Clinical trials: Scar Niche
Cesarean Wound Disruption
The Influence of Endometrial Suturing on the Risk of Uterine Scar Defect
Caesarean section (CS) is the commonest major operation performed on women worldwide with progressively rising incidence. Consequently, long-term adverse sequelae due to uterine scar defect have been increasing.
- Trial name
- NCT03851003
- Testing
- Endometrial suturing, Non- endometrial suturing, Vaginal ultrasonography
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cesarean Section Complications
Surgical Management of Cesarean Scar Ectopic Pregnancy: Hysteroscopy & Laparoscopy Outcomes
The study investigates the feasibility, safety, and outcomes of a simultaneous surgical approach for cesarean scar ectopic pregnancy (CSEP). CSEP is a prevalent and serious form of ectopic pregnancy requiring swift intervention.
- Trial name
- NCT07095647
- Testing
- Hysteroscopy
- Where
- Egypt
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Benha University
Uterus; Scar
UTERUS CLOSURE TECHNIQUES and Uterine Niche Formation
We aimed to compare 3 different uterotomy suture techniques with each other and evaluate them in terms of niche formation.1- one layer 2- double layer 3- purse string (TURAN technique)
- Trial name
- NCT05517018
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Cesarean Section Complications
Cesarean Scar Defect (CSD); Prevalence, Risk Factors And Possible Associated Symptoms
The study aims to detect the incidence of Cesarean Scar Defect (CSD) in women undergoing CS in Women Health Hospital (WHH), assiut University, to identify risk factors for development of CSD and identify the possible…
- Trial name
- isthmocele (NCT04605328)
- Testing
- Two dimension and three dimension ultrasound
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cesarean Section Complications, Uterine Bleeding
Platelet Rich Plasma for Uterine Scar
When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing.
- Conditions
- Cesarean Section Complications, Uterine Bleeding, Pelvic Pain, Menstrual Irregularity
- Trial name
- AA-PRP (NCT05224726)
- Testing
- Platelet Rich Plasma
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cesarean Section Complications
Vasopressin vs. Uterine Artery Clamping for Laparoscopic Cesarean Scar Niche Repair
This study evaluates two methods for controlling intraoperative bleeding during laparoscopic surgery to repair a cesarean scar niche (CSN).
- Trial name
- NCT07446933
- Testing
- Vasopressin Group, Bulldog Clamping Group, Standard of Care
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Cesarean Section Complications
Suture Material and C-Section Scar Niches: A Comparative Study
Defective healing of the uterine wound after a Cesarean section (CS) can lead to the formation of a CS niche (CSN). The specific technique used for closure and the type of suture material chosen are often overlooked factors that…
- Trial name
- NCT07101952
- Testing
- Braded Suture material, Multifilament vicryl suture material
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Benha University
Caesarean Scar Niche
Niche Investigated: Closure of Hysterotomy & Evaluation of 3 Suturing Techniques (Running, Interrupted, and Locked)
This study aims to explore the impact of three different suturing techniques (Running, Interrupted \& Locked) that used to close the uterine incision at the cesarean section on the formation of a cesarean scar niche
- Trial name
- NCT06695793
- Testing
- Interrupted Sutures, Locked Sutures, Running Continuous Sutures
- Where
- 5 sites in Egypt
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cesarean Section Complications, Cesarean Wound Disruption
Cesarean Scar Defect Formation After First Cesarean Section.
This study is a prospective observational study which will monitor how cesarean section in the first pregnancy will develop a cesarean scar defect.
- Conditions
- Cesarean Section Complications, Cesarean Wound Disruption, Cesarean Wound; Dehiscence
- Trial name
- NCT03966001
- Testing
- Transvaginal sonography at six months after cesarean section, Transvaginal sonography at twelve months after cesarean section
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Uludag University
Appropriate Diagnostic Criteria of Uterine Niche With Detection of Prevalence , Risk Factors and Associated Symptomes
Prevalence and Risk Factors of Uterine Niche Following Different Caesarean Section Techniques:a Hospital Based Study
The primary objective of this study is to institute clically relevant and objective sonographic criteria for the diagnosis of ceasearan section scar defect(CSSD) once the appropriate diagnostic criteria are established the…
- Trial name
- NCT04933032
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Niche
Niche In CEsarean Scar Trial (NICEST)
Rationale: Cesarean delivery (CD) rates are increasing rapidly worldwide. The consequences of cesarean section not only affect the next pregnancies such as uterine rupture or malplacentation but also cause many gynecological…
- Trial name
- NCT05312775
- Testing
- Double-layer uterine closure, Single-layer uterine closure
- Where
- Vietnam
- Volunteers
- 938 people, healthy volunteers welcome
- Sponsor
- Nguyen Thi Thu Ha
Uterine Scar, Cesarean Section Complications
Single or Double-layer Uterine Closure Techniques
There are different surgical techniques of uterine closure during cesarean. A growing data has suggested that the closure technique has an effect on uterine scar healing.
