Clinical trials: Spondylarthropathy
Arthritis, Rheumatoid, Arthritis, Psoriatic
WORKWELL: Testing Work Advice for People With Arthritis
Background: Inflammatory arthritis (IA) causes work disability, absenteeism (sick leave) and presenteeism (reduced productivity) at high cost to individuals, employers and society.
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Arthritis, Inflammatory
- Trial name
- WORKWELL (NCT03942783)
- Testing
- WORKWELL, Control
- Where
- 18 sites in United Kingdom
- Volunteers
- 249 people
- Sponsor
- University of Salford
Ankylosing Spondylitis
A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Ankylosing Spondylitis
This study is to evaluate the efficacy and safety of different doses of JAK1 inhibitor SHR0302 in subjects with active ankylosing spondylitis.
- Trial name
- NCT04481139
- Testing
- SHR0302
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Non-radiographic Spondyloarthritis
Study of Efficacy and Safety of Secukinumab in Patients With Non-radiographic Axial Spondyloarthritis
The purpose of this study was to demonstrate the clinical efficacy, safety and tolerability of secukinumab compared to placebo in patients with nr-axSpA at Week 16 as well as Week 52 and long term efficacy and safety up to Week…
- Trial name
- PREVENT (NCT02696031)
- Testing
- Secukinumab
- Where
- 139 sites in United States, Australia and 22 more
- Volunteers
- 555 people
- Sponsor
- Novartis Pharmaceuticals
Inflammatory Bowel Diseases (IBD), Ankylosing Spondylitis (AS)
The Colonic Microbiome and Mucosal Immunity in Inflammatory Bowel Disease and Ankylosing Spondylitis
This study plans to learn more about the relationship between systemic autoimmune disease, such as inflammatory bowel disease and ankylosing spondyloarthritis, bacteria in the colon, and the changes in colon tissue.
- Trial name
- NCT02389075
- Testing
- Pinch biopsies, Flexible sigmoidoscopy
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Colorado, Denver
Travelers' Diarrhea, Functional Bowel Disorders
Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD
The purpose of this study is to develop evidence on the relative efficacy of 2 rifaximin chemoprophylaxis regimens for the prevention of Travelers' Diarrhea (TD) in a deployed setting.
- Conditions
- Travelers' Diarrhea, Functional Bowel Disorders, Reactive Arthritis
- Trial name
- NCT02498301
- Testing
- Rifaximin
- Where
- 6 sites in United States, Kenya
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Arthritis, Psoriatic, Metabolic Syndrome
The DIET Trial - Dietetic Intervention in Psoriatic Arthritis
Psoriasis (Ps) and psoriatic arthritis (PsA) are associated with increased risk of metabolic syndrome (MetS), body fatness and cardiovascular risk.
- Trial name
- DIET (NCT03142503)
- Testing
- Diet + supplementation
- Volunteers
- 194 people
- Sponsor
- Federal University of São Paulo
Anti - TNF Therapy, Ankylosing Spondylitis
Anti-TNF Therapy and Nerve Conduction Studies in Ankylosing Spondylitis
Patients with ankylosing spondylitis were divided into 2 groups as anti-TNF and conventional therapy according to the treatments they were using for the last 5 years.
- Conditions
- Anti - TNF Therapy, Ankylosing Spondylitis, Neuropathy
- Trial name
- NCT04943237
- Testing
- Anti-TNF agents, Conventional therapy users for the last 5 years
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Psoriasis, Arthritis, Psoriatic
Anti-Carbamylated Protein Antibodies in Psoriatic Arthritis
Anti-carbamylated protein (anti-CarP) antibodies are present in approximately one-fourth of the patients who are seronegative for both rheumatoid factor and anti-citrullinated protein antibody and who may therefore have psoriatic…
- Trial name
- CARPAPA (NCT04173039)
- Testing
- Serum anti-CarP antibodies detection
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Association pour la Recherche Clinique et Immunologique
Axial Spondyloarthritis
Treat to Target Trial in Axial Spondylo Arthritis : The TICOSPA (Tight Control in Spondyloarthritis)
This is a not interventional, pragmatic, prospective, randomized (cluster) study to evaluate the potential benefit of a Treat to Target approach in comparison to routine treatment (i.e.
- Trial name
- TICOSPA (NCT03043846)
- Testing
- Follow-up every 3 months during 1 year (data collection in eCRF), Follow-up every month to follow the pre-defined strategy
- Where
- 18 sites in Belgium, France and 1 more
- Volunteers
- 163 people
- Sponsor
- Association de Recherche Clinique en Rhumatologie
Psoriatic Arthritis
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs
The purpose of this study is to evaluate the efficacy and safety of deucravacitinib versus placebo in participants with active psoriatic arthritis who are naïve to biologic disease-modifying anti-rheumatic drugs.
- Trial name
- NCT04908202
- Testing
- Deucravacitinib
- Where
- 183 sites in United States, Argentina and 19 more
- Volunteers
- 670 people
- Sponsor
- Bristol-Myers Squibb
Psoriatic Arthritis, Spondylitis
Tofacitinib for Reduction of Spinal Inflammation in Patients With Psoriatic ArthritiS PresenTing With Axial InvOlvement
To evaluate the efficacy of Tofacitinib in reducing inflammation in the sacroiliac joints and spine on magnetic resonance imaging (MRI) in patients with active Psoriatic Arthritis (PsA) with axial Involvement (BASDAI [Bath…
- Conditions
- Psoriatic Arthritis, Spondylitis, Sacroilitis
- Trial name
- PASTOR (NCT04062695)
- Testing
- Tofacitinib 5 MG Oral Tablet [Xeljanz]
- Where
- 19 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Ankylosing Spondylitis
Study Evaluating Etanercept in the Treatment of Subjects With Ankylosing Spondylitis
This study will represent the sponsor's first controlled study of etanercept in Chinese subjects with Ankylosing Spondytitis (AS).
- Trial name
- NCT00434044
- Testing
- Enbrel (etanercept)
- Volunteers
- 150 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Psoriatic Arthritis
Extension Study up to 3 Years for Secukinumab in Psoriatic Arthritis
This study was designed as a 3-year extension to the phase III core study CAIN457F2306. It aimed to provide continuous treatment with secukinumab in pre-filled syringes (PFS) for subjects who completed the core study…
- Trial name
- FUTURE 1 ext (NCT01892436)
- Testing
- Secukinumab
- Where
- 94 sites in United States, Argentina and 16 more
- Volunteers
- 460 people
- Sponsor
- Novartis Pharmaceuticals
Psoriatic Arthritis
Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis
The purpose of this study is to determine whether apremilast is safe and effective in the treatment of patients with psoriatic arthritis, specifically in improving signs and symptoms of psoriatic arthritis (tender and swollen…
- Trial name
- PALACE-1 (NCT01172938)
- Testing
- Apremilast 20mg, Apremilast 30mg
- Where
- 92 sites in United States, Australia and 11 more
- Volunteers
- 504 people
- Sponsor
- Amgen
Psoriatic Arthritis
Apremilast in Psoriatic Arthritis in Real-life Clinical Practice in Greece
Following the evidence from the controlled clinical trial setting on the significant clinical benefits of apremilast in the treatment of active PsA, there is a scarcity of real-life evidence on the effectiveness and the…
- Trial name
- APROACH (NCT03780504)
- Where
- Greece
- Volunteers
- 170 people
- Sponsor
- Genesis Pharma S.A.
Ankylosing Spondylitis
The Effects of Postural Changes on Plantar Pressure in Patients With Ankylosing Spondylitis
Ankylosing Spondlitis (AS) is a chronic, rheumatic disease. Foot and ankle involvement may stem from both postural changes in patients seen spinal deformity with the progress of the disease and enthesitis.
- Trial name
- NCT04820725
- Testing
- Plantar pressure and gait
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Arthritis, Psoriatic
A Study to Test Different Doses of BI 730357 and Find Out Whether They Reduce Symptoms in People With Active Psoriatic Arthritis
This study is open to adults with active psoriatic arthritis who have tender and swollen joints. The purpose of this study is to find out whether a medicine called BI 730357 helps to reduce symptoms and to prevent damage to…
- Trial name
- NCT04680676
- Testing
- BI 730357
- Sponsor
- Boehringer Ingelheim
Axial Spondyloarthritis, Ankylosing Spondylitis (AS)
The Disease Progression of Chinese Axial Spondyloarthritis in a Real-word Cohort Study
An observational, ambispective cohort to learn about the disease progression of axial spondyloarthritis (axSpA) according to the changes from baseline in measures of disease activity, function, and imaging.
- Trial name
- DPCASPA (NCT06844643)
- Where
- China
- Volunteers
- 2,250 people
- Sponsor
- China-Japan Friendship Hospital
Ankylosing Spondyloarthritis
Impact of a Gluten-free Diet on Quality of Life in Patients With Axial Spondyloarthritis.
Subclinical intestinal inflammation and gut dysbiosis have been reported in patients with spondyloarthritis (SpA). In common practice, rheumatologists are increasingly confronted with patients with inflammatory rheumatism who are…
- Trial name
- GlutenSPA (NCT04274374)
- Testing
- Gluten-Free Diet, Gluten Diet
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Rheumatoid Arthritis, Psoriatic Arthritis
Do Nanobubbles Improve Joint Hypoxia?
Inflamed joints in patients with rheumatoid arthritis and psoriatic arthritis are characterized by low oxygen levels and inflammation.
- Trial name
- NCT04844008
- Testing
- Nanobubble drink
- Where
- United Kingdom
- Sponsor
- University of Oxford
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