Clinical trials: Sepsis, completed
Septic Shock, Thrombocytopenia
Platelet Reactivity in Septic Shock
Coagulation disorders and thrombocytopenia are common in patients with septic shock. Despite the clinical relevance of sepsis-induced thrombocytopenia, few studies have focused on the prediction of thrombocytopenia in this…
- Conditions
- Septic Shock, Thrombocytopenia, Sepsis, Platelet Aggregation
- Trial name
- NCT03716310
- Testing
- platelet responsiveness evaluation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Methicillin-resistant Staphylococcus Aureus Septicemia
The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?
The purpose of this study is to evaluate which is the most appropriate parameter correlates with clinical effectiveness of vancomycin: trough drug level or AUC/MIC.
- Trial name
- NCT01995760
- Where
- Taiwan
- Volunteers
- 123 people
- Sponsor
- National Taiwan University Hospital
Dietary Habits, Endotoxemia
Effects of Non-calorie Sweeteners, Mono- and Disaccharides on Intestinal Barrier Function
The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.
- Trial name
- NCT04788680
- Testing
- Dietary intervention 1, Dietary Intervention 2, Dietary Intervention 3
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Vienna
NEC, Sepsis
Effect of L-arginine and Glutamine on Preterm
effects of enteral l-arginine to decrease feeding intolerance and risk of NEC in neonates via its role as a NO precursor. Also, enteral glutamine which may play a role as an immunomodulator on preterm neonates.
- Trial name
- preterm (NCT01263041)
- Testing
- Glutamine, l-arginine
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Candida
Candida PCR Diagnosis Strategy in Patients From Intensive Care Units
The aim of this study is to evaluate the implementation of a new technique for invasive candidiasis diagnosis by PCR. The main objective will be to evaluate the effect of this strategy on the time required to obtain results in…
- Trial name
- CANDI-PCR (NCT04874441)
- Testing
- Diagnosis strategy based on C. glabrata / krusei PCR
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Toulouse
Neonatal Sepsis
Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis
Assess the efficacy of melatonin as an adjuvant in the treatment of free radical disease in septic preterms receiving melatonin compared to those on conventional treatment through measuring the level of Malondialdehyde as a…
- Trial name
- NCT03295162
- Testing
- Melatonin 10 mg, Conventional treatment of neonatal sepsis
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Mohamed Hussein Metwally
Endotoxemia, Sepsis
Determining the Fingerprint of Endotoxin Tolerance
An explorative, prospective study in 100 healthy volunteers who will be challenged with endotoxin twice to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance
- Conditions
- Endotoxemia, Sepsis, Systemic Inflammation, Immunosuppresion
- Trial name
- 100LPS (NCT06801873)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis, Septic Shock
Clinical Efficacy of Megadose Vitamin C in Sepsis
In this multicenter, randomized, single-blind, placebo-controlled clinical trial. Patients will be randomly assigned to receive Vitamin C or placebo for 4 days or until ICU discharge (whatever come first).
- Trial name
- CEMVIS (NCT05194189)
- Testing
- Vitamin C, 5% glucose injection
- Where
- 4 sites in China
- Volunteers
- 234 people
- Sponsor
- Zhujiang Hospital
Critical Illness, Sepsis
Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE)
In this multicenter project, we will introduce AWARE (electronic interface) Using a cloud-based technology . The goal of this project is to improve compliance with best practice through the use of a new acute care interface with…
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- AWARE (NCT02039297)
- Testing
- Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation
- Where
- 6 sites in United States
- Volunteers
- 7,813 people
- Sponsor
- Mayo Clinic
Respiratory Insufficiency, Shock, Septic
Fluid Responsiveness in HFNC Patients
The plethysmographic variation index (PVi) is a measure of the respiratory-induced variations in the plethysmographic waveform. Interestingly, in mechanically ventilated patients and under certain conditions, PVi may reflect…
- Conditions
- Respiratory Insufficiency, Shock, Septic, Sepsis
- Trial name
- HIDRATE (NCT03817996)
- Testing
- Fluid challenge
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Sepsis With Multiple Organ Dysfunction (MOD)
Sepsis-damaged Organs-double-markers Identification of Organ Failure Using Fluorescent Nanoparticle Tracking Analysis
Systematic establishment of exosome proteomics in co-culture medium and clinical sepsis specimens will be done. Ubiquitination-autophagy-apoptosis biomarkers in exosomes will be detected and correlated to specific organ failure…
- Trial name
- NCT03222986
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Critical Illness, Sepsis
Sepsis Pathophysiological & Organisational Timing
This project proposes to measure delay to admission to Intensive Care (ICU). Delays in the United Kingdom NHS are widely reported possibly because there are fewer ICU beds than in many other developed health care systems.
