Clinical trials: Septic
Fungal Infection
The PK/PD of Deoxycholic Acid Amphotericin B in Invasive Fungal Infection Patients With Sepsis/Septic Shock
To explore the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis/septic shock;To compare the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis and septic…
- Trial name
- NCT05642624
- Testing
- Deoxycholic acid amphotericin B
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China
Septic Abortion
Clindamycin Once a Day in Septic Abortion
Septic abortion is a serious condition. Women with septic abortion are treated with clindamycin plus gentamicin using divided doses, i.e., thrice a day.
- Trial name
- CLINDA-PRO (NCT02309346)
- Testing
- Clindamycin
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Kidney Injury Due to Sepsis
Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy With oXiris Membrane
The new adsorbing membrane for continuous renal replacement therapy (CRRT), oXiris, can reduce plasma cytokines and endotoxins in septic shock patients with severe acute kidney injury, compared with standard membranes.
- Trial name
- HISTORIX (NCT05575024)
- Testing
- oXiris membrane, Polysulfone membrane
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Seoul National University Hospital
Septic Shock, Severe Sepsis
Echocardiography in Septic Shock
BACKGROUND: Echocardiography can provide evaluation of right or left ventricular dysfunction and volume status during resuscitation of patients with sepsis and septic shock and guide intravenous vasopressor and fluid therapy.
- Trial name
- NCT02135796
- Testing
- Echocardiography
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Intermountain Health Care, Inc.
Septic Shock
Cytokine Response in Septic Shock
This study is designed to examine the early sequential cytokine responses during antibiotic therapy and resuscitation of septic shock in relation to clinical manifestations of disease.
- Trial name
- NCT01770457
- Where
- Canada
- Volunteers
- 325 people
- Sponsor
- University of Manitoba
Shock, Septic, Sepsis
Balanced Salt Solution VS. Normal Saline Solution in Septic Shock
The Purpose of this study is to determine the impact of balanced salt solution versus chloride rich solution on clinical outcomes in paediatric severe sepsis or septic shock
- Trial name
- NCT02336620
- Testing
- Ringer acetate, Normal saline
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Septic Patients
Effects on Septic Patient's Microcirculation of the Transfusion of Different Types of Concentrated RBCs.
Aim of the study is to evaluate the effects, on microcirculation of septic patient, of three types of RBCs: 1- fresh standard RBCs (storage <10 days); 2-leukodepleted RBCs and 3-old standard RBCs (storage >15 days) respectively.
- Trial name
- NCT01584999
- Testing
- Blood transfusion
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Politecnica delle Marche
Septic Shock
The Pharmacokinetics/Pharmacodynamics of High-dose Daptomycin in Patients With Septic Shock
The first objective of this study was to characterize the pharmacokinetics and pharmacodynamics of daptomycin with a daily dose of 12mg/kg in septic shock patient; the second objective is to identify the optimal dosing scheme for…
- Trial name
- NCT02508350
- Testing
- Daptomycin, determination of plasma concentration
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zhongda Hospital
Sepsis, Critical Illness
Assessment of the Anti-inflammatory Effect of Heparin Infusion Versus Subcutaneous Injection in Septic Patients
Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), is a common and severe complication of critical illness.
- Trial name
- NCT04313790
- Testing
- Heparin Infusion, subcutaneous heparin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Damanhour University
Shock, Septic Shock
Reliability of PVI Changes During Tidal Volume Challenge in ICU Patients
The aim of this study is to assess whether changes in the plethysmography variability index, during a tidal volume challenge, can reliably detect simultaneous changes in arterial blood pressure pulsatility, in patients…
- Conditions
- Shock, Septic Shock, Sepsis, Hemodynamic Instability
- Trial name
- NCT05428423
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Bicetre Hospital
Sepsis, Septic Shock
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
The global burden of sepsis is substantial with an estimated 15 to 19 million cases per year; the vast majority of these cases occur in low income countries.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Fluid Overload
- Trial name
- NCT03335124
- Testing
- Vitamin C, Hydrocortisone, Thiamine
- Where
- Slovenia
- Volunteers
- 5 people
- Sponsor
- University Medical Centre Ljubljana
Septic Encephalopathy, Delirium
Cognitive Processing in Patients Surviving Delirium. Neuropsychological, EEG and Structural Brain Correlates.
The research program explores how delirium influenced brain function in patients surviving delirium and septic encephalopathy from a non neurological specialized ICU cohort from 2013 to 2015 in Rigshospitalet (Glostrup).
- Conditions
- Septic Encephalopathy, Delirium, Sepsis
- Trial name
- NCT03562689
- Testing
- Delirium and with septic encephalopathy.
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Septic Shock
Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock
The aim of this work is to compare two protocols (ketamine-fentanyl-midazolam versus thiopental-fentanyl-midazolam) for induction of anesthesia in patients with septic shock aiming to find the most safe protocol with regards to…
- Trial name
- NCT03104140
- Testing
- Ketamine, Thiopental
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
Septic Shock
Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study
Muscle dysfunction in intensive care units is associated with significant morbidity and mortality. During septic shock, there is an increased catabolism and systemic inflammation resulting in quantitative and qualitative muscle…
- Trial name
- SIMS (NCT07483710)
- Testing
- Evaluation of muscle dysfunction in intensive care units for septic schock patients
- Where
- 4 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sepsis, Septic Shock
Dose-response Study of Arginine Supplementation in Severe Sepsis
Pilot data in patients and data from pig studies indicate that arginine-NO metabolism is impaired in sepsis with changes in splanchnic metabolism and function, and reduced survival at low nitrate levels.
- Trial name
- NCT01775020
- Testing
- L-arginine
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Septic Shock
Survey of Non-resuscitation Fluids in Septic Shock
The objective of this study is to survey the type and the amount of non-resuscitation fluids that patients with septic shock receives during their first 5 days of ICU admission.
- Trial name
- SURF (NCT03438097)
- Where
- 9 sites in Canada, Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Sepsis, Septic Shock
Micro and Macro Circulation in Sepsis
Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link…
- Trial name
- DAISY (NCT05694455)
- Testing
- Starling Stroke Volume (Starling SV)- Passive Leg Raise, Microscan Sublingual Microscopy, Venous Excess Ultrasound Scoring (VExUS)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Sepsis, Severe Sepsis
Subpopulation-Specific Sepsis Identification Using Machine Learning
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a subpopulation-optimized…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03644940
- Testing
- CustomSight
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dascena
Septic Shock
Citrate Versus Heparin Anticoagulation: Effect on Molecules Clearances
Sepsis is responsible for 50% of all acute kidney injury (AKI) in intensive care units (ICUs), contributing greatly to multiple organ dysfunction syndrome (MODS).
- Trial name
- RCA-SHA (NCT01839578)
- Testing
- Anticoagulation to prevent clotting of the extracorporeal circuit. (regional citrate anticoagulation), Anticoagulation to prevent clotting of the extracorporeal circuit (Unfractionated heparin)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Severe Sepsis, Septic Shock
Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock
Severe sepsis and septic shock are diseases of infectious origin with a high risk of death. Antibiotic therapy is mandatory but it is unknown whether one antibiotic alone is sufficient for initial therapy.
- Trial name
- MaxSep (NCT00534287)
- Testing
- meropenem, meropenem, moxifloxacin
- Where
- 52 sites in Germany
- Volunteers
- 600 people
- Sponsor
- Kompetenznetz Sepsis
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