Clinical trials: Smell Disorder
Anosmia, Covid19
Olfactory Disfunction and Co-ultraPEALut
Olfactory dysfunction is common among patients with Corona-Virus-Infection-Disease (COVID)-19, and up to 30% of patients may report persistent disorders of smell or taste as a long-term sequelae.
- Conditions
- Anosmia, Covid19, Hyposmia, Parosmia
- Trial name
- NCT04853836
- Testing
- co-ultraPEALut, Olfactory Rehab, PEA-LUT 1 sachet
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Anosmia
Efficacy of Platelet-rich Plasma in Management of Anosmia
Olfactory dysfunction is a prevalent disorder that affects up to 20% of the general population and has significant effects on a person's quality of life as well as increased morbidity and mortality (Croy I et al., 2014;Nordin S…
- Trial name
- NCT06930248
- Testing
- Platelet rich plasma injection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Amyloidosis, Cardiac Amyloidosis
Study of Olfactory Disorders in Patients With Cardiac Amyloidosis
Amyloidosis is a disease caused by the continuous accumulation of fibrillary proteins in the extracellular matrix causing the architecture of different organs to be disrupted. The prevalence of the disease increases with age.
- Conditions
- Amyloidosis, Cardiac Amyloidosis, Olfactory Loss, Hyposmia
- Trial name
- AMYLODOR (NCT04661800)
- Testing
- Sniffin's stick test
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Olfactory Disorder, COVID-19
Simvastatin Nasal Rinses for the Treatment of COVID-19 Mediated Dysomsia
Olfactory dysfunction (OD) or changes in smell and/or taste is one of the cardinal presenting symptoms of COVID-19. Despite the prevalence of COVID and resultant OD, the pathophysiology of COVID-mediated OD is not fully…
- Trial name
- SimCA (NCT05542095)
- Testing
- Simvastatin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bacterial Vaginoses
Evaluate the Safety of a Single Oral Dose of Solosec™ (Secnidazole) 2g for the Treatment of Adolescent Girls With BV
A multi-center, open-label study to evaluate the treatment of one oral dose of 2g Solosec™ (Secnidazole) in adolescent girls with BV
- Trial name
- NCT03937869
- Testing
- Secnidazole
- Where
- 9 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lupin Research Inc
Type 2 Diabetes Mellitus, Cognitive Impairment
Establish Diagnostic Models Based on Olfactory Function and Odor-induced Brain Activation for Diabetes-Related Cognitive Impairment
This is a cross-sectional and longitudinal study to establish diagnostic models based on olfactory function assessments and odor-induced brain activation for cognitive impairment in patients with type 2 diabetes mellitus.
- Trial name
- NCT05543967
- Testing
- Cognitive assessments, Olfactory function measurements, Functional magnetic resonance imaging
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Obesity & Overweight, Insulin Resistance Syndrome
SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level
This single-center, randomized, single-blind, 2-period crossover interventional study will evaluate whether exposure to a pleasant food odor 10 minutes before a 75 g oral glucose tolerance test (OGTT) modifies glucose homeostasis…
- Trial name
- SENSILNS (NCT07638111)
- Testing
- Pleasant Food Odor Stimulation, Control Environmental Condition
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Neurotoxic Effect of Sevoflurane-Based Anaesthesia
Evaluation of Neurotoxic Effect of Sevoflurane-Based AnaesthesiaGuided by Short-Term Olfactory Identification
Nowadays there is increasing doubts about the safety of anesthesia . Anesthesiologists have to console the worried patients, who are anxious about the potential risks of anesthetic-induced brain damage, by suggesting that any…
- Trial name
- NCT03726580
- Testing
- Sevoflurane
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Tanta University
Sleep Deprivation
Olfactory Contributions to Sleep-dependent Food Craving
This within-subject experiment uses one night of acute sleep restriction (4h) vs normal sleep (8h) to study state-dependent changes in olfactory processing.
- Trial name
- SDFC (NCT04179838)
- Testing
- Sleep-Deprived, Non-Sleep Deprived
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Anosmia, Skull Base Neoplasms
Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery
The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the…
- Trial name
- NCT05912881
- Testing
- Olfactory training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Anxiety
Essential Oils for Electrocautery
The purpose of this study is to assess whether essential oil aromatherapy could improve or eliminate the smell of burnt flesh from electrocautery and subsequently mitigate patient anxiety and discomfort during dermatologic skin…
- Trial name
- NCT04260867
- Testing
- Essential Oil, No Essential Oil
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Ovarian Cancer
Early Detection of Ovarian Cancer: GC/FT-ICR Mass Spectrometry and Canine Olfaction
RATIONALE: Studying samples of exhaled breath from patients with ovarian epithelial cancer, polycystic ovarian syndrome, or endometriosis and from healthy participants in the laboratory may help doctors identify and learn more…
- Trial name
- NCT00757952
- Testing
- Fourier transform ion cyclotron resonance mass spectrometry, chromatography, diagnostic laboratory biomarker analysis
- Where
- 4 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Pine Street Foundation
Anxiety State, Symptoms and Signs
The Effect of Olfactory Mental Imagery and Cardiovascular Surgery
This study aims to examine the effect of olfactory mental imagery on physiological parameters, anxiety and symptoms after cardiovascular surgery.
- Conditions
- Anxiety State, Symptoms and Signs, Vital Signs
- Trial name
- NCT06221436
- Testing
- Mental Imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Sarcopenic Obesity
Sleep Disturbances and Biomarkers of Sarcopenic OBesity
The general objective of this study is to identify biomarkers of sleep quality, sarcopenia, insulin resistance, oxidative stress and inflammation associated with prefrailty in middle-aged and elderly obese subjects through the…
- Trial name
- SleSOB (NCT03175601)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto di Fisiologia Clinica CNR
Coronavirus Infection, Severe Acute Respiratory Syndrome
Study of the Pathogenesis of Olfactory Disorders in COVID-19
This study is a case-control study to characterize the molecular and cellular anomalies of the olfactory epithelium of COVID-19 patients with isolated anosmia, by comparison with the olfactory epithelium of non-infected subjects.
- Conditions
- Coronavirus Infection, Severe Acute Respiratory Syndrome, Sars-CoV2
- Trial name
- COVIDSMELL (NCT04366934)
- Testing
- Nasal swab, Taste and olfactory function evaluation
- Where
- 2 sites in France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Preterm, Infant, Premature, Diseases
The Effect of Lullaby and Breastmilk Smell on Preterm Newborns
The goal of this clinical trial is to investigate the effect of live lullaby from mother voice, and breast milk smell on pyhsiological parameters, comfort and maternal attachment levels of preterm newborns who are between 35-37…
- Conditions
- Preterm, Infant, Premature, Diseases, Postpartum Depression, Mother-Infant Interaction
- Trial name
- NCT05830955
- Testing
- Lullaby group, Breast milk group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Bipolar Disorder
OLFACTION AND BIPOLAR DISODER
To compare olfactory performance between patients with BD and HC and correlate their performances to neuroimaging data
- Trial name
- OLF-BP (NCT06809881)
- Testing
- olfactory testing, MRI acquisition, clinical assessment
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
SARS-CoV Infection, COVID-19
Malaysian COVID-19 Anosmia Study (Phase 2) - A Nationwide Multicentre Case-Control Study
The Malaysian COVID-19 Anosmia Study is a nationwide multicentre observational study to investigate the prevalence and characteristics of olfactory and gustatory/taste disturbances in COVID-19 infection in Malaysia, and to…
- Conditions
- SARS-CoV Infection, COVID-19, Anosmia, Dysgeusia
- Trial name
- NCT04384042
- Testing
- Patient-Reported Online Questionnaire on Olfactory & Taste Disturbances
- Where
- 14 sites in Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Sultanah Bahiyah
Stress, Anxiety
The Effects of Smell on Mood and Physical Responses
The purpose of this study is to examine the body's response to relaxing and stimulating fragrances commonly used in aromatherapy.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT00097253
- Testing
- Exposure to relaxant and stimulant odors
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Obesity, Overweight
The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior
The goal of this study is to explore whether of GLP-1 receptor agonist use is associated with differences in taste, smell, food preferences, appetite, food cravings, and responses to food cues in adults.
- Conditions
- Obesity, Overweight, Taste Perception, Olfaction
- Trial name
- NCT07611201
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Purdue University