Clinical trials: Septicemic Shock
Shock, Septic
Comparison of Vasopressin and Other Pressors in Septic Shock
The purpose of this study is to compare the classical tactics in the treatment of septic shock (dopamine, noradrenalin and dobutamine) to the use of vasopressin as first choice pressor.
- Trial name
- NCT00269685
- Testing
- vasopressin
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Sepsis, Septic Shock
Prognostic Accuracy of qSOFA, SIRS, and EWSs for In-hospital Mortality in Emergency Department
Early identification of a patient with infection who may develop sepsis is of utmost importance. Unfortunately, this remains elusive because no single clinical measure or test can reflect complex pathophysiological changes in…
- Trial name
- PASSEM (NCT05172479)
- Testing
- Measurement of qSOFA score, Measurement of SIRS criteria, Measurement of NEWS
- Where
- 20 sites in Bahrain, Kuwait and 5 more
- Volunteers
- 3,274 people
- Sponsor
- Aseer Central Hospital
Septic Shock, Tachycardia
Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility
Several data emphasize the relation between tachycardia (>90/min) and high mortality during septic shock. The investigators previously demonstrated the high mortality associated with hypercontractility, tachycardia and the…
- Conditions
- Septic Shock, Tachycardia, Mortality During Septic Shock, Beta-blocker
- Trial name
- HyperBetashock (NCT04748796)
- Testing
- echocardiography, Landiolol
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock, Ascorbic Acid Deficiency
Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.
This is a retrospective chart review that will measure the impact on outcomes in septic shock patients who were resuscitated with a novel combination of medicines called iHAT (intravenous hydrocortisone -ascorbic acid-thiamine).
- Trial name
- NCT03913468
- Testing
- Intravenous Ascorbic Acid
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Wisconsin, Madison
Sepsis, Sepsis, Severe
EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock
This study is designed to improve the outcomes for patients suffering from severe sepsis and septic shock (SS/SS) by decreasing the time from first medical contact to antibiotic administration.
- Conditions
- Sepsis, Sepsis, Severe, Septic Shock
- Trial name
- NCT04134624
- Testing
- Sepsis care bundle
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- HealthPartners Institute
Shock, Septic
Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Prediction of Death at 1 Month Among Patients With Septic Shock
A prognostic score was proposed by the investigative team to predict death at 1 month. This score is based on certain biological markers, scored under emergency conditions in the first 24 hours of routine clinical practice…
- Trial name
- SEPSICOAG (NCT01231672)
- Testing
- Routine biological analyses
- Where
- 7 sites in France
- Volunteers
- 780 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Multiple Organ Failure, Septic Shock
Early Metabolic Resuscitation for Septic Shock
This phase II trial studies how well early metabolic resuscitation therapy works in reducing multi-organ dysfunction in patients with septic shock.
- Conditions
- Multiple Organ Failure, Septic Shock, Severe Sepsis
- Trial name
- NCT03895853
- Testing
- Best Practice, early metabolic resuscitation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Gram Negative Septic Shock
Endotoxin in Gram-negative Septic Shock
The purpose of this observational study is to determine whether endotoxin levels and/or their trends can be considered predictive of morbility or mortality in septic shock caused by gram-negative bacteria, searching also for a…
- Trial name
- NCT01602354
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Sepsis, Septic Shock
Association of EASIX in Sepsis
This prospective study aims to determine the relationship between the EASIX score and mortality and prognosis in sepsis.
- Conditions
- Sepsis, Septic Shock, Septic Syndrome
- Trial name
- NCT06887439
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Severe Sepsis, Septic Shock
Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis
Severe sepsis and septic shock are diseases of infectious origin with a high risk of death. The purpose of this study is to determine whether the intravenous application of selenium (given as sodium-selenite) can reduce mortality…
- Trial name
- SISPCT (NCT00832039)
- Testing
- sodium-selenite, Procalcitonin guided therapy
- Where
- 35 sites in Germany
- Volunteers
- 1,089 people
- Sponsor
- Kompetenznetz Sepsis
Septic Shock
Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock
This study evaluates if improvement of renal resistive index when mean arterial pressure increase (at 65 mmHg to 85 mmHg) in early phase of septic shock is predictive of better renal survival.
