Clinical trials: Spinal Trauma
Acquired Brain Injury
Effects of Combined Spinal Direct Current Stimulation on Upper Limb Recovery in Acquired Brain Injury
This study will compare different polarities of transcutaneous spinal direct current stimulation combined with robotic-assisted arm training (RAT) in adults with acquired brain injury (ABI).
- Trial name
- NCT03100370
- Testing
- tsDCS-Anodal Stimulation, tsDCS-Cathodal Stimulation, Robotic-assisted training of arm and hand functions
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injury, Autonomic Dysreflexia
The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Dysregulation of blood pressure (BP), secondary to decentralized autonomic nervous system (ANS) control of the cardiovascular system, often results in chronic hypotension and orthostatic hypotension (OH) in persons with spinal…
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Baroreceptor Integrity, Sympathetic Integrity
- Trial name
- NCT02893553
- Testing
- Midodrine Hydrochloride, Pyridostigmine Bromide, Mirabegron
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury at T7-T10 Level, War Injuries Due to Bullets and Fragments
Effects of a Home-Based Rehabilitation on Anthropometric Measures, Sensory-Motor Functions and Independence After Spinal Cord Injury
Background: The scarcity of resources for spinal cord injury (SCI) rehabilitation constitutes a significant obstacle, particularly in war-torn regions experiencing a rise in such injuries.
- Conditions
- Spinal Cord Injury at T7-T10 Level, War Injuries Due to Bullets and Fragments, Spinal Cord Injury L1- L5, Spinal Cord Injury No Sensory/Motor in S4-S5
- Trial name
- HBRSCI (NCT06444672)
- Testing
- Home-based Rehabilitation program, Knee-Ankle-Foot-Orthosis
- Where
- Iraq
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Mosul
Stroke, Able Bodied
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons.
- Trial name
- NCT07401186
- Testing
- Bipolar Neural Stimulation Electrode
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Peter C. Gerszten, MD
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS)
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility…
- Conditions
- Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke
- Trial name
- INTENT (NCT07521930)
- Testing
- INTENT Neural Interface System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Paraplegia, Tetraplegia
Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI
A study comparing short-term delivery of epidural spinal stimulation versus transcutaneous spinal stimulation.
- Conditions
- Paraplegia, Tetraplegia, Paralysis, Quadraplegia
- Trial name
- NCT05095454
- Testing
- Percutaneous epidural electrical spinal stimulation, Transcutaneous electrical spinal stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kristin Zhao, PhD
Spinal Cord Diseases, Spinal Cord Injuries
Multi-speed Ergonomic Wheelchair
Over one million Americans rely on their upper extremities for manual wheelchair propulsion. Shoulder overuse injuries are prevalent among manual wheelchair users and these injuries often result in shoulder pain.
- Trial name
- NCT05776030
- Testing
- Single Speed Ergonomic Wheelchair, Multi-Speed Ergonomic Wheelchair
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Spinal Cord Injuries
Task-oriented Arm/Hand Skill Rehabilitation and Therapy Dose Dimensions in Subacute Spinal Cord Injury Rehabilitation
The study is a multicenter longitudinal observational study. The therapy content and the therapy dosage of arm/skill training for patients with cervical spinal cord injury (SCI) will be observed for the primary objective.
- Trial name
- NCT05452707
- Testing
- Observation and questionnaire of active therapy
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 47 people
- Sponsor
- Hasselt University
Spinal Cord Injuries (SCI), Spinal Cord Injury
Study on Preliminary Safety and Efficacy of Epidural Electrical Stimulation to Manage Lower Urinary Tract Dysfunction After Spinal Cord Injury
This clinical trial aims to assess the preliminary safety and efficacy of Epidural Electrical Stimulation (EES) therapy in managing lower urinary tract dysfunction in individuals with sub-acute or chronic spinal cord injury…
- Trial name
- ReeVoid (NCT06845904)
- Testing
- WaveWriter Alpha™ neurostimulation system
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spinal Cord Injuries, Exercise Training
Effect of Upper-body Rowing on Cardiometabolic Risk in Spinal Cord Injured Wheelchair Users
This randomized controlled trial will determine the effects of 12-weeks of wheelchair user-modified upper-body rowing on both traditional cardiometabolic risk factors in SCI manual wheelchair users.
