Clinical trials: Septic
Sepsis, Septic Shock
Treatment of Severe Infection With Antihyperlipidemia Drug
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors increase LDL receptors by decreasing its degradation. In sepsis the pathogenic substances, endotoxin, lipoteichoic acid, phospholipomannan are the main cause of the…
- Trial name
- NCT03634293
- Testing
- Alirocumab Injectable Product, Saline Solution
- Where
- Israel
- Volunteers
- 712 people
- Sponsor
- Wolfson Medical Center
Septic Shock
Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study
The purpose of this study is to reveal if higher doses of vasopressors in septic shock patients correlates with cerebral vasoconstriction and lower cerebral oximetry.
- Trial name
- CONSCIOUS (NCT02237833)
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Karl-Andre Wian
Toxic Shock Syndrome, Vaccination; Sepsis
rTSST-1 Variant Vaccine Phase 1 First-in-man Trail
Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- rTSST-1 (NCT02340338)
- Testing
- rTSST-1 Variant Candidate Vaccine
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH
Sepsis
Can Respiratory Rate Predict the Risk of Deterioration of Septic Patients
The primary objective is to determine if the trend in Respiratory Rate measurements provided by the device under investigation can be used to predict an increase in Sequential/Sepsis-related Organ Failure Assessment (SOFA) score.
- Trial name
- NCT03752047
- Where
- Denmark
- Volunteers
- 132 people
- Sponsor
- PMD Solutions
Septic Shock
Expression of Protein Tyrosine Phosphatase 1B (PTP1B) and Body Composition Modification in Patients With Septic Shock
With a prevalence of more than 15% in ICU, septic shock today represents a real public health problem and remains the leading cause of mortality in ICU.
- Trial name
- Coc-SEPP1B (NCT03189355)
- Testing
- Blood sampling, Bioelectrical impedance vector analysis, Muscular echography
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Rouen
Septic Shock
Evaluation of Early Administration of Levetiracetam in the Prevention and Treatment Encephalopathy in Septic Shock: Randomized, Double-blind, Placebo-controlled Trial
Sepsis-associated encephalopathy is associated with high mortality rates and long-term neuropsychiatric disorders. Currently, there is no specific treatment for sepsis-associated encephalopathy.
- Trial name
- KiSS (NCT06851078)
- Testing
- Levetiracetam IV
- Volunteers
- 280 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Cardiac Output
Milrinone Versus Placebo in Patients With Septic Shock
Sepsis is one of the most serious healthcare problems, worldwide, and financial burdens. The overall mortality of severe sepsis/septic shock was 44.5-52.6%. A common cause of death is refractory shock and multi-organ failure.
- Trial name
- NCT05122884
- Testing
- Milrinone
- Where
- 2 sites in Thailand
- Volunteers
- 64 people
- Sponsor
- Mahidol University
Emergency Surgery
Is TIme From adMission to surgEry an Independent Prognostic Factor for Survival of Patients With Gastro-intestinal Perforation Associated With Septic Shock: (TIME) An Italian Intersocietary Retrospective and Prospective Observational Trial
Gastro-intestinal perforation is a condition that can become life-threatening in case of appearance of systemic symptoms, sepsis-related peripheral hypoperfusion and single or multiple organ failure needing a prompt intervention…
- Trial name
- TIME (NCT04811755)
- Testing
- Surgical timing from ED admission to surgery
- Volunteers
- 3,276 people
- Sponsor
- San Luigi Gonzaga Hospital
Septic Shock
Hemodynamic Impact of Cytosorb and CKRT in Children With Septic Shock
Impact of the hemoadsorption with Cytosorb on hemodynamic in pediatric patients with septic shock: a prospectic pediatric pilot study
- Trial name
- PedCyto (NCT05658588)
- Testing
- Cytosorb
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Ospedale Pediatrico Bambin Gesù
Sepsis, Severe Sepsis
Endothelium in Severe Sepsis
The overall hypotheses of this project is that severe sepsis is associated with endothelial dysfunction; that endothelial dysfunction, in turn, is predictive of subsequent organ failure and death; and that protocolized…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT00793442
- Testing
- Blood Collection and Assays
- Where
- 7 sites in United States
- Volunteers
- 910 people
- Sponsor
- Beth Israel Deaconess Medical Center
Septic Shock
Effect of Shenfu Injection on the Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective single-center clinical trial aims to evaluate the circulatory and microcirculatory effects of Shenfu Injection in patients with septic shock.
