Clinical trials: Septic
Septic Shock
Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure.
The goal of this phase 2, multicenter, randomized, controlled study is to evaluate the effect of albumin treatment on B cell and other immune cell gene exptression in adults with septic shock.
- Trial name
- ALBUMIM (NCT05645887)
- Testing
- Human albumin, Saline solution
- Sponsor
- Albimmune SL
Resolution of Septic Shock With Terlipressin
Terlipressin Alone Versus the Standard Therapy With Catecholamines for Hepatic Patients With Septic Shock- Prospective Single Center Randomized Controlled Study.
The purpose of this study is to evaluate the use of terlipressin compared to standard regimen in hepatic patients with septic shock. Another aim is to compare the mortality rate \& the effects on renal functions in both groups.
- Trial name
- NCT03608514
- Testing
- Experimental
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Septic Shock, Immunocompromised Patients
BioMArkeRs of INflammation, Infection, and Immunity in the Critical Area (MARINA): the Use of Inflammatory and Immunity Biomarkers as Early Predictors of Clinical Severity, Organ Damage, Response to Treatment, and Infectious Complications in Patients Admitted to the Critical Care Area.
The MARINA study (bioMARkers of INflammation, infection, and immunity in critical cAre) is a multicenter, prospective and retrospective observational cohort study designed to evaluate the diagnostic and prognostic role of…
- Trial name
- MARINA (NCT07682766)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Sepsis, Septic Shock
Fluids in Septic Shock (FISSH)
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT03677102)
- Testing
- higher chloride crystalloid, lower chloride crystalloid
- Where
- 30 sites in Canada, Saudi Arabia
- Volunteers
- 1,113 people
- Sponsor
- McMaster University
Septic Shock, Vasopressor Resistance
Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic Shock
Septic shock is common in patients admitted to intensive care and hospital mortality occurs in close to 50% of these patients. In half of the cases, death occurs within the first 72 hours in a context of multiple organ failure…
- Trial name
- Adress-Pilot (NCT03953677)
- Testing
- Dexmedetomidine 100 Mcg/mL Intravenous Solution, 5% glucose Infusion solution
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Septic Shock
Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
Sepsis is defined as a life-threatening event due to a dysregulated immune response to an host. Blood purification techniques may be considered as a therapeutic weapon to front sepsis and septic shock.
- Trial name
- NCT03456180
- Testing
- Haemoadsorption with Cytosorb cartridge
- Volunteers
- 10 people
- Sponsor
- Università Politecnica delle Marche
Patients With Septic Shock Admitted to the ICU on Invasive Mechanical Ventilation
Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical Ventilation
Septic shock patients with invasive mechanical ventilation who were randomly enrolled in ICU were divided into esketamine group (test group) and remifentanil group (control group) according to the ratio of 1:1.
- Trial name
- NCT05551910
- Testing
- Esketamine, Remifentanil, propofol
- Volunteers
- 120 people
- Sponsor
- The First Hospital of Jilin University
Infection in ICU, Sepsis
Early Optimization of Ceftazidime Regimen in Critical Care
Hospital-acquired infections, most of which are caused by Gram-negative bacteria, are common in intensive care units and have a major impact on patient prognosis.
- Conditions
- Infection in ICU, Sepsis, Septic Shock, Pseudomonas Aeruginosa Infection
- Trial name
- FORTOPTIM_1 (NCT07085624)
- Testing
- ceftazidime, plasma ceftazidime dosage
- Where
- 8 sites in France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Septic Shock, Hypovolemia
Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help?
Fluid therapy is important in patients with sepsis and septic shock. There are many invasive and non-invasive methods to assess fluid responsiveness in patients.
- Conditions
- Septic Shock, Hypovolemia, Sepsis
- Trial name
- NCT05557461
- Testing
- End-tifdal co2, systolic, diastolic blood pressure, ppv values and vci distensibility
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bozyaka Training and Research Hospital
Sepsis, Septic Shock
Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock
Sepsis is a critical burden for a healthcare. From 2000 to 2020, the number of publications and clinical studies on the topic of Sepsis and septic shock on the National Library of Medicine resource The National Center for…
- Trial name
- NCT06404424
- Testing
- Efferon LPS, Efferon CT
- Where
- Russia
- Volunteers
- 82 people
- Sponsor
- Efferon JSC
Septic Shock
Lactic Acid in the Rectum and Life-Threatening Infection
Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of lactic acid.
- Trial name
- NCT00197938
- Testing
- Measurement of rectal lactic acid.
- Where
- 5 sites in Denmark, Finland
- Volunteers
- 130 people
- Sponsor
- Herlev Hospital
Musculoskeletal Infection, Septic Arthritis
Infrared Thermography for Diagnosis of Musculoskeletal Infections
This is a pilot proof of feasibility study to explore the efficacy of High Resolution Infrared Thermographic Imaging (HRTI) to assist with the detection of musculoskeletal infections in children.
- Conditions
- Musculoskeletal Infection, Septic Arthritis, Osteomyelitis/Septic Arthritis
- Trial name
- NCT07388017
- Testing
- High Resolution Thermal Imaging
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Septic Shock
The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation
The study aims to compare the effects of restrictive fluid management on cardiac dysfunction and vascular integrity in septic shock patients.
- Trial name
- NCT04282252
- Testing
- I.V. SOLUTIONS
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Karolinska Institutet
Sepsis, Septic Shock
Comparing Blood-Based Ratios for Predicting Outcomes in Sepsis and Septic Shock
Sepsis and septic shock are serious conditions associated with a high risk of organ dysfunction and death. Simple laboratory-based markers may help identify critically ill patients who are at greater risk of poor outcomes.
- Trial name
- NCT07819708
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Septic Shock
Proadrenomedullin and Copeptin in Patients With Septic Shock
This study evaluates the usefulness of pro-adrenomedullin (precursor of a vasodilatory peptide involved in septic shock pathogenesis) and copeptin (a stable peptide of the arginine vasopressin precursor) to predict, at the moment…
- Trial name
- proADM (NCT03104933)
- Where
- Spain
- Volunteers
- 103 people
- Sponsor
- Spanish Network for Research in Infectious Diseases
Fluid Refractory Septic Shock, Septic Shock
Adrenaline V/s Dopamine in Fuid Refractory Septic Shock
This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children.
- Trial name
- NCT07273526
- Testing
- Adrenaline, Dopamine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Laiba Qamar
Sepsis, Septic Shock
Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic Shock in Adults in the Emergency Department: a Before-and-after Study (IPA-SOS)
The goal of this observational study is to evaluate if a performance improvement program can improve the initial management of sepsis and septic shock in adults at Brest University Hospital.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Emergency Medicine
- Trial name
- IPA-SOS (NCT06657625)
- Testing
- Sepsis Performance Improvement Program
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Brest
Septic Shock
Extracorporal Cytokin Removal in Septic Shock: a Prospective, Randomized, Multicenter Clinical Trial
Sepsis and septic shock have mortality rates between 20-50%. When standard therapeutic measures fail to improve patients' condition, additional therapeutic alternatives are applied to reduce morbidity and mortality.
- Trial name
- DECRISS (NCT04742764)
- Testing
- Standard medical therapy, Standard medical therapy plus cytokine removal treatment using Cytosorb, with the adsorber changed in every 12 hours, Standard medical therapy plus cytokine removal treatment using Cytosorb, with the adsorber changed in every 24 hours
- Where
- Hungary
- Volunteers
- 135 people
- Sponsor
- University of Pecs
Gingivitis Infection
Chlorhexidine (CHX) Mouthwash With or Without an Anti-Discoloration System (ADS) During Experimental Gingivitis
Recently, a chlorhexidine product with an anti-discoloration system (ADS) was launched in the market. A comparative study was done to confirm the effectiveness of 0.2% chlorhexidine with ADS. The study was single-blinded.
- Trial name
- NCT07696364
- Testing
- Experimental gingivitis model
- Where
- Switzerland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Bern
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.