- Trial name
- NCT04390087
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Spinal Cord Injuries
Cognitive Behavioural Therapy (CBT) For Improving Emotional Well Being in Spinal Cord Injuries (SCI)
The purpose of the study is to determine whether or not a brief psychological treatment called cognitive behaviour therapy will help people who have suffered a spinal cord injury to cope better with their current circumstances.
- Trial name
- CBT (NCT00861393)
- Testing
- CBT, Waitlist CBT
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Toronto Rehabilitation Institute
Spinal Cord Injuries
Efficacy Study of the Music Glove Patients With Spinal Cord Injuries
Investigators are trying to determine the therapeutic effect of the music glove and conventional hand exercise program to patients with spinal cord injuries. All participants will be randomized into two groups: AB and BA.
- Trial name
- NCT02473614
- Testing
- Music Glove, Conventional Hand Exercise Program
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Irvine
Spinal Cord Injury, Tetraplegia
Effects of Exercise in People With Tetraplegia
This study is designed to assess the impact of exercise and supplementation on measures of fitness, function, and cardiovascular disease risk factors/modifiers in individuals with spinal cord injury (SCI).
- Trial name
- NCT01202019
- Testing
- Circuit Resistance Training (CRT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Spinal Cord Injuries, Paralysis
Adipose Stem Cells for Traumatic Spinal Cord Injury
The purpose of this study is to determine if mesenchymal stem cells (MSC) derived from the fat tissue can be safely administered into the cerebrospinal fluid (CSF) of patients with spinal cord injury.
- Trial name
- CELLTOP (NCT03308565)
- Testing
- Autologous, Adipose derived Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mohamad Bydon
Spinal Cord Injury, Acquired Brain Injury
Quality of Life in Adult Neurological Patients
The purposes of this study were to evaluate the influence of an interdisciplinary rehabilitation program in the improvement of the health-related quality of life among adult neurological patients and to identify the…
- Conditions
- Spinal Cord Injury, Acquired Brain Injury, Poliomyelitis
- Trial name
- NCT01573936
- Testing
- Physical therapy, occupational therapy, psycotherapy, medical consultations
- Volunteers
- 70 people
- Sponsor
- Associação de Assistência a Criança Deficiente
Gastrointestinal Disease
The Treatment of Acute Gastrointestinal Injury Via Ultrasound-guided Erector Spinae Plane Block
In this single-center, randomized, parallel control clinical trial, patients will be randomly assigned to two groups. The treatment group receives ultrasound-guided erector spinae plane block with routine treatment of Acute…
- Trial name
- NCT04934904
- Testing
- Ropivacaine injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Spinal Cord Injury
Pilot Study: The Role of Macrophage Migration Inhibitory Factor (MIF) in Spinal Cord Injury
The purpose of the study is to investigate inflammatory and other substances that may be elevated in the blood and blood cells following spinal cord injury (SCI).
- Trial name
- NCT00919581
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Spinal Cord Injuries, Spinal Cord Diseases
Non-Invasive Electrical and Magnetic Neuromodulation in Persons With Chronic Spinal
The objectives of this study are to (1) determine the effects of neuromodulation techniques on mobility in persons with chronic SCI, as measured by subjective and objective measures, and (2) to determine the optimal combination…
- Trial name
- RISES-T2 (NCT05994846)
- Testing
- RISES-T System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Injuries, Spinal Cord
Diaphragm Pacing After Spinal Cord Injury
Respiratory dysfunction is the leading cause of death in individuals with spinal cord injuries (SCIs). Nearly one quarter of all SCI cases involve injury to the upper spinal cord segments which impairs neural activation of the…
- Trial name
- NCT02556125
- Testing
- Diaphragm pacing
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Florida