Clinical trials: Septic
Hyperglycemia, Hypotension
Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine
Glycemic imbalances are very common in shock patients admitted to intensive care units. A blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy.
- Conditions
- Hyperglycemia, Hypotension, Shock, Septic
- Trial name
- GALI (NCT04910841)
- Testing
- CGM GUARDIAN 2
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Septic Shock
Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock
To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following levosimendan administration in patients with septic shock.
- Trial name
- NCT02963454
- Testing
- Microdialysis Probe (Muscle microdialysis), Dobutamine, Levosimendan
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- Military Hospital of Tunis
Sepsis, Early Diagnosis
The Biomarker Prediction Model of Septic Risk in Infected Patients
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Sepsis is associated with high mortality because of the complex mechanisms.
- Conditions
- Sepsis, Early Diagnosis, Biomarkers
- Trial name
- NCT05095324
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Ankle Fractures
Prospective Follow-up of the Results of Nail Arthrodesis of the Ankle
The goal of this prospective, single-center observational study is to describe the functional outcome of the surgical procedure in patient who undergone transplanted centromedullary nailing in the septic setting.
- Trial name
- PROCLOU (NCT06338566)
- Testing
- Follow-up
- Volunteers
- 20 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Interstitial Liquid, Septic Shock
Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot Study
Septic shock is a common reason for admission to intensive care units and severe infections are responsible for 6 million deaths a year worldwide.
- Trial name
- INTERSEP (NCT05039151)
- Testing
- interstitial fluid sampling, blood sampling
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Septic Shock, Vasoplegia
Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue
Mortality rates associated septic shock remains unacceptably high, around 20-50%, with refractory hypotension in half of these patients.
- Conditions
- Septic Shock, Vasoplegia, Cirrhosis, Liver, Refractory Shock
- Trial name
- CRuMBS (NCT03120637)
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 111 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Sepsis, Septic Shock
OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study
This study examines how well the Oxiris® hemofilter works over time in adults with septic shock who require continuous kidney support in the intensive care unit (ICU).
- Conditions
- Sepsis, Septic Shock, Blood Purification, Hemoadsorption
- Trial name
- OxiCLEAR (NCT07419802)
- Testing
- AN69-polyethylenimine hemofilter (Oxiris®) used for continuous veno-venous hemofiltration (CVVH)
- Where
- Latvia
- Volunteers
- 29 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Septic Shock, Arterial Pressure
Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock
The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak.
- Conditions
- Septic Shock, Arterial Pressure, Hemodynamics, Mortality
- Trial name
- SEPSISPAM (NCT01149278)
- Testing
- maintain mean arterial pressure between 80-85 mm Hg, maintain mean arterial pressure between 65-70 mm Hg
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Angers
Septic Shock, Sepsis
The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis
This study is an evaluation of the effect of Remote ischemic conditioning on sublingual microcirculation in patients with sepsis.
- Trial name
- NCT04644926
- Testing
- Remote ischemic conditioning
- Where
- Lithuania
- Volunteers
- 26 people
- Sponsor
- Lithuanian University of Health Sciences
Acute Pediatric Septic Hip Infection
Use of Arthroscopy in Treatment of Acute Pediatric Septic Hip Infection
Acute septic hip infection in pediatric population is a true orthopedic surgical emergency that require early diagnosis and prompt management.
- Trial name
- NCT06505720
- Testing
- Arthroscopic management of acute pediatric septic hip infecion, Open debridement of acute pediatric septic hip
- Volunteers
- 62 people
- Sponsor
- Hesham Mohamed Elbaseet
Septic Shock, Acute Kidney Injury
Renin and Renal Biomarker Response to Angiotensin II
Septic shock continues to exert a large economic burden around the world. Several developments have occurred that lead to the current study.
- Trial name
- NCT04558359
- Testing
- Standard of Care, Angiotensin II
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alexander Flannery
Sepsis
Flow Cytometry Analysis of the Reactive Oxygen Species in Immature Granulocytes in Septic Patient
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Early during sepsis course, immature neutrophils could be found in the bloodstream and may be less efficient than mature…
- Trial name
- SEPSIROS (NCT03846596)
- Testing
- Additional blood tube
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Limoges
Pneumonia, Sepsis
Study of Progression of Community Acquired Pneumonia in the Hospital
Pneumonia is a common infectious disease of the lung, often requiring treatment in the hospital. Clinical scoring systems are available, identifying patients not requiring hospitalization.
- Conditions
- Pneumonia, Sepsis, Shock, Septic
- Trial name
- PROGRESS (NCT02782013)
- Where
- 64 sites in Austria, Germany
- Volunteers
- 2,309 people
- Sponsor
- Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps
Septic Shock
Impact of Early Goal-Directed Therapy to Perfusion and Metabolism of Brain
Early goal directed therapy (EGDT) is an effective treatment for patients with septic shock, which is widely used in clinic. Fluid resuscitation can significantly reduce the mortality of patients with septic shock and improve the…
- Trial name
- NCT02706379
- Testing
- Local cerebral oxygen saturation
- Volunteers
- 26 people
- Sponsor
- Southeast University, China
Neonatal Disease
Analysis of Differential Proteins and Maternal Influencing Factors of Septic Shock in Neonates
1. Explore 32 weeks of premature infants or maternal pregnancy infection of newborn septic shock maternal influence factors. 2. Through maternal blood samples before delivery and labor cord blood sample screening and septic shock…
- Trial name
- NCT06206590
- Testing
- Whole-proteomic assay
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Guangdong Women and Children Hospital
Septic Shock, Sepsis
Ascorbic Acid and Thiamine Effect in Septic Shock
The aim of this study is to evaluate the efficacy of early metabolic resuscitation with combination therapy using vitamin C and thiamine in improving organ function and survival in patients with septic shock.
- Trial name
- ATESS (NCT03756220)
- Testing
- Combination therapy of vitamin C and thiamine, Normal saline solution
- Where
- 6 sites in South Korea
- Volunteers
- 116 people
- Sponsor
- Tae Gun Shin
Critically Ill, Septic Shock
Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS
The purpose of this study is to determine the most suitable dose of Fludrocortisone in reversal of sepsis and shock associated with sepsis in patients who are admitted to the ICU.
- Trial name
- FluDReSS (NCT04494789)
- Testing
- Fludrocortisone Acetate, Standard Therapy
- Where
- 9 sites in Australia
- Volunteers
- 155 people
- Sponsor
- The George Institute
Sepsis
N\L Ratio Versus L\A Ratio as a Predictor of Morbidity and Mortality in Sepsis and Septic Shock
The aim of the study is to compare between neutrophil lymphocyte ratio and lactate albumin ratio as a predictor of morbidity and mortality in sepsis and septic shock patients.
- Trial name
- NCT05825118
- Testing
- Neutrophil/Lymphocyte ratio and lactate/ albumin ratio will be measured in all patients.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Severe, Septic
Effects of Alkaline Phosphatase on Renal Function in Septic Patients
Septic shock is the most common cause of death in patients requiring intensive care. The kidney is one of the first organs to fail, stressing the importance to search for clinical interventions that may protect the kidneys during…
- Conditions
- Severe, Septic, Shock
- Trial name
- NCT00457613
- Testing
- bolus injection, followed by a continuous infusion ( 24 h) (Alkaline phosphatase)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Septic Shock, Vasodilatory Shock
Vasopressin Use in Septic Shock From Türkiye
The goal of this observational study is to examine the early hemodynamic effects and clinical outcomes of vasopressin use in patients with septic shock.
- Conditions
- Septic Shock, Vasodilatory Shock, Critical Illness Sepsis, Severe, Critical Illness
- Trial name
- (VASCO-TURK) (NCT06953297)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Karadeniz Technical University
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