- Trial name
- SEPSIR (NCT04281277)
- Testing
- increase of mean arterial pressure at 80-85 mmHg., increase of mean arterial pressure at 65-70 mmHg.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Angers
Septic Shock
ALBumin Italian Outcome Septic Shock-BALANCED Trial (ALBIOSS-BALANCED)
Septic shock is a devastating condition often observed in ICU. It is characterized by pro-inflammatory and immune responses, organ failures, high incidence of AKI and lethality.
- Trial name
- ALBIOSS-BAL (NCT03654001)
- Testing
- Albumin, Balanced
- Where
- 37 sites in Italy
- Volunteers
- 1,319 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sepsis Severe, Septic Shock
Assessment for Implementation Methods in Sepsis
Since the introduction of sepsis bundles, there have been multiple published trials that have demonstrated a consistent, strong association between implementation of sepsis "bundles" (3-hour bundle) and improved survival.
- Trial name
- AIMS (NCT05491941)
- Testing
- Sepsis Bundle
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Rhode Island Hospital
Septic Shock
Therapeutic Plasmaexchange in Early Septic Shock
Sepsis is defined by the occurrence of critical organ dysfunction in the context of infection. Unfortunately, its incidence appears to be rising, and the mortality of septic shock remains extraordinary high (> 60%).
- Trial name
- EXCHANGE (NCT04231994)
- Testing
- TPE
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Septic Shock
Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients
1. Assess the impact of midodrine administration on weaning of IV vasopressors 2. Assess the cost effectiveness of using midodrine in critically ill patients
- Trial name
- NCT03911817
- Testing
- Midodrine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Septic Shock, Calcium Sensing Receptor
Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock
In septic shock, bacterial LPS is able to activate the CaSR of cardiomyocytes inducing their apoptosis in vitro. CaSR activation in monocytes is responsible for activation of the NLRP3 inflammasome and macropinocytosis.
- Conditions
- Septic Shock, Calcium Sensing Receptor, Calcium Phosphate Disorders, Inflammation
- Trial name
- CASRCHOC (NCT06853340)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock
Adjunctive Methylene Blue in Septic Shock
Adjunctive Methylene BLUe in Septic SHock (BLUSH) is a single centre concealed-allocation parallel-group open-label randomized controlled pilot trial to ascertain the feasibility of a trial evaluating the efficacy and safety of…
- Trial name
- BLUSH (NCT06900140)
- Testing
- Methylene Blue, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Shannon M. Fernando
Septic Shock
Hydrocortisone 50 mg Every 6 Hours Compared to Hydrocortisone 300 mg Per Day in Treatment of Septic Shock.
We performed a multicenter, prospective, randomized, double-blind, pilot study in four adult medical intensive care units. Patients presenting septic shock were rapidly administered one of two regimens of hydrocortisone, either a…
- Trial name
- HSHC00582434 (NCT02768740)
- Testing
- Hydrocortisone hemisuccinate
- Volunteers
- 120 people
- Sponsor
- Association Niçoise de Réanimation Médicale
Septic Shock
Citrate Versus Heparin Anticoagulation: Effect on Molecules Clearances
Sepsis is responsible for 50% of all acute kidney injury (AKI) in intensive care units (ICUs), contributing greatly to multiple organ dysfunction syndrome (MODS).
- Trial name
- RCA-SHA (NCT01839578)
- Testing
- Anticoagulation to prevent clotting of the extracorporeal circuit. (regional citrate anticoagulation), Anticoagulation to prevent clotting of the extracorporeal circuit (Unfractionated heparin)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Sepsis
Adjunctive Granisetron Therapy in Patients With Sepsis or Septic Shock
In this prospective, single-center,randomized,controlled,single-blind clinical trial,Patients will be randomly assigned to receive granisetron or placebo for 4 days or until leaving the ICU(death or transfer from ICU to general…
- Trial name
- GRANTISS (NCT03924518)
- Testing
- Granisetron Hydrochloride
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Zhujiang Hospital
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