Clinical trials: Spinal
Bulbo-Spinal Atrophy, X-Linked, Kennedy Disease
MRI in Patients With Kennedy Disease
Kennedy disease is an inherited neuromuscular disorder that is characterized by progressive muscle wasting and weakness. It typically starts with muscle spasms and tremors in the arms, followed by muscle weakness and atrophy of…
- Trial name
- NCT02501395
- Testing
- No intervention, observational
- Where
- Denmark
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Vomiting, Nausea
Exteriorized Versus In Situ Uterine Repair at Cesarean Delivery
This study was undertaken to compare the two techniques (exteriorized vs in situ) of uterine repair with respect to patient comfort, hemodynamic changes, surgical time and blood loss, in patients undergoing elective CD under a…
- Conditions
- Vomiting, Nausea, Pain, Hypotension
- Trial name
- NCT00452972
- Testing
- Spinal Anesthesia
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Neural Tube Defects, Folic Acid Deficiency
Using Iodized Salt to Improve Serum Folate, B12 and Iron Levels
Question: How effective is fortified iodized salt in increasing serum concentrations of folate, B12 and iron among non-pregnant and non-lactating women of reproductive age? Hypothesis: Micronutrient fortified iodized salt can…
- Conditions
- Neural Tube Defects, Folic Acid Deficiency, Spina Bifida, Anencephaly-Spina Bifida
- Trial name
- NCT06904612
- Testing
- Micronutrient fortified iodized salt
- Where
- 2 sites in United States, India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hydrocephalus and Neuroscience Institute
Cesarean Section Complications
Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery
This study compared the effects of prophylactic infusion of metaraminol, phenylephrine and norepinephrine adjusted according to body weight on fetal acid-base balance and maternal hemodynamics.
- Trial name
- NCT04991662
- Testing
- metaraminol, Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Parkinson's Disease (PD), Alzheimer's Disease (AD)
Quantification of Hsp90 in the Human Brain
This study tests the radiolabeled molecule ("tracer"), [¹¹C]HSP990, using positron emission tomography (PET) imaging to assess whether it can be used to measure levels of Heat Shock Protein 90 (Hsp90).
- Conditions
- Parkinson's Disease (PD), Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS)
- Trial name
- NCT07380204
- Testing
- [11C]HSP990 PET dosimetry, [11C]HSP990 PET test-retest, [11C]HSP990 simplified scan protocol
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Paraplegia, Spinal, Myelomeningocele
Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions
The purpose of this study is to use functional MRI (fMRI) and magnetic resonance (MR) diffusion tensor imaging (DTI) to investigate brain activation and white matter changes in patients with congenital (birth defect of the spinal…
- Trial name
- NCT01208584
- Testing
- fMRI, DTI
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Degenerative Disease, Fracture
Early Mobilisation in the Surgical Robot Assisted Spinal Surgery
In this study, patients who underwent lumbar spine surgery in our hospital were included. A prospective study was conducted to investigate the effects of early mobilisation on postoperative complications, functual outcomes and…
- Trial name
- NCT04133103
- Testing
- first ambulation at 4 hour after operation
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing Jishuitan Hospital
Ossification Posterior Longitudinal Ligament, Cervical Spondylotic Myelopathy
Comparison of IONM Between Remimazolam and Propofol
Inhalation anesthetics significantly can delay latency and reduce amplitude of cortical MEPs and SSEPs signals compared to intravenous anesthetics by acting on not only GABA (γ-aminobutyric acid) receptors but also NMDA…
- Trial name
- NCT04968054
- Testing
- Arm I (Propofol), Arm II (Remimazolam)
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Psoriasis, Arthritis, Psoriatic
Comparing the Extent to Which Apremilast is Made Available in the Body After Administration as an Extended-release or Immediate-release Formulation
The main objective of this study is to compare the relative bioavailability, safety, and tolerability of extended-release and immediate-release apremilast formulations in healthy participants.
- Conditions
- Psoriasis, Arthritis, Psoriatic, Oral Ulcer
- Trial name
- NCT07908641
- Testing
- Apremilast XR, Apremilast IR
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Amgen
Cervical Spinal Cord Injruy
Improving SCI Rehabilitation Interventions by Retraining the Brain
The Long-term goal of this project is to develop upper limb rehabilitation interventions that can be utilized for cervical Spinal Cord Injury survivors.
- Trial name
- NCT03892746
- Testing
- Active tDCS + task oriented practice
- Where
- 4 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease
Effect of RECK in Posterior Spinal Fusion
"RECK" is a combination of local anesthesia medications, used for the purpose of pain control. RECK is an acronym which stands for Ropivacaine, Epinephrine, Clonidine, and Ketorolac.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Disease
- Trial name
- NCT06447194
- Testing
- Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Amyotrophic Lateral Sclerosis
Bioavailability of GDC-0134 and the Effect of Food and Proton Pump Inhibitor on Pharmacokinetics of GDC-0134 in Healthy Female Participants
This study will evaluate the pharmacokinetics and safety of GDC-0134 in healthy female volunteers of non-childbearing potential.
- Trial name
- NCT03237741
- Testing
- Reference capsule GDC-0134, Prototype capsule GDC-0134, rabeprazole
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Exercise, Low Back Pain
McGill Exercise With and Without 3-dimensional Myofascial Release Technique in Non-specific Low Back Pain
Low back pain is a complex of musculoskeletal disorders or muscular imbalance and one of the most common problems of patients referred to physiotherapy clinics, but still diagnosis and especially the provision of special back…
- Conditions
- Exercise, Low Back Pain, Lumbar, Lordosis
- Trial name
- NCT07441031
- Testing
- McGill exercise with 3 D Myofascial Release., McGill exercise without 3-D MFR
- Where
- Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Spinal Cord Injury(SCI)
The Reversal of Neuromuscular Adaptation in Human With Spinal Cord Injury II
Following injury to the spinal cord, the spinal circuit undergoes a series of adaptations. In parallel with the spinal circuit adaptation, the muscular properties also adapt.
- Trial name
- NCT01968096
- Testing
- home-based ankle continuous passive motion machine.
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Diphtheria, Tetanus
Immunogenicity and Safety of Pentaxim in South African Infants
The present clinical study will assess the immunogenicity and reactogenicity of Aventis Pasteur's DTacP-IPV// PRP~T combined vaccine (Pentavac™ or Pentaxim™) as a three-dose primary vaccination at 6, 10 and 14 weeks of age…
- Conditions
- Diphtheria, Tetanus, Haemophilus Infections, Pertussis
- Trial name
- NCT00254969
- Testing
- Diphtheria, Tetanus, Polio, Acellular Pertussis and Hib
- Where
- South Africa
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Sanofi
Inflammatory Disease, Rheumatoid Arthritis
Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism
It is a prospective follow-up. The aim is to study the maintenance of therapeutic at 10 years and 20 years of inflammatory rheumatism (rheumatoid arthritis and spondyloarthritis)
- Conditions
- Inflammatory Disease, Rheumatoid Arthritis, Spondyloarthritis
- Trial name
- PPCRNice (NCT03076866)
- Testing
- observational follow-up:clinical, radiological et biological
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Degenerated Cervical Spine, Spinal Diseases
Evaluation and Physical Therapy for Patients With Degenerated Cervical Spine
The specific aims are as follows: 1. To investigate the degree of impairment, such as range, proprioception, sensation, and electromyography (EMG) pattern of healthy, older subjects. 2.
- Trial name
- NCT00162890
- Testing
- Therapeutic exercise
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cervical Spinal Cord Plasticity
Cervical Spinal Cord Associative Plasticity
Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the…
- Trial name
- NCT07539025
- Testing
- SCAP, MagPro X100, Digitimer DS8R
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Amyotrophic Lateral Sclerosis
Intermuscular Coherence as a Biomarker for ALS
The specific aims of this study are to: 1. Determine if a painless and quick measurement of muscle activity using surface electrodes can help with the diagnosis of ALS.
- Trial name
- ALS-IMC (NCT05104710)
- Where
- 4 sites in United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Low Back Pain, Lumbago
Home Program Education for Patients With Low Back Pain
The primary purpose of this study is to assess the effect size of the change in Oswestry Disability Questionnaire (ODQ) score over the 8 week follow-up period between the video based instruction or standard of care hand-out with…
- Conditions
- Low Back Pain, Lumbago, Spinal Instability
- Trial name
- NCT02427438
- Testing
- Video, Handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
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