- Trial name
- NCT07603024
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Severe Sepsis or Septic Shock (ICD-10-GM, R65.0, R65.1)
Jena Sepsis Registry
Despite the burden of severe sepsis and septic shock deficiencies in the quality of sepsis management are recognized. Investigators present a population-based registry with easy feasibility as part of German Center for Sepsis…
- Trial name
- JenaSepsisReg (NCT02165501)
- Where
- Germany
- Volunteers
- 1,995 people
- Sponsor
- University of Jena
Septic Shock
Simultaneously Using Traditional Chinese Medicine (Si-Ni-Tang) to Treat Septic Shock Patients
The purpose of this study is to determine whether simultaneously using the traditional Chinese medicine, Si-Ni-Tang, is more effective in the treatment of septic shock patients.
- Trial name
- NCT01223430
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Changhua Christian Hospital
Septic Shock
Extracorporal Cytokin Removal in Septic Shock: a Prospective, Randomized, Multicenter Clinical Trial
Sepsis and septic shock have mortality rates between 20-50%. When standard therapeutic measures fail to improve patients' condition, additional therapeutic alternatives are applied to reduce morbidity and mortality.
- Trial name
- DECRISS (NCT04742764)
- Testing
- Standard medical therapy, Standard medical therapy plus cytokine removal treatment using Cytosorb, with the adsorber changed in every 12 hours, Standard medical therapy plus cytokine removal treatment using Cytosorb, with the adsorber changed in every 24 hours
- Where
- Hungary
- Volunteers
- 135 people
- Sponsor
- University of Pecs
Sepsis
Effects of Dietary Fiber on Bone Metabolism
Clinical and animal studies have found that sepsis can lead to a serious imbalance in the gut microecology, a reduction in probiotics, a reduction in short-chain fatty acid, a reduction in bone mass, and an increase in bone…
- Trial name
- NCT05623098
- Testing
- dietary fiber nutrients
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Zhujiang Hospital
Renal Failure
Evaluation of Renal Protection Of Dexmedetomidine Versus Midazolam As a Sedative For Septic Patients In Intensive Care Unit
Evaluation of Renal Protection Of Dexmedetomidine Versus Midazolam As a Sedative For Septic Patients In Intensive Care Unit
- Trial name
- NCT05903963
- Testing
- Midazolam, dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Sepsis, Infection
BLOOM: Pragmatic Feasibility Trial
The goal of this study is to compare two different ways of dosing cefepime, an antibiotic for very sick patients - the usual approach to dosing or a new dosing method.
- Trial name
- NCT07287332
- Testing
- Up-front individualized dosing algorithm, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Patients With Septic Shock, Surgical Patients
Dobutamine for Management of Surgical Patients With Septic Shock
Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure, despite lots of intravenous fluids. The incidence of septic shock related cardiomyopathy was 10% to 70%.
- Conditions
- Patients With Septic Shock, Surgical Patients, General Anesthesia
- Trial name
- NCT06462313
- Testing
- Dobutamine, Norepinephrine
- Where
- China
- Volunteers
- 584 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Sepsis
Evaluating the Efficacy of Channa Striata in Stabilizing eNOS in Patients With Septic.
Sepsis is an inflammation response produced by the host's immune system, which is agrravated by oxidative stress. One of the adjuvant therapy according to Surviving Sepsis Campaign Guideline is albumin, which has…
- Trial name
- NCT05596942
- Testing
- Albumin Channa Striata Extract
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Sebelas Maret
Joint Effusion
Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis
To study the diagnostic performance of infrared spectroscopy on fresh synovial fluids in early septic arthritis diagnosis in patients with acute joint effusion
- Trial name
- SYNOFRESH (NCT04004962)
- Testing
- Infrared spectroscopy
- Where
- 6 sites in France
- Volunteers
- 360 people
- Sponsor
- Rennes University Hospital
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