Clinical trials: Serrated Lesion
Residual Disease
R0 Resection Rate Between CSP, cEMR and hEMR for 1-2 cm Colorectal SSLs
Colorectal cancer is the most prevalent cancer and the third cancer related death in Taiwan. Adenoma is a precancerous lesion of colorectal cancer.
- Trial name
- NCT05117879
- Testing
- Cold snaring polypectomy/ Cold EMR/Hot EMR
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Colonic Polyp, Colonic Sessile Serrated Lesion
The CARMA Technique Study
Colonoscopic removal of polyps is an important and well-established tool in the prevention of colorectal cancers. However, high polyp recurrence rates after endoscopic resection, with resultant development of interval cancers…
- Trial name
- NCT05099432
- Testing
- CARMA technique
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Colorectal Cancer
Clinical Validation of PolyDeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System. Polydeep Advance 3
This study is a clinical validation of PolyDeep, a computer-aided polyp detection (CADe) and characterization (CADx) system. PolyDeep Advance 3 is a multicentric randomized clinical trial comparing high definition colonoscopy…
- Trial name
- NCT05513261
- Testing
- High definition colonoscopy (standard colonoscopy) in Adenoma Detection Rate, PolyDeep assisted high definition colonoscopy (CAD system) in Adenoma Detection Rate
- Where
- 3 sites in Spain
- Volunteers
- 857 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Artificial Intelligence
Artificial Intelligence (AI) Assisted Real-time Adenoma Detection and Classification During Colonoscopies
This is a pragmatic, double-blind, randomized, controlled trial, to evaluate the effect of implementing a Computer-assisted detection (CADe) system within the routine clinical practice of Canadian healthcare institutions.
- Trial name
- CAG-SIG-AI (NCT05244278)
- Testing
- Medtronic-GI genius (CADe system for detecting colorectal polyps)
- Where
- Canada
- Volunteers
- 1,596 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Neoplasm, Sessile Serrated Lesion
Detection and Characterization of Sessile Serrated Lesions (SSL) of the Right Colon
There are a few studies regarding Sessile Serrated Lesions (SSL). They are recently identified as precancerous lesions. Yet, digestive tract serrated lesions would be part of a new colic carcinogenesis way : the serrated tumor…
- Conditions
- Colorectal Neoplasm, Sessile Serrated Lesion, Neoplasms
- Trial name
- Lesion SSL (NCT02861885)
- Testing
- Chromoendoscopy
- Where
- 6 sites in France
- Volunteers
- 71 people
- Sponsor
- Hospices Civils de Lyon
Sessile Serrated Lesion, CADe
USAGE OF ARITIFICIAL INTELLIGENCE IN AIDING WITH COLONIC SESSILE SERRATED LESIONS DETECTION AND DIAGNOSIS (AI-SSL)
The aim of this study is to is to evaluate if a real-time Computer Aided Detection (CADe) system can help improve the detection of SSL(sessile serrated lesions) versus a conventional colonoscopy (CC) using white light…
- Trial name
- AI-SSLD (NCT07650344)
- Testing
- usage of CADe system
- Where
- 3 sites in Singapore
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- National Healthcare Group, Singapore
Colorectal Neoplasms, Colorectal Polyp
MS Versus NICE for Colorectal Lesions
OBJECTIVE: Our study aimed to compare a recently-developed endoscopic classification with an established one for colorectal lesions in a randomised trial between 2013 and 2015.
- Trial name
- NCT02963207
- Testing
- Modified Sano's classification, NICE classification
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Lyell McEwin Hospital
Peripheral Arterial Disease, Critical Limb Ischemia
Serranator Recoil Study
The study objective is to assess the ability to define and measure post treatment recoil in infrapopliteal arteries. Preliminary evidence as to the differences between serration angioplasty and standard balloon angioplasty as…
- Trial name
- NCT05161039
- Testing
- Serranator, POBA
- Where
- 2 sites in United States, Germany
- Volunteers
- 20 people
- Sponsor
- Cagent Vascular LLC
Colorectal Neoplasms, Colonic Polyps
Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study
This prospective randomized controlled study aims to evaluate the diagnostic accuracy of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for detection and optical characterization of…
- Conditions
- Colorectal Neoplasms, Colonic Polyps, Adenoma, Serrated Polyps
- Trial name
- INSIGHT (NCT07797361)
- Testing
- White Light Endoscopy, Versatile Intelligent Staining Technology, Spectral Flexible Imaging
- Where
- Brazil
- Volunteers
- 990 people
- Sponsor
- Alexandre Vontobel Padoin
Colon Adenomas, Colon Polyps
Impact of Computer-aided Detection System on the Right Colon Adenoma Miss Rate
This is a prospective, multicenter randomized controlled trial designed to determine whether the use of computer-aided detection system could reduce the miss rates of adenomas, SSLs, and polyps in the proximal colon during tandem…
- Conditions
- Colon Adenomas, Colon Polyps, Sessile Serrated Lesion
- Trial name
- NCT07308743
- Testing
- Computer-aided detection-assisted colonoscopy, Conventional white-light colonoscopy
- Where
- China
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Colon Cancer
Narrow-Band Imaging Versus Standard White Light for the Detection of Serrated Lesions in the Proximal Colon
This is a study to determine if using Narrow-Band Imaging of the colon, rather than the usual white light on the colon, will improve the detection of a type of polyp called serrated.
- Trial name
- NCT01572428
- Testing
- Inspection with Narrow-Band Imaging(NBI), Standard White Light
- Where
- United States
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colorectal Cancer, Colon Adenoma
Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay
The primary aim of this study is to determine the rate of total metachronous advanced neoplasia (TMAN) detection after index detection of serrated lesions (SL) [sessile serrated polyps (SSPs), traditional serrated adenomas…
- Trial name
- SSL follow-up (NCT05355363)
- Testing
- Standard Colonoscopy
- Where
- Canada
- Volunteers
- 727 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Sessile Serrated Lesion
EMR Versus CSP in the Treatment of Sessile Serrated Lesions Less Than 10mm in Size
A prospective, single-center, open-label, randomized controlled study to compare the effectiveness and safety of endoscopic mucosal resection (EMR) and cold snare polypectomy (CSP) in treating colorectal sessile serrated lesions…
- Trial name
- NCT06609031
- Testing
- endoscopic mucosal resection, Cold snare polypectomy
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Fudan University
Colorectal Sessile Serrated Lesion
Narrow Band Imaging Versus White Light for the Detection and Miss of Sessile Serrated Lesion
Narrow band imaging(NBI) could improve the detection of colorectal lesions, previous investigations demonstrated its potential in detecting not only colorectal adenoma but non-adenomatous polyps, including sessile serrated…
- Trial name
- NCT05684328
- Testing
- WLI Then NBI Withdrawal, NBI Then WLI Withdrawal
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Changhai Hospital
Sessile Serrated Lesion, Serrated Polyp
Study on the Association Between Serrated Polyps and Metachronous Advanced Colorectal Neoplastic Lesions
This study aims to explore the risk factors associated with the development of ACN and same-site ACN in patients with SP, thereby informing the optimization of clinical surveillance strategies
- Trial name
- NCT07678788
- Volunteers
- 750 people
- Sponsor
- Changhai Hospital
Colorectal Adenoma, Sessile Serrated Lesion
Evaluation of 'WAYMED Endo CL CS' for Automated Detection and Diagnosis of Colorectal Adenoma and Non-Adenoma Lesions
The purpose of this clinical trial is to evaluate the effectiveness of the computer-aided diagnosis (CADx) software, 'WAYMED endo CL CS', which assists medical specialists by automatically analyzing colorectal endoscopic images…
- Conditions
- Colorectal Adenoma, Sessile Serrated Lesion, Hyperplastic Polyp, Carcinoma
- Trial name
- NCT07470827
- Testing
- WAYMED endo CL CS, Reference standard review
- Where
- South Korea
- Volunteers
- 1,178 people
- Sponsor
- WAYCEN Inc
Polyposis
Endocuff for Surveillance of Serrated Polyposis Syndrome
Serrated Polyposis Syndrome (SPS) is a high-risk condition for colorectal cancer (CRC). SPS patients have a cumulative CRC risk of 1.9% in 5 years despite a strict endoscopic surveillance in specialized centers.
- Trial name
- NCT02592603
- Testing
- Endocuff-assisted Colonoscopy
- Where
- Spain
- Volunteers
- 125 people
- Sponsor
- Hospital Clinic of Barcelona
Colonic Polyp, Colorectal Polyp
COLO-DETECT: Can an Artificial Intelligence Device Increase Detection of Polyps During Colonoscopy?
COLO-DETECT is a clinical trial to evaluate whether an Artificial Intelligence device ("GI Genius", manufactured by Medtronic) can identify more polyps (pre-cancerous growths of the bowel lining) during colonoscopy (large bowel…
- Conditions
- Colonic Polyp, Colorectal Polyp, Colorectal Adenoma, Colorectal Adenomatous Polyp
- Trial name
- NCT04723758
- Testing
- GI Genius-assisted diagnostic colonoscopy, Diagnostic Colonoscopy
- Where
- 10 sites in United Kingdom
- Volunteers
- 2,032 people
- Sponsor
- South Tyneside and Sunderland NHS Foundation Trust
Adenoma Colon, Serrated Polyp
Cold EMR Vs Standard EMR for the Treatment of Large Nonpedunculated Homogeneous Colorectal Lesions
This study compares the effectiveness in complete resection (absence of recurrence at 6 months) the two different techniques for performing endoscopic mucosal resection (EMR) of nonpedunculated homogeneous colorectal lesions >20mm
- Conditions
- Adenoma Colon, Serrated Polyp, Serrated Adenoma, Colorectal Neoplasms
- Trial name
- NCT04418843
- Testing
- Standard Endoscopic Mucosal Resection, Cold Snare Endoscopic Mucosal Resection
- Where
- Spain
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Oscar Nogales
Colon Polyp, Colon Adenoma
Cold Snare Piecemeal Resection vs Cold Snare Endoscopic Mucosal Resection
The study will compare the use of cold snare piecemeal resection (CSPR) vs cold endoscopic mucosal resection (Cold EMR). The study will include two cohorts: one cohort for conventional adenomas 10-19mm in size and one cohort for…
- Conditions
- Colon Polyp, Colon Adenoma, Serrated Polyp
- Trial name
- CARDINAL (NCT06462521)
- Testing
- Cold Snare Piecemeal Resection (CSPR), Cold Snare Endoscopic Mucosal Resection (Cold EMR)
- Where
- 9 sites in United States, Canada
- Volunteers
- 570 people
- Sponsor
- Indiana University