Clinical trials: Saliva
Periodontitis and Diabetitis
Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients
Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized by bleeding and inflamed gingival, resorption of alveolar bone.
- Trial name
- NCT00399620
- Testing
- Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up).
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
SARS-CoV2 Infection
The School SPIT Study - Elementary Schools in High COVID-19 Incidence Regions
This study will conduct an evaluation of a program that is being implemented SickKids / Toronto Public Health that provides take-home saliva testing kits in schools.
- Trial name
- NCT05055492
- Testing
- Take home saliva kits
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Covid19
The Salivary Raman COVID-19 Fingerprint
The outbreak of coronavirus disease 2019 (COVID-19), caused by infection of SARS-CoV-2, has rapidly spread to become a worldwide pandemic.
- Trial name
- NCT04583306
- Testing
- Raman analysis of saliva, characterization of the Raman database and building of the classification model
- Where
- 5 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Primary Hypertension
Dietary Nitrate and the Oral Microbiome in Children With Primary Hypertension
Children and adolescents with primary hypertension (high blood pressure without an underlying secondary cause) are at increased risk of cardiovascular disease in adulthood.
- Trial name
- NCT07236125
- Testing
- No active intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yelda Kasımoğlu
Dental Plaque
Antibacterial Effect of the Infusion of Green Tea Used as a Mouthwash on Saliva and Bacterial Plaque
Given that the participation of oral microorganisms in the development of the most prevalent pathologies of the oral cavity is unquestionable, efforts have been made to create agents that allow controlling these bacteria.
- Trial name
- NCT04410666
- Testing
- Green Tea mouthwash
- Where
- Paraguay
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Julieta María Méndez Romero
Heart Failure, Periodontitis
Periodontitis Treatment and Heart Failure
Heart failure (HF) is a rapidly growing public health issue affecting more than 40 million individuals globally; while gum disease with bone loss affects 50% of people in general.
- Trial name
- NCT07036289
- Testing
- Mechanical Treatment
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Taubate
Gingivitis, Periodontal Disease
Rapid Point-of-Care Salivary Diagnostic for Periodontal Health
The purpose of this study is to learn if a chair-side testing device will accurately measure levels of a salivary biomarker and thus indicate if a patient has periodontal health, gingivitis or periodontal disease.
- Trial name
- NCT02403297
- Testing
- Quik Check PD
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Innovative Diagnostics Inc
Vaginal Microbiome, Skin Microbiome
Integrated Genetic and Functional Analysis of the Female Microbiome in a Flemish Cohort
The aim of the project is to improve our knowledge on the stability and temporal dynamics of the Flemish female microbiome (vagina, skin and saliva) in relation to different lifestyle factors and environmental conditions and to…
- Conditions
- Vaginal Microbiome, Skin Microbiome, Saliva Microbiome
- Trial name
- Isala (NCT04319536)
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Risk Reduction, Occupational Exposure
Aerosol Generation in Dental Clinics
The study examines 4 different methods to reduce dental bioaerosol spread in orthodontic procedures.
- Conditions
- Risk Reduction, Occupational Exposure, Dentist-Patient Transmission
- Trial name
- NCT05468099
- Testing
- Chlorhexidine mouthwash and Povidone-Iodine, High volume evacuator, High volume evactuator and saliva ejector
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Periodontal Diseases, Periimplant Diseases
Markers of Bone Destruction and Oxidative Stress in Peri-implantitis
The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant…
- Trial name
- NCT07397884
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Long QT Syndrome
Long QT Syndrome Screening in Newborns
The purpose of this project is to test a new, very compact, 12-lead ECG device as a way to detect long QT syndrome (LQTS) in infants. The device -- called QTScreen -- was developed in Phase I of this project.
- Trial name
- NCT02412709
- Testing
- QTScreen ECG Recorder
- Where
- 3 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- QT Medical, Inc.
Attention Deficit Hyperactivity Disorders, Caries, Dental
Salivary Bacteria and Oral Health Status in Children With ADHD
Attention deficit and hyperactivity (ADHD) affect 6% of school-aged children. Few studies reported higher prevalence of caries and restorations among children with ADHD. Methylphenidate is the drug of choice to treat ADHD.
- Conditions
- Attention Deficit Hyperactivity Disorders, Caries, Dental, Xerostomia
- Trial name
- ADHD (NCT00966394)
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Tetanus
TETANUS Antibody Detection in Saliva Study
This study aims to design, develop and optimise a non-invasive, saliva sample-based point-of-care lateral flow test for use in low and middle income settings that can return a qualitative result on whether an individual has or…
- Trial name
- TETANUS (NCT07446166)
- Testing
- Point of care, saliva-based lateral flow test, Blood based immunoassay
- Where
- Rwanda
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Child, Saliva
Effect of 5% Aqueous Propolis in Salivary and Dental Plaque pH in Children
This study aims to investigate the changes in saliva and dental plaque pH after consuming sugar-free chewing gum containing 5% of aqueous propolis in children aged between 8-11 years.
- Conditions
- Child, Saliva, Dental Plaque
- Trial name
- NCT05793099
- Testing
- Effect of aqueous propolis gums in salivary and dental plaque pH in children
- Where
- Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Damascus University
Smoking Cessation
Social Determinants and Smoking Cessation
The goal of this study is to learn about the influence of the social and physical environment on smoking cessation (quitting smoking) among smokers.
- Trial name
- NCT01310842
- Testing
- Questionnaires, Nicotine Patch Therapy, Counseling Sessions
- Where
- United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Alcohol Use Disorder, Alcohol Dependence
The Impact of Heavy Alcohol Use on Saliva and Oral Health
Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke.
- Trial name
- NCT06684483
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Comparison of Salivary Paxillin Levels in OPMLs and OSCC to Healthy Subjects
Evaluation of the Levels of Salivary Paxillin Oral Premalignant and Malignant Lesions
This investigation was carried out to analyze and compare the salivary paxillin levels between oral premalignant and malignant lesions (OPMLs), OSCC and the healthy controls in order to assess its potential role as a biomarker of…
- Trial name
- NCT06154551
- Testing
- Paxillin biomarker
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Gingivitis
Effect of a 2-week Sugar Stress on Bacterial Profiles in Whole Saliva
Dental caries is a non-communicable biofilm-mediated disease affecting both crown and exposed root surfaces in the primary and permanent dentitions.
- Trial name
- NCT04199897
- Testing
- Succrose rinsing, Probiotic lozenges, xylitol rinsing
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Plaque, Dental
Arginine Plaque Metabolism Pilot Clinical Study
Proof of concept clinical study to measure plaque metabolism and the prebiotic efficacy of arginine-containing toothpaste.
- Trial name
- NCT06954779
- Testing
- Colgate Cavity Protection, TOM's Superior Sensitivity Relief Toothpaste
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive