Clinical trials: Sperm
DNA Damage, DNA Strand Breaks
Comparison of Two Different Sperm Processing Methods and Their Effects on Sperm DNA Fragmentation and Embryo Development
The goal of this clinical trial is to learn if the LensHooke CA0 device lowers DNA fragmentation in sperm samples compared to a gradient/swim-up technique. The main questions it aims to answer are: 1.
- Conditions
- DNA Damage, DNA Strand Breaks, Sperm DNA Fragmentation
- Trial name
- NCT06990841
- Testing
- sperm separation device
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Richard Kordus, PhD, HCLD (ABB)
Male Infertility, Low Sperm Quality
A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Male Fertility
This study will evaluate the effects of the WeNatal For Him supplement on markers of male fertility over a 3-month period. The trial is a single-arm, unblinded study enrolling 40 male participants who will take 3 capsules of the…
- Conditions
- Male Infertility, Low Sperm Quality, Low Testosterone, Low Energy
- Trial name
- NCT07740161
- Testing
- WeNatal For Him Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- WeNatal
Sperm DNA Fragmentation, Sperm DNA Impact on ART Outcomes
Clinical Thresholds of Double-strand Breaks in Sperm's DNA in ART
The goal of this prospective observational study is to learn about the impact of double-strand sperm DNA fragmentation (dsSDF) on assisted reproductive technology (ART) outcomes and to derive clinically relevant threshold values…
- Trial name
- DSBs (NCT07621991)
- Testing
- LensHooke X12 Device
- Where
- 2 sites in India
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
Obesity-related Poor Sperm Quality, Gut Microbiota
Effects of Soluble Fiber Supplements on Sperm Quality in Males With Obesity: a Randomized Trial
Obesity-related poor sperm quality is a significant public health issue, acting as a major contributor to male infertility. Dietary intervention has emerged as an effective strategy to manage obesity and improve sperm quality.
- Trial name
- NCT07112248
- Testing
- inulin
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Severe Oligoasthenoteratozoospermia, Sperm Quality
PRP Improves Blastocyst Formation in ICSI Cycles
The goal of this clinical trial is to learn if platelet rich plasma (PRP) works to improve embryo development rates and embryo quality in IVF cycles, involving male adult patients with severe sperm disorders.
- Conditions
- Severe Oligoasthenoteratozoospermia, Sperm Quality, Spermatazoa Disorders, Sperm Parameters in Fertile and Infertile Men
- Trial name
- PRP ICSI SOAT (NCT07579858)
- Testing
- Platelet Rich Plasma
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stella Maris Women and Children Hospital
ICSI, Testicular Sperm Extraction in Azoospermic Patients
Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential
This study aims to investigate the effectiveness and safety of assisted oocyte activation (AOA) using Ca²⁺ ionophores in cases of total fertilization failure (TFF) due to oocyte activation deficiency (OAD).
- Conditions
- ICSI, Testicular Sperm Extraction in Azoospermic Patients, Male Infertility, PGT-A
- Trial name
- (Ca²⁺) (NCT07570342)
- Testing
- Group 1: Oocyte Activation (OA) CultActive, Group 2: Oocyte Activation (OA) Ionomycin, Group 3: Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Sperm Cryodamage
Effect of PRP in Donor Semen During Cryoprervation
Sperm cryopreservation allows the preservation of sperm biological function for long periods of time for later use in assisted reproductive techniques (ART).
- Trial name
- PRP (NCT07504575)
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI Alicante
Male Contraception, Semen Volume
Effects of NLS-133, a Potential Non-Hormonal "On-Demand" Male Contraceptive
NLS-133-CLIN001 is a Phase 2a study designed to assess the safety, tolerability, and effects of NLS-133 (combination of two FDA-approved agents) compared to an active control (FDA-approved pharmacologic agent) or placebo on semen…
- Conditions
- Male Contraception, Semen Volume, Sperm Motility
- Trial name
- NCT07393334
- Testing
- NLS-133, Active Comparator #1
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Next Life Sciences
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sperm DNA Fragmentation, Infertility, Male
Impact of Escitalopram on Sperm DNA Fragmentation
Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation.
- Trial name
- NCT03527043
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Oligospermia, Sperm Count, Low
Creatine and Ubiquinol for Sperm Quality
This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men.
- Trial name
- CRESPAQ10 (NCT06202469)
- Testing
- Supplement 1, Supplement 2
- Where
- Serbia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Sperm Capacitation
Capacitation-associated Protein Tyrosine Phosphorylation As a Possible Biomarker of Sperm Selection
Sperm undergo complex selection processes and physiological changes as they move through the female reproductive tract. Ejaculated-sperm must undergo a set of molecular and biochemical changes globally named as capacitation in…
- Trial name
- FOSFOTIR (NCT04962100)
- Testing
- Analysis of capacitation-associated tyrosine phosphorylation in human sperm by flow cytometry
- Where
- Spain
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Sperm Classification
Sperm Video Recording Protocol
The purpose of this study is to obtain anonymous video clips of male semen at high magnification, to manually select out of the video spermatozoon images, and to manually classify their morphology by qualified embryologists based…
- Trial name
- NCT06150846
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- BAIBYS Fertility
Sperm Quality, Obesity
Obesity With Sperm Quality in Men With Fertility Need
This study aims to investigate the impact of different types of obesity on sperm quality. Participants will be divided into three groups: a normal BMI group, an obese group without pudendal fat wrapping the testicles, and an…
- Conditions
- Sperm Quality, Obesity, Sex Hormones, Visceral Fat
- Trial name
- NCT06353880
- Testing
- Participants will be categorized into three groups based on BMI and the presence of pudendal fat deposition.
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yu xiaowei
Autologous Platelet-rich Plasma Supplement, Sperm Cryopreservation
The Effects of Autologous Platelet-rich Plasma Supplement During Sperm Cryopreservation on Post-cryopreserved Sperm Quality
Sperm cryopreservation is an essential procedure for male fertility in certain situations, like cancer, vasectomy or other obstructive surgeries, autoimmunity diseases, immunosuppressive therapeutic strategies, or when the male…
- Conditions
- Autologous Platelet-rich Plasma Supplement, Sperm Cryopreservation, Post-cryopreserved Sperm Quality, Semen Analysis
- Trial name
- NCT06258759
- Testing
- autologous platelet-rich plasma supplement, no autologous platelet-rich plasma supplement
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Intracytoplasmic Sperm Injection, Sperm
Sperm Selection by Rheotaxis and Thermotaxis in In-Situ Handmade Microfluidics of Fluidic Walls in the Same ICSI Plate
Microfluidics technologies are proving their capability to select suitable sperm for ICSI, especially those that take advantage of the rheotaxic properties of sperm migration.
- Conditions
- Intracytoplasmic Sperm Injection, Sperm, Microfluidics
- Trial name
- IS-MFluidics (NCT06243926)
- Testing
- Sperm selection for ICSI
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CREA Medicina de la Reproducción SL
to Aid in Sperm Selection for ICSI
User Site Testing Study to Evaluate Usability of the Q300™ Device Under "Real-life Conditions" in a Reproductive Laboratory Environment Use
User Site Testing Study to evaluate usability of the Q300™ device under "real-life conditions" in a reproductive laboratory environment use.
- Trial name
- NCT06232720
- Testing
- Q300 QART Medical
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- QART Medical
Sperm DNA Fragmentation, Male Fertility
Impact of Telomere Biology and Sperm DNA Fragmentation on Embryonic Development
The proposed project we intend to assess the implication of the telomeric pathway in male infertility. To get this, several analyzes will be carried out: 1. Determination of the TL by means of two methods: Q-FISH and PCR. 2.
- Conditions
- Sperm DNA Fragmentation, Male Fertility, Telomeres, Sperm
- Trial name
- NCT05508217
- Where
- Spain
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Sperm Antibodies, Sex Ratio
Effects of Male-specific Antibodies on Sex Ratio
Investigation of the ability of antibodies from vasectomized men in binding to Y-spermatozoa as a possible explanation of the lower sex ratio observed after microinsemination using epididymal sperm from vasectomized men.
- Trial name
- NCT02267252
- Testing
- Antibody-sperm binding
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Intracytoplasmic Sperm Injection, Infertility, Male
Outcome of Using Sperm Bound to the Zona Pellucida of Immature Oocytes for Intracytoplasmic Sperm Injection (ICSI)
In vivo, the zona pellucida (ZP) of the oocyte can bind to normally functional sperm. The ZP-sperm interaction is one of the final steps of natural selection during their journey in the female reproductive tract.
- Trial name
- NCT05724979
- Testing
- ZP-binding
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University