Clinical trials: Spinal Plasticity
Spinal Cord Injuries
Longitudinal Assessment of Spinal Cord Structural Plasticity Using DTI in SCI Patients
This study will apply novel magnetic resonance imaging (MRI) techniques to investigation of spinal cord injury (SCI) to learn how nerve fibers repair and neural cells regain ability to control muscle during the rehabilitation.
- Trial name
- NCT03069222
- Testing
- Standard Rehabilitative Treatment
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Amyotrophic Lateral Sclerosis
Spinal Cord Associative Plasticity for ALS
Veterans are at higher risk than non-Veterans of falling ill with amyotrophic lateral sclerosis (ALS). The investigators have shown that synchronized stimulation over the brain and cervical spinal cord can temporarily strengthen…
- Trial name
- NCT06172621
- Testing
- Spinal Cord Associative Plasticity (SCAP), Upper extremity task-oriented exercise
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development
SCI - Spinal Cord Injury
Vagus Nerve Stimulation (VNS) in Spinal Cord Injury (SCI) Adaptive Follow-On Study
This study is an open label extension of the SCI EFS clinical trial (NCT04288245) that developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury.
- Trial name
- SCI-AFOS (NCT06351111)
- Testing
- Active VNS
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas at Dallas
Orthopedic Disorder of Spine, Neurologic Disorder
A fMRI Study of Compressive Spinal Cord
Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly.
- Trial name
- CSM Plasticity (NCT03504254)
- Testing
- MRI examination
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Cervical Spinal Cord Plasticity
Cervical Spinal Cord Associative Plasticity
Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the…
- Trial name
- NCT07539025
- Testing
- SCAP, MagPro X100, Digitimer DS8R
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Spinal Cord Injuries
BioFLO for Respiratory Recovery in SCI
Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (~15) of breathing low oxygen air to stimulate spinal neuroplasticity.
- Trial name
- NCT06011876
- Testing
- Acute Intermittent Hypoxia (AIH), Acute Intermittent Hypercapnic-Hypoxia (AIHH)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Florida
Spinal Cord Injuries
Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury
Early detection of response to therapeutic intervention is vital, as it will enable early termination of intervention in non-responding patients, prevent unnecessary financial burden, and allow for early changes to the…
- Trial name
- NCT03854214
- Testing
- Functional Electric Stimulation cycling, Passive cycling
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Amyotrophic Lateral Sclerosis
Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is characterized clinically by abnormalities of both upper motor neurons (UMN) and lower motor neurons (LMN). The presence of UMN signs is not always easy to establish.
- Trial name
- NCT01959373
- Testing
- electroencephalograms (EEG), electro-myography (EMG)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Blindness, Cerebrovascular Accident
Mechanisms of Human Plasticity in the Human System
The purpose of this study is to investigate the physiology associated with plasticity of the motor system. Plasticity refers to the process by which neighboring brain cells assume the responsibilities of damaged or diseased brain…
- Conditions
- Blindness, Cerebrovascular Accident, Spinal Cord Injury
- Trial name
- NCT00001661
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries
Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury
While physical exercise remains the foundation for any rehabilitation therapy, the team seeks to improve the benefits of exercise by combining it with the concept of "Fire Together, Wire Together" - when brain stimulation is…
- Trial name
- NCT06104735
- Testing
- Synaptic Pairing Interval, Frequency, Bouts
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Bronx VA Medical Center
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Spinal Cord Injury, Acute
NISCI - Nogo Inhibition in Spinal Cord Injury
The purpose of the NISCI trial is to test if an antibody therapy can improve movement and quality of life of tetraplegic patients. A previous trial showed this treatment is safe and well accepted.
- Trial name
- NISCI (NCT03935321)
- Testing
- NG-101
- Where
- 13 sites in Czechia, Germany and 2 more
- Volunteers
- 129 people
- Sponsor
- University of Zurich
Spinal Cord Injuries
Spinal Cord Stimulation and Training
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of…
- Trial name
- NCT05472584
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Electrophysiology assessment - spinal motoneuron
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Spinal Cord Injury
Effect of Prolonged Electrical Stimulation on Neural Plasticity in Spinal Cord Injury
Electrical stimulation (pulses of electricity applied over the skin of your wrist) and activity-based hand exercise have been shown to improve motor skill and strength in individuals with stroke and have recently been shown to…
- Trial name
- NCT00387673
- Testing
- Somatosensory Stimulation and Massed Practice Training
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Spinocerebellar Ataxias
Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity
Effective walking and balance require not only lower limb muscle strength but also coordinated movement. For individuals with Spinocerebellar Ataxia (SCA), rehabilitation strategies targeting coordination are essential to…
- Trial name
- NCT06600269
- Testing
- Cycling Training
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung University
Spinal Cord Injury, Tetraplegia/Tetraparesis
MEP Up-conditioning to Target Corticospinal Plasticity
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist…
- Trial name
- uMEP2 (NCT06989905)
- Testing
- Up-conditioning of the wrist extensor motor evoked potential
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Urinary Bladder, Neurogenic, Blood Pressure
Recovery of Bladder and Sexual Function After Human Spinal Cord Injury
This study will incorporate critical cross viscero-visceral intersystem interactions to investigate in a controlled laboratory setting the extent, severity, and frequency of occurrence of autonomic dysreflexia with respect to…
- Conditions
- Urinary Bladder, Neurogenic, Blood Pressure, Autonomic Dysreflexia, Bowel Incontinence
- Trial name
- NCT04193709
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Louisville
Neuralgia, Spinal Cord Injuries
Immersive Virtual Reality for Chronic Neuropathic Pain After Spinal Cord Injury: A Feasibility Trial
The aim of this study is to provide critical information about the efficacy of Immersive Virtual Reality (IVR) to decrease the experience of neuropathic pain in the upper and lower extremities of people with a spinal cord injury.
- Conditions
- Neuralgia, Spinal Cord Injuries, Chronic Pain
- Trial name
- NCT04700033
- Testing
- Somatic IVR (sIVR), Distractive IVR (dIVR), Control IVR (cIVR)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injuries, Neurogenic Bladder
Pediatric Locomotor Training Bladder Study
Bladder dysfunction is one of the most important factors influencing duration and quality of life in children with spinal cord injury.
- Trial name
- NCT03559036
- Testing
- Locomotor Training
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Spinal Cord Injury
Enhancing STDP After Spinal Cord Injury
The overall goal is to develop new clinical approaches to restore limb function after spinal cord injury (SCI). Corticospinal tract (CST) axons are involved in controlling limb function.
- Trial name
- NCT02701777
- Testing
- STDP, Training, Multisite-STDP
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development