- Conditions
- Uterine Scar, Cesarean Section Complications, Cesarean Section; Dehiscence
- Trial name
- NCT03629028
- Testing
- Residual myometrium thickness, Niche Presence, Adjacent myometrium thickness
- Where
- Turkey (Türkiye)
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Safak Baran Yilmaz
Isthmocele
Can Cesarean Scar Defects be Prevented?
In this study, uterotomy after cesarean section was performed using 3 different suture techniques and aimed to demonstrate the potential of the baseball suture technique to prevent the isthmusel complication known as cesarean…
- Trial name
- NCT06761495
- Testing
- Baseball Suturing Technique, Single-Layer Locked Continuous Suturing Technique, Single-Layer Unlocked Continuous Suturing Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istinye University
Isthmocele, Uterine Scar Defects
Cesarean Scar Defects After Uterine Closure by Double-layer Barbed or Smooth Suture
Late sequelae of a cesarean section related to a uterine scar defects include gynecological symptoms and obstetric complications.
- Conditions
- Isthmocele, Uterine Scar Defects, Cesarean Section Complications, Uterine Niche
- Trial name
- NCT04825821
- Testing
- Clinical and ultrasonographic assessment
- Where
- Italy
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Cesarean Section, Dehiscence
Incidence of Uterine Cesarean Scar Niche After Cesarean Delivery
To assess the incidence of cesarean scar niche and its risk factors in a prospectively collected population.
- Trial name
- NCT05900492
- Testing
- cesarean section
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Uterine Scar From Previous Cesarean Delivery (Diagnosis)
Uterine Niche After Cesarean Section
In the past decade several articles have described a defect that can be seen on ultrasound at the site of cesarean delivery scar, known as a 'niche' .An incompletely healed scar is a long-term complication of cesarean delivery…
- Trial name
- AMSRM (NCT03787381)
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Isthmocele, Cesarean Scar Defect
Clinical Impact of Uterine Repair During Cesarean Section with Barbed Suture on the Incidence of Isthmocele
Pregnant women, irrespective of their pregnancy risk, who undergo a cesarean section for any reason will be randomized to one of two suturing techniques: conventional suture or barbed suture for uterine repair after the cesarean…
- Conditions
- Isthmocele, Cesarean Scar Defect, Pelvic Pain, Spotting
- Trial name
- CESARIS (NCT06691750)
- Testing
- Barbed suture, Conventional smooth suture
- Where
- Spain
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
CS Scar Defect(Niche) How to Avoid
Incidence of Caesarean Scar Defect in Cases of Cesarean Section With and Without Bladder Flap Dissection
Anatomically Uterine niche is an iatrogenic pouch-like defect at the site of previous caesarean scar due to defective tissue healing.
- Trial name
- NCT06503627
- Testing
- bladder flap dissection
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Uterine Scar Defect
Double-layer Versus Purse Uterine Closure Techniques : Impact on Residual Myometrial Thickness After Cesarean
There are different surgical techniques of uterine closure during cesarean. Currently data suggest that the double layer unlocked closure technique is associated with better uterine scar healing, and this technique is considered…
- Trial name
- NCT04871022
- Testing
- Double layer closure of the hysterotomy, Purse closure of the hysterotomy
- Where
- Tunisia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Pregnancy Related
Cesarean 123 Trial: Randomized Trial Comparing Single, Double and Triple Layer Uterine Closures During Cesarean Delivery
The goal of this clinical trial is to compare post-operative uterine scar thickness in people who have had the uterus closed during cesarean sections by one of three different methods.
- Trial name
- C123T (NCT05750394)
- Testing
- Uterine layers closed, Suture Type, Endometrium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital