Clinical trials: Sickle Cell Disorders
Sickle Cell Disease and G6PD Deficiency
Screening of Coexistence Between Sickle Cell Anaemia and G6PD Deficiency
G6PD deficiency may have a subtle effect on the severity of hemolysis and also worsen the degree of anaemia in SCD when the two disorders coexist.
- Trial name
- NCT06615024
- Testing
- G6pd enzyme sickling test, G6PD enzyme and sickling test, G6PD enzyme and HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fatma Hussein Mahmoud
Sickle Cell Disease
Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease
The purpose of the study is to Evaluate the Effect of Ticagrelor versus Placebo in Reducing the Rate of Vaso-Occlusive Crises in Paediatric Patients with Sickle Cell Disease
- Trial name
- HESTIA3 (NCT03615924)
- Testing
- Ticagrelor
- Where
- 55 sites in United States, Belgium and 14 more
- Volunteers
- 193 people
- Sponsor
- AstraZeneca
Sickle Cell Disease
Do Alemtuzumab Levels Predict T Cell Chimerism After MSD SCT for SCD?
Rationale: Non-myeloablative allogeneic stem cell transplantation (SCT) has become a feasible curative treatment option for sickle cell disease (SCD) patients with an available matched sibling donor.
- Trial name
- PREDICT (NCT05905770)
- Testing
- Alemtuzumab Injection [Campath]
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sickle Cell Disease, Pain
Psychometric Evaluation of the IPPAQ in Pediatric Patients With Sickle Cell Disease Hospitalized With Vasoocclusive Pain
Historically, sickle cell disease has not been viewed in the chronic pain paradigm because of its recurrent nature. Patients with sickle cell disease may be hospitalized for extended periods of time.
- Trial name
- NCT01058473
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Connecticut Children's Medical Center
Sickle Cell Disease, Zinc Deficiency
Zinc Supplementation in Children With Sickle Cell Disease in Western Kenya
Zinc is a nutritionally essential trace element found in previous studies to reduce growth retardation and improve immune function, which may also result in decreased incidence of infectious diseases including malaria, pneumonia…
- Conditions
- Sickle Cell Disease, Zinc Deficiency, Infection
- Trial name
- NCT03293641
- Testing
- Zinc Sulfate Tablets, Standard of Care
- Volunteers
- 40 people
- Sponsor
- Lucas Otieno Tina, MD MSc
Sickle Cell Disease
Phase 1/2 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HQK-1001 Administered Daily in Patients With Sickle Cell Disease
The purpose of this study is to assess the safety and tolerability of HQK-1001 administered for a total of 12 weeks (with one dosing break) in subjects with sickle cell disease.
- Trial name
- NCT00842088
- Testing
- HQK-1001
- Where
- 9 sites in United States, Jamaica
- Volunteers
- 24 people
- Sponsor
- HemaQuest Pharmaceuticals Inc.
Anemia, Sickle Cell, Chronic Pain
tDCS Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease
So far, no study investigated the safety and efficacy analgesic of transcranial direct current stimulation (tDCS) associated to peripheral electrical stimulation (PES) in individuals with SCD who suffer from chronic pain.
- Trial name
- tDCS/PES_SCD (NCT02813629)
- Testing
- tDCS plus PES
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Faculdade Adventista da Bahia
Sickle Cell Disease
Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease
The purpose of this study is to measure whether PCV21 vaccine (investigational pneumococcal vaccine) is safe and can help the body to develop germ-fighting agents called "antibodies" (immunogenicity) compared with 20vPCV…
- Trial name
- NCT07247188
- Testing
- PCV21, 20vPCV
- Where
- 7 sites in United States, Dominican Republic
- Volunteers
- 100 people
- Sponsor
- Sanofi
Sickle Cell Disease
Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia:
Despite important advances in the current understanding of sickle cell vaso-occlusion, the basis of its control and prevention remain partially unknown.
- Trial name
- STRESS (NCT03368924)
- Testing
- SCA patients (SS genotype)
- Where
- Guadeloupe
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Sickle Cell Disease (SCD)
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
The WeDecide study is a large observational study comparing the long-term effects of matched related donor hematopoietic stem cell transplantation (MRD HCT) and non-transplant disease-modifying therapies (NT-DMT) for pediatric…
- Trial name
- WeDecide (NCT06941389)
- Where
- 37 sites in United States, Canada
- Volunteers
- 480 people
- Sponsor
- University of Rochester
Sickle Cell Disease
Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease
The goal of this study is to evaluate the effects of transauricular vagus and trigeminal nerve stimulation on the treatment of pain in children with Sickle Cell Disease.
- Trial name
- NCT07090668
- Testing
- tAN device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Sickle Cell Disease, Sickle Cell Anemia
Hematopoietic Stem Cell Transplant for Sickle Cell Disease
This is a study of patients with sickle cell disease. It aims to find out if people with sickle cell disease can be cured by changing their immune system before they have blood stem cell transplants.
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, SCD
- Trial name
- NCT02065596
- Testing
- Fludarabine, Hematopoietic Stem Cell Transplant (HSCT)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Case Comprehensive Cancer Center
Sickle Cell Anemia
Pressure Pain Tolerance in Relation to Balance and Strength in Children
Sickle cell disease (SCD) is the most frequent life-threatening genetic hemoglobinopathy in the world and occurs due to the synthesis of abnormal hemoglobin S (HbS).Cells with sickle cell hemoglobin are stiff and sticky.
- Trial name
- NCT06529874
- Testing
- Pressure pain tolerance measurement using Digital Pressure Algometer, Balance assessment using HUMAC balance system, Lower limb muscular strength using Lafayette hand held dynamometer
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Adly A Adam
Sickle Cell Disease, Pain Crisis Recurrent
Effectiveness of Laying-on-of-hands for Sickle Cell Disease
The objective of this study is to evaluate the effectiveness of 1-year administration of laying-on-of-hands on the morbidity and mortality of patients with sickle cell disease in Africa.
- Conditions
- Sickle Cell Disease, Pain Crisis Recurrent, Anemia, Infection
- Trial name
- NCT01518218
- Testing
- laying-on-of-hands
- Where
- Democratic Republic of the Congo
- Volunteers
- 40 people
- Sponsor
- MOA Health Science Foundation
Neutropenia, Sickle Cell Disease
Decitabine for High-Risk Sickle Cell Disease
Background: In sickle cell disease (SCD), the proteins in the red blood cells that carry oxygen do not behave normally. In parts of the body where there are low levels of oxygen or where oxygen is used more, the sickle hemoglobin…
- Trial name
- NCT01375608
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease
iCanCope With Sickle Cell Pain
The project will test a tailored web and smartphone-based application (iCanCope with SCD) to improve pain self-management and functioning in youth (aged 12-18) with sickle cell disease.
- Trial name
- NCT03201874
- Testing
- Pain self-management, Education
- Where
- 4 sites in United States, Canada
- Volunteers
- 137 people
- Sponsor
- Seattle Children's Hospital
Sickle Cell Disease
A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)
The primary objective of the 1701-202 STRONG SCD study is to evaluate the safety and tolerability of different dose levels of IW-1701 compared with placebo when administered daily for approximately 12 weeks to patients with…
- Trial name
- STRONG SCD (NCT03285178)
- Testing
- IW-1701
- Where
- 37 sites in United States, Lebanon and 1 more
- Volunteers
- 88 people
- Sponsor
- Cyclerion Therapeutics
Sickle Cell Disease
Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical Care
Background: Sickle cell disease (SCD) is caused by a genetic defect that affects how hemoglobin is made. Due to this, people with SCD have abnormally-shaped red blood cells, which can result in poor oxygen transport in the body…
- Trial name
- NCT03167450
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Sickle Cell Disease, Sickle Cell Anemia
Hydroxyurea Optimization Through Precision Study
Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to standard weight-based dosing for…
- Trial name
- HOPS (NCT03789591)
- Testing
- Hydroxyurea
- Where
- 13 sites in United States
- Volunteers
- 104 people
- Sponsor
- Lifespan
Sickle Cell Disease
Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
The goal of this short term prospective Phase II study is to compare the effects of two alternate daily doses of zinc (25 and 40 mg/day) in 34 randomly assigned homozygous Sickle Cell Disease (SCD-SS) patients aged 15-40 years…
- Trial name
- ZnSCD (NCT06260891)
- Testing
- 25 mg/day zinc, 40 mg/day zinc
- Where
- 6 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of California, San Francisco
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