- Trial name
- SPOT(Light) (NCT01099813)
- Where
- United Kingdom
- Volunteers
- 15,602 people
- Sponsor
- Intensive Care National Audit & Research Centre
Septic Shock
Effect of Norepinephrine Administration on Ventricular Systolic Function in Septic Shock
This observational, pharmacological, prospective study aims to assess the improvement of ventricular systolic function mediated by norepinephrine (NE) administration in preload non-responders septic shock patients.
- Trial name
- NCT05355961
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Septic Shock, Vasodilatory Shock
Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock
This trial will be a randomized controlled single-center pilot trial comparing the use of angiotensin II versus standard-of-care (SOC) vasopressor therapy in adult patients with persistent vasodilatory shock despite moderate-dose…
- Trial name
- DARK-Sepsis (NCT05824767)
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of New Mexico
Medical Education, Simulation Training
Effectiveness of Simulation Based Training in Implementing One Hour Bundle Sepsis
This study aimed to compare simulation training with conventional training (case-based discussion only) to improve team performance in implementing one-hour sepsis bundle in the intensive care unit
- Conditions
- Medical Education, Simulation Training, Sepsis
- Trial name
- NCT05076721
- Testing
- Simulation training, Case-based discussion training
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
LRTI, Sepsis
Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis
The TAILORED-Treatment consortium was established to develop new tools aimed to increase the effectiveness of antibiotic and antifungal therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in…
- Conditions
- LRTI, Sepsis, Fungal Infections, Bacteremia
- Trial name
- TailoredT (NCT02025699)
- Where
- Israel
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Intensive Care Unit Acquired Weakness, Sepsis, Severe
Is NMES Treatment in Sepsis/ Septic Shock Patients Protective in Development of ICU-AW?
Background: Sarcopenia (muscle weakness) characterized by a decrease in muscle mass, strength and performance is a condition that increases with old age.
- Trial name
- NCT04833621
- Testing
- NMES GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Ondokuz Mayıs University
Sepsis
Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial
Background: Dexmedetomidine, a highly selective arfa2-adrenergic agonist, is known to be a unique sedative agent which causes less acute tolerance, drug addiction and withdrawal compared with gamma-aminobutyrate (GABA) agonists.
- Trial name
- DESIRE (NCT01760967)
- Testing
- Dexmedetomidine
- Where
- Japan
- Volunteers
- 203 people
- Sponsor
- Wakayama Medical University
Sepsis
Impact of a Prehospital Sepsis Protocol on Timely Antibiotic Administration and Subsequent Adverse Events
The primary purpose of this study is to evaluate the impact of an Emergency Medical Services (EMS) based sepsis screening and early warning protocol on the timing of early sepsis care in the Emergency Department (ED).
- Trial name
- IMPRESS (NCT05502107)
- Testing
- PRESS Intervention
- Where
- 3 sites in United States
- Volunteers
- 984 people
- Sponsor
- Emory University
Sepsis, Thiamine Deficiency
Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)
This research is a clinical trial with a Randomized Controlled Trial (RCT) design. The purpose is to identify the effect of intravenous thiamine administration compared to normal saline placebo on glucagon levels and ROS levels…
- Trial name
- NCT05663164
- Testing
- Vitamin B
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Sumatera Utara
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