testing
- QPX9003 for IV Infusion
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Qpex Biopharma, Inc.
IPF
A Study to Evaluate the Safety, Tolerability, PK and PD of HNC1058
The purpose of this First-in-Human study is to evaluate the safety and tolerability after single ascending oral doses of HNC1058 given to healthy subjects, compared to placebo.
- Trial name
- NCT05803850
- Testing
- HNC1058 Capsules
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Guangzhou Henovcom Bioscience Co. Ltd.
Healthy
A Study of Single and Multiple Ascending Doses of TC-5214 in Japanese Healthy Elderly Male and Female Volunteers
The purpose of this study is to assess safety, tolerability and pharmacokinetics of TC-5214 in elderly healthy Japanese volunteers.
- Trial name
- NCT01392820
- Testing
- TC-5214
- Where
- Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Safety and Tolerability
SAD Evaluation of Safety, Tolerability, PK, and PD of MDI-2517 in Healthy Participants
This is a Phase 1 study to test the safety and drug effects of MDI-2517 when given once in healthy volunteers.
- Trial name
- NCT06453824
- Testing
- MDI-2517
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- MDI Therapeutics, Inc.
Parkinson's Disease
A Study to Evaluate the Safety, Tolerability, PK and PD of HNC364 Injectable Suspension
This is a non-randomized, dose-escalation first-in-human study to evaluate the safety, tolerability, PK, and PD of HNC364 following intramuscular administration of single ascending doses.
- Trial name
- NCT05523570
- Testing
- HNC364
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Guangzhou Henovcom Bioscience Co. Ltd.
Depression, Postpartum, Stress, Psychological
MAMA NO STRESS Project. The Effects of the "HAPPY MAMA" Intervention
This study evaluates the effects of a postpartum intervention in increasing the maternal well-being and self-efficacy of Italian women in the first one to six months after childbirth, as well as in reducing postpartum depression…
- Conditions
- Depression, Postpartum, Stress, Psychological, Postpartum Sadness, Self Efficacy
- Trial name
- NCT04093791
- Testing
- Collective Intervention "G", Individual Intervention "I"
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Healthy Volunteers - Male and Female
A Phase I Trial of Subcutaneous QLS7305 in Healthy Adults
The goal of this clinical trial is to evaluate the safety, tolerability, and preliminary characteristics of the investigational drug QLS7305 in healthy adult participants in China.
- Trial name
- NCT07313150
- Testing
- QLS7305 Injection
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Healthy Volunteers.
AZD6423 SAD/MAD Study in Healthy Volunteers
This is a randomized, double-blind, placebo-controlled study of single and multiple ascending dosage levels of AZD6423 in healthy volunteers.
- Trial name
- AZD6423 (NCT01926366)
- Testing
- AZD6423
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers, Atopic Diathesis and Atopic Dermatitis
Single Dose and Multiple Dose Study to Assess Safety and Tolerability of LOU064
This is a 6-part first-in-human study in up to approximately 184 participants. Parts 1 to 5 is in health volunteers and part 6 is in subjects with atopic dermatitis.
- Trial name
- NCT03918980
- Testing
- LOU064
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Healthy Adult Male Volunteers
Clinical Pharmacology Study of MT-3534 in Healthy Adult Male Volunteers
This study is planned to investigate the safety, tolerability, and pharmacokinetics when a single intravenous dose of MT-3534 or a placebo is given to healthy adult male volunteers.
- Trial name
- NCT06482346
- Testing
- MT-3534
- Where
- Japan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma Corporation
Healthy
A Phase 1, SAD and MAD to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Oral FB-101 in Healthy Adult Male Subjects
This is a Phase 1, randomized, double-blind, placebo-controlled study consisting of SAD and MAD investigation at a single clinical trial center conducted in healthy adult male subjects assessing the safety, tolerability, PK, and…
- Trial name
- NCT07126704
- Testing
- FB-101
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- 1ST Biotherapeutics, Inc.
Healthy
CORT125281 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)
This initial Phase I study will evaluate the dose-related safety and tolerability pharmacokinetics (PK) of CORT125281, and CORT125324 (active metabolite), and pharmacodynamics (PD) after single and multiple ascending oral doses…
- Trial name
- NCT03335956
- Testing
- CORT125281, 40mg, fasted, Prednisone 25mg, fasted, Pioglitazone 15mg Tablet
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
Healthy Volunteer
A Single-Ascending-Dose Study of RO5469754 in Healthy Volunteers
This randomized, observer-blinded, placebo-controlled study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of RO5469754 in healthy volunteers.
- Trial name
- NCT01620931
- Testing
- RO5469754
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Eosinophilic Esophagitis, Celiac Disease
Dose Escalation Study to Evaluate an Experimental New Treatment (CALY-002) in Healthy Subjects and Subjects With Celiac Disease and Eosinophilic Esophagitis
This is a single and multiple ascending study to characterize the safety, PK, PD and clinical effect in healthy volunteers and participants with Celiac Disease and Eosinophilic Esophagitis.
- Trial name
- NCT04593251
- Testing
- CALY-002
- Where
- 13 sites in Belgium, Finland and 3 more
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Calypso Biotech BV
Healthy Volunteers, Sickle Cell Disease
A SAD/MAD to Assess the Safety, PK/PD of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients
FT-4202 is an oral small-molecule agonist of pyruvate kinase red blood cell isozyme (PKR) being developed for the treatment of hemolytic anemias.
- Trial name
- NCT03815695
- Where
- 18 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Forma Therapeutics, Inc.
Social Anxiety Disorder, Body Dysmorphic Disorder
Individual Factors of CBT Underlying Success
The purpose of this study is to understand why some individuals respond fully to cognitive behavioral therapy and others do not, based on multiple sources of data such as neural, neurocognitive, clinical, and self-report data.
- Trial name
- I-FOCUS (NCT06678295)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy
SAD and MAD Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of TD-1473 in Healthy Subjects
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of single ascending doses and multiple ascending doses of the investigational drug TD-1473 compared to placebo in healthy subjects.
- Trial name
- NCT02657122
- Testing
- TD-1473 for SAD, TD-1473 for MAD
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
General Anxiety Disorder, Social Anxiety Disorder
A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder
This study is being conducted to evaluate the safety and effectiveness of memantine Add-On treatment of patients who are currently taking an SNRI or SSRI and who remain anxious and symptomatic despite treatment.
- Trial name
- NCT00411398
- Testing
- Namenda/Memantine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University