Clinical trials: Sequelae of Stroke
Stroke Sequelae, Deep Brain Stimulation
Safety and Efficacy Study of Implantable Neuromodulation for Poststroke Hemiplegia
Background: Hemiplegia is a common complication after a stroke. Studies have shown that traditional medical and rehabilitation treatments are not good for improving patients' motor function, deep brain stimulation (DBS) and vagus…
- Conditions
- Stroke Sequelae, Deep Brain Stimulation, Vagus Nerve Stimulation, Motor Recovery
- Trial name
- NCT06121947
- Testing
- The DBS electrodes are implanted into MLR., The electrodes are implanted into the patient's vagus nerve
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Chinese PLA General Hospital
Stroke Sequelae
Telerehabilitation for Post-stroke Patients
In the last few years, there has been an increasing shift towards outpatients setting in the care of patients with stroke. Unfortunately, this led to a high percentage of discharged patients who did not receive an adequate amount…
- Trial name
- NCT04413240
- Testing
- Telerehabilitation, Conventional rehabilitation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Universita di Verona
Cerebrovascular Disorders, Cerebral Stroke
Using Repetitive Transcranial Magnetic Stimulation (rTMS) in the Rehabilitation of Chronic Spatial Neglect After Stroke
Visuospatial neglect is a common neurological symptom which appears following strokes on regions of the right hemisphere of the brain.
- Conditions
- Cerebrovascular Disorders, Cerebral Stroke, VISIO-spatial Neglect, VISUO-spatial Extinction
- Trial name
- NEGLECT (NCT01000103)
- Testing
- Real rTMS
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Stroke Sequelae
Post-stroke Pathway: Analysis and Link With One Year Sequelae in a French Cohort of Stroke Patients
The link between post-stroke pathways and patient sequelae have not yet been clearly defined. The main purpose is to identify the post-stroke life pathways components associated with sequalae at 3 months and 1 year after the…
- Trial name
- PAPASéPA (NCT03865173)
- Testing
- Telephone Interview
- Where
- 13 sites in France
- Volunteers
- 1,138 people
- Sponsor
- University Hospital, Bordeaux
Stroke Sequelae, Massage
Effect of Tecar in Addition of Functional Massage in Post-stroke Spasticity
Spasticity is due to an abnormal processing of a normal input from muscle spindles in the spinal cord.
- Conditions
- Stroke Sequelae, Massage, Spasticity, Muscle, Electrotherapy
- Trial name
- Tecar (NCT04824768)
- Testing
- Tecar Therapy
- Where
- 2 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Universitat Internacional de Catalunya
Stroke, Stroke Sequelae
Efficacy of Rehabilitation Using Action Observation and Muscle Stimulation in Post-stroke Patients.
Stroke is the third most common cause of disability worldwide and leads to upper limb motor disease in more than half of people affected.
- Trial name
- OTHELLO (NCT06055569)
- Testing
- Rehabilitation protocol: AOT+NMES, Rehabilitation protocol: Action Observation Therapy (AOT), Observation of motor-neutral stimuli (MNO)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke Sequelae, Cognitive Impairment
Cognitive Effectiveness of Somatotherapy and Occupational Therapy in Post-Stroke Patients.
The objective of this study was to evaluate the cognitive effectiveness of somatotherapy and occupational therapy in post-stroke patients by measuring their cognitive potential outcomes using the Montreal Cognitive Assessment…
- Trial name
- CESTO (NCT07635069)
- Testing
- Somatotherapy and Occupational Therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Iqra National University
Spasticity as Sequela of Stroke
Spasticity and Treatment Satisfaction Among Stroke Survivors
To investigate, through ethnography, changes in symptom burden and disability and their effects/interference on patient functioning, ability to perform activities of daily living (ADL) and quality of life (QoL) throughout the…
- Trial name
- REBOT (NCT03995524)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Ipsen
Spasticity as Sequela of Stroke
Home Based Electrical Stimulation on Post-stroke Lower Limb Tightness.
Spasticity is a common complication post stroke. Post-stroke spasticity along with weakness and lack of coordination result in gait abnormalities and functional limitations.
- Trial name
- NCT04932668
- Testing
- Feasibility and Impact of Home-based Electrical Stimulation Program
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- University of Malaya
Stroke Sequelae, Spastic Hemiplegia
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex
The purpose of this thesis is to research the effect of oral baclofen treatment and botulinum toxin injection treatments over the electromyographic nociceptive flexor reflex (NFR) threshold in hemiplegic patients with spasticity.
- Trial name
- NCT03860662
- Testing
- Nociceptor flexor reflex, Botox, Baclofen
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Stroke Sequelae
Balance Systems Protocol for Subacute Phase Stroke Patients.
The aim of the study is to evaluate if the application of a protocol focused on the equilibrium systems versus the conventional treatments decreases the time to acquire equilibrium in standing, the risk of falls and favors the…
- Trial name
- BSPStroke (NCT03406026)
- Testing
- Balance System Protocol Stroke, Control Stroke
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Universitat Internacional de Catalunya
Stroke, Brain Ischemia
Use of Minocicline in Patients With Stroke
The investigators will evaluate the National Institute of Health Stroke Scale/Score (NIHSS)in patients with stroke, and then give Minocycline 100mg po every 12 hours or placebo for five days, then perform periodic evaluations to…
- Conditions
- Stroke, Brain Ischemia, Paralysis
- Trial name
- NCT01556802
- Testing
- Minocicline
- Where
- Colombia
- Volunteers
- 134 people
- Sponsor
- Hospital Universitario Hernando Moncaleano Perdomo
Stroke, Stroke, Acute
Data Collection of Patients Admitted to the Stroke Unit
The purpose of this prospective observational study is to create a database in which data will be collected from every patient admitted to the Stroke unit and who has explicitly given his or her informed consent for this data…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- PRODA-STROKE (NCT04956185)
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Ghent
Ischemic Stroke
Stem Cell Infusion in the Treatment of Patients with Neurological Sequelae After Ischemic Stroke
This trial is to investigate the safety and potential therapeutic efficacy of allogeneic administration of umbilical cord-derived MSCs (UC-MSCs) in combination with standard neurological complications after ischemic stroke…
- Trial name
- NCT05292625
- Testing
- UC-MSC infusion via intravenous route, UC-MSC infusion via intrathecal route, standard stroke treatment and rehabilitation therapy
- Where
- Vietnam
- Volunteers
- 48 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Stroke, Acute, Stroke, Ischemic
Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients
Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- NCT05179473
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Stroke Sequelae, Stroke ( 3 Months After Onset)
Clinical Implementation of Multichannel Functional Electrical Stimulation Device for Gait Rehabilitation in Subchronic Stroke: A Feasibility Study
The goal of this interventional study is to evaluate the effect of multichannel functionnal electrical stimulation for subchronic stroke gait rehabilitation.
- Trial name
- NCT07211672
- Testing
- Multichannel functionnal electrical stimulation
- Volunteers
- 5 people
- Sponsor
- TOPMED
Spasticity as Sequela of Stroke
Effects of Dry Needling on Electromyographic Activity and Ultrasonographic Characteristics in Post-Stroke Spasticity
Stroke is a global health problem, with an incidence in Europe of 147/100,000 people per year. It is estimated that 43% of them present spasticity throughout the first year, causing disability, hindering mobility and…
- Trial name
- NCT06017960
- Testing
- Dry needling + usual care
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Universidad de Zaragoza
Stroke, Ischemic, Stroke Hemorrhagic
Radial Extracorporeal Shock Wave Therapy and Visual Feedback Balance Training on Lower Limb Post-Stroke Spasticity, Trunk Performance and Balance:
This study assess the relationship between lower limb spasticity and trunk movements during static and dynamic balance in post-stroke patients who also underwent conventional physical therapy, visual feedback balance training and…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke, Spastic Gait
- Trial name
- NCT05196633
- Testing
- radial extracorporeal shock wave therapy
- Where
- Romania
- Volunteers
- 23 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Spasticity as Sequela of Stroke
Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity
This study aims to evaluate the efficacy of a combined treatment approach for post-stroke upper limb spasticity using phenol neurolysis and botulinum toxin (BoNT).
- Trial name
- NCT07440173
- Testing
- phenol neurolysis, Botulinum Toxin - A injections
- Volunteers
- 60 people
- Sponsor
- Assiut University
Endovascular Thrombectomy, Ischemic Cerebrovascular Accident
A Trial to Assess the Efficacy and Safety of OTR4132-MD in Patients With Acute Ischemic Stroke
The MaTRISS 2 study is a phase 2 randomized, double-blinded and placebo-controlled trial aimed at recruiting 60 subjects (30 placebo and 30 active) from 15 stroke centers in France.
- Trial name
- MATRISS-II (NCT06700824)
- Testing
- OTR4132
- Where
- 15 sites in France
- Volunteers
- 60 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement